Matt Kaeberlein

Department of Pathology, University of Washington

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JoVE Journal Publications

ArticleTotal : 4	Year
Publication title Cited by 201	2009
Publication title Cited by 91	2009
Publication title Cited by 168	2009
Publication title Cited by 5	2020

Other Publications

Article	Year
Saccharomyces cerevisiae MPT5 and SSD1 function in parallel pathways to promote cell wall integrity. Genetics\| PubMed ID: 11805047	2002
Mutations in Saccharomyces cerevisiae gene SIR2 can have differential effects on in vivo silencing phenotypes and in vitro histone deacetylation activity. Molecular biology of the cell\| PubMed ID: 11950950	2002
AGEID: a database of aging genes and interventions. Mechanisms of ageing and development\| PubMed ID: 12044961	2002
Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration. Nature\| PubMed ID: 12124627	2002
High osmolarity extends life span in Saccharomyces cerevisiae by a mechanism related to calorie restriction. Molecular and cellular biology\| PubMed ID: 12391171	2002
Saccharomyces cerevisiae SSD1-V confers longevity by a Sir2p-independent mechanism. Genetics\| PubMed ID: 15126388	2004
Sir2-independent life span extension by calorie restriction in yeast. PLoS biology\| PubMed ID: 15328540	2004
Aging-related research in the "-omics" age. Science of aging knowledge environment : SAGE KE\| PubMed ID: 15498757	2004
Large-scale identification in yeast of conserved ageing genes. Mechanisms of ageing and development\| PubMed ID: 15610758	2005
Substrate-specific activation of sirtuins by resveratrol. The Journal of biological chemistry\| PubMed ID: 15684413	2005
Genes determining yeast replicative life span in a long-lived genetic background. Mechanisms of ageing and development\| PubMed ID: 15722108	2005
The enigmatic role of Sir2 in aging. Cell\| PubMed ID: 16286003	2005
Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients. Science (New York, N.Y.)\| PubMed ID: 16293764	2005
Increased life span due to calorie restriction in respiratory-deficient yeast. PLoS genetics\| PubMed ID: 16311627	2005
Extension of chronological life span in yeast by decreased TOR pathway signaling. Genes & development\| PubMed ID: 16418483	2006
Comment on "HST2 mediates SIR2-independent life-span extension by calorie restriction". Science (New York, N.Y.)\| PubMed ID: 16741098	2006
Genome-wide approaches to understanding human ageing. Human genomics\| PubMed ID: 16848980	2006
Lifespan extension in Caenorhabditis elegans by complete removal of food. Aging cell\| PubMed ID: 17081160	2006
Medicine: grapes versus gluttony. Nature\| PubMed ID: 17086197	2006
Genome-wide identification of conserved longevity genes in yeast and worms. Mechanisms of ageing and development\| PubMed ID: 17126379	2007
Sirtuin-independent effects of nicotinamide on lifespan extension from calorie restriction in yeast. Aging cell\| PubMed ID: 17129213	2006
The sensitivity of yeast mutants to oleic acid implicates the peroxisome and other processes in membrane function. Genetics\| PubMed ID: 17151231	2007
Sir2 and calorie restriction in yeast: a skeptical perspective. Ageing research reviews\| PubMed ID: 17512264	2007
Recent developments in yeast aging. PLoS genetics\| PubMed ID: 17530929	2007
Does resveratrol activate yeast Sir2 in vivo? Aging cell\| PubMed ID: 17635418	2007
Molecular basis of ageing. EMBO reports\| PubMed ID: 17823613	2007
Protein translation, 2007. Aging cell\| PubMed ID: 17941970	2007
Single-gene deletions that restore mating competence to diploid yeast. FEMS yeast research\| PubMed ID: 17995956	2008
Dietary restriction by bacterial deprivation increases life span in wild-derived nematodes. Experimental gerontology\| PubMed ID: 18083317	2008
A method for high-throughput quantitative analysis of yeast chronological life span. The journals of gerontology. Series A, Biological sciences and medical sciences\| PubMed ID: 18314444	2008
