Cecilia M. Giachelli

Department of Bioengineering, University of Washington

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 3	2024

Other Publications

Article	Year
NF-kappaB mediates alphavbeta3 integrin-induced endothelial cell survival. The Journal of cell biology\| PubMed ID: 9585425	1998
Ectopic calcification: gathering hard facts about soft tissue mineralization. The American journal of pathology\| PubMed ID: 10079244	1999
Effects of cyclosporine in osteopontin null mice. Kidney international\| PubMed ID: 12081566	2002
Inactivation of the osteopontin gene enhances vascular calcification of matrix Gla protein-deficient mice: evidence for osteopontin as an inducible inhibitor of vascular calcification in viv... The Journal of experimental medicine\| PubMed ID: 12391016	2002
Osteopontin inhibits mineral deposition and promotes regression of ectopic calcification. The American journal of pathology\| PubMed ID: 12466120	2002
Immunohistologic labeling of murine endothelium. Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology\| PubMed ID: 12684163	2003
Vascular calcification: in vitro evidence for the role of inorganic phosphate. Journal of the American Society of Nephrology : JASN\| PubMed ID: 12939385	2003
Biomimetic peptides that engage specific integrin-dependent signaling pathways and bind to calcium phosphate surfaces. Journal of biomedical materials research. Part A\| PubMed ID: 14517863	2003
Characterization and analysis of osteopontin-immobilized poly(2-hydroxyethyl methacrylate) surfaces. Journal of biomedical materials research. Part A\| PubMed ID: 14517893	2003
Expression and function of the integrin alpha9beta1 in bovine aortic valve interstitial cells. The Journal of heart valve disease\| PubMed ID: 14565714	2003
Adhesive protein interactions with chitosan: consequences for valve endothelial cell growth on tissue-engineering materials. Journal of biomedical materials research. Part A\| PubMed ID: 14566796	2003
Regulation of cardiovascular calcification. Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology\| PubMed ID: 15033154	2004
Enhancing the biological activity of immobilized osteopontin using a type-1 collagen affinity coating. Journal of biomedical materials research. Part A\| PubMed ID: 15174104	2004
Hyaluronic acid grafting mitigates calcification of glutaraldehyde-fixed bovine pericardium. Journal of biomedical materials research. Part A\| PubMed ID: 15227678	2004
Mechanisms of vascular calcification in uremia. Seminars in nephrology\| PubMed ID: 15490398	2004
Elevated extracellular calcium levels induce smooth muscle cell matrix mineralization in vitro. Kidney international\| PubMed ID: 15569318	2004
The CC chemokine ligand, CCL2/MCP1, participates in macrophage fusion and foreign body giant cell formation. The American journal of pathology\| PubMed ID: 15579457	2004
Vascular calcification mechanisms. Journal of the American Society of Nephrology : JASN\| PubMed ID: 15579497	2004
Src kinase activity is required for integrin alphaVbeta3-mediated activation of nuclear factor-kappaB. The Journal of biological chemistry\| PubMed ID: 15695822	2005
Free fatty acid impairment of nitric oxide production in endothelial cells is mediated by IKKbeta. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 15731493	2005
Mitigation of ectopic calcification in osteopontin-deficient mice by exogenous osteopontin. Calcified tissue international\| PubMed ID: 15812576	2005
Smooth muscle cells deficient in osteopontin have enhanced susceptibility to calcification in vitro. Cardiovascular research\| PubMed ID: 15820201	2005
Regulation of vascular calcification: roles of phosphate and osteopontin. Circulation research\| PubMed ID: 15831823	2005
Calcification of advanced atherosclerotic lesions in the innominate arteries of ApoE-deficient mice: potential role of chondrocyte-like cells. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 15845913	2005
