Pieter S. Hiemstra

PulmoScience Laboratory, Leiden University Medical Center

Affiliated withLeiden University Medical Center

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 25	2023

Other Publications

Article	Year
World Congress on Lung Health and 10th ERS Annual Congress 30 August-3 September 2000, Florence, Italy. Respiratory research\| PubMed ID: 11667983	2000
Expression of beta-defensin 1 and 2 mRNA by human monocytes, macrophages and dendritic cells. Immunology\| PubMed ID: 12153515	2002
An angiogenic role for the human peptide antibiotic LL-37/hCAP-18. The Journal of clinical investigation\| PubMed ID: 12782669	2003
Neutrophil defensins enhance lung epithelial wound closure and mucin gene expression in vitro. American journal of respiratory cell and molecular biology\| PubMed ID: 12871849	2004
Are rhinovirus-induced airway responses in asthma aggravated by chronic allergen exposure? American journal of respiratory and critical care medicine\| PubMed ID: 12893645	2003
Rhinovirus increases human beta-defensin-2 and -3 mRNA expression in cultured bronchial epithelial cells. FEMS immunology and medical microbiology\| PubMed ID: 12900056	2003
Series introduction: Innate host defense of the respiratory epithelium. Journal of leukocyte biology\| PubMed ID: 14612432	2004
The antimicrobial peptide LL-37 activates innate immunity at the airway epithelial surface by transactivation of the epidermal growth factor receptor. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 14662872	2003
Gene expression profile and histopathology of experimental bronchopulmonary dysplasia induced by prolonged oxidative stress. Free radical biology & medicine\| PubMed ID: 14990357	2004
Bacterial products increase expression of the human cathelicidin hCAP-18/LL-37 in cultured human sinus epithelial cells. FEMS immunology and medical microbiology\| PubMed ID: 15364108	2004
TGF-beta differentially regulates TH2 cytokine-induced eotaxin and eotaxin-3 release by human airway smooth muscle cells. The Journal of allergy and clinical immunology\| PubMed ID: 15480317	2004
Interactions between neutrophil-derived antimicrobial peptides and airway epithelial cells. Journal of leukocyte biology\| PubMed ID: 15591123	2005
Transcriptional response of bronchial epithelial cells to Pseudomonas aeruginosa: identification of early mediators of host defense. Physiological genomics\| PubMed ID: 15701729	2005
Eotaxin-2 and eotaxin-3 expression is associated with persistent eosinophilic bronchial inflammation in patients with asthma after allergen challenge. The Journal of allergy and clinical immunology\| PubMed ID: 15805998	2005
The human cathelicidin LL-37: a multifunctional peptide involved in infection and inflammation in the lung. Pulmonary pharmacology & therapeutics\| PubMed ID: 15939310	2005
Host defense effector molecules in mucosal secretions. FEMS immunology and medical microbiology\| PubMed ID: 16051067	2005
Bronchial CD8 cell infiltrate and lung function decline in asthma. American journal of respiratory and critical care medicine\| PubMed ID: 16085937	2005
Cytokine-dependent proliferation of human CD34+ progenitor cells in the absence of serum is suppressed by their progeny's production of serine proteinases. Stem cells (Dayton, Ohio)\| PubMed ID: 16109763	2006
Development of novel LL-37 derived antimicrobial peptides with LPS and LTA neutralizing and antimicrobial activities for therapeutic application. Peptides\| PubMed ID: 16274847	2006
Effects of cigarette smoke condensate on proliferation and wound closure of bronchial epithelial cells in vitro: role of glutathione. Respiratory research\| PubMed ID: 16309548	2005
Expression of epidermal growth factors and their receptors in the bronchial epithelium of subjects with chronic obstructive pulmonary disease. American journal of clinical pathology\| PubMed ID: 16393673	2006
A molecular signature of epithelial host defense: comparative gene expression analysis of cultured bronchial epithelial cells and keratinocytes. BMC genomics\| PubMed ID: 16420688	2006
Human cathelicidin LL-37 is a chemoattractant for eosinophils and neutrophils that acts via formyl-peptide receptors. International archives of allergy and immunology\| PubMed ID: 16557028	2006
Epithelial differentiation is a determinant in the production of eotaxin-2 and -3 by bronchial epithelial cells in response to IL-4 and IL-13. Molecular immunology\| PubMed ID: 16740309	2007
The antimicrobial peptide LL-37 enhances IL-8 release by human airway smooth muscle cells. The Journal of allergy and clinical immunology\| PubMed ID: 16750994	2006
