Jack Greenblatt

Department of Molecular Genetics, University of Toronto

Research Area

Biography

Jack Greenblatt has not added Biography.
If you are Jack Greenblatt and would like to personalize this page please email our Author Liaison for assistance.

JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 9	2012
Publication title Cited by 11	2012

Other Publications

Article	Year
COMPASS, a histone H3 (Lysine 4) methyltransferase required for telomeric silencing of gene expression. The Journal of biological chemistry\| PubMed ID: 11805083	2002
Evidence that the KH RNA-binding domains influence the action of the E. coli NusA protein. Journal of molecular biology\| PubMed ID: 12083510	2002
Regulation of transcription elongation by phosphorylation. Biochimica et biophysica acta\| PubMed ID: 12213657	2002
RNA polymerase II elongation factors of Saccharomyces cerevisiae: a targeted proteomics approach. Molecular and cellular biology\| PubMed ID: 12242279	2002
Bridging structural biology and genomics: assessing protein interaction data with known complexes. Trends in genetics : TIG\| PubMed ID: 12350343	2002
Bre1, an E3 ubiquitin ligase required for recruitment and substrate selection of Rad6 at a promoter. Molecular cell\| PubMed ID: 12535539	2003
Solution structure of the carboxyl-terminal domain of RAP74 and NMR characterization of the FCP1-binding sites of RAP74 and human TFIIB. Biochemistry\| PubMed ID: 12578358	2003
Specific homeodomain-DNA interactions are required for HOX11-mediated transformation. Blood\| PubMed ID: 12586625	2003
The Paf1 complex is required for histone H3 methylation by COMPASS and Dot1p: linking transcriptional elongation to histone methylation. Molecular cell\| PubMed ID: 12667454	2003
NMR structure of a complex containing the TFIIF subunit RAP74 and the RNA polymerase II carboxyl-terminal domain phosphatase FCP1. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12732728	2003
Methylation of histone H3 by Set2 in Saccharomyces cerevisiae is linked to transcriptional elongation by RNA polymerase II. Molecular and cellular biology\| PubMed ID: 12773564	2003
Protein profiling with Epstein-Barr nuclear antigen-1 reveals an interaction with the herpesvirus-associated ubiquitin-specific protease HAUSP/USP7. The Journal of biological chemistry\| PubMed ID: 12783858	2003
Organization and function of APT, a subcomplex of the yeast cleavage and polyadenylation factor involved in the formation of mRNA and small nucleolar RNA 3'-ends. The Journal of biological chemistry\| PubMed ID: 12819204	2003
A panoramic view of yeast noncoding RNA processing. Cell\| PubMed ID: 12837249	2003
A Bayesian networks approach for predicting protein-protein interactions from genomic data. Science (New York, N.Y.)\| PubMed ID: 14564010	2003
A Snf2 family ATPase complex required for recruitment of the histone H2A variant Htz1. Molecular cell\| PubMed ID: 14690608	2003
Purification and assay of Saccharomyces cerevisiae phosphatase that acts on the C-terminal domain of the largest subunit of RNA polymerase II. Methods in enzymology\| PubMed ID: 14712662	2003
The ctf13-30/CTF13 genomic haploinsufficiency modifier screen identifies the yeast chromatin remodeling complex RSC, which is required for the establishment of sister chromatid cohesion. Molecular and cellular biology\| PubMed ID: 14729968	2004
Transitions in RNA polymerase II elongation complexes at the 3' ends of genes. The EMBO journal\| PubMed ID: 14739930	2004
High-definition macromolecular composition of yeast RNA-processing complexes. Molecular cell\| PubMed ID: 14759368	2004
Global mapping of the yeast genetic interaction network. Science (New York, N.Y.)\| PubMed ID: 14764870	2004
ESF1 is required for 18S rRNA synthesis in Saccharomyces cerevisiae. Nucleic acids research\| PubMed ID: 15056729	2004
Dephosphorylation of RNA polymerase I by Fcp1p is required for efficient rRNA synthesis. The Journal of biological chemistry\| PubMed ID: 15073185	2004
