Lei Wu

Core Facility of West China Hospital, Sichuan University

Affiliated withSichuan University Shaoxing University Zhejiang University School of Medicine

Research Area

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JoVE Journal Publications

ArticleTotal : 3	Year
Publication title	2024
Publication title	2025
Publication title	2026

Other Publications

Article	Year
Combined SVM-based and docking-based virtual screening for retrieving novel inhibitors of c-Met. European journal of medicinal chemistry\| PubMed ID: 21641696	2011
Identification of CK2 inhibitors with new scaffolds by a hybrid virtual screening approach based on Bayesian model; pharmacophore hypothesis and molecular docking. Journal of molecular graphics & modelling\| PubMed ID: 22516037	2012
Anti-tumor and anti-viral activities of Galanthus nivalis agglutinin (GNA)-related lectins. Glycoconjugate journal\| PubMed ID: 22893111	2013
Pillar[5]arene-based diglycolamides for highly efficient separation of americium(III) and europium(III). Dalton transactions (Cambridge, England : 2003)\| PubMed ID: 24434919	2014
Ditopic CMPO-pillar[5]arenes as unique receptors for efficient separation of americium(III) and europium(III). Chemical communications (Cambridge, England)\| PubMed ID: 25671799	2015
A non-symmetric pillar[5]arene based on triazole-linked 8-oxyquinolines as a sequential sensor for thorium(IV) followed by fluoride ions. Dalton transactions (Cambridge, England : 2003)\| PubMed ID: 25689727	2015
Human eukaryotic elongation factor 1A forms oligomers through specific cysteine residues. Acta biochimica et biophysica Sinica\| PubMed ID: 26515794	2015
Polygonatum odoratum lectin induces apoptosis and autophagy by regulation of microRNA-1290 and microRNA-15a-3p in human lung adenocarcinoma A549 cells. International journal of biological macromolecules\| PubMed ID: 26562549	2016
Rheological properties of glutaraldehyde-crosslinked collagen solutions analyzed quantitatively using mechanical models. Materials science & engineering. C, Materials for biological applications\| PubMed ID: 27040190	2016
Role of reactive oxygen species-mediated MAPK and NF-κB activation in polygonatum cyrtonema lectin-induced apoptosis and autophagy in human lung adenocarcinoma A549 cells. Journal of biochemistry\| PubMed ID: 27318358	2016
Enhanced Oral Delivery of Protein Drugs Using Zwitterion-Functionalized Nanoparticles to Overcome both the Diffusion and Absorption Barriers. ACS applied materials & interfaces\| PubMed ID: 27588330	2016
Highly efficient extraction of actinides with pillar[5]arene-derived diglycolamides in ionic liquids via a unique mechanism involving competitive host-guest interactions. Dalton transactions (Cambridge, England : 2003)\| PubMed ID: 27872927	2016
A pH-responsive sequential-disassembly nanohybrid for mitochondrial targeting. Nanoscale\| PubMed ID: 27910990	2017
Subcellular co-delivery of two different site-oriented payloads for tumor therapy. Nanoscale\| PubMed ID: 28067924	2017
Lipid nanovehicles with adjustable surface properties for overcoming multiple barriers simultaneously in oral administration. International journal of pharmaceutics\| PubMed ID: 28185960	2017
Systematic evaluation of the toxicity and biodistribution of virus mimicking mucus-penetrating DLPC-NPs as oral drug delivery system. International journal of pharmaceutics\| PubMed ID: 28743553	2017
Bioinspired butyrate-functionalized nanovehicles for targeted oral delivery of biomacromolecular drugs. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 28774842	2017
Engineering nanomaterials to overcome the mucosal barrier by modulating surface properties. Advanced drug delivery reviews\| PubMed ID: 28989056	2018
The combination of endolysosomal escape and basolateral stimulation to overcome the difficulties of "easy uptake hard transcytosis" of ligand-modified nanoparticles in oral drug delivery. Nanoscale\| PubMed ID: 29303184	2018
