Brahm H. Segal

Departments of Medicine and Immunology, Roswell Park Cancer Institute

Affiliated withRoswell Park Cancer Institute University at Buffalo School of Medicine university of buffalo

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 15	2012
Publication title Cited by 3	2014

Other Publications

Article	Year
Thioglycollate peritonitis in mice lacking C5, 5-lipoxygenase, or p47(phox): complement, leukotrienes, and reactive oxidants in acute inflammation. Journal of leukocyte biology\| PubMed ID: 11867678	2002
Invasive pulmonary filamentous fungal infection in a patient receiving inhaled corticosteroid therapy. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America\| PubMed ID: 12173150	2002
Efficacy of high-efficiency particulate air filtration in preventing aspergillosis in immunocompromised patients with hematologic malignancies. Infection control and hospital epidemiology : the official journal of the Society of Hospital Epidemiologists of America\| PubMed ID: 12269451	2002
Phagocyte NADPH oxidase, but not inducible nitric oxide synthase, is essential for early control of Burkholderia cepacia and chromobacterium violaceum infection in mice. Infection and immunity\| PubMed ID: 12496167	2003
Fungal infections in nontransplant patients with hematologic malignancies. Infectious disease clinics of North America\| PubMed ID: 12512188	2002
Deficiency of NADPH oxidase components p47phox and gp91phox caused granulomatous synovitis and increased connective tissue destruction in experimental arthritis models. The American journal of pathology\| PubMed ID: 14507659	2003
p47phox deficiency impairs NF-kappa B activation and host defense in Pseudomonas pneumonia. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 14734763	2004
Linezolid-resistant Enterococcus faecalis isolated from a cord blood transplant recipient. Journal of clinical microbiology\| PubMed ID: 15071066	2004
Invasive filamentous fungal infections in allogeneic hematopoietic stem cell transplant recipients after recovery from neutropenia: clinical, radiologic, and pathologic characteristics. Mycopathologia\| PubMed ID: 15770441	2005
Posaconazole as salvage therapy in patients with chronic granulomatous disease and invasive filamentous fungal infection. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America\| PubMed ID: 15889369	2005
Long-term use of oral beclomethasone dipropionate for the treatment of gastrointestinal graft-versus-host disease. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation\| PubMed ID: 16041308	2005
Current approaches to diagnosis and treatment of invasive aspergillosis. American journal of respiratory and critical care medicine\| PubMed ID: 16387806	2006
Antibacterial prophylaxis in patients with cancer and neutropenia. The New England journal of medicine\| PubMed ID: 16395832	2006
Immunotherapy for fungal infections. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America\| PubMed ID: 16421795	2006
Effect of amphotericin B and micafungin combination on survival, histopathology, and fungal burden in experimental aspergillosis in the p47phox-/- mouse model of chronic granulomatous diseas... Antimicrobial agents and chemotherapy\| PubMed ID: 16436692	2006
Dapsone-induced methemoglobinemia after hematopoietic stem cell transplantation. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation\| PubMed ID: 16443522	2006
Heat shock proteins as vaccine adjuvants in infections and cancer. Drug discovery today\| PubMed ID: 16713905	2006
Aspergillus fumigatus extract differentially regulates antigen-specific CD4+ and CD8+ T cell responses to promote host immunity. Journal of leukocyte biology\| PubMed ID: 16793916	2006
Review of epidemiology, diagnosis, and treatment of invasive mould infections in allogeneic hematopoietic stem cell transplant recipients. Mycopathologia\| PubMed ID: 16830186	2006
Altered granulopoietic profile and exaggerated acute neutrophilic inflammation in mice with targeted deficiency in the sialyltransferase ST6Gal I. Blood\| PubMed ID: 16849643	2006
Clinical research in the lay press: irresponsible journalism raises a huge dose of doubt. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America\| PubMed ID: 16983616	2006
