Stephan A. Grupp

Cell and Gene Therapy Laboratory, Children’s Hospital of Philadelphia

Affiliated withChildren’s Hospital of Philadelphia Perelman School of Medicine at the University of Pennsylvania

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 7	2023

Other Publications

Article	Year
Cytoplasmic micro heavy chain confers sensitivity to dexamethasone-induced apoptosis in early B-lineage acute lymphoblastic leukemia. Cancer research\| PubMed ID: 12154021	2002
Role of the BCR complex in B cell development, activation, and leukemic transformation. Immunologic research\| PubMed ID: 12857978	2003
RNA-transfected CD40-activated B cells induce functional T-cell responses against viral and tumor antigen targets: implications for pediatric immunotherapy. Blood\| PubMed ID: 14630810	2004
Rapamycin is active against B-precursor leukemia in vitro and in vivo, an effect that is modulated by IL-7-mediated signaling. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 14657335	2003
Unmasking Evans syndrome: T-cell phenotype and apoptotic response reveal autoimmune lymphoproliferative syndrome (ALPS). Blood\| PubMed ID: 15542578	2005
The mTOR inhibitor CCI-779 induces apoptosis and inhibits growth in preclinical models of primary adult human ALL. Blood\| PubMed ID: 16195324	2006
Collection, storage, and infusion of stem cells in children with high-risk neuroblastoma: saving for a rainy day. Pediatric blood & cancer\| PubMed ID: 16429413	2006
Use of G-CSF in matched sibling donor pediatric allogeneic transplantation: a consensus statement from the Children's Oncology Group (COG) Transplant Discipline Committee and Pediatric Blood... Pediatric blood & cancer\| PubMed ID: 16463346	2006
Rapamycin improves lymphoproliferative disease in murine autoimmune lymphoproliferative syndrome (ALPS). Blood\| PubMed ID: 16757690	2006
Immunosurveillance and survivin-specific T-cell immunity in children with high-risk neuroblastoma. Journal of clinical oncology : official journal of the American Society of Clinical Oncology\| PubMed ID: 17179106	2006
Targeting Notch signaling in autoimmune and lymphoproliferative disease. Blood\| PubMed ID: 17925488	2008
Thymic stromal-derived lymphopoietin induces proliferation of pre-B leukemia and antagonizes mTOR inhibitors, suggesting a role for interleukin-7Ralpha signaling. Cancer research\| PubMed ID: 17942929	2007
Immunotherapy for pediatric cancer. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation\| PubMed ID: 18162219	2008
mTOR inhibitors are synergistic with methotrexate: an effective combination to treat acute lymphoblastic leukemia. Blood\| PubMed ID: 18544682	2008
Late effects in survivors of tandem peripheral blood stem cell transplant for high-risk neuroblastoma. Pediatric blood & cancer\| PubMed ID: 18623215	2008
Novel molecular and cellular therapeutic targets in acute lymphoblastic leukemia and lymphoproliferative disease. Immunologic research\| PubMed ID: 18716718	2008
Treatment with sirolimus results in complete responses in patients with autoimmune lymphoproliferative syndrome. British journal of haematology\| PubMed ID: 19208097	2009
Mammalian target of rapamycin inhibitors and their potential role in therapy in leukaemia and other haematological malignancies. British journal of haematology\| PubMed ID: 19344392	2009
Chimeric receptors containing CD137 signal transduction domains mediate enhanced survival of T cells and increased antileukemic efficacy in vivo. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 19384291	2009
Long-term protection from syngeneic acute lymphoblastic leukemia by CpG ODN-mediated stimulation of innate and adaptive immune responses. Blood\| PubMed ID: 19636062	2009
A phase I/II study of the safety and efficacy of the addition of sirolimus to tacrolimus/methotrexate graft versus host disease prophylaxis after allogeneic haematopoietic cell transplantati... British journal of haematology\| PubMed ID: 19744131	2009
Interferon-gamma-dependent infiltration of human T cells into neuroblastoma tumors in vivo. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 19825945	2009