Novel Solid Lipid Nanoparticle with Endosomal Escape Function for Oral Delivery of Insulin. ACS applied materials & interfaces\| PubMed ID: 29484890	2018
Induction and Amelioration of Methotrexate-Induced Gastrointestinal Toxicity are Related to Immune Response and Gut Microbiota. EBioMedicine\| PubMed ID: 30049384	2018
Transport Mechanisms of Butyrate Modified Nanoparticles: Insight into "Easy Entry, Hard Transcytosis" of Active Targeting System in Oral Administration. Molecular pharmaceutics\| PubMed ID: 30102863	2018
Novel Self-Assembled Micelles Based on Cholesterol-Modified Antimicrobial Peptide (DP7) for Safe and Effective Systemic Administration in Animal Models of Bacterial Infection. Antimicrobial agents and chemotherapy\| PubMed ID: 30201818	2018
Multifunctional Nanoparticles Enable Efficient Oral Delivery of Biomacromolecules via Improving Payload Stability and Regulating the Transcytosis Pathway. ACS applied materials & interfaces\| PubMed ID: 30207680	2018
Prevotella copri is associated with carboplatin-induced gut toxicity. Cell death & disease\| PubMed ID: 31558709	2019
Nanoparticles with surface features of dendritic oligopeptides as potential oral drug delivery systems. Journal of materials chemistry. B\| PubMed ID: 32129375	2020
Iron-mimic peptide converts transferrin from foe to friend for orally targeting insulin delivery. Journal of materials chemistry. B\| PubMed ID: 32254488	2018
A strategy for developing effective orally-delivered nanoparticles through modulation of the surface "hydrophilicity/hydrophobicity balance". Journal of materials chemistry. B\| PubMed ID: 32263598	2017
Core-shell stability of nanoparticles plays an important role for overcoming the intestinal mucus and epithelium barrier. Journal of materials chemistry. B\| PubMed ID: 32263756	2016
Enhanced nuclear delivery of anti-cancer drugs using micelles containing releasable membrane fusion peptide and nuclear-targeting retinoic acid. Journal of materials chemistry. B\| PubMed ID: 32263908	2017
Promoting apical-to-basolateral unidirectional transport of nanoformulations by manipulating the nutrient-absorption pathway. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 32277961	2020
A novel in silico antimicrobial peptide DP7 combats MDR Pseudomonas aeruginosa and related biofilm infections. The Journal of antimicrobial chemotherapy\| PubMed ID: 32737484	2020
A chromosome-scale reference genome of Lobularia maritima, an ornamental plant with high stress tolerance. Horticulture research\| PubMed ID: 33328471	2020
Status of Immunotherapy Acceptance in Chinese Patients With Multiple Sclerosis: Analysis of . Frontiers in neurology\| PubMed ID: 33897605	2021
Halogen-Free Flame Retardant Polypropylene Fibers with Modified Intumescent Flame Retardant: Preparation, Characterization, Properties and Mode of Action. Polymers\| PubMed ID: 34372156	2021
Self-Stabilized Supramolecular Assemblies Constructed from PEGylated Dendritic Peptide Conjugate for Augmenting Tumor Retention and Therapy. Advanced science (Weinheim, Baden-Wurttemberg, Germany)\| PubMed ID: 34623034	2021
Identification of MDM2, YTHDF2 and DDX21 as potential biomarkers and targets for treatment of type 2 diabetes. Biochemical and biophysical research communications\| PubMed ID: 34688145	2021
A DNA Nanoraft-Based Cytokine Delivery Platform for Alleviation of Acute Kidney Injury. ACS nano\| PubMed ID: 34723467	2021
An extension of the RIGHT statement for introductions and interpretations of clinical practice guidelines: RIGHT for INT. Journal of evidence-based medicine\| PubMed ID: 35416438	2022
Structure and properties of halogen-free flame retardant and phosphorus-containing aromatic poly(1,3,4-oxadiazole)s fiber. RSC advances\| PubMed ID: 35519946	2019
Pulsed electromagnetic fields attenuate glucocorticoid-induced bone loss by targeting senescent LepR bone marrow mesenchymal stromal cells. Biomaterials advances\| PubMed ID: 35527160	2022
A Multi-Scale Simulation Study of Irradiation Swelling of Silicon Carbide. Materials (Basel, Switzerland)\| PubMed ID: 35591343	2022