Bromodomain factor 1 (Bdf1) is phosphorylated by protein kinase CK2. Molecular and cellular biology\| PubMed ID: 15143168	2004
Exploration of essential gene functions via titratable promoter alleles. Cell\| PubMed ID: 15242642	2004
Sequential Peptide Affinity (SPA) system for the identification of mammalian and bacterial protein complexes. Journal of proteome research\| PubMed ID: 15253427	2004
RPAP1, a novel human RNA polymerase II-associated protein affinity purified with recombinant wild-type and mutated polymerase subunits. Molecular and cellular biology\| PubMed ID: 15282305	2004
Regulation of chromosome stability by the histone H2A variant Htz1, the Swr1 chromatin remodeling complex, and the histone acetyltransferase NuA4. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15353583	2004
Interaction of Fcp1 phosphatase with elongating RNA polymerase II holoenzyme, enzymatic mechanism of action, and genetic interaction with elongator. The Journal of biological chemistry\| PubMed ID: 15563457	2005
The yeast Rat1 exonuclease promotes transcription termination by RNA polymerase II. Nature\| PubMed ID: 15565157	2004
A role for SlyD in the Escherichia coli hydrogenase biosynthetic pathway. The Journal of biological chemistry\| PubMed ID: 15569666	2005
The functional landscape of mouse gene expression. Journal of biology\| PubMed ID: 15588312	2004
INO80 and gamma-H2AX interaction links ATP-dependent chromatin remodeling to DNA damage repair. Cell\| PubMed ID: 15607974	2004
Proteasome involvement in the repair of DNA double-strand breaks. Molecular cell\| PubMed ID: 15610744	2004
Histone H2B ubiquitylation is associated with elongating RNA polymerase II. Molecular and cellular biology\| PubMed ID: 15632065	2005
H2B ubiquitin protease Ubp8 and Sgf11 constitute a discrete functional module within the Saccharomyces cerevisiae SAGA complex. Molecular and cellular biology\| PubMed ID: 15657441	2005
Interaction network containing conserved and essential protein complexes in Escherichia coli. Nature\| PubMed ID: 15690043	2005
The Shwachman-Bodian-Diamond syndrome protein family is involved in RNA metabolism. The Journal of biological chemistry\| PubMed ID: 15701634	2005
Maintenance of low histone ubiquitylation by Ubp10 correlates with telomere-proximal Sir2 association and gene silencing. Molecular cell\| PubMed ID: 15721261	2005
Interactions of the HIV-1 Tat and RAP74 proteins with the RNA polymerase II CTD phosphatase FCP1. Biochemistry\| PubMed ID: 15723517	2005
Navigating the chaperone network: an integrative map of physical and genetic interactions mediated by the hsp90 chaperone. Cell\| PubMed ID: 15766533	2005
The highly conserved glutamic acid 791 of Rpb2 is involved in the binding of NTP and Mg(B) in the active center of human RNA polymerase II. Nucleic acids research\| PubMed ID: 15886393	2005
Esf2p, a U3-associated factor required for small-subunit processome assembly and compaction. Molecular and cellular biology\| PubMed ID: 15964808	2005
BUR kinase selectively regulates H3 K4 trimethylation and H2B ubiquitylation through recruitment of the PAF elongation complex. Current biology : CB\| PubMed ID: 16040246	2005
Identification and characterization of Elf1, a conserved transcription elongation factor in Saccharomyces cerevisiae. Molecular and cellular biology\| PubMed ID: 16260625	2005
Exploration of the function and organization of the yeast early secretory pathway through an epistatic miniarray profile. Cell\| PubMed ID: 16269340	2005
Cotranscriptional set2 methylation of histone H3 lysine 36 recruits a repressive Rpd3 complex. Cell\| PubMed ID: 16286008	2005
A phosphatase complex that dephosphorylates gammaH2AX regulates DNA damage checkpoint recovery. Nature\| PubMed ID: 16299494	2006
Formation of a distinctive complex between the inducible bacterial lysine decarboxylase and a novel AAA+ ATPase. The Journal of biological chemistry\| PubMed ID: 16301313	2006
Interactions of the Escherichia coli hydrogenase biosynthetic proteins: HybG complex formation. FEBS letters\| PubMed ID: 16412426	2006
