Bernd Meibohm

Department of Pharmaceutical Sciences, University of Tennessee Health Science Center

Affiliated withUniversity of Tennessee Health Science Center

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 2	2023

Other Publications

Article	Year
The effect of CYP3A5 and MDR1 polymorphic expression on cyclosporine oral disposition in renal transplant patients. Journal of clinical pharmacology\| PubMed ID: 12817518	2003
Real-time PCR-based genotyping assay for CXCR2 polymorphisms. Clinica chimica acta; international journal of clinical chemistry\| PubMed ID: 14967163	2004
Pharmacokinetic aspects of biotechnology products. Journal of pharmaceutical sciences\| PubMed ID: 15295780	2004
SYBR Green-based real-time PCR allelic discrimination assay for beta2-adrenergic receptor polymorphisms. Analytical biochemistry\| PubMed ID: 16026755	2005
The clinical pharmacokinetics of phosphodiesterase-5 inhibitors for erectile dysfunction. Journal of clinical pharmacology\| PubMed ID: 16100293	2005
Population pharmacokinetic studies in pediatrics: issues in design and analysis. The AAPS journal\| PubMed ID: 16353925	2005
G2677T and C3435T genotype and haplotype are associated with hepatic ABCB1 (MDR1) expression. Journal of clinical pharmacology\| PubMed ID: 16490813	2006
LC/MS/MS in drug development: targeting the brain. BioTechniques\| PubMed ID: 16528912	2005
Discovery of novel isoxazolines as anti-tuberculosis agents. Bioorganic & medicinal chemistry letters\| PubMed ID: 17937983	2007
Population pharmacokinetics of cetuximab in patients with squamous cell carcinoma of the head and neck. Journal of clinical pharmacology\| PubMed ID: 18218786	2008
Biopharmaceutics, pharmacokinetics and pharmacodynamics of antituberculosis drugs. Current medicinal chemistry\| PubMed ID: 18393850	2008
Pharmacokinetically-guided lead optimization of nitrofuranylamide anti-tuberculosis agents. The AAPS journal\| PubMed ID: 18446516	2008
A microbiological assessment of novel nitrofuranylamides as anti-tuberculosis agents. The Journal of antimicrobial chemotherapy\| PubMed ID: 18693235	2008
A tandem mass spectrometry assay for the simultaneous determination of acetaminophen, caffeine, phenytoin, ranitidine, and theophylline in small volume pediatric plasma specimens. Clinica chimica acta; international journal of clinical chemistry\| PubMed ID: 18796299	2008
Concepts and challenges in quantitative pharmacology and model-based drug development. The AAPS journal\| PubMed ID: 19003542	2008
A simple in vitro PK/PD model system to determine time-kill curves of drugs against Mycobacteria. Tuberculosis (Edinburgh, Scotland)\| PubMed ID: 19748318	2009
Predictors of mortality in elderly subjects with obstructive airway disease: the PILE score. Annals of epidemiology\| PubMed ID: 20159492	2010
Genetic ancestry in lung-function predictions. The New England journal of medicine\| PubMed ID: 20647190	2010
Population pharmacokinetics of therapeutic monoclonal antibodies. Clinical pharmacokinetics\| PubMed ID: 20818831	2010
Discovery of novel 2-aryl-4-benzoyl-imidazoles targeting the colchicines binding site in tubulin as potential anticancer agents. Journal of medicinal chemistry\| PubMed ID: 20919720	2010
Pharmacokinetics of a combination of Δ9-tetrahydro-cannabinol and celecoxib in a porcine model of hemorrhagic shock. Biopharmaceutics & drug disposition\| PubMed ID: 21341278	2011
In vitro pharmacokinetic/pharmacodynamic models in anti-infective drug development: focus on TB. Future medicinal chemistry\| PubMed ID: 21359155	2010
Is age-related decline in lean mass and physical function accelerated by obstructive lung disease or smoking? Thorax\| PubMed ID: 21724748	2011
Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. Nature genetics\| PubMed ID: 21946350	2011
Comparative performance of cell life span and cell transit models for describing erythropoietic drug effects. The AAPS journal\| PubMed ID: 22005901	2011
Population pharmacokinetic/pharmacodynamic analyses as the basis for dosing of therapeutic monoclonal antibodies. Clinical pharmacokinetics\| PubMed ID: 22087868	2011
Characterizing the impact of renal impairment on the clinical pharmacology of biologics. Journal of clinical pharmacology\| PubMed ID: 22232754	2012
Immunogenicity to therapeutic proteins: impact on PK/PD and efficacy. The AAPS journal\| PubMed ID: 22407289	2012
Evaluation of vancomycin dosing regimens in preterm and term neonates using Monte Carlo simulations. Pharmacotherapy\| PubMed ID: 22488303	2012
Genetic ancestry-smoking interactions and lung function in African Americans: a cohort study. PloS one\| PubMed ID: 22737244	2012
The influence of abdominal visceral fat on inflammatory pathways and mortality risk in obstructive lung disease. The American journal of clinical nutrition\| PubMed ID: 22811442	2012
The current role of model-based drug development. Expert opinion on drug discovery\| PubMed ID: 22823084	2010
Genome Wide Association Studies Identify CHRNA5/3 and HTR4 in the Development of Airflow Obstruction. American journal of respiratory and critical care medicine\| PubMed ID: 22837378	2012
Developing a gene expression model for predicting ventilator-associated pneumonia in trauma patients: a pilot study. PloS one\| PubMed ID: 22916119	2012
Antitubercular nitrofuran isoxazolines with improved pharmacokinetic properties. Bioorganic & medicinal chemistry\| PubMed ID: 22995771	2012
Simple and sensitive assay for quantification of oseltamivir and its active metabolite oseltamivir carboxylate in human plasma using high-performance liquid chromatography coupled with elect... Journal of pharmaceutical and biomedical analysis\| PubMed ID: 23000242	2013
Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function. PLoS genetics\| PubMed ID: 23284291	2012
Strategic biomarkers for drug development in treating rare diseases and diseases in neonates and infants. The AAPS journal\| PubMed ID: 23334978	2013
Applications of pharmacometrics in the clinical development and pharmacotherapy of anti-infectives. Expert review of clinical pharmacology\| PubMed ID: 23473593	2013
Pharmacokinetics and pharmacokinetic-pharmacodynamic correlations of therapeutic peptides. Clinical pharmacokinetics\| PubMed ID: 23719681	2013
Pharmacokinetic profile of spectinomycin in rats. Die Pharmazie\| PubMed ID: 24020122	2013
Spectinamides: a new class of semisynthetic antituberculosis agents that overcome native drug efflux. Nature medicine\| PubMed ID: 24464186	2014
Novel endogenous glycan therapy for retinal diseases: safety, in vitro stability, ocular pharmacokinetic modeling, and biodistribution. The AAPS journal\| PubMed ID: 24470212	2014
Pentacyclic nitrofurans with in vivo efficacy and activity against nonreplicating Mycobacterium tuberculosis. PloS one\| PubMed ID: 24505329	2014
Large-scale genome-wide association studies and meta-analyses of longitudinal change in adult lung function. PloS one\| PubMed ID: 24983941	2014
Protein engineering for improved pharmacologic characteristics of established monoclonal antibody-based therapeutics. Clinical pharmacokinetics\| PubMed ID: 25212704	2014
Effects of alcohol on human carboxylesterase drug metabolism. Clinical pharmacokinetics\| PubMed ID: 25511794	2015