Physically Cross-Linked DNA Hydrogel-Based Sustained Cytokine Delivery for Diabetic Alveolar Bone Rebuilding. ACS applied materials & interfaces\| PubMed ID: 35638566	2022
Milk-derived exosomes exhibit versatile effects for improved oral drug delivery. Acta pharmaceutica Sinica. B\| PubMed ID: 35847507	2022
Treatment outcomes of injectable thermosensitive hydrogel containing bevacizumab in intervertebral disc degeneration. Frontiers in bioengineering and biotechnology\| PubMed ID: 36213074	2022
CT-based transformer model for non-invasively predicting the Fuhrman nuclear grade of clear cell renal cell carcinoma. Frontiers in oncology\| PubMed ID: 36249050	2022
Mimicking natural cholesterol assimilation to elevate the oral delivery of liraglutide for type II diabetes therapy. Asian journal of pharmaceutical sciences\| PubMed ID: 36382301	2022
Efficacy and safety of neoadjuvant immunotherapy in resectable esophageal or gastroesophageal junction carcinoma: A pooled analysis of prospective clinical trials. Frontiers in immunology\| PubMed ID: 36591306	2022
Sustained delivery of IL-10 by self-assembling peptide hydrogel to reprogram macrophages and promote diabetic alveolar bone defect healing. Dental materials : official publication of the Academy of Dental Materials\| PubMed ID: 36931990	2023
Identification of priority pathogens for aetiological diagnosis in adults with community-acquired pneumonia in China: a multicentre prospective study. BMC infectious diseases\| PubMed ID: 37059987	2023
A robust mixed-charge zwitterionic polyurethane coating integrated with antibacterial and anticoagulant functions for interventional blood-contacting devices. Journal of materials chemistry. B\| PubMed ID: 37530181	2023
Low-Temperature Assembling Strategy of a Nacre-Inspired Lamellar Configuration to Upcycling Biaxially Oriented Polypropylene Film Waste. ACS omega\| PubMed ID: 37663481	2023
Multifunctional DNA-Based Hydrogel Promotes Diabetic Alveolar Bone Defect Reconstruction. Small (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 37919857	2023
Antibacterial and DNA-Based Hydrogels In Situ Block TNF-α to Promote Diabetic Alveolar Bone Rebuilding. Macromolecular rapid communications\| PubMed ID: 38014713	2023
Evolving landscape of treatments targeting the microenvironment of liver metastases in non-small cell lung cancer. Chinese medical journal\| PubMed ID: 38251678	2024
Effects of Leader Narcissism on Career Success of Employees: An Interpersonal Relationship Perspective. Frontiers in psychology\| PubMed ID: 34987439	2021
The Adoption of QR Code Mobile Payment Technology During COVID-19: A Social Learning Perspective. Frontiers in psychology\| PubMed ID: 35250694	2021
Analysis on spatial development mode of eco-sports tourism in Grand Canal landscape environment culture belt. Environmental monitoring and assessment\| PubMed ID: 36260258	2022
An identity threat perspective on why and when employee voice brings abusive supervision. Frontiers in psychology\| PubMed ID: 37351437	2023
[Detection of human papillomavirus in the upper respiratory tract in children without recurrent respiratory papillomatosis]. Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery\| PubMed ID: 23328034	2012
Glial Heterotopia of the Middle Ear and Eustachian Tube in Children. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery\| PubMed ID: 23358952	2013
Epigenetics of hyper-responsiveness to allergen challenge following intrauterine growth retardation rat. Respiratory research\| PubMed ID: 25391516	2014
Variants of Interferon Regulatory Factor 5 are Associated with Neither Neuromyelitis Optica Nor Multiple Sclerosis in the Southeastern Han Chinese Population. Chinese medical journal\| PubMed ID: 26112714	2015
Variants of Interleukin-7/Interleukin-7 Receptor Alpha are Associated with Both Neuromyelitis Optica and Multiple Sclerosis Among Chinese Han Population in Southeastern China. Chinese medical journal\| PubMed ID: 26608987	2015
