Charalabos Pothoulakis

Center for Inflammatory Bowel Diseases, The University of California Los Angeles, Los Angeles

Affiliated withThe University of California Los Angeles, Los Angeles University of California, Los Angeles

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 2	2012
Publication title Cited by 6	2019

Other Publications

Article	Year
Role of substance P in the regulation of glucose metabolism via insulin signaling-associated pathways. Endocrinology\| PubMed ID: 22009727	2011
Nerves and Intestinal Mast Cells Modulate Responses to Enterotoxins. News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society\| PubMed ID: 11390763	1998
Protein kinase C signaling regulates ZO-1 translocation and increased paracellular flux of T84 colonocytes exposed to Clostridium difficile toxin A. The Journal of biological chemistry\| PubMed ID: 11729192	2002
Genetic deficiency in the chemokine receptor CCR1 protects against acute Clostridium difficile toxin A enteritis in mice. Gastroenterology\| PubMed ID: 11875005	2002
Mechanism of lovastatin-induced apoptosis in intestinal epithelial cells. Carcinogenesis\| PubMed ID: 11895868	2002
Clostridium difficile toxin A triggers human colonocyte IL-8 release via mitochondrial oxygen radical generation. Gastroenterology\| PubMed ID: 11910356	2002
Corticotropin-releasing hormone antagonists possess anti-inflammatory effects in the mouse ileum. Gastroenterology\| PubMed ID: 12145804	2002
Substance P-stimulated interleukin-8 expression in human colonic epithelial cells involves Rho family small GTPases. The Biochemical journal\| PubMed ID: 12169092	2002
Protective role of HSP72 against Clostridium difficile toxin A-induced intestinal epithelial cell dysfunction. American journal of physiology. Cell physiology\| PubMed ID: 12490434	2003
Neurotensin stimulates IL-8 expression in human colonic epithelial cells through Rho GTPase-mediated NF-kappa B pathways. American journal of physiology. Cell physiology\| PubMed ID: 12584113	2003
Regulation of the NK-1 receptor gene expression in human macrophage cells via an NF-kappa B site on its promoter. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12594338	2003
Leptin mediates Clostridium difficile toxin A-induced enteritis in mice. Gastroenterology\| PubMed ID: 12612907	2003
Development of microbial-human enterocyte interaction: cholera toxin. Pediatric research\| PubMed ID: 12736381	2003
Clostridium difficile toxin B is an inflammatory enterotoxin in human intestine. Gastroenterology\| PubMed ID: 12891543	2003
A neurokinin 1 receptor antagonist reduces an ongoing ileal pouch inflammation and the response to a subsequent inflammatory stimulus. American journal of physiology. Gastrointestinal and liver physiology\| PubMed ID: 12893626	2003
Rho GTPases as therapeutic targets for the treatment of inflammatory diseases. Expert opinion on therapeutic targets\| PubMed ID: 14498821	2003
MEK is a key modulator for TLR5-induced interleukin-8 and MIP3alpha gene expression in non-transformed human colonic epithelial cells. The Journal of biological chemistry\| PubMed ID: 15069060	2004
Corticotropin-releasing hormone (CRH) requirement in Clostridium difficile toxin A-mediated intestinal inflammation. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15159534	2004
Metalloproteinase-dependent transforming growth factor-alpha release mediates neurotensin-stimulated MAP kinase activation in human colonic epithelial cells. The Journal of biological chemistry\| PubMed ID: 15247267	2004
Metalloproteinases and transforming growth factor-alpha mediate substance P-induced mitogen-activated protein kinase activation and proliferation in human colonocytes. The Journal of biological chemistry\| PubMed ID: 15319441	2004
Rifalazil treats and prevents relapse of clostridium difficile-associated diarrhea in hamsters. Antimicrobial agents and chemotherapy\| PubMed ID: 15388461	2004
Bacterial infections: small intestine and colon. Current opinion in gastroenterology\| PubMed ID: 15699889	2003
Repeated exposure to water avoidance stress in rats: a new model for sustained visceral hyperalgesia. American journal of physiology. Gastrointestinal and liver physiology\| PubMed ID: 15746211	2005
Neurotensin stimulates interleukin-8 expression through modulation of I kappa B alpha phosphorylation and p65 transcriptional activity: involvement of protein kinase C alpha. Molecular pharmacology\| PubMed ID: 15755906	2005