The Saccharomyces cerevisiae histone H2A variant Htz1 is acetylated by NuA4. Genes & development\| PubMed ID: 16543219	2006
Global landscape of protein complexes in the yeast Saccharomyces cerevisiae. Nature\| PubMed ID: 16554755	2006
A genome-wide screen identifies the evolutionarily conserved KEOPS complex as a telomere regulator. Cell\| PubMed ID: 16564010	2006
Systems-level analyses identify extensive coupling among gene expression machines. Molecular systems biology\| PubMed ID: 16738550	2006
PIPE: a protein-protein interaction prediction engine based on the re-occurring short polypeptide sequences between known interacting protein pairs. BMC bioinformatics\| PubMed ID: 16872538	2006
Investigating the in vivo activity of the DeaD protein using protein-protein interactions and the translational activity of structured chloramphenicol acetyltransferase mRNAs. Journal of cellular biochemistry\| PubMed ID: 16983699	2007
The RNA polymerase II kinase Ctk1 regulates positioning of a 5' histone methylation boundary along genes. Molecular and cellular biology\| PubMed ID: 17088384	2007
Toward a comprehensive atlas of the physical interactome of Saccharomyces cerevisiae. Molecular & cellular proteomics : MCP\| PubMed ID: 17200106	2007
Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction map. Nature\| PubMed ID: 17314980	2007
Identifying functional modules in the physical interactome of Saccharomyces cerevisiae. Proteomics\| PubMed ID: 17370254	2007
Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme. Molecular cell\| PubMed ID: 17643375	2007
The minimum information required for reporting a molecular interaction experiment (MIMIx). Nature biotechnology\| PubMed ID: 17687370	2007
Genomic location of the human RNA polymerase II general machinery: evidence for a role of TFIIF and Rpb7 at both early and late stages of transcription. The Biochemical journal\| PubMed ID: 17848138	2008
Association with the origin recognition complex suggests a novel role for histone acetyltransferase Hat1p/Hat2p. BMC biology\| PubMed ID: 17880717	2007
Examining protein protein interactions using endogenously tagged yeast arrays: the cross-and-capture system. Genome research\| PubMed ID: 17989249	2007
Interacting proteins Rtt109 and Vps75 affect the efficiency of non-homologous end-joining in Saccharomyces cerevisiae. Archives of biochemistry and biophysics\| PubMed ID: 18036332	2008
Pax7 activates myogenic genes by recruitment of a histone methyltransferase complex. Nature cell biology\| PubMed ID: 18066051	2008
The Glc7 phosphatase subunit of the cleavage and polyadenylation factor is essential for transcription termination on snoRNA genes. Molecular cell\| PubMed ID: 18342605	2008
Transcription termination: pulling out all the stops. Cell\| PubMed ID: 18358802	2008
Chaperone control of the activity and specificity of the histone H3 acetyltransferase Rtt109. Molecular and cellular biology\| PubMed ID: 18458063	2008
A histone code for chromatin assembly. Cell\| PubMed ID: 18662534	2008
eSGA: E. coli synthetic genetic array analysis. Nature methods\| PubMed ID: 18677321	2008
Biosynthesis of the respiratory formate dehydrogenases from Escherichia coli: characterization of the FdhE protein. Archives of microbiology\| PubMed ID: 18716757	2008
Local coherence in genetic interaction patterns reveals prevalent functional versatility. Bioinformatics (Oxford, England)\| PubMed ID: 18718945	2008
Interaction of the deubiquitinating enzyme Ubp2 and the e3 ligase Rsp5 is required for transporter/receptor sorting in the multivesicular body pathway. PloS one\| PubMed ID: 19165343	2009
Stable complex formation between HIV Rev and the nucleosome assembly protein, NAP1, affects Rev function. Virology\| PubMed ID: 19339032	2009
Control of transcriptional elongation and cotranscriptional histone modification by the yeast BUR kinase substrate Spt5. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19365074	2009
Conserved network of proteins essential for bacterial viability. Journal of bacteriology\| PubMed ID: 19376873	2009