Ethanol lock therapy: a pilot infusion study in infants. The Annals of pharmacotherapy\| PubMed ID: 25632063	2015
Clinical pharmacology of bispecific antibody constructs. Journal of clinical pharmacology\| PubMed ID: 25707960	2015
Aminomethyl spectinomycins as therapeutics for drug-resistant respiratory tract and sexually transmitted bacterial infections. Science translational medicine\| PubMed ID: 25995221	2015
Human Ontogeny of Drug Transporters: Review and Recommendations of the Pediatric Transporter Working Group. Clinical pharmacology and therapeutics\| PubMed ID: 26088472	2015
Preclinical evaluation of SMM-189, a cannabinoid receptor 2-specific inverse agonist. Pharmacology research & perspectives\| PubMed ID: 26196013	2015
Pattern Recognition in Pharmacokinetic Data Analysis. The AAPS journal\| PubMed ID: 26338231	2016
In vitro and in vivo Evaluation of Synergism between Anti-Tubercular Spectinamides and Non-Classical Tuberculosis Antibiotics. Scientific reports\| PubMed ID: 26365087	2015
Effect of Ethanol on the Metabolic Characteristics of HIV-1 Integrase Inhibitor Elvitegravir and Elvitegravir/Cobicistat with CYP3A: An Analysis Using a Newly Developed LC-MS/MS Method. PloS one\| PubMed ID: 26872388	2016
Tissue Penetration of a Novel Spectinamide Antibiotic for the Treatment of Tuberculosis. The AAPS journal\| PubMed ID: 26984832	2016
Phase II Metabolic Pathways of Spectinamide Antitubercular Agents: A Comparative Study of the Reactivity of 4-Substituted Pyridines to Glutathione Conjugation. MedChemComm\| PubMed ID: 27042286	2016
Expression Patterns of Organic Anion Transporting Polypeptides 1B1 and 1B3 Protein in Human Pediatric Liver. Drug metabolism and disposition: the biological fate of chemicals\| PubMed ID: 27098745	2016
Drug Development of Therapeutic Monoclonal Antibodies. BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy\| PubMed ID: 27342605	2016
Translational PK/PD of anti-infective therapeutics. Drug discovery today. Technologies\| PubMed ID: 27978987	2016
Immune Suppression During Preclinical Drug Development Mitigates Immunogenicity-Mediated Impact on Therapeutic Exposure. The AAPS journal\| PubMed ID: 28070711	2017
Structure-Activity Relationships of Spectinamide Antituberculosis Agents: A Dissection of Ribosomal Inhibition and Native Efflux Avoidance Contributions. ACS infectious diseases\| PubMed ID: 28081607	2017
Alterations in cellular pharmacokinetics and pharmacodynamics of elvitegravir in response to ethanol exposure in HIV-1 infected monocytic (U1) cells. PloS one\| PubMed ID: 28231276	2017
A New Combination of a Pleuromutilin Derivative and Doxycycline for Treatment of Multidrug-Resistant Acinetobacter baumannii. Journal of medicinal chemistry\| PubMed ID: 28291943	2017
Regulatory and Ethical Issues in Pediatric Clinical Research: Recommendations From a Panel Discussion. Journal of clinical pharmacology\| PubMed ID: 28513861	2017
Core Entrustable Professional Activities in Clinical Pharmacology for Entering Residency: Biologics. Journal of clinical pharmacology\| PubMed ID: 28614591	2017
Influence of Ethanol on Darunavir Hepatic Clearance and Intracellular PK/PD in HIV-Infected Monocytes, and CYP3A4-Darunavir Interactions Using Inhibition and in Silico Binding Studies. Pharmaceutical research\| PubMed ID: 28616684	2017
Pharmacokinetics of Monoclonal Antibodies. CPT: pharmacometrics & systems pharmacology\| PubMed ID: 28653357	2017
Comparison of caffeine disposition following administration by oral solution (energy drink) and inspired powder (AeroShot) in human subjects. British journal of clinical pharmacology\| PubMed ID: 28758694	2017
