Arnold J. Levine

The Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey

Affiliated withUniversity of Medicine and Dentistry of New Jersey Institute for Advanced Study, Princeton, New Jersey Rutgers University

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 39	2012
Publication title Cited by 117	2014

Other Publications

Article	Year
WISP-1 attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. Genes & development\| PubMed ID: 11782444	2002
p53 regulates cell survival by inhibiting PIK3CA in squamous cell carcinomas. Genes & development\| PubMed ID: 11959846	2002
Novel gain of function activity of p53 mutants: activation of the dUTPase gene expression leading to resistance to 5-fluorouracil. Oncogene\| PubMed ID: 12096336	2002
Stochastic gene expression in a single cell. Science (New York, N.Y.)\| PubMed ID: 12183631	2002
Overexpression of WISP-1 down-regulated motility and invasion of lung cancer cells through inhibition of Rac activation. The Journal of biological chemistry\| PubMed ID: 12529380	2003
CIAP1 and the serine protease HTRA2 are involved in a novel p53-dependent apoptosis pathway in mammals. Genes & development\| PubMed ID: 12569127	2003
The presence of p53 mutations in human osteosarcomas correlates with high levels of genomic instability. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12972634	2003
Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 14657337	2003
Dynamics of the p53-Mdm2 feedback loop in individual cells. Nature genetics\| PubMed ID: 14730303	2004
P53 is a tumor suppressor gene. Cell\| PubMed ID: 15055586	2004
Activation of NF-kappaB and inhibition of p53-mediated apoptosis by API2/mucosa-associated lymphoid tissue 1 fusions promote oncogenesis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15184680	2004
Actvation of NF-kappaB by the API2/MALT1 fusions inhibits p53 dependant but not FAS induced apoptosis: a directional link between NF-kappaB and p53. Cell cycle (Georgetown, Tex.)\| PubMed ID: 15280657	2004
Tissue-specific codon usage and the expression of human genes. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15314228	2004
Epigenetic and genetic loss of Hic1 function accentuates the role of p53 in tumorigenesis. Cancer cell\| PubMed ID: 15488761	2004
A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans. Cell\| PubMed ID: 15550242	2004
In the quest for stable rescuing mutants of p53: computational mutagenesis of flexible loop L1. Biochemistry\| PubMed ID: 15683227	2005
MDM2 is a central node in the p53 pathway: 12 years and counting. Current cancer drug targets\| PubMed ID: 15720184	2005
Comparison of the protein-protein interfaces in the p53-DNA crystal structures: towards elucidation of the biological interface. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15738397	2005
The p53 pathway: positive and negative feedback loops. Oncogene\| PubMed ID: 15838523	2005
A chromatin-associated and transcriptionally inactive p53-Mdm2 complex occurs in mdm2 SNP309 homozygous cells. The Journal of biological chemistry\| PubMed ID: 15908423	2005
The coordinate regulation of the p53 and mTOR pathways in cells. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15928081	2005
A plausible model for the digital response of p53 to DNA damage. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16186499	2005
The contribution of the Trp/Met/Phe residues to physical interactions of p53 with cellular proteins. Physical biology\| PubMed ID: 16204849	2005
Detection of functional single-nucleotide polymorphisms that affect apoptosis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16260726	2005
A relative-entropy algorithm for genomic fingerprinting captures host-phage similarities. Journal of bacteriology\| PubMed ID: 16321941	2005
A robust meta-classification strategy for cancer detection from MS data. Proteomics\| PubMed ID: 16342141	2006
Robust diagnosis of non-Hodgkin lymphoma phenotypes validated on gene expression data from different laboratories. Genome informatics. International Conference on Genome Informatics\| PubMed ID: 16362926	2005
A robust meta-classification strategy for cancer diagnosis from gene expression data. Proceedings / IEEE Computational Systems Bioinformatics Conference, CSB. IEEE Computational Systems Bioinformatics Conference\| PubMed ID: 16447989	2005
Coordination and communication between the p53 and IGF-1-AKT-TOR signal transduction pathways. Genes & development\| PubMed ID: 16452501	2006
Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis. Nature reviews. Cancer\| PubMed ID: 16453012	2006
Comparison of the human and worm p53 structures suggests a way for enhancing stability. Biochemistry\| PubMed ID: 16548519	2006
The regulation of exosome secretion: a novel function of the p53 protein. Cancer research\| PubMed ID: 16651434	2006