Esophageal epithelial cell interaction with synthetic and natural scaffolds for tissue engineering. Biomaterials\| PubMed ID: 15913763	2005
Controlling osteopontin orientation on surfaces to modulate endothelial cell adhesion. Journal of biomedical materials research. Part A\| PubMed ID: 15920735	2005
The role of osteopontin in foreign body giant cell formation. Biomaterials\| PubMed ID: 15949549	2005
Activation of IKKbeta by glucose is necessary and sufficient to impair insulin signaling and nitric oxide production in endothelial cells. Journal of molecular and cellular cardiology\| PubMed ID: 15978611	2005
Arteriosclerosis, calcium phosphate deposition and cardiovascular disease in uremia: current concepts at the bench. Current opinion in nephrology and hypertension\| PubMed ID: 16205469	2005
Role of the sodium-dependent phosphate cotransporter, Pit-1, in vascular smooth muscle cell calcification. Circulation research\| PubMed ID: 16527991	2006
Development of an esophagus acellular matrix tissue scaffold. Tissue engineering\| PubMed ID: 16548690	2006
Mimicking cell-cell interactions at the biomaterial-cell interface for control of stem cell differentiation. Journal of biomedical materials research. Part A\| PubMed ID: 16758464	2006
Osteoprotegerin inactivation accelerates advanced atherosclerotic lesion progression and calcification in older ApoE-/- mice. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 16840715	2006
Molecular mediators of alphavbeta3-induced endothelial cell survival. Journal of vascular research\| PubMed ID: 16888388	2006
Mechanisms of vascular calcification. Advances in chronic kidney disease\| PubMed ID: 17200044	2007
Sodium-dependent phosphate cotransporters and vascular calcification. Current opinion in nephrology and hypertension\| PubMed ID: 17565274	2007
Delivery of non-viral gene carriers from sphere-templated fibrin scaffolds for sustained transgene expression. Biomaterials\| PubMed ID: 17675152	2007
Osteopontin: a multifunctional molecule regulating chronic inflammation and vascular disease. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 17717292	2007
A fibrinogen-based precision microporous scaffold for tissue engineering. Biomaterials\| PubMed ID: 17765302	2007
BMP-2 promotes phosphate uptake, phenotypic modulation, and calcification of human vascular smooth muscle cells. Atherosclerosis\| PubMed ID: 18179800	2008
Role of carbonic anhydrase II in ectopic calcification. Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology\| PubMed ID: 18402839	2009
The influence of surface mineral and osteopontin on the formation and function of murine bone marrow-derived osteoclasts. Journal of materials science. Materials in medicine\| PubMed ID: 18483788	2008
Crosslinking of an oesophagus acellular matrix tissue scaffold. Journal of tissue engineering and regenerative medicine\| PubMed ID: 18618611	2008
Microporous nanofibrous fibrin-based scaffolds for bone tissue engineering. Biomaterials\| PubMed ID: 18640716	2008
Methods to promote Notch signaling at the biomaterial interface and evaluation in a rafted organ culture model. Journal of biomedical materials research. Part A\| PubMed ID: 18985776	2009
Osteoprotegerin and RANKL differentially regulate angiogenesis and endothelial cell function. Angiogenesis\| PubMed ID: 19105036	2009
The emerging role of phosphate in vascular calcification. Kidney international\| PubMed ID: 19145240	2009
Smooth muscle cells give rise to osteochondrogenic precursors and chondrocytes in calcifying arteries. Circulation research\| PubMed ID: 19197075	2009
Phosphate feeding induces arterial medial calcification in uremic mice: role of serum phosphorus, fibroblast growth factor-23, and osteopontin. Kidney international\| PubMed ID: 19322138	2009
Immobilization of alkaline phosphatase on microporous nanofibrous fibrin scaffolds for bone tissue engineering. Biomaterials\| PubMed ID: 19501906	2009
The role of osteopontin in inflammatory processes. Journal of cell communication and signaling\| PubMed ID: 19798593	2009