Advances in the management and understanding of autoimmune lymphoproliferative syndrome (ALPS). British journal of haematology\| PubMed ID: 19930184	2010
Identifying autoimmune lymphoproliferative syndrome in children with Evans syndrome: a multi-institutional study. Blood\| PubMed ID: 20068224	2010
Anti-CD13 Abs in children with extensive chronic GVHD and their relation to soluble CD13 after allogeneic blood and marrow transplantation from a Children's Oncology Groups Study, ASCT0031. Bone marrow transplantation\| PubMed ID: 20190833	2010
Autologous and allogeneic cellular therapies for high-risk pediatric solid tumors. Pediatric clinics of North America\| PubMed ID: 20307711	2010
Adoptive cellular therapy. Current topics in microbiology and immunology\| PubMed ID: 20700700	2011
Anti-GD2 antibody with GM-CSF, interleukin-2, and isotretinoin for neuroblastoma. The New England journal of medicine\| PubMed ID: 20879881	2010
Cutting edge: Lymphoproliferation caused by Fas deficiency is dependent on the transcription factor eomesodermin. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 21076068	2010
Statins are active in acute lymphoblastic leukaemia (ALL): a therapy that may treat ALL and prevent avascular necrosis. British journal of haematology\| PubMed ID: 21554258	2011
Early and late extensive chronic graft-versus-host disease in children is characterized by different Th1/Th2 cytokine profiles: findings of the Children's Oncology Group Study ASCT0031. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation\| PubMed ID: 21669298	2011
Randomized trial of hydroxychloroquine for newly diagnosed chronic graft-versus-host disease in children: a Children's Oncology Group study. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation\| PubMed ID: 21689773	2012
Phase I study of temsirolimus in pediatric patients with recurrent/refractory solid tumors. Journal of clinical oncology : official journal of the American Society of Clinical Oncology\| PubMed ID: 21690471	2011
T cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemia. Science translational medicine\| PubMed ID: 21832238	2011
Treatment of advanced leukemia in mice with mRNA engineered T cells. Human gene therapy\| PubMed ID: 21838572	2011
Noninvasive bioluminescent imaging of primary patient acute lymphoblastic leukemia: a strategy for preclinical modeling. Blood\| PubMed ID: 21856863	2011
Neuroblastoma: issues in transplantation. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation\| PubMed ID: 22226119	2012
The future is now: chimeric antigen receptors as new targeted therapies for childhood cancer. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 22589486	2012
Feasibility of a tandem autologous peripheral blood stem cell transplant regimen for high risk neuroblastoma in a cooperative group setting: a Pediatric Oncology Group study: a report from t... Pediatric blood & cancer\| PubMed ID: 22744917	2012
Targeting the PI3K/AKT/mTOR signaling axis in children with hematologic malignancies. Paediatric drugs\| PubMed ID: 22845486	2012
Genetic alterations activating kinase and cytokine receptor signaling in high-risk acute lymphoblastic leukemia. Cancer cell\| PubMed ID: 22897847	2012
Targeting JAK1/2 and mTOR in murine xenograft models of Ph-like acute lymphoblastic leukemia. Blood\| PubMed ID: 22955920	2012
Adoptive transfer of autologous T cells improves T-cell repertoire diversity and long-term B-cell function in pediatric patients with neuroblastoma. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 23092876	2012
Children's Oncology Group's 2013 blueprint for research: stem cell transplantation. Pediatric blood & cancer\| PubMed ID: 23255402	2013
Sirolimus pharmacokinetics in early postmyeloablative pediatric blood and marrow transplantation. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation\| PubMed ID: 23266742	2013
A pilot study of tandem high-dose chemotherapy with stem cell rescue as consolidation for high-risk neuroblastoma: Children's Oncology Group study ANBL00P1. Bone marrow transplantation\| PubMed ID: 23334272	2013
Allogeneic hematopoietic cell transplantation for neuroblastoma: the CIBMTR experience. Bone marrow transplantation\| PubMed ID: 23419433	2013