The SERPINE2 gene and chronic obstructive pulmonary disease. American journal of human genetics\| PubMed ID: 16773582	2006
Exploring host-pathogen interactions at the epithelial surface: application of transcriptomics in lung biology. American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 17041013	2007
Adenovirus-specific CD4+ T cell clones recognizing endogenous antigen inhibit viral replication in vitro through cognate interaction. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 17142788	2006
Small airways dysfunction and neutrophilic inflammation in bronchial biopsies and BAL in COPD. Chest\| PubMed ID: 17218556	2007
Demonstration of bacterial cells and glycocalyx in biofilms on human tonsils. Archives of otolaryngology--head & neck surgery\| PubMed ID: 17309977	2007
Bronchial inflammation and airway responses to deep inspiration in asthma and chronic obstructive pulmonary disease. American journal of respiratory and critical care medicine\| PubMed ID: 17379851	2007
Inhaled nitric oxide attenuates pulmonary inflammation and fibrin deposition and prolongs survival in neonatal hyperoxic lung injury. American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 17384081	2007
Human neutrophil peptide-1 inhibits both the classical and the lectin pathway of complement activation. Molecular immunology\| PubMed ID: 17448537	2007
Reduction in sputum neutrophil and eosinophil numbers by the PDE4 inhibitor roflumilast in patients with COPD. Thorax\| PubMed ID: 17573446	2007
The role of epithelial beta-defensins and cathelicidins in host defense of the lung. Experimental lung research\| PubMed ID: 18075828	2007
An antimicrobial peptide modulates epithelial responses to bacterial products. The Laryngoscope\| PubMed ID: 18300705	2008
Expression of smooth muscle and extracellular matrix proteins in relation to airway function in asthma. The Journal of allergy and clinical immunology\| PubMed ID: 18405955	2008
Comparison of exhaled breath condensate pH using two commercially available devices in healthy controls, asthma and COPD patients. Respiratory research\| PubMed ID: 19703285	2009
Effect of fluticasone with and without salmeterol on pulmonary outcomes in chronic obstructive pulmonary disease: a randomized trial. Annals of internal medicine\| PubMed ID: 19841453	2009
Association of MMP-2 polymorphisms with severe and very severe COPD: a case control study of MMPs-1, 9 and 12 in a European population. BMC medical genetics\| PubMed ID: 20078883	2010
Expression patterns of protein C inhibitor in mouse development. Journal of molecular histology\| PubMed ID: 20229239	2010
Recent advances in alveolar biology: evolution and function of alveolar proteins. Respiratory physiology & neurobiology\| PubMed ID: 20433956	2010
Multidrug resistance-associated protein-1 (MRP1) genetic variants, MRP1 protein levels and severity of COPD. Respiratory research\| PubMed ID: 20487524	2010
LL-37 directs macrophage differentiation toward macrophages with a proinflammatory signature. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 20610648	2010
Severe congenital neutropenia in a multigenerational family with a novel neutrophil elastase (ELANE) mutation. Annals of hematology\| PubMed ID: 20803142	2011
Pro-inflammatory mechanisms of muscarinic receptor stimulation in airway smooth muscle. Respiratory research\| PubMed ID: 20875145	2010
The role of IREB2 and transforming growth factor beta-1 genetic variants in COPD: a replication case-control study. BMC medical genetics\| PubMed ID: 21320324	2011
Smoking status and anti-inflammatory macrophages in bronchoalveolar lavage and induced sputum in COPD. Respiratory research\| PubMed ID: 21426578	2011
IL-4 and IL-13 exposure during mucociliary differentiation of bronchial epithelial cells increases antimicrobial activity and expression of antimicrobial peptides. Respiratory research\| PubMed ID: 21529380	2011
PRAME-specific Allo-HLA-restricted T cells with potent antitumor reactivity useful for therapeutic T-cell receptor gene transfer. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 21771875	2011
Hepatocyte-specific IKKβ expression aggravates atherosclerosis development in APOE*3-Leiden mice. Atherosclerosis\| PubMed ID: 21798539	2012
A quantitative method for detection of spliced X-box binding protein-1 (XBP1) mRNA as a measure of endoplasmic reticulum (ER) stress. Cell stress & chaperones\| PubMed ID: 22038282	2012
α1-antitrypsin production by proinflammatory and antiinflammatory macrophages and dendritic cells. American journal of respiratory cell and molecular biology\| PubMed ID: 22162908	2012
Difference in symptom severity between early and late grass pollen season in patients with seasonal allergic rhinitis. Clinical and translational allergy\| PubMed ID: 22410160	2011