Issues related to the design and interpretation of clinical trials of salvage therapy for invasive mold infection. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America\| PubMed ID: 17083020	2006
Multicenter, noncomparative study of caspofungin in combination with other antifungals as salvage therapy in adults with invasive aspergillosis. Cancer\| PubMed ID: 17103444	2006
Acid aspiration-induced lung inflammation and injury are exacerbated in NADPH oxidase-deficient mice. American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 17114280	2007
Treatment of invasive aspergillosis with posaconazole in patients who are refractory to or intolerant of conventional therapy: an externally controlled trial. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America\| PubMed ID: 17143808	2007
Prevention and early treatment of invasive fungal infection in patients with cancer and neutropenia and in stem cell transplant recipients in the era of newer broad-spectrum antifungal agent... Clinical infectious diseases : an official publication of the Infectious Diseases Society of America\| PubMed ID: 17205448	2007
Modeling the combination of amphotericin B, micafungin, and nikkomycin Z against Aspergillus fumigatus in vitro using a novel response surface paradigm. Antimicrobial agents and chemotherapy\| PubMed ID: 17325217	2007
Antibacterial prophylaxis in patients with neutropenia. Journal of the National Comprehensive Cancer Network : JNCCN\| PubMed ID: 17335692	2007
Ganciclovir inhibits lymphocyte proliferation by impairing DNA synthesis. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation\| PubMed ID: 17580254	2007
Combination antifungals: an update. Expert review of anti-infective therapy\| PubMed ID: 17914921	2007
Immunotherapy for fungal infections with special emphasis on central nervous system infections. Neurology India\| PubMed ID: 17921655	2007
Role of macrophages in host defense against aspergillosis and strategies for immune augmentation. The oncologist\| PubMed ID: 18039634	2007
Treatment of aspergillosis: clinical practice guidelines of the Infectious Diseases Society of America. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America\| PubMed ID: 18177225	2008
Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous disease. Nature\| PubMed ID: 18185592	2008
Prevention and treatment of cancer-related infections. Journal of the National Comprehensive Cancer Network : JNCCN\| PubMed ID: 18319048	2008
Broad-spectrum antifungal prophylaxis in patients with cancer at high risk for invasive mold infections: point. Journal of the National Comprehensive Cancer Network : JNCCN\| PubMed ID: 18319049	2008
Revised definitions of invasive fungal disease from the European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of ... Clinical infectious diseases : an official publication of the Infectious Diseases Society of America\| PubMed ID: 18462102	2008
Defining responses to therapy and study outcomes in clinical trials of invasive fungal diseases: Mycoses Study Group and European Organization for Research and Treatment of Cancer consensus ... Clinical infectious diseases : an official publication of the Infectious Diseases Society of America\| PubMed ID: 18637757	2008
Antifungal agents in hematopoietic stem cell transplantation. Current pharmaceutical design\| PubMed ID: 18691111	2008
Invasive aspergillosis in chronic granulomatous disease. Medical mycology : official publication of the International Society for Human and Animal Mycology\| PubMed ID: 19296367	2009
Aspergillosis. The New England journal of medicine\| PubMed ID: 19403905	2009
Prevention and treatment of invasive fungal diseases in neutropenic patients. Current opinion in infectious diseases\| PubMed ID: 19506476	2009
Prevention, diagnosis, and treatment of invasive fungal infections in patients with cancer and neutropenia. Journal of the National Comprehensive Cancer Network : JNCCN\| PubMed ID: 19780254	2004
Infection control measures to prevent invasive mould diseases in hematopoietic stem cell transplant recipients. Mycopathologia\| PubMed ID: 19859825	2009
Editorial: Special issue, "invasive fungal diseases in allogeneic hematopoietic stem cell transplant recipients". Mycopathologia\| PubMed ID: 19937130	2009
Altered eosinophil profile in mice with ST6Gal-1 deficiency: an additional role for ST6Gal-1 generated by the P1 promoter in regulating allergic inflammation. Journal of leukocyte biology\| PubMed ID: 20007243	2010