Dietary restriction suppresses proteotoxicity and enhances longevity by an hsf-1-dependent mechanism in Caenorhabditis elegans. Aging cell\| PubMed ID: 18331616	2008
Quantitative evidence for conserved longevity pathways between divergent eukaryotic species. Genome research\| PubMed ID: 18340043	2008
Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4. Cell\| PubMed ID: 18423200	2008
The biological sciences section program at the 60th Annual Meeting of the Gerontological Society of America. The journals of gerontology. Series A, Biological sciences and medical sciences\| PubMed ID: 18426956	2008
Age- and calorie-independent life span extension from dietary restriction by bacterial deprivation in Caenorhabditis elegans. BMC developmental biology\| PubMed ID: 18457595	2008
The ongoing saga of sirtuins and aging. Cell metabolism\| PubMed ID: 18590685	2008
Longevity genomics across species. Current genomics\| PubMed ID: 18660849	2007
Cell biology: A molecular age barrier. Nature\| PubMed ID: 18685697	2008
Protein translation, 2008. Aging cell\| PubMed ID: 18782345	2008
Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity. PloS one\| PubMed ID: 19030232	2008
A molecular mechanism of chronological aging in yeast. Cell cycle (Georgetown, Tex.)\| PubMed ID: 19305133	2009
Proteasomal regulation of the hypoxic response modulates aging in C. elegans. Science (New York, N.Y.)\| PubMed ID: 19372390	2009
Histone H4 lysine 16 acetylation regulates cellular lifespan. Nature\| PubMed ID: 19516333	2009
A genomic approach to yeast chronological aging. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 19521821	2009
The TOR pathway comes of age. Biochimica et biophysica acta\| PubMed ID: 19539012	2009
Ageing: A midlife longevity drug? Nature\| PubMed ID: 19606132	2009
The hypoxic response and aging. Cell cycle (Georgetown, Tex.)\| PubMed ID: 19633411	2009
Hot topics in aging research: protein translation, 2009. Aging cell\| PubMed ID: 19747234	2009
Attenuation of age-related metabolic dysfunction in mice with a targeted disruption of the Cbeta subunit of protein kinase A. The journals of gerontology. Series A, Biological sciences and medical sciences\| PubMed ID: 19776218	2009
Cell signaling. Aging is RSKy business. Science (New York, N.Y.)\| PubMed ID: 19797648	2009
Spermidine surprise for a long life. Nature cell biology\| PubMed ID: 19884883	2009
Resveratrol and rapamycin: are they anti-aging drugs? BioEssays : news and reviews in molecular, cellular and developmental biology\| PubMed ID: 20091754	2010
YODA: software to facilitate high-throughput analysis of chronological life span, growth rate, and survival in budding yeast. BMC bioinformatics\| PubMed ID: 20298554	2010
Lessons on longevity from budding yeast. Nature\| PubMed ID: 20336133	2010
A role for SIRT1 in the hypoxic response. Molecular cell\| PubMed ID: 20620950	2010
The hypoxia-inducible factor HIF-1 functions as both a positive and negative modulator of aging. Biological chemistry\| PubMed ID: 20707608	2010
Regulation of mRNA translation as a conserved mechanism of longevity control. Advances in experimental medicine and biology\| PubMed ID: 20886753	2010
Restoration of senescent human diploid fibroblasts by modulation of the extracellular matrix. Aging cell\| PubMed ID: 21108727	2011
Hot topics in aging research: protein translation and TOR signaling, 2010. Aging cell\| PubMed ID: 21176090	2011
Quantitative evidence for early life fitness defects from 32 longevity-associated alleles in yeast. Cell cycle (Georgetown, Tex.)\| PubMed ID: 21191185	2011
HIF-1 modulates longevity and healthspan in a temperature-dependent manner. Aging cell\| PubMed ID: 21241450	2011
A genomic analysis of chronological longevity factors in budding yeast. Cell cycle (Georgetown, Tex.)\| PubMed ID: 21447998	2011
Trinations aging symposium. Mechanisms of ageing and development\| PubMed ID: 21771608	2011
Sir2 deletion prevents lifespan extension in 32 long-lived mutants. Aging cell\| PubMed ID: 21902802	2011