Toll-like receptor (TLR2 and TLR4) polymorphisms and chronic obstructive pulmonary disease. PloS one\| PubMed ID: 22952638	2012
Profiling the proteome of exhaled breath condensate in healthy smokers and COPD patients by LC-MS/MS. International journal of molecular sciences\| PubMed ID: 23203040	2012
Resveratrol protects against atherosclerosis, but does not add to the antiatherogenic effect of atorvastatin, in APOE*3-Leiden.CETP mice. The Journal of nutritional biochemistry\| PubMed ID: 23337345	2013
Systemic inflammation and lung function impairment in morbidly obese subjects with the metabolic syndrome. Journal of obesity\| PubMed ID: 23509614	2013
CD8(+) T cells characterize early smoking-related airway pathology in patients with asthma. Respiratory medicine\| PubMed ID: 23639272	2013
Inhaled steroids modulate extracellular matrix composition in bronchial biopsies of COPD patients: a randomized, controlled trial. PloS one\| PubMed ID: 23667615	2013
Development and validation of a 5-day-ahead hay fever forecast for patients with grass-pollen-induced allergic rhinitis. International journal of biometeorology\| PubMed ID: 23780494	2014
Airway gene expression in COPD is dynamic with inhaled corticosteroid treatment and reflects biological pathways associated with disease activity. Thorax\| PubMed ID: 23925644	2014
Development of a nose cream containing the synthetic antimicrobial peptide P60.4Ac for eradication of methicillin-resistant Staphylococcus aureus carriage. Journal of pharmaceutical sciences\| PubMed ID: 23955373	2013
Increase in net activity of serine proteinases but not gelatinases after local endotoxin exposure in the peripheral airways of healthy subjects. PloS one\| PubMed ID: 24086430	2013
Increased ERK signalling promotes inflammatory signalling in primary airway epithelial cells expressing Z α1-antitrypsin. Human molecular genetics\| PubMed ID: 24097797	2014
The effect of PPE-induced emphysema and chronic LPS-induced pulmonary inflammation on atherosclerosis development in APOE*3-LEIDEN mice. PloS one\| PubMed ID: 24303000	2013
Recent progress in peptide vaccination in cancer with a focus on non-small-cell lung cancer. Expert review of vaccines\| PubMed ID: 24308580	2014
pH in exhaled breath condensate and nasal lavage as a biomarker of air pollution-related inflammation in street traffic-controllers and office-workers. Clinics (Sao Paulo, Brazil)\| PubMed ID: 24473505	2013
Steroid resistance in COPD? Overlap and differential anti-inflammatory effects in smokers and ex-smokers. PloS one\| PubMed ID: 24505290	2014
Susceptibility to chronic mucus hypersecretion, a genome wide association study. PloS one\| PubMed ID: 24714607	2014
LL-37-derived peptides eradicate multidrug-resistant Staphylococcus aureus from thermally wounded human skin equivalents. Antimicrobial agents and chemotherapy\| PubMed ID: 24841266	2014
Efficient and sensitive identification and quantification of airborne pollen using next-generation DNA sequencing. Molecular ecology resources\| PubMed ID: 24893805	2015
Genome-wide association analysis identifies six new loci associated with forced vital capacity. Nature genetics\| PubMed ID: 24929828	2014
Dissecting the genetics of chronic mucus hypersecretion in smokers with and without COPD. The European respiratory journal\| PubMed ID: 25234806	2015
Club cells, CC10 and self-control at the epithelial surface. The European respiratory journal\| PubMed ID: 25271220	2014
Function of monocytes and monocyte-derived macrophages in α1-antitrypsin deficiency. The European respiratory journal\| PubMed ID: 25323228	2015
Brown adipose tissue takes up plasma triglycerides mostly after lipolysis. Journal of lipid research\| PubMed ID: 25351615	2015
Reproducibility of exhaled nitric oxide measurements in overweight and obese adults. BMC research notes\| PubMed ID: 25366981	2014
Muscarinic M3 receptors on structural cells regulate cigarette smoke-induced neutrophilic airway inflammation in mice. American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 25381025	2014
Genome-Wide Association Study Identification of Novel Loci Associated with Airway Responsiveness in Chronic Obstructive Pulmonary Disease. American journal of respiratory cell and molecular biology\| PubMed ID: 25514360	2015
Asthma-COPD overlap. Clinical relevance of genomic signatures of type 2 inflammation in chronic obstructive pulmonary disease. American journal of respiratory and critical care medicine\| PubMed ID: 25611785	2015