Clostridium difficile toxoid vaccine in recurrent C. difficile-associated diarrhea. Gastroenterology\| PubMed ID: 15765411	2005
Clostridium difficile toxin A regulates inducible cyclooxygenase-2 and prostaglandin E2 synthesis in colonocytes via reactive oxygen species and activation of p38 MAPK. The Journal of biological chemistry\| PubMed ID: 15767259	2005
Clostridium difficile toxin B activates the EGF receptor and the ERK/MAP kinase pathway in human colonocytes. Gastroenterology\| PubMed ID: 15825081	2005
Substance P-stimulated interleukin-8 expression in human colonic epithelial cells involves protein kinase Cdelta activation. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 15917399	2005
Pathophysiological role of Toll-like receptor 5 engagement by bacterial flagellin in colonic inflammation. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16157881	2005
Clostridium difficile toxin A-induced colonocyte apoptosis involves p53-dependent p21(WAF1/CIP1) induction via p38 mitogen-activated protein kinase. Gastroenterology\| PubMed ID: 16344056	2005
Saccharomyces boulardii produces a soluble anti-inflammatory factor that inhibits NF-kappaB-mediated IL-8 gene expression. Biochemical and biophysical research communications\| PubMed ID: 16529714	2006
Induction of colitis causes inflammatory responses in fat depots: evidence for substance P pathways in human mesenteric preadipocytes. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16549770	2006
Ghrelin stimulates interleukin-8 gene expression through protein kinase C-mediated NF-kappaB pathway in human colonic epithelial cells. Journal of cellular biochemistry\| PubMed ID: 16552751	2006
Substance P stimulates cyclooxygenase-2 and prostaglandin E2 expression through JAK-STAT activation in human colonic epithelial cells. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 16585602	2006
Role of MyD88 in phosphatidylinositol 3-kinase activation by flagellin/toll-like receptor 5 engagement in colonic epithelial cells. The Journal of biological chemistry\| PubMed ID: 16644730	2006
The role of neurokinin 1 receptors in the maintenance of visceral hyperalgesia induced by repeated stress in rats. Gastroenterology\| PubMed ID: 16697737	2006
Saccharomyces boulardii inhibits ERK1/2 mitogen-activated protein kinase activation both in vitro and in vivo and protects against Clostridium difficile toxin A-induced enteritis. The Journal of biological chemistry\| PubMed ID: 16816386	2006
Epithelial cell I kappa B-kinase beta has an important protective role in Clostridium difficile toxin A-induced mucosal injury. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 16818780	2006
Effects of NT on gastrointestinal motility and secretion, and role in intestinal inflammation. Peptides\| PubMed ID: 16872719	2006
Corticotropin-releasing hormone receptor 2-deficient mice have reduced intestinal inflammatory responses. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 16920976	2006
Identification of depot-specific human fat cell progenitors through distinct expression profiles and developmental gene patterns. American journal of physiology. Endocrinology and metabolism\| PubMed ID: 16985259	2007
Interleukin-6 genetic ablation protects from trinitrobenzene sulfonic acid-induced colitis in mice. Putative effect of antiinflammatory cytokines. Neuroimmunomodulation\| PubMed ID: 17077645	2006
Immunomodulatory properties of substance P: the gastrointestinal system as a model. Annals of the New York Academy of Sciences\| PubMed ID: 17192554	2006
Neurotensin stimulates expression of early growth response gene-1 and EGF receptor through MAP kinase activation in human colonic epithelial cells. International journal of cancer. Journal international du cancer\| PubMed ID: 17230532	2007
Substance P mediates antiapoptotic responses in human colonocytes by Akt activation. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17264209	2007
Role of neuropeptides in inflammatory bowel disease. Inflammatory bowel diseases\| PubMed ID: 17343284	2007
Enteric glia regulate intestinal barrier function and inflammation via release of S-nitrosoglutathione. Gastroenterology\| PubMed ID: 17408650	2007
Urocortin II mediates pro-inflammatory effects in human colonocytes via corticotropin-releasing hormone receptor 2alpha. Gut\| PubMed ID: 17412781	2007