Elevated proteasome capacity extends replicative lifespan in Saccharomyces cerevisiae. PLoS genetics\| PubMed ID: 21931558	2011
Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila. Nature\| PubMed ID: 21938067	2011
Composition and acidification of the culture medium influences chronological aging similarly in vineyard and laboratory yeast. PloS one\| PubMed ID: 21949725	2011
Genome-wide analysis of yeast aging. Sub-cellular biochemistry\| PubMed ID: 22094426	2012
The MDT-15 subunit of mediator interacts with dietary restriction to modulate longevity and fluoranthene toxicity in Caenorhabditis elegans. PloS one\| PubMed ID: 22132200	2011
A new chronological survival assay in mammalian cell culture. Cell cycle (Georgetown, Tex.)\| PubMed ID: 22214665	2012
Ribosome deficiency protects against ER stress in Saccharomyces cerevisiae. Genetics\| PubMed ID: 22377630	2012
Midlife gene expressions identify modulators of aging through dietary interventions. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22509016	2012
Replicative and chronological aging in Saccharomyces cerevisiae. Cell metabolism\| PubMed ID: 22768836	2012
Yeast as a model to understand the interaction between genotype and the response to calorie restriction. FEBS letters\| PubMed ID: 22828279	2012
Rapamycin reverses elevated mTORC1 signaling in lamin A/C-deficient mice, rescues cardiac and skeletal muscle function, and extends survival. Science translational medicine\| PubMed ID: 22837538	2012
pH neutralization protects against reduction in replicative lifespan following chronological aging in yeast. Cell cycle (Georgetown, Tex.)\| PubMed ID: 22871733	2012
Elevated MTORC1 signaling and impaired autophagy. Autophagy\| PubMed ID: 23064282	2013
Stress profiling of longevity mutants identifies Afg3 as a mitochondrial determinant of cytoplasmic mRNA translation and aging. Aging cell\| PubMed ID: 23167605	2013
Dietary restriction and mitochondrial function link replicative and chronological aging in Saccharomyces cerevisiae. Experimental gerontology\| PubMed ID: 23235143	2013
mTOR is a key modulator of ageing and age-related disease. Nature\| PubMed ID: 23325216	2013
End-of-life cell cycle arrest contributes to stochasticity of yeast replicative aging. FEMS yeast research\| PubMed ID: 23336757	2013
Life-span extension from hypoxia in Caenorhabditis elegans requires both HIF-1 and DAF-16 and is antagonized by SKN-1. The journals of gerontology. Series A, Biological sciences and medical sciences\| PubMed ID: 23419779	2013
A natural polymorphism in rDNA replication origins links origin activation with calorie restriction and lifespan. PLoS genetics\| PubMed ID: 23505383	2013
Longevity and aging. F1000prime reports\| PubMed ID: 23513177	2013
Genome-Wide RNAi Longevity Screens in Caenorhabditis elegans. Current genomics\| PubMed ID: 23633911	2012
Molecular mechanisms underlying genotype-dependent responses to dietary restriction. Aging cell\| PubMed ID: 23837470	2013
The ribosomal protein Rpl22 controls ribosome composition by directly repressing expression of its own paralog, Rpl22l1. PLoS genetics\| PubMed ID: 23990801	2013
Yeast replicative aging: a paradigm for defining conserved longevity interventions. FEMS yeast research\| PubMed ID: 24119093	2014
Preserving youth: does rapamycin deliver? Science translational medicine\| PubMed ID: 24225941	2013
Deciphering the role of natural variation in age-related protein homeostasis. BMC biology\| PubMed ID: 24228595	2013
mTOR inhibition alleviates mitochondrial disease in a mouse model of Leigh syndrome. Science (New York, N.Y.)\| PubMed ID: 24231806	2013
UV-photoconversion of ethosuximide from a longevity-promoting compound to a potent toxin. PloS one\| PubMed ID: 24340038	2013
mTOR Inhibition: From Aging to Autism and Beyond. Scientifica\| PubMed ID: 24379984	2013
Lifespan extension conferred by endoplasmic reticulum secretory pathway deficiency requires induction of the unfolded protein response. PLoS genetics\| PubMed ID: 24391512	2014