The innate immune function of airway epithelial cells in inflammatory lung disease. The European respiratory journal\| PubMed ID: 25700381	2015
Basal cells contribute to innate immunity of the airway epithelium through production of the antimicrobial protein RNase 7. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 25712218	2015
Brown fat activation reduces hypercholesterolaemia and protects from atherosclerosis development. Nature communications\| PubMed ID: 25754609	2015
Vitamin D, vitamin D binding protein, and longitudinal outcomes in COPD. PloS one\| PubMed ID: 25803709	2015
Effect of bariatric surgery on asthma control, lung function and bronchial and systemic inflammation in morbidly obese subjects with asthma. Thorax\| PubMed ID: 25934136	2015
Tiotropium attenuates IL-13-induced goblet cell metaplasia of human airway epithelial cells. Thorax\| PubMed ID: 25995156	2015
Local and systemic XAGE-1b-specific immunity in patients with lung adenocarcinoma. Cancer immunology, immunotherapy : CII\| PubMed ID: 26025564	2015
Prevention of exacerbations in patients with COPD and vitamin D deficiency through vitamin D supplementation (PRECOVID): a study protocol. BMC pulmonary medicine\| PubMed ID: 26399451	2015
Therapeutic potential of soluble guanylate cyclase modulators in neonatal chronic lung disease. American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 26432873	2015
Antimicrobial Peptides and Innate Lung Defenses: Role in Infectious and Noninfectious Lung Diseases and Therapeutic Applications. Chest\| PubMed ID: 26502035	2016
Nasal Levels of Antimicrobial Peptides in Allergic Asthma Patients and Healthy Controls: Differences and Effect of a Short 1,25(OH)2 Vitamin D3 Treatment. PloS one\| PubMed ID: 26545199	2015
Parallel activities and interactions between antimicrobial peptides and complement in host defense at the airway epithelial surface. Molecular immunology\| PubMed ID: 26597202	2015
The positive prognostic effect of stromal CD8+ tumor-infiltrating T cells is restrained by the expression of HLA-E in non-small cell lung carcinoma. Oncotarget\| PubMed ID: 26658106	2016
Prediction of Long-Term Benefits of Inhaled Steroids by Phenotypic Markers in Moderate-to-Severe COPD: A Randomized Controlled Trial. PloS one\| PubMed ID: 26659582	2015
Regulation of YKL-40 expression by corticosteroids: effect on pro-inflammatory macrophages in vitro and its modulation in COPD in vivo. Respiratory research\| PubMed ID: 26696093	2015
TNF-α and IL-1β-activated human mesenchymal stromal cells increase airway epithelial wound healing in vitro via activation of the epidermal growth factor receptor. Respiratory research\| PubMed ID: 26753875	2016
MicroRNA-223 controls the expression of histone deacetylase 2: a novel axis in COPD. Journal of molecular medicine (Berlin, Germany)\| PubMed ID: 26864305	2016
IL-13 and the Airway Epithelium. It Is All in the Genes. American journal of respiratory and critical care medicine\| PubMed ID: 26871666	2016
Microbes and asthma: Opportunities for intervention. The Journal of allergy and clinical immunology\| PubMed ID: 26947981	2016
Murine models of cardiovascular comorbidity in chronic obstructive pulmonary disease. American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 26993520	2016
Neutrophil-derived alpha defensins control inflammation by inhibiting macrophage mRNA translation. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 27044108	2016
Regeneration of the lung: Lung stem cells and the development of lung mimicking devices. Respiratory research\| PubMed ID: 27107715	2016
Antimicrobial Peptide P60.4Ac-Containing Creams and Gel for Eradication of Methicillin-Resistant Staphylococcus aureus from Cultured Skin and Airway Epithelial Surfaces. Antimicrobial agents and chemotherapy\| PubMed ID: 27114278	2016
Cellular response of mucociliary differentiated primary bronchial epithelial cells to diesel exhaust. American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 27190060	2016
Lung function decline in asthma patients with elevated bronchial CD8, CD4 and CD3 cells. The European respiratory journal\| PubMed ID: 27230446	2016
Azithromycin differentially affects the IL-13-induced expression profile in human bronchial epithelial cells. Pulmonary pharmacology & therapeutics\| PubMed ID: 27246785	2016
Childhood allergies and asthma: New insights on environmental exposures and local immunity at the lung barrier. Current opinion in immunology\| PubMed ID: 27254380	2016
The Dutch National Program for Respiratory Research. The Lancet. Respiratory medicine\| PubMed ID: 27304557	2016
Airway hyperresponsiveness in chronic obstructive pulmonary disease: A marker of asthma-chronic obstructive pulmonary disease overlap syndrome? The Journal of allergy and clinical immunology\| PubMed ID: 27345171	2016