MDM2 SNP309 accelerates tumor formation in a gender-specific and hormone-dependent manner. Cancer research\| PubMed ID: 16707433	2006
MDM2 SNP309 accelerates colorectal tumour formation in women. Journal of medical genetics\| PubMed ID: 16825430	2006
Comparison of avian and human influenza A viruses reveals a mutational bias on the viral genomes. Journal of virology\| PubMed ID: 16987977	2006
Haplotype structure and selection of the MDM2 oncogene in humans. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17360557	2007
A single nucleotide polymorphism in the MDM2 gene disrupts the oscillation of p53 and MDM2 levels in cells. Cancer research\| PubMed ID: 17363597	2007
The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways. Cancer research\| PubMed ID: 17409411	2007
Sequence analysis of p53 response-elements suggests multiple binding modes of the p53 tetramer to DNA targets. Nucleic acids research\| PubMed ID: 17439973	2007
Declining p53 function in the aging process: a possible mechanism for the increased tumor incidence in older populations. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17921246	2007
Reconstructing signal transduction pathways: challenges and opportunities. Annals of the New York Academy of Sciences\| PubMed ID: 17934060	2007
Probing potential binding modes of the p53 tetramer to DNA based on the symmetries encoded in p53 response elements. Nucleic acids research\| PubMed ID: 17986463	2007
High expression of lymphocyte-associated genes in node-negative HER2+ breast cancers correlates with lower recurrence rates. Cancer research\| PubMed ID: 18006808	2007
p53 regulates maternal reproduction through LIF. Nature\| PubMed ID: 18046411	2007
Highly conserved regions of influenza a virus polymerase gene segments are critical for efficient viral RNA packaging. Journal of virology\| PubMed ID: 18094182	2008
Suppression of immediate-early viral gene expression by herpesvirus-coded microRNAs: implications for latency. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18378902	2008
An information-theoretic analysis of genetics, gender and age in cancer patients. PloS one\| PubMed ID: 18398474	2008
The computational detection of functional nucleotide sequence motifs in the coding regions of organisms. Experimental biology and medicine (Maywood, N.J.)\| PubMed ID: 18408149	2008
The tumor suppressor p53: cancer and aging. Cell cycle (Georgetown, Tex.)\| PubMed ID: 18414039	2008
p53: a new player in reproduction. Cell cycle (Georgetown, Tex.)\| PubMed ID: 18414047	2008
Patterns of evolution and host gene mimicry in influenza and other RNA viruses. PLoS pathogens\| PubMed ID: 18535658	2008
Anomalies in the influenza virus genome database: new biology or laboratory errors? Journal of virology\| PubMed ID: 18579605	2008
A recoding method to improve the humoral immune response to an HIV DNA vaccine. PloS one\| PubMed ID: 18791646	2008
Why do we not yet have a human immunodeficiency virus vaccine? Journal of virology\| PubMed ID: 18829744	2008
P53 mutations in lymphomas: position matters. Blood\| PubMed ID: 18840714	2008
The genetics of the p53 pathway, apoptosis and cancer therapy. Nature reviews. Drug discovery\| PubMed ID: 19043449	2008
The common mechanisms of transformation by the small DNA tumor viruses: The inactivation of tumor suppressor gene products: p53. Virology\| PubMed ID: 19081592	2009
The regulation of the endosomal compartment by p53 the tumor suppressor gene. The FEBS journal\| PubMed ID: 19302216	2009
Non-random reassortment in human influenza A viruses. Influenza and other respiratory viruses\| PubMed ID: 19453489	2008
Single-nucleotide polymorphisms in the p53 pathway regulate fertility in humans. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19470478	2009
Altered tumor formation and evolutionary selection of genetic variants in the human MDM4 oncogene. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19497887	2009
Patterns of oligonucleotide sequences in viral and host cell RNA identify mediators of the host innate immune system. PloS one\| PubMed ID: 19536338	2009
A polymorphic variant in human MDM4 associates with accelerated age of onset of estrogen receptor negative breast cancer. Carcinogenesis\| PubMed ID: 19762336	2009
Recent natural selection identifies a genetic variant in a regulatory subunit of protein phosphatase 2A that associates with altered cancer risk and survival. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 19773383	2009
The first 30 years of p53: growing ever more complex. Nature reviews. Cancer\| PubMed ID: 19776744	2009
Stem cell biology meets p53. Nature biotechnology\| PubMed ID: 19816447	2009
One billion years of p53/p63/p73 evolution. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19826090	2009
The regulation of human reproduction by p53 and its pathway. Cell cycle (Georgetown, Tex.)\| PubMed ID: 19884797	2009