Generation of mouse conditional and null alleles of the type III sodium-dependent phosphate cotransporter PiT-1. Genesis (New York, N.Y. : 2000)\| PubMed ID: 19882669	2009
Discoidin domain receptor-1 deficiency attenuates atherosclerotic calcification and smooth muscle cell-mediated mineralization. The American journal of pathology\| PubMed ID: 19893047	2009
Vitamin D receptor activators induce an anticalcific paracrine program in macrophages: requirement of osteopontin. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 19948844	2010
Characterization of mandibular bone in a mouse model of chronic kidney disease. Journal of periodontology\| PubMed ID: 20151810	2010
Runx2/Cbfa1, but not loss of myocardin, is required for smooth muscle cell lineage reprogramming toward osteochondrogenesis. Journal of cellular biochemistry\| PubMed ID: 20564193	2010
Phosphate and vascular calcification: Emerging role of the sodium-dependent phosphate co-transporter PiT-1. Thrombosis and haemostasis\| PubMed ID: 20664908	2010
Matrix remodeling in vascular calcification associated with chronic kidney disease. Journal of the American Society of Nephrology : JASN\| PubMed ID: 20798261	2010
Elastin degradation and vascular smooth muscle cell phenotype change precede cell loss and arterial medial calcification in a uremic mouse model of chronic kidney disease. The American journal of pathology\| PubMed ID: 21281809	2011
Direct effects of phosphate on vascular cell function. Advances in chronic kidney disease\| PubMed ID: 21406295	2011
Arterial calcification in chronic kidney disease: key roles for calcium and phosphate. Circulation research\| PubMed ID: 21885837	2011
Combination of Sleeping Beauty transposition and chemically induced dimerization selection for robust production of engineered cells. Nucleic acids research\| PubMed ID: 22402491	2012
Sources of cells that contribute to atherosclerotic intimal calcification: an in vivo genetic fate mapping study. Cardiovascular research\| PubMed ID: 22436847	2012
Engineering biomaterials to integrate and heal: the biocompatibility paradigm shifts. Biotechnology and bioengineering\| PubMed ID: 22592568	2012
Vitamin D receptor agonists increase klotho and osteopontin while decreasing aortic calcification in mice with chronic kidney disease fed a high phosphate diet. Kidney international\| PubMed ID: 22932118	2012
RANKL enhances macrophage paracrine pro-calcific activity in high phosphate-treated smooth muscle cells: dependence on IL-6 and TNF-α. Journal of vascular research\| PubMed ID: 22948607	2012
High phosphate feeding promotes mineral and bone abnormalities in mice with chronic kidney disease. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association\| PubMed ID: 23045434	2013
Smooth muscle cell plasticity: fact or fiction? Circulation research\| PubMed ID: 23093573	2013
Osteopontin mediates macrophage chemotaxis via α4 and α9 integrins and survival via the α4 integrin. Journal of cellular biochemistry\| PubMed ID: 23192608	2013
Prevascularized microtemplated fibrin scaffolds for cardiac tissue engineering applications. Tissue engineering. Part A\| PubMed ID: 23317311	2013
Fibroblast growth factor 23 is not associated with and does not induce arterial calcification. Kidney international\| PubMed ID: 23389416	2013
Vascular calcification: an update on mechanisms and challenges in treatment. Calcified tissue international\| PubMed ID: 23456027	2013
Sodium-dependent phosphate cotransporters and phosphate-induced calcification of vascular smooth muscle cells: redundant roles for PiT-1 and PiT-2. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 23968976	2013
An inducible, ligand-independent receptor activator of NF-κB gene to control osteoclast differentiation from monocytic precursors. PloS one\| PubMed ID: 24386387	2013
Engineered biomaterials control differentiation and proliferation of human-embryonic-stem-cell-derived cardiomyocytes via timed Notch activation. Stem cell reports\| PubMed ID: 24672751	2014