ADAM17 and EGFR regulate IL-6 receptor and amphiregulin mRNA expression and release in cigarette smoke-exposed primary bronchial epithelial cells from patients with chronic obstructive pulmo... Physiological reports\| PubMed ID: 27561911	2016
Basic science of electronic cigarettes: assessment in cell culture and in vivo models. Respiratory research\| PubMed ID: 27717371	2016
Functional characterisation of bone marrow-derived mesenchymal stromal cells from COPD patients. ERJ open research\| PubMed ID: 27730190	2016
Xenobiotic metabolism in differentiated human bronchial epithelial cells. Archives of toxicology\| PubMed ID: 27738743	2017
Cigarette Smoke Modulates Repair and Innate Immunity following Injury to Airway Epithelial Cells. PloS one\| PubMed ID: 27829065	2016
Airway inflammation in COPD after long-term withdrawal of inhaled corticosteroids. The European respiratory journal\| PubMed ID: 28049170	2017
Standard radiotherapy but not chemotherapy impairs systemic immunity in non-small cell lung cancer. Oncoimmunology\| PubMed ID: 28123900	2016
Diesel exhaust alters the response of cultured primary bronchial epithelial cells from patients with chronic obstructive pulmonary disease (COPD) to non-typeable Haemophilus influenzae. Respiratory research\| PubMed ID: 28129777	2017
Antibacterial Defense of Human Airway Epithelial Cells from Chronic Obstructive Pulmonary Disease Patients Induced by Acute Exposure to Nontypeable Haemophilus influenzae: Modulation by Ciga... Journal of innate immunity\| PubMed ID: 28171878	2017
Proinflammatory Cytokines Impair Vitamin D-Induced Host Defense in Cultured Airway Epithelial Cells. American journal of respiratory cell and molecular biology\| PubMed ID: 28231019	2017
Antimicrobial peptide levels are linked to airway inflammation, bacterial colonisation and exacerbations in chronic obstructive pulmonary disease. The European respiratory journal\| PubMed ID: 28298400	2017
Defining asthma-COPD overlap syndrome: a population-based study. The European respiratory journal\| PubMed ID: 28461292	2017
Use of airway epithelial cell culture to unravel the pathogenesis and study treatment in obstructive airway diseases. Pulmonary pharmacology & therapeutics\| PubMed ID: 28502841	2017
Airway inflammation in COPD after long-term withdrawal of inhaled corticosteroids. The European respiratory journal\| PubMed ID: 28619964	2017
The effect of tiotropium in combination with olodaterol on house dust mite-induced allergic airway disease. Pulmonary pharmacology & therapeutics\| PubMed ID: 28687462	2017
Cigarette smoke differentially affects IL-13-induced gene expression in human airway epithelial cells. Physiological reports\| PubMed ID: 28701525	2017
Bone Morphogenetic Protein 9 Protects against Neonatal Hyperoxia-Induced Impairment of Alveolarization and Pulmonary Inflammation. Frontiers in physiology\| PubMed ID: 28751863	2017
The Effects of Selective Hematopoietic Expression of Human IL-37 on Systemic Inflammation and Atherosclerosis in LDLr-Deficient Mice. International journal of molecular sciences\| PubMed ID: 28792474	2017
Pre-surgical Pulmonary Rehabilitation in Asthma Patients Undergoing Bariatric Surgery. Obesity surgery\| PubMed ID: 28831733	2017
Acute and chronic effects of treatment with mesenchymal stromal cells on LPS-induced pulmonary inflammation, emphysema and atherosclerosis development. PloS one\| PubMed ID: 28910300	2017
Airway Epithelial Barrier Dysfunction in Chronic Obstructive Pulmonary Disease: Role of Cigarette Smoke Exposure. American journal of respiratory cell and molecular biology\| PubMed ID: 28933915	2018
microRNA profiling in lung tissue and bronchoalveolar lavage of cigarette smoke-exposed mice and in COPD patients: a translational approach. Scientific reports\| PubMed ID: 28993685	2017
Human lung epithelial cell cultures for analysis of inhaled toxicants: Lessons learned and future directions. Toxicology in vitro : an international journal published in association with BIBRA\| PubMed ID: 29155131	2018
Reprogramming of cellular metabolism: driver for airway remodelling in COPD? The European respiratory journal\| PubMed ID: 29191957	2017
Pulmonary function, exhaled nitric oxide and symptoms in asthma patients with obesity: a cross-sectional study. Respiratory research\| PubMed ID: 29212496	2017
Associations of Serum 25(OH)D Concentrations with Lung Function, Airway Inflammation and Common Cold in the General Population. Nutrients\| PubMed ID: 29301349	2018