Propranolol treatment of subglottic hemangiomas: a review of the literature. International journal of clinical and experimental medicine\| PubMed ID: 26884900	2015
Novel Function of Extracellular Matrix Protein 1 in Suppressing Th17 Cell Development in Experimental Autoimmune Encephalomyelitis. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 27316685	2016
Serum cytokine profile contributes to discriminating M. pneumoniae pneumonia in children. Cytokine\| PubMed ID: 27475111	2016
Clinical features and mutation spectrum in Chinese patients with CADASIL: A multicenter retrospective study. CNS neuroscience & therapeutics\| PubMed ID: 28710804	2017
Clonorchiasis Complicated with Diffuse Parenchymal Lung Disease in Children. Chinese medical journal\| PubMed ID: 29176155	2017
Reply to "Clonorchiasis or Paragonimiasis?". Chinese medical journal\| PubMed ID: 29483405	2018
Variant of Associated with Increasing Risk in Chinese Patients with Relapsing-remitting Multiple Sclerosis. Chinese medical journal\| PubMed ID: 29521285	2018
Fatal choking in infants and children treated in a pediatric intensive care unit: A 7- year experience. International journal of pediatric otorhinolaryngology\| PubMed ID: 29859591	2018
Residual airway foreign bodies in children who underwent rigid bronchoscopy. International journal of pediatric otorhinolaryngology\| PubMed ID: 30639987	2019
Foreign body aspiration in children with negative multi-detector Computed Tomography results: Own experience during 2011-2018. International journal of pediatric otorhinolaryngology\| PubMed ID: 31174024	2019
Flexible Bronchoscopy Combined with Rigid Bronchoscopy for Treatment of Scarring in the Bronchus Caused by a Foreign Body. Case reports in medicine\| PubMed ID: 31316565	2019
Unusual Bronchial Foreign Bodies with Localized Bronchiectasis in Five Children. Case reports in medicine\| PubMed ID: 32089700	2019
Curcumin exerts protective effects against hypoxia‑reoxygenation injury via the enhancement of apurinic/apyrimidinic endonuclease 1 in SH‑SY5Y cells: Involvement of the PI3K/AKT pathway. International journal of molecular medicine\| PubMed ID: 32124937	2020
Nomogram for Prediction of Bronchial Mucus Plugs in Children with Mycoplasma pneumoniae Pneumonia. Scientific reports\| PubMed ID: 32165709	2020
Characteristic of gut microbiota in southeastern Chinese patients with neuromyelitis optica spectrum disorders. Multiple sclerosis and related disorders\| PubMed ID: 32534438	2020
The Important Role of Endoscopy in Management of Pediatric Pseudomembranous Necrotizing Tracheitis. Frontiers in pediatrics\| PubMed ID: 32733826	2020
Airway microbiota in children with bronchial mucus plugs caused by Mycoplasma pneumoniae pneumonia. Respiratory medicine\| PubMed ID: 32843185	2020
Common genetic variants in PRRC2A are associated with both neuromyelitis optica spectrum disorder and multiple sclerosis in Han Chinese population. Journal of neurology\| PubMed ID: 32862241	2021
Andersen-Tawil syndrome associated with myopathy. World journal of emergency medicine\| PubMed ID: 33014226	2020
Interventional therapy via flexible bronchoscopy in the management of foreign body-related occlusive endobronchial granulation tissue formation in children. Pediatric pulmonology\| PubMed ID: 33104291	2021
MCC950, a NLRP3 inhibitor, ameliorates lipopolysaccharide-induced lung inflammation in mice. Bioorganic & medicinal chemistry\| PubMed ID: 33360197	2021
Expression and prognostic value of E2F3 transcription factor in non-small cell lung cancer. Oncology letters\| PubMed ID: 33841572	2021
Case Report: Resection of Giant Endotracheal Hamartoma by Electrosurgical Snaring via Fiberoptic Bronchoscopy in a 9-Year-Old Boy. Frontiers in pediatrics\| PubMed ID: 33987147	2021
Clinical Impact of Metagenomic Next-Generation Sequencing of Bronchoalveolar Lavage in the Diagnosis and Management of Pneumonia: A Multicenter Prospective Observational Study. The Journal of molecular diagnostics : JMD\| PubMed ID: 34197923	2021
