Sharon A. Tooze

Molecular Cell Biology of Autophagy, The Francis Crick Institute

Affiliated withThe Francis Crick Institute

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 3	2023

Other Publications

Article	Year
Activation of ULK Kinase and Autophagy by GABARAP Trafficking from the Centrosome Is Regulated by WAC and GM130. Molecular cell\| PubMed ID: 26687599	2015
TBC1D14 regulates autophagy via the TRAPP complex and ATG9 traffic. The EMBO journal\| PubMed ID: 26711178	2016
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy\| PubMed ID: 26799652	2016
GABARAP activates ULK1 and traffics from the centrosome dependent on Golgi partners WAC and GOLGA2/GM130. Autophagy\| PubMed ID: 26986052	2016
Clec16a is Critical for Autolysosome Function and Purkinje Cell Survival. Scientific reports\| PubMed ID: 26987296	2016
Digesting the Expanding Mechanisms of Autophagy. Trends in cell biology\| PubMed ID: 27050762	2016
TBC1D14 and TRAPP - Regulating autophagy through ATG9. Cell cycle (Georgetown, Tex.)\| PubMed ID: 27105289	2016
TBC1D14 sets the TRAPP for ATG9. Autophagy\| PubMed ID: 27171758	2016
An siRNA screen for ATG protein depletion reveals the extent of the unconventional functions of the autophagy proteome in virus replication. The Journal of cell biology\| PubMed ID: 27573464	2016
Rabs and GAPs in starvation-induced autophagy. Small GTPases\| PubMed ID: 27669114	2016
Autophagy Captures the Nobel Prize. Cell\| PubMed ID: 27912049	2016
So Long Tom! Traffic (Copenhagen, Denmark)\| PubMed ID: 28008716	2017
Molecular Mechanisms of Autophagy-Part B. Journal of molecular biology\| PubMed ID: 28087262	2017
Fundamental mechanisms deliver the Nobel Prize to Ohsumi. Traffic (Copenhagen, Denmark)\| PubMed ID: 28097732	2017
A switch from canonical to noncanonical autophagy shapes B cell responses. Science (New York, N.Y.)\| PubMed ID: 28183981	2017
Quantifying Autophagic Structures in Mammalian Cells Using Confocal Microscopy. Methods in enzymology\| PubMed ID: 28253957	2017
ATG4B contains a C-terminal LIR motif important for binding and efficient cleavage of mammalian orthologs of yeast Atg8. Autophagy\| PubMed ID: 28287329	2017
Molecular Pathways Controlling Autophagy in Pancreatic Cancer. Frontiers in oncology\| PubMed ID: 28316954	2017
Editorial overview: Celebrating the advances in cell biology from China. Traffic (Copenhagen, Denmark)\| PubMed ID: 28513089	2017
Molecular definitions of autophagy and related processes. The EMBO journal\| PubMed ID: 28596378	2017
Centriolar Satellites Control GABARAP Ubiquitination and GABARAP-Mediated Autophagy. Current biology : CB\| PubMed ID: 28712572	2017
Autophagy pathway: Cellular and molecular mechanisms. Autophagy\| PubMed ID: 28933638	2018
Control of GABARAP-mediated autophagy by the Golgi complex, centrosome and centriolar satellites. Biology of the cell\| PubMed ID: 28990689	2018
Membrane dynamics and organelle biogenesis-lipid pipelines and vesicular carriers. BMC biology\| PubMed ID: 29089042	2017
Centrosome to autophagosome signaling: Specific GABARAP regulation by centriolar satellites. Autophagy\| PubMed ID: 29099272	2017
Vps34 PI 3-kinase inactivation enhances insulin sensitivity through reprogramming of mitochondrial metabolism. Nature communications\| PubMed ID: 29180704	2017
A molecular perspective of mammalian autophagosome biogenesis. The Journal of biological chemistry\| PubMed ID: 29371398	2018
SNAREing an ARP requires a LIR. The Journal of cell biology\| PubMed ID: 29449316	2018
mTOR independent alteration in ULK1 Ser758 phosphorylation following chronic LRRK2 kinase inhibition. Bioscience reports\| PubMed ID: 29563162	2018
Identification and Validation of Novel Autophagy Regulators Using an Endogenous Readout siGENOME Screen. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 30610710	2019
Autophagy Pathway Mapping to Elucidate the Function of Novel Autophagy Regulators Identified by High-Throughput Screening. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 30610711	2019
MDH1 and MPP7 Regulate Autophagy in Pancreatic Ductal Adenocarcinoma. Cancer research\| PubMed ID: 30765601	2019
Members of the autophagy class III phosphatidylinositol 3-kinase complex I interact with GABARAP and GABARAPL1 via LIR motifs. Autophagy\| PubMed ID: 30767700	2019