Chimeric antigen receptor-modified T cells for acute lymphoid leukemia. The New England journal of medicine\| PubMed ID: 23527958	2013
Cytokine release syndrome after blinatumomab treatment related to abnormal macrophage activation and ameliorated with cytokine-directed therapy. Blood\| PubMed ID: 23678006	2013
Regimen-specific effects of RNA-modified chimeric antigen receptor T cells in mice with advanced leukemia. Human gene therapy\| PubMed ID: 23883116	2013
Challenges and opportunities for international cooperative studies in pediatric hematopoeitic cell transplantation: priorities of the Westhafen Intercontinental Group. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation\| PubMed ID: 23883618	2013
Purged versus non-purged peripheral blood stem-cell transplantation for high-risk neuroblastoma (COG A3973): a randomised phase 3 trial. The Lancet. Oncology\| PubMed ID: 23890779	2013
Toxicity management for patients receiving novel T-cell engaging therapies. Current opinion in pediatrics\| PubMed ID: 24362408	2014
Relation of clinical culture method to T-cell memory status and efficacy in xenograft models of adoptive immunotherapy. Cytotherapy\| PubMed ID: 24439255	2014
The addition of sirolimus to tacrolimus/methotrexate GVHD prophylaxis in children with ALL: a phase 3 Children's Oncology Group/Pediatric Blood and Marrow Transplant Consortium trial. Blood\| PubMed ID: 24497539	2014
iNKT cell cytotoxic responses control T-lymphoma growth in vitro and in vivo. Cancer immunology research\| PubMed ID: 24563871	2014
Antibody-modified T cells: CARs take the front seat for hematologic malignancies. Blood\| PubMed ID: 24578504	2014
Preclinical targeting of human acute myeloid leukemia and myeloablation using chimeric antigen receptor-modified T cells. Blood\| PubMed ID: 24596416	2014
Managing cytokine release syndrome associated with novel T cell-engaging therapies. Cancer journal (Sudbury, Mass.)\| PubMed ID: 24667956	2014
Current concepts in the diagnosis and management of cytokine release syndrome. Blood\| PubMed ID: 24876563	2014
Engineered T cells for cancer therapy. Cancer immunology, immunotherapy : CII\| PubMed ID: 24943274	2014
Will post-transplantation cell therapies for pediatric patients become standard of care? Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation\| PubMed ID: 25064748	2015
Nature of tumor control by permanently and transiently modified GD2 chimeric antigen receptor T cells in xenograft models of neuroblastoma. Cancer immunology research\| PubMed ID: 25104548	2014
TNF-receptor inhibitor therapy for the treatment of children with idiopathic pneumonia syndrome. A joint Pediatric Blood and Marrow Transplant Consortium and Children's Oncology Group Study ... Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation\| PubMed ID: 25270958	2015
Chimeric antigen receptor T cells for sustained remissions in leukemia. The New England journal of medicine\| PubMed ID: 25317870	2014
Advances in T-cell therapy for ALL. Best practice & research. Clinical haematology\| PubMed ID: 25455270	2014
Efficacy of JAK/STAT pathway inhibition in murine xenograft models of early T-cell precursor (ETP) acute lymphoblastic leukemia. Blood\| PubMed ID: 25645356	2015
Chimeric antigen receptor T-cell therapy for ALL. Hematology. American Society of Hematology. Education Program\| PubMed ID: 25696911	2014
IgH-V(D)J NGS-MRD measurement pre- and early post-allotransplant defines very low- and very high-risk ALL patients. Blood\| PubMed ID: 25862561	2015
Risk factors and timing of relapse after allogeneic transplantation in pediatric ALL: for whom and when should interventions be tested? Bone marrow transplantation\| PubMed ID: 25961775	2015
Roadblocks to success for RNA CARs in solid tumors. Oncoimmunology\| PubMed ID: 25964863	2014
CD19-targeted chimeric antigen receptor T-cell therapy for acute lymphoblastic leukemia. Blood\| PubMed ID: 25999455	2015
Eradication of B-ALL using chimeric antigen receptor-expressing T cells targeting the TSLPR oncoprotein. Blood\| PubMed ID: 26041741	2015
Chimeric Antigen Receptor- and TCR-Modified T Cells Enter Main Street and Wall Street. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 26188068	2015