Therapeutic Application of an Extract of Ameliorates the Development of Allergic Airway Disease. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 29352004	2018
Effect of diesel exhaust generated by a city bus engine on stress responses and innate immunity in primary bronchial epithelial cell cultures. Toxicology in vitro : an international journal published in association with BIBRA\| PubMed ID: 29408669	2018
Farm dust reduces viral load in human bronchial epithelial cells by increasing barrier function and antiviral responses. The Journal of allergy and clinical immunology\| PubMed ID: 29425849	2018
Assembly 3: Basic and Translational Sciences. Breathe (Sheffield, England)\| PubMed ID: 29515672	2018
Effects of E-Cigarette Use on Human Lung Tissue. On Harm Reduction and Causing Harm. American journal of respiratory and critical care medicine\| PubMed ID: 29518342	2018
Aberrant epithelial differentiation by cigarette smoke dysregulates respiratory host defence. The European respiratory journal\| PubMed ID: 29545277	2018
Mesenchymal stromal cells: a novel therapy for the treatment of chronic obstructive pulmonary disease? Thorax\| PubMed ID: 29653970	2018
Response to Comment on "Therapeutic Application of an Extract of Ameliorates the Development of Allergic Airway Disease". Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 29685947	2018
Airway Epithelial Cell Function and Respiratory Host Defense in Chronic Obstructive Pulmonary Disease. Chinese medical journal\| PubMed ID: 29692382	2018
Predictive value of eosinophils and neutrophils on clinical effects of ICS in COPD. Respirology (Carlton, Vic.)\| PubMed ID: 29696728	2018
Basic and translational research in the . The European respiratory journal\| PubMed ID: 29724787	2018
A novel method for expansion and differentiation of mouse tracheal epithelial cells in culture. Scientific reports\| PubMed ID: 29743551	2018
Aerobic Exercise Protects from Pseudomonas aeruginosa-Induced Pneumonia in Elderly Mice. Journal of innate immunity\| PubMed ID: 29843140	2018
Immunomodulatory innate defence regulator (IDR) peptide alleviates airway inflammation and hyper-responsiveness. Thorax\| PubMed ID: 29853649	2018
Stem cell-based Lung-on-Chips: The best of both worlds? Advanced drug delivery reviews\| PubMed ID: 30009883	2019
Contribution of Host Defence Proteins and Peptides to Host-Microbiota Interactions in Chronic Inflammatory Lung Diseases. Vaccines\| PubMed ID: 30060554	2018
Retinoic acid signaling balances adult distal lung epithelial progenitor cell growth and differentiation. EBioMedicine\| PubMed ID: 30236449	2018
Electronic cigarettes: a task force report from the European Respiratory Society. The European respiratory journal\| PubMed ID: 30464018	2019
How to write a response to the reviewers of your manuscript. Breathe (Sheffield, England)\| PubMed ID: 30519299	2018
Dynamic differences in dietary polyunsaturated fatty acid metabolism in sputum of COPD patients and controls. Biochimica et biophysica acta. Molecular and cell biology of lipids\| PubMed ID: 30528790	2019
Effect of long-term corticosteroid treatment on microRNA and gene-expression profiles in COPD. The European respiratory journal\| PubMed ID: 30846474	2019
TGF-β activation impairs fibroblast ability to support adult lung epithelial progenitor cell organoid formation. American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 30969812	2019
TGF-β1 Impairs Vitamin D-Induced and Constitutive Airway Epithelial Host Defense Mechanisms. Journal of innate immunity\| PubMed ID: 30970352	2020
Antimicrobial Host Defence Peptides: Immunomodulatory Functions and Translational Prospects. Advances in experimental medicine and biology\| PubMed ID: 30980358	2019
Macrophage function in chronic obstructive pulmonary disease: The many faces of notch signalling. EBioMedicine\| PubMed ID: 31047859	2019
From the pathophysiology of the human lung alveolus to epigenetic editing: Congress 2018 highlights from ERS Assembly 3 "Basic and Translational Science.". ERJ open research\| PubMed ID: 31111040	2019
Extract of Helicobacter pylori Ameliorates Parameters of Airway Inflammation and Goblet Cell Hyperplasia following Repeated Allergen Exposure. International archives of allergy and immunology\| PubMed ID: 31242493	2019
Blood eosinophil count and airway epithelial transcriptome relationships in COPD versus asthma. Allergy\| PubMed ID: 31506971	2020
Airway and alveolar epithelial cells in culture. The European respiratory journal\| PubMed ID: 31515398	2019
Sputum microbiota and inflammation at stable state and during exacerbations in a cohort of chronic obstructive pulmonary disease (COPD) patients. PloS one\| PubMed ID: 31527888	2019