Development. Chemical warfare in the battle of the sexes. Science (New York, N.Y.)\| PubMed ID: 24482469	2014
Nar1 deficiency results in shortened lifespan and sensitivity to paraquat that is rescued by increased expression of mitochondrial superoxide dismutase. Mechanisms of ageing and development\| PubMed ID: 24486555	2014
The mitochondrial unfolded protein response and increased longevity: cause, consequence, or correlation? Experimental gerontology\| PubMed ID: 24518875	2014
Buffering the pH of the culture medium does not extend yeast replicative lifespan. F1000Research\| PubMed ID: 24555104	2013
Activation of the mitochondrial unfolded protein response does not predict longevity in Caenorhabditis elegans. Nature communications\| PubMed ID: 24662282	2014
Caffeine extends life span, improves healthspan, and delays age-associated pathology in Caenorhabditis elegans. Longevity & healthspan\| PubMed ID: 24764514	2012
Inactivation of yeast Isw2 chromatin remodeling enzyme mimics longevity effect of calorie restriction via induction of genotoxic stress response. Cell metabolism\| PubMed ID: 24814484	2014
Rejuvenation: it's in our blood. Cell metabolism\| PubMed ID: 24988454	2014
The SAGA histone deubiquitinase module controls yeast replicative lifespan via Sir2 interaction. Cell reports\| PubMed ID: 25043177	2014
A Drosophila model of mitochondrial disease caused by a complex I mutation that uncouples proton pumping from electron transfer. Disease models & mechanisms\| PubMed ID: 25085991	2014
Replicative life span analysis in budding yeast. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 25213254	2014
Rapamycin and ageing: when, for how long, and how much? Journal of genetics and genomics = Yi chuan xue bao\| PubMed ID: 25269671	2014
Modulating mTOR in aging and health. Interdisciplinary topics in gerontology\| PubMed ID: 25341517	2015
Syringaresinol protects against hypoxia/reoxygenation-induced cardiomyocytes injury and death by destabilization of HIF-1α in a FOXO3-dependent mechanism. Oncotarget\| PubMed ID: 25415049	2015
Enhanced longevity by ibuprofen, conserved in multiple species, occurs in yeast through inhibition of tryptophan import. PLoS genetics\| PubMed ID: 25521617	2014
Fertile waters for aging research. Cell\| PubMed ID: 25723160	2015
Why is aging conserved and what can we do about it? PLoS biology\| PubMed ID: 25923592	2015
PMT1 deficiency enhances basal UPR activity and extends replicative lifespan of Saccharomyces cerevisiae. Age (Dordrecht, Netherlands)\| PubMed ID: 25936926	2015
MicroRNA transcriptome analysis identifies miR-365 as a novel negative regulator of cell proliferation in Zmpste24-deficient mouse embryonic fibroblasts. Mutation research\| PubMed ID: 25983189	2015
The Biology of Aging: Citizen Scientists and Their Pets as a Bridge Between Research on Model Organisms and Human Subjects. Veterinary pathology\| PubMed ID: 26077786	2016
H3K36 methylation promotes longevity by enhancing transcriptional fidelity. Genes & development\| PubMed ID: 26159996	2015
Dose-dependent effects of mTOR inhibition on weight and mitochondrial disease in mice. Frontiers in genetics\| PubMed ID: 26257774	2015
Transcription errors induce proteotoxic stress and shorten cellular lifespan. Nature communications\| PubMed ID: 26304740	2015
Systematic analysis of asymmetric partitioning of yeast proteome between mother and daughter cells reveals "aging factors" and mechanism of lifespan asymmetry. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 26351681	2015
Searching for the elusive mitochondrial longevity signal in C. elegans. Worm\| PubMed ID: 26430544	2014
A Comprehensive Analysis of Replicative Lifespan in 4,698 Single-Gene Deletion Strains Uncovers Conserved Mechanisms of Aging. Cell metabolism\| PubMed ID: 26456335	2015
Tether mutations that restore function and suppress pleiotropic phenotypes of the C. elegans isp-1(qm150) Rieske iron-sulfur protein. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 26504246	2015