Chimeric antigen receptor T cells persist and induce sustained remissions in relapsed refractory chronic lymphocytic leukemia. Science translational medicine\| PubMed ID: 26333935	2015
Sirolimus is effective in relapsed/refractory autoimmune cytopenias: results of a prospective multi-institutional trial. Blood\| PubMed ID: 26504182	2016
Convergence of Acquired Mutations and Alternative Splicing of CD19 Enables Resistance to CART-19 Immunotherapy. Cancer discovery\| PubMed ID: 26516065	2015
Early memory phenotypes drive T cell proliferation in patients with pediatric malignancies. Science translational medicine\| PubMed ID: 26738796	2016
Phase 3 trial of defibrotide for the treatment of severe veno-occlusive disease and multi-organ failure. Blood\| PubMed ID: 26825712	2016
T cells targeting NY-ESO-1 demonstrate efficacy against disseminated neuroblastoma. Oncoimmunology\| PubMed ID: 26942053	2016
Identification of Predictive Biomarkers for Cytokine Release Syndrome after Chimeric Antigen Receptor T-cell Therapy for Acute Lymphoblastic Leukemia. Cancer discovery\| PubMed ID: 27076371	2016
CAR T Cell Therapy in Acute Lymphoblastic Leukemia and Potential for Chronic Lymphocytic Leukemia. Current treatment options in oncology\| PubMed ID: 27098534	2016
Inhibition of precursor B-cell malignancy progression by toll-like receptor ligand-induced immune responses. Leukemia\| PubMed ID: 27220664	2016
Cytokine Release Syndrome after Haploidentical Stem Cell Transplantation. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation\| PubMed ID: 27543158	2016
Dual CD19 and CD123 targeting prevents antigen-loss relapses after CD19-directed immunotherapies. The Journal of clinical investigation\| PubMed ID: 27571406	2016
Cytokine Release Syndrome After Chimeric Antigen Receptor T Cell Therapy for Acute Lymphoblastic Leukemia. Critical care medicine\| PubMed ID: 27632680	2017
Corrigendum to "Advances in T-cell therapy for ALL" [Best Pract Res Clin Haematol 27 (2014) 222-228]. Best practice & research. Clinical haematology\| PubMed ID: 27742067	2016
Potent efficacy of combined PI3K/mTOR and JAK or ABL inhibition in murine xenograft models of Ph-like acute lymphoblastic leukemia. Blood\| PubMed ID: 27777238	2017
Repeated loss of target surface antigen after immunotherapy in primary mediastinal large B cell lymphoma. American journal of hematology\| PubMed ID: 27779774	2017
Optimized depletion of chimeric antigen receptor T cells in murine xenograft models of human acute myeloid leukemia. Blood\| PubMed ID: 28246194	2017
Refining megatherapy, improving outcome in neuroblastoma. The Lancet. Oncology\| PubMed ID: 28259607	2017
Defibrotide for Patients with Hepatic Veno-Occlusive Disease/Sinusoidal Obstruction Syndrome: Interim Results from a Treatment IND Study. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation\| PubMed ID: 28285079	2017
IFN-γ directly inhibits murine B-cell precursor leukemia-initiating cell proliferation early in life. European journal of immunology\| PubMed ID: 28295300	2017
Earlier defibrotide initiation post-diagnosis of veno-occlusive disease/sinusoidal obstruction syndrome improves Day +100 survival following haematopoietic stem cell transplantation. British journal of haematology\| PubMed ID: 28444784	2017
Monocyte lineage-derived IL-6 does not affect chimeric antigen receptor T-cell function. Cytotherapy\| PubMed ID: 28506444	2017
Cellular kinetics of CTL019 in relapsed/refractory B-cell acute lymphoblastic leukemia and chronic lymphocytic leukemia. Blood\| PubMed ID: 28935694	2017
Single agent and synergistic combinatorial efficacy of first-in-class small molecule imipridone ONC201 in hematological malignancies. Cell cycle (Georgetown, Tex.)\| PubMed ID: 29157092	2018
High-Affinity GD2-Specific CAR T Cells Induce Fatal Encephalitis in a Preclinical Neuroblastoma Model. Cancer immunology research\| PubMed ID: 29180536	2018
Preclinical efficacy of daratumumab in T-cell acute lymphoblastic leukemia. Blood\| PubMed ID: 29305553	2018
Tisagenlecleucel in Children and Young Adults with B-Cell Lymphoblastic Leukemia. The New England journal of medicine\| PubMed ID: 29385370	2018