Follow-up study of airway microbiota in children with persistent wheezing. Respiratory research\| PubMed ID: 34315459	2021
Cardiopulmonary bypass as a bridge for bronchial foreign body removal in a child with pulmonary artery sling: A case report. Medicine\| PubMed ID: 34397925	2021
Primary intratracheal neurilemmoma in a 10-year-old girl: A case report. World journal of clinical cases\| PubMed ID: 34734071	2021
External Validation of the Prognostic Value of an Immune-Associated Gene Panel for Clear Cell Renal Cell Carcinomas. Frontiers in cell and developmental biology\| PubMed ID: 35004689	2021
Clinical Features of Hypersensitivity Pneumonitis in Children: A Single Center Study. Frontiers in pediatrics\| PubMed ID: 35127590	2021
Pseudomembranous necrotizing laryngotracheobronchitis due to Mycoplasma pneumoniae: a case report and literature review. BMC infectious diseases\| PubMed ID: 35197010	2022
Metabolomics of bronchoalveolar lavage in children with persistent wheezing. Respiratory research\| PubMed ID: 35718784	2022
Management of Inedible Airway Foreign Bodies in Pediatric Rigid Bronchoscopy: Experience From a National Children's Regional Medical Center in China. Frontiers in pediatrics\| PubMed ID: 35813380	2022
Orthologous microsatellites, transposable elements, and DNA deletions correlate with generation time and body mass in neoavian birds. Science advances\| PubMed ID: 36044583	2022
Vocal nodules in children: Laryngoscopic morphological classification aids prognostic judgment. Frontiers in pediatrics\| PubMed ID: 36147819	2022
Extranasopharyngeal angiofibroma in children: A case report. World journal of clinical cases\| PubMed ID: 36158007	2022
The clinical application of flexible bronchoscopy in a neonatal intensive care unit. Frontiers in pediatrics\| PubMed ID: 36299699	2022
Single-cell transcriptomic characterization reveals the landscape of airway remodeling and inflammation in a cynomolgus monkey model of asthma. Frontiers in immunology\| PubMed ID: 36439114	2022
Pharmacokinetics and Tissue Distribution of Nasal Spray of a Novel Muscarinic Receptor Blocker, 101BHG-D01, in Dogs and Rats. Current drug metabolism\| PubMed ID: 36464876	2022
Effects of subcutaneous immunotherapy in allergic rhinitis children sensitive to dust mites. Allergologia et immunopathologia\| PubMed ID: 36617826	2023
Salivary IgG4 Levels Contribute to Assessing the Efficacy of Subcutaneous Immunotherapy in Children with Asthma or Allergic Rhinitis. Journal of clinical medicine\| PubMed ID: 36836200	2023
Case report: Primary alveolar soft-part sarcoma of the lung in a child. Frontiers in surgery\| PubMed ID: 36891549	2023
A combination of flexible and rigid bronchoscopy in the successful removal of a residual fish bone from a peripheral bronchus: A case report. Frontiers in pediatrics\| PubMed ID: 36896398	2023
Causal relationship between outdoor atmospheric quality and pediatric asthma visits in hangzhou. Heliyon\| PubMed ID: 36942216	2023
Successful management of tracheal lobular capillary hemangioma with arterial embolization followed by electrosurgical snaring flexible bronchoscopy in an 11-year-old boy: A case report and ... Frontiers in medicine\| PubMed ID: 37020672	2023
Association between MEF2 family gene polymorphisms and susceptibility to multiple sclerosis in Chinese population. Acta neurologica Belgica\| PubMed ID: 37572262	2024
Pulmonary mucoepidermoid carcinoma in children: two case reports and a review of the literature. Frontiers in pediatrics\| PubMed ID: 37772041	2023
Beyond radiologist-level liver lesion detection on multi-phase contrast-enhanced CT images by deep learning. iScience\| PubMed ID: 38026220	2023
Dental aspiration in a pediatric patient: a case report. The Journal of international medical research\| PubMed ID: 38041829	2023
A missed foreign body aspiration masquerading as congenital pulmonary airway malformation in a nine-year-old boy: A case report and literature review. Respiratory medicine case reports\| PubMed ID: 38124993	2023