Biochemical Genetic Pathways that Modulate Aging in Multiple Species. Cold Spring Harbor perspectives in medicine\| PubMed ID: 26525455	2015
Sorbitol treatment extends lifespan and induces the osmotic stress response in Caenorhabditis elegans. Frontiers in genetics\| PubMed ID: 26579191	2015
Cell nonautonomous activation of flavin-containing monooxygenase promotes longevity and health span. Science (New York, N.Y.)\| PubMed ID: 26586189	2015
Aneuploidy shortens replicative lifespan in Saccharomyces cerevisiae. Aging cell\| PubMed ID: 26762766	2016
Healthy aging: The ultimate preventative medicine. Science (New York, N.Y.)\| PubMed ID: 26785476	2015
Microfluidic technologies for yeast replicative lifespan studies. Mechanisms of ageing and development\| PubMed ID: 27015709	2017
Defining Molecular Basis for Longevity Traits in Natural Yeast Isolates. NPJ aging and mechanisms of disease\| PubMed ID: 27030810	2015
The dog aging project: translational geroscience in companion animals. Mammalian genome : official journal of the International Mammalian Genome Society\| PubMed ID: 27143112	2016
New functional and biophysical insights into the mitochondrial Rieske iron-sulfur protein from genetic suppressor analysis in C. elegans. Worm\| PubMed ID: 27383074	2016
New insights into cell non-autonomous mechanisms of the C. elegans hypoxic response. Worm\| PubMed ID: 27383456	2016
Rapamycin in aging and disease: maximizing efficacy while minimizing side effects. Oncotarget\| PubMed ID: 27384492	2016
Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice. eLife\| PubMed ID: 27549339	2016
Age-associated vulval integrity is an important marker of nematode healthspan. Age (Dordrecht, Netherlands)\| PubMed ID: 27566309	2016
Rapamycin enhances survival in a Drosophila model of mitochondrial disease. Oncotarget\| PubMed ID: 27741510	2016
Dietary restriction and lifespan: Lessons from invertebrate models. Ageing research reviews\| PubMed ID: 28007498	2017
CAN1 Arginine Permease Deficiency Extends Yeast Replicative Lifespan via Translational Activation of Stress Response Genes. Cell reports\| PubMed ID: 28228255	2017
Systems biology approach to late-onset Alzheimer's disease genome-wide association study identifies novel candidate genes validated using brain expression data and Caenorhabditis elegans exp... Alzheimer's & dementia : the journal of the Alzheimer's Association\| PubMed ID: 28242297	2017
Asymptomatic heart valve dysfunction in healthy middle-aged companion dogs and its implications for cardiac aging. GeroScience\| PubMed ID: 28299636	2017
Transaldolase inhibition impairs mitochondrial respiration and induces a starvation-like longevity response in Caenorhabditis elegans. PLoS genetics\| PubMed ID: 28355222	2017
Environmental Canalization of Life Span and Gene Expression in Caenorhabditis elegans. The journals of gerontology. Series A, Biological sciences and medical sciences\| PubMed ID: 28369388	2017
A randomized controlled trial to establish effects of short-term rapamycin treatment in 24 middle-aged companion dogs. GeroScience\| PubMed ID: 28374166	2017
Flavin-containing monooxygenases in aging and disease: Emerging roles for ancient enzymes. The Journal of biological chemistry\| PubMed ID: 28515321	2017
Inter-organ regulation of haem homeostasis. Nature cell biology\| PubMed ID: 28659637	2017
A system to identify inhibitors of mTOR signaling using high-resolution growth analysis in Saccharomyces cerevisiae. GeroScience\| PubMed ID: 28707282	2017
Rapamycin treatment attenuates age-associated periodontitis in mice. GeroScience\| PubMed ID: 28889220	2017
Hepatic S6K1 Partially Regulates Lifespan of Mice with Mitochondrial Complex I Deficiency. Frontiers in genetics\| PubMed ID: 28919908	2017
Genetic interaction with temperature is an important determinant of nematode longevity. Aging cell\| PubMed ID: 28940623	2017