Toxicity management after chimeric antigen receptor T cell therapy: one size does not fit 'ALL'. Nature reviews. Clinical oncology\| PubMed ID: 29434335	2018
Grading of cytokine release syndrome associated with the CAR T cell therapy tisagenlecleucel. Journal of hematology & oncology\| PubMed ID: 29499750	2018
Disease burden and conditioning regimens in ASCT1221, a randomized phase II trial in children with juvenile myelomonocytic leukemia: A Children's Oncology Group study. Pediatric blood & cancer\| PubMed ID: 29528181	2018
False-positive results with select HIV-1 NAT methods following lentivirus-based tisagenlecleucel therapy. Blood\| PubMed ID: 29669777	2018
Defibrotide for the treatment of hepatic veno-occlusive disease/sinusoidal obstruction syndrome following nontransplant-associated chemotherapy: Final results from a post hoc analysis of dat... Pediatric blood & cancer\| PubMed ID: 29873895	2018
Nonviral RNA chimeric antigen receptor-modified T cells in patients with Hodgkin lymphoma. Blood\| PubMed ID: 29925499	2018
CAR-T in the clinic: drive with care. Gene therapy\| PubMed ID: 29961080	2018
Purification of mRNA Encoding Chimeric Antigen Receptor Is Critical for Generation of a Robust T-Cell Response. Human gene therapy\| PubMed ID: 30024272	2019
Reducing Culture Improves the Antileukemic Activity of Chimeric Antigen Receptor (CAR) T Cells. Cancer immunology research\| PubMed ID: 30030295	2018
CD19 Alterations Emerging after CD19-Directed Immunotherapy Cause Retention of the Misfolded Protein in the Endoplasmic Reticulum. Molecular and cellular biology\| PubMed ID: 30104252	2018
Tisagenlecleucel for the treatment of B-cell acute lymphoblastic leukemia. Expert review of anticancer therapy\| PubMed ID: 30111196	2018
Neurotoxicity after CTL019 in a pediatric and young adult cohort. Annals of neurology\| PubMed ID: 30178481	2018
Clinical Pharmacology of Tisagenlecleucel in B-cell Acute Lymphoblastic Leukemia. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 30190371	2018
Induction of resistance to chimeric antigen receptor T cell therapy by transduction of a single leukemic B cell. Nature medicine\| PubMed ID: 30275568	2018
Genetic mechanisms of target antigen loss in CAR19 therapy of acute lymphoblastic leukemia. Nature medicine\| PubMed ID: 30275569	2018
Defibrotide for the treatment of hepatic veno-occlusive disease/sinusoidal obstruction syndrome with multiorgan failure. International journal of hematologic oncology\| PubMed ID: 30302228	2017
CD3/CD19 Depleted Matched and Mismatched Unrelated Donor Hematopoietic Stem Cell Transplant with Targeted T Cell Addback Is Associated with Excellent Outcomes in Pediatric Patients with Nonm... Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation\| PubMed ID: 30312755	2019
A novel antibody-TCR (AbTCR) platform combines Fab-based antigen recognition with gamma/delta-TCR signaling to facilitate T-cell cytotoxicity with low cytokine release. Cell discovery\| PubMed ID: 30479831	2018
Chimeric antigen receptor (CAR) T therapies for the treatment of hematologic malignancies: clinical perspective and significance. Journal for immunotherapy of cancer\| PubMed ID: 30514386	2018
Clinical Utilization of Chimeric Antigen Receptor T Cells in B Cell Acute Lymphoblastic Leukemia: An Expert Opinion from the European Society for Blood and Marrow Transplantation and the Ame... Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation\| PubMed ID: 30576834	2019
ASTCT Consensus Grading for Cytokine Release Syndrome and Neurologic Toxicity Associated with Immune Effector Cells. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation\| PubMed ID: 30592986	2019
Naïve T-cell Deficits at Diagnosis and after Chemotherapy Impair Cell Therapy Potential in Pediatric Cancers. Cancer discovery\| PubMed ID: 30630850	2019
Higher Reported Lung Dose Received During Total Body Irradiation for Allogeneic Hematopoietic Stem Cell Transplantation in Children With Acute Lymphoblastic Leukemia Is Associated With Infer... International journal of radiation oncology, biology, physics\| PubMed ID: 30807822	2019
