stereotaxic-surgery-for-excitotoxic-lesion-specific-brain-areas-adult

Stereotaxic Surgery for Excitotoxic Lesion of Specific Brain Areas in the Adult Rat

Many behavioral functions in mammals, including rodents and humans, are mediated principally by discrete brain regions. A common method for discerning the ...

University of California Berkeley

Audiogenic stress is a well-documented phenomenon in laboratory rodents. Despite the recommendation in the Guide for the Care and Use of Laboratory Animals to consider noise a concern in the animal facility, only a small body of literature empirically addresses the effects of facility noise on laboratory rodents, particularly mice. The objective of this study was to determine whether facility noise generated by a vacuum cleaner induces an acute stress response in a commonly used strain of laboratory mouse under common housing conditions. In each of 2 experiments, 10 young adult, female C57BL/6Cr mice were exposed for 1 h to noise produced by a vacuum cleaner, and 10 control mice were not. In the first experiment, fecal samples were collected to measure concentrations of fecal corticosterone metabolites just before and 2, 4, 6, 8, 10, 14, 24, and 32 h after noise exposure. In the second experiment, stress-sensitive behavioral tests were performed 2 d before, immediately after, and 24 h after noise exposure. Physiologic and behavioral measurements indicated that vacuum cleaner noise did not cause an acute stress response in the noise-exposed mice but may have affected the diurnal variation of their corticosterone levels. These findings could contribute to the development of best practices in noise-control protocols for animal facilities.

Article	Year
Transfusion\| PubMed ID: 12430669	2002
Brain research\| PubMed ID: 19540213	2009
Vector borne and zoonotic diseases (Larchmont, N.Y.)\| PubMed ID: 20017717	2010
Lab animal\| PubMed ID: 20305627	2010
Vacuum-cleaner noise and acute stress responses in female C57BL/6 mice (Mus musculus). Journal of the American Association for Laboratory Animal Science : JAALAS\| PubMed ID: 20587160	2010

Kelly Jensen

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