Sergei Zolotukhin

Department of Pediatrics, University of Florida

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 1	2024

Other Publications

Article	Year
Efficient photoreceptor-targeted gene expression in vivo by recombinant adeno-associated virus. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 9192666	1997
Transduction of human and mouse pancreatic islet cells using a bicistronic recombinant adeno-associated viral vector. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 11829522	2002
Streamlined large-scale production of recombinant adeno-associated virus (rAAV) vectors. Methods in enzymology\| PubMed ID: 11883083	2002
Production and purification of serotype 1, 2, and 5 recombinant adeno-associated viral vectors. Methods (San Diego, Calif.)\| PubMed ID: 12413414	2002
Identification of amino acid residues in the capsid proteins of adeno-associated virus type 2 that contribute to heparan sulfate proteoglycan binding. Journal of virology\| PubMed ID: 12768018	2003
Sustained peripheral expression of transgene adiponectin offsets the development of diet-induced obesity in rats. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 14617771	2003
Adeno-associated virus type 2 VP2 capsid protein is nonessential and can tolerate large peptide insertions at its N terminus. Journal of virology\| PubMed ID: 15163751	2004
Recombinant AAV viral vectors pseudotyped with viral capsids from serotypes 1, 2, and 5 display differential efficiency and cell tropism after delivery to different regions of the central ne... Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 15294177	2004
Efficient transduction of vascular endothelial cells with recombinant adeno-associated virus serotype 1 and 5 vectors. Human gene therapy\| PubMed ID: 15761263	2005
Gene therapy for obesity. Expert opinion on biological therapy\| PubMed ID: 15833072	2005
Successful production of pseudotyped rAAV vectors using a modified baculovirus expression system. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 16213797	2005
Production, purification, crystallization and preliminary X-ray analysis of adeno-associated virus serotype 8. Acta crystallographica. Section F, Structural biology and crystallization communications\| PubMed ID: 16511095	2005
Production, purification, crystallization and preliminary X-ray structural studies of adeno-associated virus serotype 5. Acta crystallographica. Section F, Structural biology and crystallization communications\| PubMed ID: 16511195	2005
Production, purification and preliminary X-ray crystallographic studies of adeno-associated virus serotype 1. Acta crystallographica. Section F, Structural biology and crystallization communications\| PubMed ID: 17142915	2006
A dual role of EGFR protein tyrosine kinase signaling in ubiquitination of AAV2 capsids and viral second-strand DNA synthesis. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 17440440	2007
Ectopic expression of Wnt10b decreases adiposity and improves glucose homeostasis in obese rats. American journal of physiology. Endocrinology and metabolism\| PubMed ID: 17578883	2007
Structure of adeno-associated virus serotype 8, a gene therapy vector. Journal of virology\| PubMed ID: 17728238	2007
Production, purification and preliminary X-ray crystallographic studies of adeno-associated virus serotype 7. Acta crystallographica. Section F, Structural biology and crystallization communications\| PubMed ID: 18084098	2007
Synergy between leptin therapy and a seemingly negligible amount of voluntary wheel running prevents progression of dietary obesity in leptin-resistant rats. Diabetes\| PubMed ID: 18086903	2008
Optimization of recombinant adeno-associated viral vectors for human beta-globin gene transfer and transgene expression. Human gene therapy\| PubMed ID: 18399730	2008
Next generation of adeno-associated virus 2 vectors: point mutations in tyrosines lead to high-efficiency transduction at lower doses. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18511559	2008
Tyrosine-phosphorylation of AAV2 vectors and its consequences on viral intracellular trafficking and transgene expression. Virology\| PubMed ID: 18834608	2008
High-efficiency transduction of the mouse retina by tyrosine-mutant AAV serotype vectors. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 19066593	2009
An inducible system for highly efficient production of recombinant adeno-associated virus (rAAV) vectors in insect Sf9 cells. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19279219	2009
Production, purification and preliminary X-ray crystallographic studies of adeno-associated virus serotype 9. Acta crystallographica. Section F, Structural biology and crystallization communications\| PubMed ID: 19574648	2009
An animal model of PDH deficiency using AAV8-siRNA vector-mediated knockdown of pyruvate dehydrogenase E1Î±. Molecular genetics and metabolism\| PubMed ID: 20685142	2010
High-efficiency transduction and correction of murine hemophilia B using AAV2 vectors devoid of multiple surface-exposed tyrosines. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 20736929	2010
Neutralizing antibodies against AAV serotypes 1, 2, 6, and 9 in sera of commonly used animal models. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 21915102	2012
Salivary PYY: a putative bypass to satiety. PloS one\| PubMed ID: 22028819	2011
Structural insight into the unique properties of adeno-associated virus serotype 9. Journal of virology\| PubMed ID: 22496238	2012
High-efficiency transduction of human monocyte-derived dendritic cells by capsid-modified recombinant AAV2 vectors. Vaccine\| PubMed ID: 22497875	2012
Distribution of Y-receptors in murine lingual epithelia. PloS one\| PubMed ID: 23050020	2012