Sustained plasma hepcidin suppression and iron elevation by Anticalin-derived hepcidin antagonist in cynomolgus monkey. British journal of pharmacology\| PubMed ID: 29329501	2018
Primary Lung Dendritic Cell Cultures to Assess Efficacy of Spectinamide-1599 Against Intracellular . Frontiers in microbiology\| PubMed ID: 30186246	2018
Tannic acid-inspired paclitaxel nanoparticles for enhanced anticancer effects in breast cancer cells. Journal of colloid and interface science\| PubMed ID: 30292104	2019
Pharmacometric Applications and Challenges in the Development of Therapeutic Antibodies in Immuno-Oncology. Current pharmacology reports\| PubMed ID: 30319936	2018
The Journey to AAPS 2020: a Reflection from Strategic Planning to PharmSci 360. AAPS PharmSciTech\| PubMed ID: 30390237	2018
The Journey to AAPS 2020: a Reflection from Strategic Planning to PharmSci 360. The AAPS journal\| PubMed ID: 30392015	2018
Dynamic time-kill curve characterization of spectinamide antibiotics 1445 and 1599 for the treatment of tuberculosis. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences\| PubMed ID: 30419293	2019
Comparative pharmacokinetics of spectinamide 1599 after subcutaneous and intrapulmonary aerosol administration in mice. Tuberculosis (Edinburgh, Scotland)\| PubMed ID: 30711150	2019
Core Entrustable Professional Activities in Clinical Pharmacology for Entering Residency: Common Problem Drugs and How to Prescribe Them. Journal of clinical pharmacology\| PubMed ID: 30768795	2019
Population pharmacokinetic meta-analysis of individual data to design the first randomized efficacy trial of vancomycin in neonates and young infants. The Journal of antimicrobial chemotherapy\| PubMed ID: 31049551	2019
Development and Characterization of a Dry Powder Formulation for Anti-Tuberculosis Drug Spectinamide 1599. Pharmaceutical research\| PubMed ID: 31321552	2019
Sterilization of Mycobacterium tuberculosis infected samples using methanol preserves anti-tuberculosis drugs for subsequent pharmacological testing studies. Tuberculosis (Edinburgh, Scotland)\| PubMed ID: 31378268	2019
Cross-Linked Polyphenol-Based Drug Nano-Self-Assemblies Engineered to Blockade Prostate Cancer Senescence. ACS applied materials & interfaces\| PubMed ID: 31553876	2019
Immunogenicity in Clinical Practice and Drug Development: When is it Significant? Clinical and translational science\| PubMed ID: 31762152	2020
Effective Removal of Dabigatran by Idarucizumab or Hemodialysis: A Physiologically Based Pharmacokinetic Modeling Analysis. Clinical pharmacokinetics\| PubMed ID: 32020532	2020
Pharmacokinetics and Clinical Pharmacology of Monoclonal Antibodies in Pediatric Patients. Paediatric drugs\| PubMed ID: 32052309	2020
Physiologically-Based Pharmacokinetic (PBPK) Modeling Providing Insights into Fentanyl Pharmacokinetics in Adults and Pediatric Patients. Pharmaceutics\| PubMed ID: 32977559	2020
Pharmacological principles guiding prolonged glucocorticoid treatment in ARDS. Intensive care medicine\| PubMed ID: 33150472	2020
Discovery of -(3,4-Dimethylphenyl)-4-(4-isobutyrylphenyl)-2,3,3a,4,5,9b-hexahydrofuro[3,2-]quinoline-8-sulfonamide as a Potent Dual MDM2/XIAP Inhibitor. Journal of medicinal chemistry\| PubMed ID: 33556244	2021
Use of Real-World Data and Pharmacometric Modeling in Support of Lacosamide Dosing in Pediatric Patients Under 4 Years of Age. Journal of clinical pharmacology\| PubMed ID: 33599301	2021
Drug Clearance in Neonates: A Combination of Population Pharmacokinetic Modelling and Machine Learning Approaches to Improve Individual Prediction. Clinical pharmacokinetics\| PubMed ID: 34041714	2021
Pediatric Dose Selection for Therapeutic Proteins. Journal of clinical pharmacology\| PubMed ID: 34185910	2021