Global functional atlas of Escherichia coli encompassing previously uncharacterized proteins. PLoS biology\| PubMed ID: 19402753	2009
Systematic characterization of the protein interaction network and protein complexes in Saccharomyces cerevisiae using tandem affinity purification and mass spectrometry. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 19521826	2009
An atlas of chaperone-protein interactions in Saccharomyces cerevisiae: implications to protein folding pathways in the cell. Molecular systems biology\| PubMed ID: 19536198	2009
Sequential peptide affinity purification system for the systematic isolation and identification of protein complexes from Escherichia coli. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 19544035	2009
Two-color cell array screen reveals interdependent roles for histone chaperones and a chromatin boundary regulator in histone gene repression. Molecular cell\| PubMed ID: 19683497	2009
Systems-level approaches for identifying and analyzing genetic interaction networks in Escherichia coli and extensions to other prokaryotes. Molecular bioSystems\| PubMed ID: 19763343	2009
A systematic characterization of Cwc21, the yeast ortholog of the human spliceosomal protein SRm300. RNA (New York, N.Y.)\| PubMed ID: 19789211	2009
An acetylated form of histone H2A.Z regulates chromosome architecture in Schizosaccharomyces pombe. Nature structural & molecular biology\| PubMed ID: 19915592	2009
A lentiviral functional proteomics approach identifies chromatin remodeling complexes important for the induction of pluripotency. Molecular & cellular proteomics : MCP\| PubMed ID: 20305087	2010
The evolutionary landscape of the chromatin modification machinery reveals lineage specific gains, expansions, and losses. Proteins\| PubMed ID: 20455264	2010
DAnCER: disease-annotated chromatin epigenetics resource. Nucleic acids research\| PubMed ID: 20876685	2011
The program for processing newly synthesized histones H3.1 and H4. Nature structural & molecular biology\| PubMed ID: 20953179	2010
Epistatic relationships reveal the functional organization of yeast transcription factors. Molecular systems biology\| PubMed ID: 20959818	2010
Structure of a SLC26 anion transporter STAS domain in complex with acyl carrier protein: implications for E. coli YchM in fatty acid metabolism. Structure (London, England : 1993)\| PubMed ID: 21070944	2010
Expanding the landscape of chromatin modification (CM)-related functional domains and genes in human. PloS one\| PubMed ID: 21124763	2010
Defining the budding yeast chromatin-associated interactome. Molecular systems biology\| PubMed ID: 21179020	2010
A dual function of the CRISPR-Cas system in bacterial antivirus immunity and DNA repair. Molecular microbiology\| PubMed ID: 21219465	2011
OrthoNets: simultaneous visual analysis of orthologs and their interaction neighborhoods across different organisms. Bioinformatics (Oxford, England)\| PubMed ID: 21257609	2011
Ribosome-dependent ATPase interacts with conserved membrane protein in Escherichia coli to modulate protein synthesis and oxidative phosphorylation. PloS one\| PubMed ID: 21556145	2011
Array-based synthetic genetic screens to map bacterial pathways and functional networks in Escherichia coli. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 21815091	2011
Identification of mammalian protein complexes by lentiviral-based affinity purification and mass spectrometry. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 21877275	2011
Genetic interaction maps in Escherichia coli reveal functional crosstalk among cell envelope biogenesis pathways. PLoS genetics\| PubMed ID: 22125496	2011
Control of the RNA polymerase II phosphorylation state in promoter regions by CTD interaction domain-containing proteins RPRD1A and RPRD1B. Transcription\| PubMed ID: 22231121	2011
Hsp110 is required for spindle length control. The Journal of cell biology\| PubMed ID: 22908312	2012
Interaction landscape of membrane-protein complexes in Saccharomyces cerevisiae. Nature\| PubMed ID: 22940862	2012