Inhalation of panaxadiol alleviates lung inflammation inhibiting TNFA/TNFAR and IL7/IL7R signaling between macrophages and epithelial cells. Journal of ginseng research\| PubMed ID: 38223829	2024
Mind shift I: Fructus Aurantii - Rhizoma Chuanxiong synergistically anchors stress-induced depression-like behaviours and gastrointestinal dysmotility cluster by regulating psycho-immune-neu... Phytomedicine : international journal of phytotherapy and phytopharmacology\| PubMed ID: 38552437	2024
Plastic bronchitis associated with human bocavirus 1 infection in children. Pediatric pulmonology\| PubMed ID: 38869182	2024
Cotton Ball Aspiration Leading to Pulmonary Complications in a Child. The American journal of case reports\| PubMed ID: 39126143	2024
Pediatric plastic bronchitis associated with smoke inhalation and influenza A: case report and literature review. BMC pulmonary medicine\| PubMed ID: 39160495	2024
The short-term association between environmental variables and daily pediatric asthma patient visits in Hangzhou, China: A time-series study. Heliyon\| PubMed ID: 39328572	2024
Progress in the Application of Bronchoscopic Cryotherapy in Pediatric Pulmonary Diseases. Children (Basel, Switzerland)\| PubMed ID: 39334662	2024
Association of Mite Molecular Sensitization Profiles with Respiratory Allergies and Asthma Control in Children from East China. Journal of asthma and allergy\| PubMed ID: 39398316	2024
Development and validation of a deep learning pipeline to diagnose ovarian masses using ultrasound screening: a retrospective multicenter study. EClinicalMedicine\| PubMed ID: 39640935	2024
ZBP1 senses splicing aberration through Z-RNA to promote cell death. Molecular cell\| PubMed ID: 40267920	2025
Population Pharmacokinetics-Pharmacodynamics and Exposure-Response of Ropeginterferon Alfa-2b in Chinese and Japanese Patients With Polycythemia Vera. Pharmacology research & perspectives\| PubMed ID: 40313042	2025
Use of Endoscopic Ultrasound with Bronchoscope-Guided Fine-Needle Aspiration (EUS-B-FNA) in Pediatric Cases. Children (Basel, Switzerland)\| PubMed ID: 40426797	2025
Difficult removal of an endobronchial foreign body: pen cap aspiration: a case report. Journal of medical case reports\| PubMed ID: 40537860	2025
Effective Treatment of Cicatricial Airway Stenosis via Flexible Bronchoscopic Intervention. Pediatric pulmonology\| PubMed ID: 40539723	2025
Lonidamine alleviates inflammation and tissue remodeling in a mouse model of eosinophilic chronic sinusitis: A single-cell transcriptomics study. International immunopharmacology\| PubMed ID: 40700828	2025
Cryotherapy via Flexible Bronchoscopy for Pediatric Plastic Bronchitis: A Case Report. The American journal of case reports\| PubMed ID: 40798854	2025
Intestinal necrosis due to nonocclusive mesenteric ischemia in a child with Mycoplasma pneumoniae pneumonia: a case report. BMC infectious diseases\| PubMed ID: 40836324	2025
Bibliometric analysis of surface electromyography trends in stroke rehabilitation research. Frontiers in neurology\| PubMed ID: 40860978	2025
Clinical characteristics of SFTPC gene mutations in children: a single-center experience. Italian journal of pediatrics\| PubMed ID: 40890883	2025
Lentiviral Gene Delivery Rescues Ciliary Defects in Patient-Derived Airway Organoids from Primary Ciliary Dyskinesia. Human gene therapy\| PubMed ID: 40947900	2025
Conservation genomics of two endangered buntings reveal genetic diversity before and after severe population declines. BMC biology\| PubMed ID: 41034993	2025
Advances in pediatric flexible bronchoscopy. World journal of pediatrics : WJP\| PubMed ID: 41045338	2025
Diagnosis and management of postcricoid cushion in infants: A single-center experience. International journal of pediatric otorhinolaryngology\| PubMed ID: 41076953	2025
Acquired Subglottic Stenosis in a 2-Month-Old Infant After Prolonged Intubation Associated With Pertussis Pneumonia: A Case Report. The American journal of case reports\| PubMed ID: 41390935	2025