Tisagenlecleucel Model-Based Cellular Kinetic Analysis of Chimeric Antigen Receptor-T Cells. CPT: pharmacometrics & systems pharmacology\| PubMed ID: 30848084	2019
Reply. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation\| PubMed ID: 30910604	2019
Clinical utilization of Chimeric Antigen Receptor T-cells (CAR-T) in B-cell acute lymphoblastic leukemia (ALL)-an expert opinion from the European Society for Blood and Marrow Transplantatio... Bone marrow transplantation\| PubMed ID: 31092900	2019
Effect of Tandem Autologous Stem Cell Transplant vs Single Transplant on Event-Free Survival in Patients With High-Risk Neuroblastoma: A Randomized Clinical Trial. JAMA\| PubMed ID: 31454045	2019
CAR T cell viability release testing and clinical outcomes: is there a lower limit? Blood\| PubMed ID: 31554634	2019
Retention of CD19 intron 2 contributes to CART-19 resistance in leukemias with subclonal frameshift mutations in CD19. Leukemia\| PubMed ID: 31591467	2020
Patient-reported quality of life after tisagenlecleucel infusion in children and young adults with relapsed or refractory B-cell acute lymphoblastic leukaemia: a global, single-arm, phase 2 ... The Lancet. Oncology\| PubMed ID: 31606419	2019
Systemic and local immunity following adoptive transfer of NY-ESO-1 SPEAR T cells in synovial sarcoma. Journal for immunotherapy of cancer\| PubMed ID: 31651363	2019
Efficacy and safety of tisagenlecleucel in Japanese pediatric and young adult patients with relapsed/refractory B cell acute lymphoblastic leukemia. International journal of hematology\| PubMed ID: 31709501	2020
More precisely defining risk peri-HCT in pediatric ALL: pre- vs post-MRD measures, serial positivity, and risk modeling. Blood advances\| PubMed ID: 31714961	2019
CAR T-cell therapy is effective for CD19-dim B-lymphoblastic leukemia but is impacted by prior blinatumomab therapy. Blood advances\| PubMed ID: 31738832	2019
Partially CD3-Depleted Unrelated and Haploidentical Donor Peripheral Stem Cell Transplantation Has Favorable Graft-versus-Host Disease and Survival Rates in Pediatric Hematologic Malignancy. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation\| PubMed ID: 31765697	2020
Subcutaneous immunoglobulin replacement following CD19-specific chimeric antigen receptor T-cell therapy for B-cell acute lymphoblastic leukemia in pediatric patients. Pediatric blood & cancer\| PubMed ID: 31793170	2020
The MAGIC algorithm probability is a validated response biomarker of treatment of acute graft-versus-host disease. Blood advances\| PubMed ID: 31816061	2019
CD19-targeting CAR T cell immunotherapy outcomes correlate with genomic modification by vector integration. The Journal of clinical investigation\| PubMed ID: 31845905	2020
Impaired Death Receptor Signaling in Leukemia Causes Antigen-Independent Resistance by Inducing CAR T-cell Dysfunction. Cancer discovery\| PubMed ID: 32001516	2020
Dissecting the Tumor-Immune Landscape in Chimeric Antigen Receptor T-cell Therapy: Key Challenges and Opportunities for a Systems Immunology Approach. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 32127393	2020
Chimeric Antigen Receptor T Cell Therapy During the COVID-19 Pandemic. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation\| PubMed ID: 32298807	2020
Prospective Evaluation of Radiation Dose Escalation in Patients With High-Risk Neuroblastoma and Gross Residual Disease After Surgery: A Report From the Children's Oncology Group ANBL0532 St... Journal of clinical oncology : official journal of the American Society of Clinical Oncology\| PubMed ID: 32530765	2020
Thoracic duct lymphatic fluid harbors phenotypically naive T cells for use in adoptive T-cell therapy. Cytotherapy\| PubMed ID: 32622753	2020
Multisystem inflammatory syndrome in children and COVID-19 are distinct presentations of SARS-CoV-2. The Journal of clinical investigation\| PubMed ID: 32730233	2020
Analysis of Time to Complete Response after Defibrotide Initiation in Patients with Hepatic Veno-Occlusive Disease/Sinusoidal Obstruction Syndrome after Hematopoietic Cell Transplantation. Transplantation and cellular therapy\| PubMed ID: 32950693	2021
Diagnostic biomarkers to differentiate sepsis from cytokine release syndrome in critically ill children. Blood advances\| PubMed ID: 33095872	2020