Perioperative proADM-change is associated with the development of acute respiratory distress syndrome in critically ill cardiac surgery patients: a prospective cohort study. Biomarkers in medicine\| PubMed ID: 31544475	2019
Translation of findings to patients with asthma: a timely and compelling challenge. The European respiratory journal\| PubMed ID: 31601723	2019
The respiratory virome and exacerbations in patients with chronic obstructive pulmonary disease. PloS one\| PubMed ID: 31647831	2019
Osteopontin Expression in Small Airway Epithelium in Copd is Dependent on Differentiation and Confined to Subsets of Cells. Scientific reports\| PubMed ID: 31664154	2019
Mitochondria: at the crossroads of regulating lung epithelial cell function in chronic obstructive pulmonary disease. American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 31693390	2020
Innate Immunity of the Lung. Journal of innate immunity\| PubMed ID: 31801141	2020
Author Correction: Osteopontin Expression in Small Airway Epithelium in Copd is Dependent on Differentiation and Confined to Subsets of Cells. Scientific reports\| PubMed ID: 31937899	2020
Tumor mutational load, CD8 T cells, expression of PD-L1 and HLA class I to guide immunotherapy decisions in NSCLC patients. Cancer immunology, immunotherapy : CII\| PubMed ID: 32047958	2020
ERS International Congress, Madrid, 2019: highlights from the Basic and Translational Science Assembly. ERJ open research\| PubMed ID: 32154289	2020
In vitro modelling of alveolar repair at the air-liquid interface using alveolar epithelial cells derived from human induced pluripotent stem cells. Scientific reports\| PubMed ID: 32218519	2020
Modulation of Airway Epithelial Innate Immunity and Wound Repair by M(GM-CSF) and M(M-CSF) Macrophages. Journal of innate immunity\| PubMed ID: 32289801	2020
Short-term and long-term effect of a high-intensity pulmonary rehabilitation programme in obese patients with asthma: a randomised controlled trial. The European respiratory journal\| PubMed ID: 32299852	2020
Adiposity is a confounding factor which largely explains the association of serum vitamin D concentrations with C-reactive protein, leptin and adiponectin. Cytokine\| PubMed ID: 32325367	2020
Vitamin D Deficiency in Asthma and Chronic Obstructive Pulmonary Disease. A Chicken-or-Egg Story. American journal of respiratory and critical care medicine\| PubMed ID: 32352312	2020
Host-microbe cross-talk in the lung microenvironment: implications for understanding and treating chronic lung disease. The European respiratory journal\| PubMed ID: 32430415	2020
Suramin Inhibits SARS-CoV-2 Infection in Cell Culture by Interfering with Early Steps of the Replication Cycle. Antimicrobial agents and chemotherapy\| PubMed ID: 32513797	2020
Wnt/β-catenin signaling is critical for regenerative potential of distal lung epithelial progenitor cells in homeostasis and emphysema. Stem cells (Dayton, Ohio)\| PubMed ID: 32526076	2020
Tiotropium and Fluticasone Inhibit Rhinovirus-Induced Mucin Production via Multiple Mechanisms in Differentiated Airway Epithelial Cells. Frontiers in cellular and infection microbiology\| PubMed ID: 32637364	2020
Impact of the Local Inflammatory Environment on Mucosal Vitamin D Metabolism and Signaling in Chronic Inflammatory Lung Diseases. Frontiers in immunology\| PubMed ID: 32754156	2020
RAGE and TLR4 differentially regulate airway hyperresponsiveness: Implications for COPD. Allergy\| PubMed ID: 32799375	2021
An emerging class of air pollutants: Potential effects of microplastics to respiratory human health? The Science of the total environment\| PubMed ID: 32827829	2020
A new portable sampler to monitor pollen at street level in the environment of patients. The Science of the total environment\| PubMed ID: 32887011	2020
Air-Liquid Interface Models for Respiratory Toxicology Research: Consensus Workshop and Recommendations. Applied in vitro toxicology\| PubMed ID: 32953944	2018
Bronchial gene expression signature associated with rate of subsequent FEV decline in individuals with and at risk of COPD. Thorax\| PubMed ID: 33972452	2022
Novel insights into surfactant protein C trafficking revealed through the study of a pathogenic mutant. The European respiratory journal\| PubMed ID: 34049951	2022
Gender specific airway gene expression in COPD sub-phenotypes supports a role of mitochondria and of different types of leukocytes. Scientific reports\| PubMed ID: 34145303	2021
Repairing damaged lungs using regenerative therapy. Current opinion in pharmacology\| PubMed ID: 34161852	2021