Functional consequences of alteration of N-linked glycosylation sites on the neurokinin 1 receptor. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17563389	2007
Protease-activated receptor 2, dipeptidyl peptidase I, and proteases mediate Clostridium difficile toxin A enteritis. Gastroenterology\| PubMed ID: 17570216	2007
Inflammation and apoptosis in Clostridium difficile enteritis is mediated by PGE2 up-regulation of Fas ligand. Gastroenterology\| PubMed ID: 17854595	2007
Obesity, innate immunity and gut inflammation. Current opinion in gastroenterology\| PubMed ID: 17906444	2007
Comparative efficacies of rifaximin and vancomycin for treatment of Clostridium difficile-associated diarrhea and prevention of disease recurrence in hamsters. Antimicrobial agents and chemotherapy\| PubMed ID: 18195066	2008
Substance P as a novel anti-obesity target. Gastroenterology\| PubMed ID: 18325388	2008
Gastrin-mediated interleukin-8 and cyclooxygenase-2 gene expression: differential transcriptional and posttranscriptional mechanisms. Gastroenterology\| PubMed ID: 18395088	2008
Corticotropin-releasing hormone deficiency is associated with reduced local inflammation in a mouse model of experimental colitis. Endocrinology\| PubMed ID: 18403481	2008
gp96 is a human colonocyte plasma membrane binding protein for Clostridium difficile toxin A. Infection and immunity\| PubMed ID: 18411291	2008
Toll-like receptor 5 engagement modulates tumor development and growth in a mouse xenograft model of human colon cancer. Gastroenterology\| PubMed ID: 18538140	2008
Substance P-mediated expression of the pro-angiogenic factor CCN1 modulates the course of colitis. The American journal of pathology\| PubMed ID: 18599605	2008
Melanin-concentrating hormone as a mediator of intestinal inflammation. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18650383	2008
Neuropeptides, mesenteric fat, and intestinal inflammation. Annals of the New York Academy of Sciences\| PubMed ID: 19076372	2008
Substance P, obesity, and gut inflammation. Current opinion in endocrinology, diabetes, and obesity\| PubMed ID: 19104238	2009
Role of spinal microglia in visceral hyperalgesia and NK1R up-regulation in a rat model of chronic stress. Gastroenterology\| PubMed ID: 19249394	2009
Substance P promotes expansion of human mesenteric preadipocytes through proliferative and antiapoptotic pathways. American journal of physiology. Gastrointestinal and liver physiology\| PubMed ID: 19282377	2009
Principles and clinical implications of the brain-gut-enteric microbiota axis. Nature reviews. Gastroenterology & hepatology\| PubMed ID: 19404271	2009
Neurotensin induces IL-6 secretion in mouse preadipocytes and adipose tissues during 2,4,6,-trinitrobenzensulphonic acid-induced colitis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19443690	2009
Clostridium difficile toxin A binds colonocyte Src causing dephosphorylation of focal adhesion kinase and paxillin. Experimental cell research\| PubMed ID: 19481075	2009
Saccharomyces boulardii inhibits EGF receptor signaling and intestinal tumor growth in Apc(min) mice. Gastroenterology\| PubMed ID: 19482027	2009
Activation of phosphatidylinositol 3-kinase/protein kinase B by corticotropin-releasing factor in human monocytes. Endocrinology\| PubMed ID: 19628576	2009
Bacillus polyfermenticus ameliorates colonic inflammation by promoting cytoprotective effects in colitic mice. The Journal of nutrition\| PubMed ID: 19675103	2009
Serotonin has a critical role in the pathogenesis of experimental colitis. Gastroenterology\| PubMed ID: 19789088	2009
The anticancer effect of probiotic Bacillus polyfermenticus on human colon cancer cells is mediated through ErbB2 and ErbB3 inhibition. International journal of cancer. Journal international du cancer\| PubMed ID: 19876926	2010
Corticotropin-releasing hormone family of peptides regulates intestinal angiogenesis. Gastroenterology\| PubMed ID: 20206175	2010
TRIF modulates TLR5-dependent responses by inducing proteolytic degradation of TLR5. The Journal of biological chemistry\| PubMed ID: 20452988	2010
The angiogenic effect of probiotic Bacillus polyfermenticus on human intestinal microvascular endothelial cells is mediated by IL-8. American journal of physiology. Gastrointestinal and liver physiology\| PubMed ID: 20501448	2009