Time to 'Mind the Gap' in novel small molecule drug discovery for direct-acting antivirals for SARS-CoV-2. Current opinion in virology\| PubMed ID: 34256351	2021
X-ray Crystallography-Guided Design, Antitumor Efficacy, and QSAR Analysis of Metabolically Stable Cyclopenta-Pyrimidinyl Dihydroquinoxalinone as a Potent Tubulin Polymerization Inhibitor. Journal of medicinal chemistry\| PubMed ID: 34406768	2021
Preclinical Evaluation of Inhalational Spectinamide-1599 Therapy against Tuberculosis. ACS infectious diseases\| PubMed ID: 34546724	2021
Drug Repurposing to Identify Nilotinib as a Potential SARS-CoV-2 Main Protease Inhibitor: Insights from a Computational and Study. Journal of chemical information and modeling\| PubMed ID: 34666487	2021
Knowledge Gaps in the Pharmacokinetics of Therapeutic Proteins in Pediatric Patients. Frontiers in pharmacology\| PubMed ID: 35222051	2022
Colchicine-Binding Site Agent CH-2-77 as a Potent Tubulin Inhibitor Suppressing Triple-Negative Breast Cancer. Molecular cancer therapeutics\| PubMed ID: 35499388	2022
Alcohol inhibits the metabolism of dimethyl fumarate to the active metabolite responsible for decreasing relapse frequency in the treatment of multiple sclerosis. PloS one\| PubMed ID: 36441753	2022
SB226, an inhibitor of tubulin polymerization, inhibits paclitaxel-resistant melanoma growth and spontaneous metastasis. Cancer letters\| PubMed ID: 36596380	2023
Spray dried tigecycline dry powder aerosols for the treatment of Nontuberculous mycobacterial pulmonary infections. Tuberculosis (Edinburgh, Scotland)\| PubMed ID: 36716525	2023
Barriers to global pharmacometrics: educational challenges and opportunities across the globe. CPT: pharmacometrics & systems pharmacology\| PubMed ID: 36960632	2023
TNX-1500, a crystallizable fragment-modified anti-CD154 antibody, prolongs nonhuman primate renal allograft survival. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons\| PubMed ID: 37019335	2023
TNX-1500, a crystallizable fragment-modified anti-CD154 antibody, prolongs nonhuman primate cardiac allograft survival. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons\| PubMed ID: 37030662	2023
Efficacy of a brain-penetrant antiviral in lethal Venezuelan and eastern equine encephalitis mouse models. Science translational medicine\| PubMed ID: 37043558	2023
Novel, Brain-Permeable, Cross-Species Benzothiazole Inhibitors of Microsomal Prostaglandin E Synthase-1 (mPGES-1) Dampen Neuroinflammation and . ACS pharmacology & translational science\| PubMed ID: 37082746	2023
Design, Synthesis, and Biological Evaluation of Pyrimidine Dihydroquinoxalinone Derivatives as Tubulin Colchicine Site-Binding Agents That Displayed Potent Anticancer Activity Both In Vitro ... ACS pharmacology & translational science\| PubMed ID: 37082747	2023
Characterization of spectinamide 1599 efficacy against different mycobacterial phenotypes. Tuberculosis (Edinburgh, Scotland)\| PubMed ID: 37120915	2023
Use of Machine Learning for Dosage Individualization of Vancomycin in Neonates. Clinical pharmacokinetics\| PubMed ID: 37300630	2023
Clinical and Translational Pharmacology Considerations for Anti-infectives Approved Under the FDA Animal Rule. Clinical pharmacokinetics\| PubMed ID: 37326917	2023
Development of a Minimalistic Physiologically Based Pharmacokinetic (mPBPK) Model for the Preclinical Development of Spectinamide Antibiotics. Pharmaceutics\| PubMed ID: 37376207	2023
The inducible prostaglandin E synthase (mPGES-1) in neuroinflammatory disorders. Experimental biology and medicine (Maywood, N.J.)\| PubMed ID: 37515545	2023