Society for Immunotherapy of Cancer (SITC) clinical practice guideline on immune effector cell-related adverse events. Journal for immunotherapy of cancer\| PubMed ID: 33335028	2020
Risk-Adapted Preemptive Tocilizumab to Prevent Severe Cytokine Release Syndrome After CTL019 for Pediatric B-Cell Acute Lymphoblastic Leukemia: A Prospective Clinical Trial. Journal of clinical oncology : official journal of the American Society of Clinical Oncology\| PubMed ID: 33417474	2021
Beyond the storm - subacute toxicities and late effects in children receiving CAR T cells. Nature reviews. Clinical oncology\| PubMed ID: 33495553	2021
Practical guidelines for monitoring and management of coagulopathy following tisagenlecleucel CAR T-cell therapy. Blood advances\| PubMed ID: 33496754	2021
Will allogeneic CAR T cells for CD19 malignancies take autologous CAR T cells 'off the shelf'? Nature reviews. Clinical oncology\| PubMed ID: 33608691	2021
Improving and Maintaining Responses in Pediatric B-Cell Acute Lymphoblastic Leukemia Chimeric Antigen Receptor-T Cell Therapy. Cancer journal (Sudbury, Mass.)\| PubMed ID: 33750075	2021
Integrative Bulk and Single-Cell Profiling of Premanufacture T-cell Populations Reveals Factors Mediating Long-Term Persistence of CAR T-cell Therapy. Cancer discovery\| PubMed ID: 33820778	2021
Immune Reconstitution Following TCRαβ/CD19-Depleted Hematopoietic Cell Transplantation for Hematologic Malignancy in Pediatric Patients. Transplantation and cellular therapy\| PubMed ID: 33830028	2021
Absolute lymphocyte count proliferation kinetics after CAR T-cell infusion impact response and relapse. Blood advances\| PubMed ID: 33881465	2021
Antigen-independent activation enhances the efficacy of 4-1BB-costimulated CD22 CAR T cells. Nature medicine\| PubMed ID: 33888899	2021
Single-cell multiomics dissection of basal and antigen-specific activation states of CD19-targeted CAR T cells. Journal for immunotherapy of cancer\| PubMed ID: 34006631	2021
CAR-T cells: Early successes in blood cancer and challenges in solid tumors. Acta pharmaceutica Sinica. B\| PubMed ID: 34094824	2021
Humanized CD19-Targeted Chimeric Antigen Receptor (CAR) T Cells in CAR-Naive and CAR-Exposed Children and Young Adults With Relapsed or Refractory Acute Lymphoblastic Leukemia. Journal of clinical oncology : official journal of the American Society of Clinical Oncology\| PubMed ID: 34156874	2021
Pooled safety analysis of tisagenlecleucel in children and young adults with B cell acute lymphoblastic leukemia. Journal for immunotherapy of cancer\| PubMed ID: 34353848	2021
Tisagenlecleucel immunogenicity in relapsed/refractory acute lymphoblastic leukemia and diffuse large B-cell lymphoma. Blood advances\| PubMed ID: 34432863	2021
Distinct Bioenergetic Features of Human Invariant Natural Killer T Cells Enable Retained Functions in Nutrient-Deprived States. Frontiers in immunology\| PubMed ID: 34434191	2021
CD19-targeted chimeric antigen receptor T-cell therapy for CNS relapsed or refractory acute lymphocytic leukaemia: a post-hoc analysis of pooled data from five clinical trials. The Lancet. Haematology\| PubMed ID: 34560014	2021
Blinatumomab Nonresponse and High-Disease Burden Are Associated With Inferior Outcomes After CD19-CAR for B-ALL. Journal of clinical oncology : official journal of the American Society of Clinical Oncology\| PubMed ID: 34767461	2022
Impact of high-risk cytogenetics on outcomes for children and young adults receiving CD19-directed CAR T-cell therapy. Blood\| PubMed ID: 34871373	2022
Unrelated donor α/β T cell- and B cell-depleted HSCT for the treatment of pediatric acute leukemia. Blood advances\| PubMed ID: 34872106	2022
Potential Role of IFNγ Inhibition in Refractory Cytokine Release Syndrome Associated with CAR T-cell Therapy. Blood cancer discovery\| PubMed ID: 35015687	2022
Next-Generation Sequencing of Minimal Residual Disease for Predicting Relapse after Tisagenlecleucel in Children and Young Adults with Acute Lymphoblastic Leukemia. Blood cancer discovery\| PubMed ID: 35019853	2022