Electrophysiological Measures of Aging Pharynx Function in C. elegans Reveal Enhanced Organ Functionality in Older, Long-lived Mutants. The journals of gerontology. Series A, Biological sciences and medical sciences\| PubMed ID: 29165668	2019
Oral health in geroscience: animal models and the aging oral cavity. GeroScience\| PubMed ID: 29282653	2018
Corrigendum: Hepatic S6K1 Partially Regulates Lifespan of Mice with Mitochondrial Complex I Deficiency. Frontiers in genetics\| PubMed ID: 29285026	2017
The paths of mortality: how understanding the biology of aging can help explain systems behavior of single cells. Current opinion in systems biology\| PubMed ID: 29552673	2018
Reactivation of RNA metabolism underlies somatic restoration after adult reproductive diapause in . eLife\| PubMed ID: 30070633	2018
How healthy is the healthspan concept? GeroScience\| PubMed ID: 30084059	2018
Genetic screen identifies adaptive aneuploidy as a key mediator of ER stress resistance in yeast. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 30185560	2018
Research to Promote Longevity and Health Span in Companion Dogs: A Pediatric Perspective. The American journal of bioethics : AJOB\| PubMed ID: 30339074	2018
mTOR inhibitors may benefit kidney transplant recipients with mitochondrial diseases. Kidney international\| PubMed ID: 30471880	2019
Rapamycin and Alzheimer's disease: Time for a clinical trial? Science translational medicine\| PubMed ID: 30674654	2019
Defining the impact of mutation accumulation on replicative lifespan in yeast using cancer-associated mutator phenotypes. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 30718408	2019
Age-dependent deterioration of nuclear pore assembly in mitotic cells decreases transport dynamics. eLife\| PubMed ID: 31157618	2019
In vivo measurements reveal a single 5'-intron is sufficient to increase protein expression level in Caenorhabditis elegans. Scientific reports\| PubMed ID: 31235724	2019
Phenotypic and Genotypic Consequences of CRISPR/Cas9 Editing of the Replication Origins in the rDNA of . Genetics\| PubMed ID: 31292210	2019
Trajectories of Aging: How Systems Biology in Yeast Can Illuminate Mechanisms of Personalized Aging. Proteomics\| PubMed ID: 31385433	2019
An inexpensive microscopy system for microfluidic studies in budding yeast. Translational medicine of aging\| PubMed ID: 31511839	2019
Cross species application of quantitative neuropathology assays developed for clinical Alzheimer's disease samples. Pathobiology of aging & age related diseases\| PubMed ID: 31528297	2019
DNA damage checkpoint activation impairs chromatin homeostasis and promotes mitotic catastrophe during aging. eLife\| PubMed ID: 31714209	2019
WormBot, an open-source robotics platform for survival and behavior analysis in C. elegans. GeroScience\| PubMed ID: 31728898	2019
Latest advances in aging research and drug discovery. Aging\| PubMed ID: 31770722	2019
Desexing Dogs: A Review of the Current Literature. Animals : an open access journal from MDPI\| PubMed ID: 31817504	2019
Chaperone biomarkers of lifespan and penetrance track the dosages of many other proteins. Nature communications\| PubMed ID: 31844058	2019
Loss of vacuolar acidity results in iron-sulfur cluster defects and divergent homeostatic responses during aging in Saccharomyces cerevisiae. GeroScience\| PubMed ID: 31975050	2020
The antifungal plant defensin HsAFP1 induces autophagy, vacuolar dysfunction and cell cycle impairment in yeast. Biochimica et biophysica acta. Biomembranes\| PubMed ID: 32145284	2020
DDS promotes longevity through a microbiome-mediated starvation signal. Translational medicine of aging\| PubMed ID: 32190786	2019
Rb analog Whi5 regulates G1 to S transition and cell size but not replicative lifespan in budding yeast. Translational medicine of aging\| PubMed ID: 32190787	2019
Translational geroscience: A new paradigm for 21 century medicine. Translational medicine of aging\| PubMed ID: 32219192	2017