Development of Novel Recombinant AAV Vectors and Strategies for the Potential Gene Therapy of Hemophilia. Journal of genetic syndromes & gene therapy\| PubMed ID: 23264889	2012
Structural insights into adeno-associated virus serotype 5. Journal of virology\| PubMed ID: 23926356	2013
Modulation of taste responsiveness by the satiation hormone peptide YY. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 24043261	2013
Salivary peptide tyrosine-tyrosine 3-36 modulates ingestive behavior without inducing taste aversion. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 24259562	2013
OneBac: platform for scalable and high-titer production of adeno-associated virus serotype 1-12 vectors for gene therapy. Human gene therapy\| PubMed ID: 24299301	2014
Vector design Tour de Force: integrating combinatorial and rational approaches to derive novel adeno-associated virus variants. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 25048217	2014
Identification of low-expressing transcripts of the NPY receptors' family in the murine lingual epithelia. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 25218388	2014
A simplified purification protocol for recombinant adeno-associated virus vectors. Molecular therapy. Methods & clinical development\| PubMed ID: 26015974	2014
OneBac 2.0: Sf9 Cell Lines for Production of AAV5 Vectors with Enhanced Infectivity and Minimal Encapsidation of Foreign DNA. Human gene therapy\| PubMed ID: 26134901	2015
E Pluribus Unum: 50 Years of Research, Millions of Viruses, and One Goal--Tailored Acceleration of AAV Evolution. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 26388463	2015
Altering Tropism of rAAV by Directed Evolution. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 26611585	2016
Adeno-Associated Virus Type 2 and Hepatocellular Carcinoma? Human gene therapy\| PubMed ID: 26690810	2015
Snord116 is critical in the regulation of food intake and body weight. Scientific reports\| PubMed ID: 26726071	2016
High-accuracy biodistribution analysis of adeno-associated virus variants by double barcode sequencing. Molecular therapy. Methods & clinical development\| PubMed ID: 26793739	2015
Prader-Willi Critical Region, a Non-Translated, Imprinted Central Regulator of Bone Mass: Possible Role in Skeletal Abnormalities in Prader-Willi Syndrome. PloS one\| PubMed ID: 26824232	2016
Limited ATF4 Expression in Degenerating Retinas with Ongoing ER Stress Promotes Photoreceptor Survival in a Mouse Model of Autosomal Dominant Retinitis Pigmentosa. PloS one\| PubMed ID: 27144303	2016
OneBac 2.0: Sf9 Cell Lines for Production of AAV1, AAV2, and AAV8 Vectors with Minimal Encapsidation of Foreign DNA. Human gene therapy methods\| PubMed ID: 28125901	2017
Evaluation of engineered AAV capsids for hepatic factor IX gene transfer in murine and canine models. Journal of translational medicine\| PubMed ID: 28460646	2017
An Immune-Competent Murine Model to Study Elimination of AAV-Transduced Hepatocytes by Capsid-Specific CD8 T Cells. Molecular therapy. Methods & clinical development\| PubMed ID: 28480313	2017
Direct Head-to-Head Evaluation of Recombinant Adeno-associated Viral Vectors Manufactured in Human versus Insect Cells. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 28890324	2017
Helper-free Production of Laboratory Grade AAV and Purification by Iodixanol Density Gradient Centrifugation. Molecular therapy. Methods & clinical development\| PubMed ID: 30073177	2018
Achieving High-Yield Production of Functional AAV5 Gene Delivery Vectors via Fedbatch in an Insect Cell-One Baculovirus System. Molecular therapy. Methods & clinical development\| PubMed ID: 30886878	2019
Taste Receptor Cells in Mice Express Receptors for the Hormone Adiponectin. Chemical senses\| PubMed ID: 31125082	2019
Removal of Endotoxin from rAAV Samples Using a Simple Detergent-Based Protocol. Molecular therapy. Methods & clinical development\| PubMed ID: 31649960	2019
Engineering and Selection of a Novel AAV3B Variant with High Hepatocyte Tropism and Reduced Seroreactivity. Molecular therapy. Methods & clinical development\| PubMed ID: 33145371	2020
Applying machine learning to predict viral assembly for adeno-associated virus capsid libraries. Molecular therapy. Methods & clinical development\| PubMed ID: 33511242	2021
The CRTC1-MAML2 fusion is the major oncogenic driver in mucoepidermoid carcinoma. JCI insight\| PubMed ID: 33830080	2021
Mixture interactions at mammalian olfactory receptors are dependent on the cellular environment. Scientific reports\| PubMed ID: 33927269	2021
A comprehensive study of a 29-capsid AAV library in a non-human primate central nervous system. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 34298128	2021
Y1 receptors modulate taste-related behavioral responsiveness in male mice to prototypical gustatory stimuli. Hormones and behavior\| PubMed ID: 34509673	2021
Scratching the surface of RGD-directed AAV capsid engineering. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 34699781	2021
AAV capsid design: A Goldilocks challenge. Trends in molecular medicine\| PubMed ID: 35093287	2022
Identification of Novel Retinal Pericyte-Targeting rAAV Vectors Through Directed Evolution. Translational vision science & technology\| PubMed ID: 36018583	2022
Characterization of a Bioengineered AAV3B Capsid Variant with Enhanced Hepatocyte Tropism and Immune Evasion. Human gene therapy\| PubMed ID: 36950804	2023
Intravitreal injection of a rationally designed AAV capsid library in non-human primate identifies variants with enhanced retinal transduction and neutralizing antibody evasion. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 37814449	2023
Exploring the Comprehensive Kozak Sequence Landscape for AAV Production in Sf9 System. Viruses\| PubMed ID: 37896760	2023
Rational Design of AAV-rh74, AAV3B, and AAV8 with Limited Liver Targeting. Viruses\| PubMed ID: 38005848	2023