Tisagenlecleucel in pediatric and young adult patients with Down syndrome-associated relapsed/refractory acute lymphoblastic leukemia. Leukemia\| PubMed ID: 35422096	2022
Preinfusion factors impacting relapse immunophenotype following CD19 CAR T cells. Blood advances\| PubMed ID: 35482927	2023
Cytosine base editing enables quadruple-edited allogeneic CART cells for T-ALL. Blood\| PubMed ID: 35560156	2022
Single-cell antigen-specific landscape of CAR T infusion product identifies determinants of CD19-positive relapse in patients with ALL. Science advances\| PubMed ID: 35675405	2022
Comprehensive Serum Proteome Profiling of Cytokine Release Syndrome and Immune Effector Cell-Associated Neurotoxicity Syndrome Patients with B-Cell ALL Receiving CAR T19. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 35705524	2022
A novel antibody-TCR (AbTCR) T-cell therapy is safe and effective against CD19-positive relapsed/refractory B-cell lymphoma. Journal of cancer research and clinical oncology\| PubMed ID: 35776199	2023
Low rate of subsequent malignant neoplasms after CD19 CAR T-cell therapy. Blood advances\| PubMed ID: 35834728	2022
Statistical Considerations for Analyses of Time-To-Event Endpoints in Oncology Clinical Trials: Illustrations with CAR-T Immunotherapy Studies. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 35838646	2022
Correction for Bagashev et al., "CD19 Alterations Emerging after CD19-Directed Immunotherapy Cause Retention of the Misfolded Protein in the Endoplasmic Reticulum". Molecular and cellular biology\| PubMed ID: 35976030	2022
Biomarker correlates with response to NY-ESO-1 TCR T cells in patients with synovial sarcoma. Nature communications\| PubMed ID: 36075914	2022
Characterization of Leukemic Resistance to CD19-Targeted CAR T-cell Therapy through Deep Genomic Sequencing. Cancer immunology research\| PubMed ID: 36255409	2023
Impact of poverty and neighborhood opportunity on outcomes for children treated with CD19-directed CAR T-cell therapy. Blood\| PubMed ID: 36351239	2023
Three-Year Update of Tisagenlecleucel in Pediatric and Young Adult Patients With Relapsed/Refractory Acute Lymphoblastic Leukemia in the ELIANA Trial. Journal of clinical oncology : official journal of the American Society of Clinical Oncology\| PubMed ID: 36399695	2023
Automation of Hematopoietic Cell Transplantation Outcomes Reporting Leads to Dramatic Reduction in Errors Reported to Real-World Data Registry. Transplantation and cellular therapy\| PubMed ID: 36610491	2023
Reply to W.H. Tong et al. Journal of clinical oncology : official journal of the American Society of Clinical Oncology\| PubMed ID: 36898064	2023
Defibrotide plus best standard of care compared with best standard of care alone for the prevention of sinusoidal obstruction syndrome (HARMONY): a randomised, multicentre, phase 3 trial. The Lancet. Haematology\| PubMed ID: 37001534	2023
The utility of biomarkers in acute GVHD prognostication. Blood advances\| PubMed ID: 37142257	2023
Impact of diagnostic and end-of-induction Curie scores with tandem high-dose chemotherapy and autologous transplants for metastatic high-risk neuroblastoma: A report from the Children's Onco... Pediatric blood & cancer\| PubMed ID: 37199022	2023
Prevention of veno-occlusive disease/sinusoidal obstruction syndrome: a never-ending story and no easy answer. Bone marrow transplantation\| PubMed ID: 37231094	2023
Phase 2 study of natalizumab plus standard corticosteroid treatment for high-risk acute graft-versus-host disease. Blood advances\| PubMed ID: 37235690	2023
Incidence, clinical presentation, risk factors, outcomes, and biomarkers in de novo late acute GVHD. Blood advances\| PubMed ID: 37315175	2023
Defibrotide prophylaxis for prevention of sinusoidal obstruction syndrome - Authors' reply. The Lancet. Haematology\| PubMed ID: 37407140	2023
INSPIRED Symposium Part 1: Clinical Variables Associated with Improved Outcomes for Children and Young Adults treated with Chimeric Antigen Receptor T cells for B cell Acute Lymphoblastic Le... Transplantation and cellular therapy\| PubMed ID: 37481241	2023
In vivo hematopoietic stem cell modification by mRNA delivery. Science (New York, N.Y.)\| PubMed ID: 37499029	2023