Chemosensitivity profiles identify polymorphisms in the p53 network genes 14-3-3tau and CD44 that affect sarcoma incidence and survival. Cancer research\| PubMed ID: 19996285	2010
Differential levels of transcription of p53-regulated genes by the arginine/proline polymorphism: p53 with arginine at codon 72 favors apoptosis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 20019240	2010
Germline mutations and polymorphisms in the origins of cancers in women. Journal of oncology\| PubMed ID: 20111735	2010
Higher order Boolean networks as models of cell state dynamics. Journal of theoretical biology\| PubMed ID: 20303985	2010
The regulation of energy metabolism and the IGF-1/mTOR pathways by the p53 protein. Trends in cell biology\| PubMed ID: 20399660	2010
Fine-scale detection of population-specific linkage disequilibrium using haplotype entropy in the human genome. BMC genetics\| PubMed ID: 20416085	2010
Identifying mRNA targets of microRNA dysregulated in cancer: with application to clear cell Renal Cell Carcinoma. BMC systems biology\| PubMed ID: 20420713	2010
The origins and evolution of the p53 family of genes. Cold Spring Harbor perspectives in biology\| PubMed ID: 20516129	2010
p53 and NF-ÎºB: different strategies for responding to stress lead to a functional antagonism. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 20530750	2010
Negative regulation of tumor suppressor p53 by microRNA miR-504. Molecular cell\| PubMed ID: 20542001	2010
Polymorphic variants in TSC1 and TSC2 and their association with breast cancer phenotypes. Breast cancer research and treatment\| PubMed ID: 20658316	2011
A genetic variant in a PP2A regulatory subunit encoded by the PPP2R2B gene associates with altered breast cancer risk and recurrence. International journal of cancer. Journal international du cancer\| PubMed ID: 20669227	2011
Unexpected inheritance: multiple integrations of ancient bornavirus and ebolavirus/marburgvirus sequences in vertebrate genomes. PLoS pathogens\| PubMed ID: 20686665	2010
A high-frequency regulatory polymorphism in the p53 pathway accelerates tumor development. Cancer cell\| PubMed ID: 20832750	2010
Sequences from ancestral single-stranded DNA viruses in vertebrate genomes: the parvoviridae and circoviridae are more than 40 to 50 million years old. Journal of virology\| PubMed ID: 20861255	2010
Gene Amplifications in Well-Differentiated Pancreatic Neuroendocrine Tumors Inactivate the p53 Pathway. Genes & cancer\| PubMed ID: 20871795	2010
Association of nuclear localization of a long interspersed nuclear element-1 protein in breast tumors with poor prognostic outcomes. Genes & cancer\| PubMed ID: 20948976	2010
The control of the metabolic switch in cancers by oncogenes and tumor suppressor genes. Science (New York, N.Y.)\| PubMed ID: 21127244	2010
Inactivation of p53 in breast cancers correlates with stem cell transcriptional signatures. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21149740	2010
Regulation of female reproduction by p53 and its family members. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 21402718	2011
The p53 family: guardians of maternal reproduction. Nature reviews. Molecular cell biology\| PubMed ID: 21427767	2011
Topology based data analysis identifies a subgroup of breast cancers with a unique mutational profile and excellent survival. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21482760	2011
Monographs editor. Genes & cancer\| PubMed ID: 21779506	2011
Introduction: The Changing Directions of p53 Research. Genes & cancer\| PubMed ID: 21785490	2011
Parkin, a p53 target gene, mediates the role of p53 in glucose metabolism and the Warburg effect. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21930938	2011
Molecular classification of prostate cancer using curated expression signatures. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22123976	2011
The evolution of the p53 family of genes. Cell cycle (Georgetown, Tex.)\| PubMed ID: 22214668	2012
Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway. Cell\| PubMed ID: 22265415	2012
Viral reassortment as an information exchange between viral segments. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22331898	2012
Chronic restraint stress attenuates p53 function and promotes tumorigenesis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22509031	2012
Allele-specific p53 mutant reactivation. Cancer cell\| PubMed ID: 22624712	2012
Amplified Loci on Chromosomes 8 and 17 Predict Early Relapse in ER-Positive Breast Cancers. PloS one\| PubMed ID: 22719901	2012
Attenuation of the Retinoblastoma Pathway in Pancreatic Neuroendocrine Tumors Due to Increased Cdk4/Cdk6. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 22761470	2012
A Cell-Penetrating Bispecific Antibody for Therapeutic Regulation of Intracellular Targets. Molecular cancer therapeutics\| PubMed ID: 22863609	2012