NADPH oxidase limits innate immune responses in the lungs in mice. PloS one\| PubMed ID: 20300512	2010
Pulmonary aspergillosis: clinical presentation, diagnostic tests, management and complications. Current opinion in pulmonary medicine\| PubMed ID: 20375786	2010
Role of NADPH oxidase in host defense against aspergillosis. Medical mycology : official publication of the International Society for Human and Animal Mycology\| PubMed ID: 20560866	2011
Proceedings from the 4th Advances Against Aspergillosis Conference, February 4-6, 2010, Rome, Italy. Medical mycology : official publication of the International Society for Human and Animal Mycology\| PubMed ID: 21108577	2011
Antifungal prophylaxis and therapy in patients with hematological malignancies and hematopoietic stem cell transplant recipients. Expert review of anti-infective therapy\| PubMed ID: 21133669	2010
Chronic granulomatous disease: lessons from a rare disorder. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation\| PubMed ID: 21195301	2011
Nrf2 regulates chronic lung inflammation and B-cell responses to nontypeable Haemophilus influenzae. American journal of respiratory cell and molecular biology\| PubMed ID: 21216970	2011
Characterization of vancomycin pharmacokinetics in the adult acute myeloid leukemia population. Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners\| PubMed ID: 21521799	2012
Transmission of resistant bacteria in intensive care. The New England journal of medicine\| PubMed ID: 21864175	2011
Thematic issue: immunity, inflammation and fungal infections. Immunological investigations\| PubMed ID: 21985300	2011
Role of NADPH oxidase versus neutrophil proteases in antimicrobial host defense. PloS one\| PubMed ID: 22163282	2011
Reactive oxygen species produced by the NADPH oxidase 2 complex in monocytes protect mice from bacterial infections. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 22491245	2012
Regulation of innate immunity by NADPH oxidase. Free radical biology & medicine\| PubMed ID: 22583699	2012
Elevating body temperature enhances hematopoiesis and neutrophil recovery after total body irradiation in an IL-1-, IL-17-, and G-CSF-dependent manner. Blood\| PubMed ID: 22806894	2012
Interferon regulatory factor-8 is important for histone deacetylase inhibitor-mediated antitumor activity. PloS one\| PubMed ID: 23028998	2012
Tracing conidial fate and measuring host cell antifungal activity using a reporter of microbial viability in the lung. Cell reports\| PubMed ID: 23200858	2012
NADPH oxidase and Nrf2 regulate gastric aspiration-induced inflammation and acute lung injury. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 23296708	2013
NETosis and NADPH oxidase: at the intersection of host defense, inflammation, and injury. Frontiers in immunology\| PubMed ID: 23459634	2013
Identification of myeloid cell subsets in murine lungs using flow cytometry. American journal of respiratory cell and molecular biology\| PubMed ID: 23492192	2013
Monocyte- and macrophage-targeted NADPH oxidase mediates antifungal host defense and regulation of acute inflammation in mice. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 23509361	2013
NADPH oxidase limits lipopolysaccharide-induced lung inflammation and injury in mice through reduction-oxidation regulation of NF-κB activity. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 23530143	2013
Myeloid-derived suppressor cells modulate immune responses independently of NADPH oxidase in the ovarian tumor microenvironment in mice. PloS one\| PubMed ID: 23922763	2013
NF-κB inhibition after cecal ligation and puncture reduces sepsis-associated lung injury without altering bacterial host defense. Mediators of inflammation\| PubMed ID: 24347827	2013
NADPH oxidase promotes neutrophil extracellular trap formation in pulmonary aspergillosis. Infection and immunity\| PubMed ID: 24549323	2014
Nrf2 amplifies oxidative stress via induction of Klf9. Molecular cell\| PubMed ID: 24613345	2014
Prevention of infection in cancer patients. Cancer treatment and research\| PubMed ID: 24706235	2014
Dectin-1-Dependent LC3 Recruitment to Phagosomes Enhances Fungicidal Activity in Macrophages. The Journal of infectious diseases\| PubMed ID: 24842831	2014