Suppression of autophagy during mitosis via CUL4-RING ubiquitin ligases-mediated WIPI2 polyubiquitination and proteasomal degradation. Autophagy\| PubMed ID: 30898011	2019
ATG9A shapes the forming autophagosome through Arfaptin 2 and phosphatidylinositol 4-kinase IIIβ. The Journal of cell biology\| PubMed ID: 30917996	2019
A mutation in the major autophagy gene, WIPI2, associated with global developmental abnormalities. Brain : a journal of neurology\| PubMed ID: 30968111	2019
Molecular determinants regulating selective binding of autophagy adapters and receptors to ATG8 proteins. Nature communications\| PubMed ID: 31053714	2019
Axonal autophagosome maturation defect through failure of ATG9A sorting underpins pathology in AP-4 deficiency syndrome. Autophagy\| PubMed ID: 31142229	2020
ATG9A supplies PtdIns4P to the autophagosome initiation site. Autophagy\| PubMed ID: 31204568	2019
Autophagy, Inflammation, and Metabolism (AIM) Center in its second year. Autophagy\| PubMed ID: 31234750	2019
Expression of WIPI2B counteracts age-related decline in autophagosome biogenesis in neurons. eLife\| PubMed ID: 31309927	2019
Twenty years of Traffic. Traffic (Copenhagen, Denmark)\| PubMed ID: 31854088	2020
The Golgi as an Assembly Line to the Autophagosome. Trends in biochemical sciences\| PubMed ID: 32307224	2020
Emerging roles of ATG proteins and membrane lipids in autophagosome formation. Cell discovery\| PubMed ID: 32509328	2020
Path to autophagy therapeutics with Beth Levine. Nature reviews. Molecular cell biology\| PubMed ID: 32770126	2020
The phosphatidylinositol 3-phosphate-binding protein SNX4 controls ATG9A recycling and autophagy. Journal of cell science\| PubMed ID: 33468622	2021
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy\| PubMed ID: 33634751	2021
Phosphorylation of the LIR Domain of SCOC Modulates ATG8 Binding Affinity and Specificity. Journal of molecular biology\| PubMed ID: 33845085	2021
Membrane supply and remodeling during autophagosome biogenesis. Current opinion in cell biology\| PubMed ID: 33930785	2021
ATG4: More Than a Protease? Trends in cell biology\| PubMed ID: 33972154	2021
SAMM50 acts with p62 in piecemeal basal- and OXPHOS-induced mitophagy of SAM and MICOS components. The Journal of cell biology\| PubMed ID: 34037656	2021
Corrigendum to Phosphorylation of the LIR Domain of SCOC Modulates ATG8 Binding Affinity and Specificity. Journal of molecular biology\| PubMed ID: 34052024	2021
Phosphoproteomic identification of ULK substrates reveals VPS15-dependent ULK/VPS34 interplay in the regulation of autophagy. The EMBO journal\| PubMed ID: 34121209	2021
ATG9A protects the plasma membrane from programmed and incidental permeabilization. Nature cell biology\| PubMed ID: 34257406	2021
SAMM50 is a receptor for basal piecemeal mitophagy and acts with SQSTM1/p62 in OXPHOS-induced mitophagy. Autophagy\| PubMed ID: 34275433	2021
Autophagy in major human diseases. The EMBO journal\| PubMed ID: 34459017	2021
The ingenious ULKs: expanding the repertoire of the ULK complex with phosphoproteomics. Autophagy\| PubMed ID: 34520329	2021
Homozygous missense variants cause a congenital disorder of autophagy with neurodevelopmental impairments of variable clinical severity and disease course. Brain communications\| PubMed ID: 34557665	2021
Autophagy coordinates chondrocyte development and early joint formation in zebrafish. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 34708458	2021
Unraveling membrane properties at the organelle-level with LipidDyn. Computational and structural biotechnology journal\| PubMed ID: 35860415	2022
ATG9A and ATG2A form a heteromeric complex essential for autophagosome formation. Molecular cell\| PubMed ID: 36347259	2022
Loss of NDR1/2 kinases impairs endomembrane trafficking and autophagy leading to neurodegeneration. Life science alliance\| PubMed ID: 36446521	2023
Membrane association of the ATG8 conjugation machinery emerges as a key regulatory feature for autophagosome biogenesis. FEBS letters\| PubMed ID: 37259601	2023
Autophagosome membrane expansion is mediated by the N-terminus and -membrane association of human ATG8s. eLife\| PubMed ID: 37288820	2023