Clostridium difficile toxin A decreases acetylation of tubulin, leading to microtubule depolymerization through activation of histone deacetylase 6, and this mediates acute inflammation. The Journal of biological chemistry\| PubMed ID: 20696758	2010
Corticotropin-releasing factor regulates TLR4 expression in the colon and protects mice from colitis. Gastroenterology\| PubMed ID: 20732324	2010
TRIF mediates Toll-like receptor 5-induced signaling in intestinal epithelial cells. The Journal of biological chemistry\| PubMed ID: 20855887	2010
Substance P modulates colitis-associated fibrosis. The American journal of pathology\| PubMed ID: 20889569	2010
Insulin-like growth factor-1 receptor transactivation modulates the inflammatory and proliferative responses of neurotensin in human colonic epithelial cells. The Journal of biological chemistry\| PubMed ID: 21212273	2011
Constitutive TL1A (TNFSF15) expression on lymphoid or myeloid cells leads to mild intestinal inflammation and fibrosis. PloS one\| PubMed ID: 21264313	2011
Activation of corticotropin-releasing factor receptor 2 mediates the colonic motor coping response to acute stress in rodents. Gastroenterology\| PubMed ID: 21277852	2011
Substance P (SP)-neurokinin-1 receptor (NK-1R) alters adipose tissue responses to high-fat diet and insulin action. Endocrinology\| PubMed ID: 21467195	2011
Neuropeptide - adipose tissue communication and intestinal pathophysiology. Current pharmaceutical design\| PubMed ID: 21548874	2011
The neurotensin receptor-1 promotes tumor development in a sporadic but not an inflammation-associated mouse model of colon cancer. International journal of cancer. Journal international du cancer\| PubMed ID: 21630261	2012
Role of astrocytes and altered regulation of spinal glutamatergic neurotransmission in stress-induced visceral hyperalgesia in rats. American journal of physiology. Gastrointestinal and liver physiology\| PubMed ID: 21719739	2011
Cathelicidin signaling via the Toll-like receptor protects against colitis in mice. Gastroenterology\| PubMed ID: 21762664	2011
Neurotensin signaling activates microRNAs-21 and -155 and Akt, promotes tumor growth in mice, and is increased in human colon tumors. Gastroenterology\| PubMed ID: 21806946	2011
The insect peptide coprisin prevents Clostridium difficile-mediated acute inflammation and mucosal damage through selective antimicrobial activity. Antimicrobial agents and chemotherapy\| PubMed ID: 21807975	2011
Host S-nitrosylation inhibits clostridial small molecule-activated glucosylating toxins. Nature medicine\| PubMed ID: 21857653	2011
The effects of acute and chronic psychological stress on bladder function in a rodent model. Urology\| PubMed ID: 21868072	2011
Substance P induces CCN1 expression via histone deacetylase activity in human colonic epithelial cells. The American journal of pathology\| PubMed ID: 21945803	2011
Lin28A and Lin28B inhibit let-7 microRNA biogenesis by distinct mechanisms. Cell\| PubMed ID: 22118463	2011
Constitutive TL1A expression under colitogenic conditions modulates the severity and location of gut mucosal inflammation and induces fibrostenosis. The American journal of pathology\| PubMed ID: 22138299	2012
Serum and colonic mucosal immune markers in irritable bowel syndrome. The American journal of gastroenterology\| PubMed ID: 22158028	2012
Clostridial toxins: sensing a target in a hostile gut environment. Gut microbes\| PubMed ID: 22356854	2012
Adipose tissue and inflammatory bowel disease pathogenesis. Inflammatory bowel diseases\| PubMed ID: 22407798	2012
Neurotensin-induced proinflammatory signaling in human colonocytes is regulated by Î²-arrestins and endothelin-converting enzyme-1-dependent endocytosis and resensitization of neurotensin re... The Journal of biological chemistry\| PubMed ID: 22416137	2012
Efficacy and safety of the probiotic Saccharomyces boulardii for the prevention and therapy of gastrointestinal disorders. Therapeutic advances in gastroenterology\| PubMed ID: 22423260	2012
Elevated lipopolysaccharide in the colon evokes intestinal inflammation, aggravated in immune modulator-impaired mice. American journal of physiology. Gastrointestinal and liver physiology\| PubMed ID: 22723263	2012
The antimicrobial peptide cathelicidin modulates Clostridium difficile-associated colitis and toxin A-mediated enteritis in mice. Gut\| PubMed ID: 22760006	2012
Antimicrobial Peptides and Colitis. Current pharmaceutical design\| PubMed ID: 22950497	2012