Loss of PiT-1 results in abnormal endocytosis in the yolk sac visceral endoderm. Mechanisms of development\| PubMed ID: 25138534	2014
A current understanding of vascular calcification in CKD. American journal of physiology. Renal physiology\| PubMed ID: 25143458	2014
Calcific aortic valve disease: a consensus summary from the Alliance of Investigators on Calcific Aortic Valve Disease. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 25189570	2014
Phosphate uptake-independent signaling functions of the type III sodium-dependent phosphate transporter, PiT-1, in vascular smooth muscle cells. Experimental cell research\| PubMed ID: 25684711	2015
Runx2 Expression in Smooth Muscle Cells Is Required for Arterial Medial Calcification in Mice. The American journal of pathology\| PubMed ID: 25987250	2015
SLC20A2 Deficiency in Mice Leads to Elevated Phosphate Levels in Cerbrospinal Fluid and Glymphatic Pathway-Associated Arteriolar Calcification, and Recapitulates Human Idiopathic Basal Gangl... Brain pathology (Zurich, Switzerland)\| PubMed ID: 26822507	2017
Slc20a2 deficiency results in fetal growth restriction and placental calcification associated with thickened basement membranes and novel CD13 and lamininα1 expressing cells. Reproductive biology\| PubMed ID: 26952749	2016
Osteopontin protects against high phosphate-induced nephrocalcinosis and vascular calcification. Kidney international\| PubMed ID: 27083280	2016
Runx2 deletion in smooth muscle cells inhibits vascular osteochondrogenesis and calcification but not atherosclerotic lesion formation. Cardiovascular research\| PubMed ID: 27671804	2016
Vascular calcification in CKD-MBD: Roles for phosphate, FGF23, and Klotho. Bone\| PubMed ID: 27847254	2017
Osteoclast precursors do not express CD68: results from CD68 promoter-driven RANK transgenic mice. FEBS letters\| PubMed ID: 28173622	2017
Noncanonical Wnts at the Cusp of Fibrocalcific Signaling Processes in Human Calcific Aortic Valve Disease. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 28228443	2017
Loss of PiT-2 results in abnormal bone development and decreased bone mineral density and length in mice. Biochemical and biophysical research communications\| PubMed ID: 29133259	2018
Role of smooth muscle cells in vascular calcification: implications in atherosclerosis and arterial stiffness. Cardiovascular research\| PubMed ID: 29514202	2018
Increased Calcific Aortic Valve Disease in response to a diabetogenic, procalcific diet in the LDLrApoB mouse model. Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology\| PubMed ID: 29539583	2018
PiT-2, a type III sodium-dependent phosphate transporter, protects against vascular calcification in mice with chronic kidney disease fed a high-phosphate diet. Kidney international\| PubMed ID: 30041812	2018
Slc20a1/Pit1 and Slc20a2/Pit2 are essential for normal skeletal myofiber function and survival. Scientific reports\| PubMed ID: 32080237	2020
Adapter Protein RapGEF1 Is Required for ERK1/2 Signaling in Response to Elevated Phosphate in Vascular Smooth Muscle Cells. Journal of vascular research\| PubMed ID: 33951626	2021
Engineered osteoclasts resorb necrotic alveolar bone in anti-RANKL antibody-treated mice. Bone\| PubMed ID: 34375732	2021
Role of Runx2 in Calcific Aortic Valve Disease in Mouse Models. Frontiers in cardiovascular medicine\| PubMed ID: 34778386	2021
Dissecting specific Wnt components governing osteogenic differentiation potential by human periodontal ligament stem cells through interleukin-6. Scientific reports\| PubMed ID: 37270571	2023
Comparison of osteoclast differentiation protocols from human induced pluripotent stem cells of different tissue origins. Research square\| PubMed ID: 37461708	2023
Comparison of osteoclast differentiation protocols from human induced pluripotent stem cells of different tissue origins. Stem cell research & therapy\| PubMed ID: 37936199	2023