Comparison of genome-wide gene expression profiling by RNA Sequencing microarray in bronchial biopsies of COPD patients before and after inhaled corticosteroid treatment: does it provide ne... ERJ open research\| PubMed ID: 34164552	2021
The Course of AαVal541 as a Proteinase 3 Specific Neo-Epitope after Alpha-1-Antitrypsin Augmentation in Severe Deficient Patients. International journal of molecular sciences\| PubMed ID: 34360796	2021
Disease modeling following organoid-based expansion of airway epithelial cells. American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 34378410	2021
Factors associated with physical activity among COPD patients with mild or moderate airflow obstruction. Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace\| PubMed ID: 34523325	2021
Kallikrein-related peptidase 5 contributes to the remodeling and repair of bronchial epithelium. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 34582061	2021
Determinants of expression of SARS-CoV-2 entry-related genes in upper and lower airways. Allergy\| PubMed ID: 34698405	2022
Prolonged activation of nasal immune cell populations and development of tissue-resident SARS-CoV-2-specific CD8 T cell responses following COVID-19. Nature immunology\| PubMed ID: 34937933	2022
The lower airways microbiome and antimicrobial peptides in idiopathic pulmonary fibrosis differ from chronic obstructive pulmonary disease. PloS one\| PubMed ID: 34990493	2022
Lung epithelial cells interact with immune cells and bacteria to shape the microenvironment in tuberculosis. Thorax\| PubMed ID: 35017314	2022
Organoid-based expansion of patient-derived primary alveolar type 2 cells for establishment of alveolus epithelial Lung-Chip cultures. American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 35137633	2022
Role of air pollutants in airway epithelial barrier dysfunction in asthma and COPD. European respiratory review : an official journal of the European Respiratory Society\| PubMed ID: 35321933	2022
Performance of Five Metagenomic Classifiers for Virus Pathogen Detection Using Respiratory Samples from a Clinical Cohort. Pathogens (Basel, Switzerland)\| PubMed ID: 35335664	2022
Dysregulated mitochondrial metabolism upon cigarette smoke exposure in various human bronchial epithelial cell models. Disease models & mechanisms\| PubMed ID: 35344036	2022
High miR203a-3p and miR-375 expression in the airways of smokers with and without COPD. Scientific reports\| PubMed ID: 35379844	2022
Vitamin D supplementation in chronic obstructive pulmonary disease patients with low serum vitamin D: a randomized controlled trial. The American journal of clinical nutrition\| PubMed ID: 35383823	2022
Personalized Pollen Monitoring and Symptom Scores: A Feasibility Study in Grass Pollen Allergic Patients. Frontiers in allergy\| PubMed ID: 35387060	2021
3D Lung-on-Chip Model Based on Biomimetically Microcurved Culture Membranes. ACS biomaterials science & engineering\| PubMed ID: 35502997	2022
Host succinate inhibits influenza virus infection through succinylation and nuclear retention of the viral nucleoprotein. The EMBO journal\| PubMed ID: 35506364	2022
Association of bronchial steroid inducible methylation quantitative trait loci with asthma and chronic obstructive pulmonary disease treatment response. Clinical and translational allergy\| PubMed ID: 36036237	2022
Keratin 8 is a scaffolding and regulatory protein of ERAD complexes. Cellular and molecular life sciences : CMLS\| PubMed ID: 36045259	2022
Early transcriptional responses of bronchial epithelial cells to whole cigarette smoke mirror those of in-vivo exposed human bronchial mucosa. Respiratory research\| PubMed ID: 36056356	2022
The lower airways microbiota and antimicrobial peptides indicate dysbiosis in sarcoidosis. Microbiome\| PubMed ID: 36258251	2022
Cigarette Smoke Impairs Airway Epithelial Wound Repair: Role of Modulation of Epithelial-Mesenchymal Transition Processes and Notch-1 Signaling. Antioxidants (Basel, Switzerland)\| PubMed ID: 36290742	2022
SARS-CoV-2-specific CD4 and CD8 T cell responses can originate from cross-reactive CMV-specific T cells. eLife\| PubMed ID: 36408799	2022
Combination of IL-17A/F and TNF-α uniquely alters the bronchial epithelial cell proteome to enhance proteins that augment neutrophil migration. Journal of inflammation (London, England)\| PubMed ID: 36517803	2022
Th2 high and mast cell gene signatures are associated with corticosteroid sensitivity in COPD. Thorax\| PubMed ID: 36598042	2023
Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk. Nature genetics\| PubMed ID: 36914875	2023
Smoking increases expression of the SARS-CoV-2 spike protein-binding long ACE2 isoform in bronchial epithelium. Respiratory research\| PubMed ID: 37170105	2023