Zeger Debyser

Molecular Virology and Gene Therapy, KU Leuven

Affiliated withKU Leuven

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 8	2012

Other Publications

Article	Year
Characterization of lentiviral vector-mediated gene transfer in adult mouse brain. Human gene therapy\| PubMed ID: 11975850	2002
DNA-induced polymerization of HIV-1 integrase analyzed with fluorescence fluctuation spectroscopy. The Journal of biological chemistry\| PubMed ID: 12147698	2002
New class of HIV integrase inhibitors that block viral replication in cell culture. Current biology : CB\| PubMed ID: 12176326	2002
In search of authentic inhibitors of HIV-1 integration. Antiviral chemistry & chemotherapy\| PubMed ID: 12180645	2002
Inhibition of human immunodeficiency virus type 1 integration by diketo derivatives. Antimicrobial agents and chemotherapy\| PubMed ID: 12234864	2002
HIV-1 integrase forms stable tetramers and associates with LEDGF/p75 protein in human cells. The Journal of biological chemistry\| PubMed ID: 12407101	2003
env chimeric virus technology for evaluating human immunodeficiency virus susceptibility to entry inhibitors. Antimicrobial agents and chemotherapy\| PubMed ID: 12435701	2002
Establishment of an in vitro assay system mimicking human immunodeficiency virus type 1-induced neural cell death and evaluation of inhibitors thereof. Journal of virological methods\| PubMed ID: 12609687	2003
Impact of the central polypurine tract on the kinetics of human immunodeficiency virus type 1 vector transduction. Journal of virology\| PubMed ID: 12663775	2003
N-aminoimidazole derivatives inhibiting retroviral replication via a yet unidentified mode of action. Journal of medicinal chemistry\| PubMed ID: 12672256	2003
LEDGF/p75 is essential for nuclear and chromosomal targeting of HIV-1 integrase in human cells. The Journal of biological chemistry\| PubMed ID: 12796494	2003
Neuropathology and neurodegeneration in rodent brain induced by lentiviral vector-mediated overexpression of alpha-synuclein. Brain pathology (Zurich, Switzerland)\| PubMed ID: 12946025	2003
Development of resistance against diketo derivatives of human immunodeficiency virus type 1 by progressive accumulation of integrase mutations. Journal of virology\| PubMed ID: 14557631	2003
Lentiviral vector-mediated delivery of short hairpin RNA results in persistent knockdown of gene expression in mouse brain. Human gene therapy\| PubMed ID: 14670130	2003
A short course on virology / vectorology / gene therapy. Current gene therapy\| PubMed ID: 14683447	2003
Biosafety of lentiviral vectors. Current gene therapy\| PubMed ID: 14683448	2003
Expression of HIV-1 integrase in CEM cells inhibits HIV-1 replication. The journal of gene medicine\| PubMed ID: 15026988	2004
Identification and characterization of a functional nuclear localization signal in the HIV-1 integrase interactor LEDGF/p75. The Journal of biological chemistry\| PubMed ID: 15163664	2004
Efficient 3D database screening for novel HIV-1 IN inhibitors. Journal of chemical information and computer sciences\| PubMed ID: 15272853	2004
Multiple mutations in human immunodeficiency virus-1 integrase confer resistance to the clinical trial drug S-1360. AIDS (London, England)\| PubMed ID: 15577623	2004
Evaluation of the activity of HIV-1 integrase over-expressed in eukaryotic cells. Biochemical and biophysical research communications\| PubMed ID: 15629457	2005
Positional effects of the central DNA flap in HIV-1-derived lentiviral vectors. Biochemical and biophysical research communications\| PubMed ID: 15707975	2005
The interaction of LEDGF/p75 with integrase is lentivirus-specific and promotes DNA binding. The Journal of biological chemistry\| PubMed ID: 15749713	2005
Measuring protein-protein interactions inside living cells using single color fluorescence correlation spectroscopy. Application to human immunodeficiency virus type 1 integrase and LEDGF/p7... FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 15788449	2005
Integrase mutants defective for interaction with LEDGF/p75 are impaired in chromosome tethering and HIV-1 replication. The Journal of biological chemistry\| PubMed ID: 15855167	2005
HIV-1 integration: an interplay between HIV-1 integrase, cellular and viral proteins. AIDS reviews\| PubMed ID: 15875659	2005
Hematopoietic stem cell-based gene therapy against HIV infection: promises and caveats. AIDS reviews\| PubMed ID: 15875660	2005
Upscaling of lentiviral vector production by tangential flow filtration. The journal of gene medicine\| PubMed ID: 15906396	2005
Mutations in both env and gag genes are required for HIV-1 resistance to the polysulfonic dendrimer SPL2923, as corroborated by chimeric virus technology. Antiviral chemistry & chemotherapy\| PubMed ID: 16130523	2005
Pharmacophore-based design of HIV-1 integrase strand-transfer inhibitors. Journal of medicinal chemistry\| PubMed ID: 16250669	2005
Cellular co-factors of HIV-1 integration. Trends in biochemical sciences\| PubMed ID: 16403635	2006
The aggregation of alpha-synuclein is stimulated by FK506 binding proteins as shown by fluorescence correlation spectroscopy. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 16410343	2006
Non-invasive imaging of neuropathology in a rat model of alpha-synuclein overexpression. Neurobiology of aging\| PubMed ID: 16423428	2007
Transient and stable knockdown of the integrase cofactor LEDGF/p75 reveals its role in the replication cycle of human immunodeficiency virus. Journal of virology\| PubMed ID: 16439544	2006
Lentiviral vectors mediate efficient and stable gene transfer in adult neural stem cells in vivo. Human gene therapy\| PubMed ID: 16776572	2006
Noninvasive monitoring of long-term lentiviral vector-mediated gene expression in rodent brain with bioluminescence imaging. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 16820324	2006
Comparison of lentiviral vector titration methods. BMC biotechnology\| PubMed ID: 16836756	2006
Parkin protects against neurotoxicity in the 6-hydroxydopamine rat model for Parkinson's disease. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 16914382	2006
The central DNA flap of the human immunodeficiency virus type 1 is important for viral replication. Biochemical and biophysical research communications\| PubMed ID: 16962998	2006
Overexpression of the lens epithelium-derived growth factor/p75 integrase binding domain inhibits human immunodeficiency virus replication. Journal of virology\| PubMed ID: 16987986	2006
Concise review: therapeutic strategies for Parkinson disease based on the modulation of adult neurogenesis. Stem cells (Dayton, Ohio)\| PubMed ID: 17082225	2007
Identification of the LEDGF/p75 binding site in HIV-1 integrase. Journal of molecular biology\| PubMed ID: 17137594	2007
Simple criterion for selection of flavonoid compounds with anti-HIV activity. Bioorganic & medicinal chemistry letters\| PubMed ID: 17189684	2007
Synthesis and preliminary evaluation of 18F- or 11C-labeled bicyclic nucleoside analogues as potential probes for imaging varicella-zoster virus thymidine kinase gene expression using positr... Journal of medicinal chemistry\| PubMed ID: 17298046	2007
Comparative analysis of adeno-associated viral vector serotypes 1, 2, 5, 7, and 8 in mouse brain. Human gene therapy\| PubMed ID: 17343566	2007
Virus evolution reveals an exclusive role for LEDGF/p75 in chromosomal tethering of HIV. PLoS pathogens\| PubMed ID: 17397262	2007
Fetal gene transfer with lentiviral vectors: long-term in vivo follow-up evaluation in a rat model. American journal of obstetrics and gynecology\| PubMed ID: 17403419	2007
Synthesis and biological evaluation of an 123I-labeled bicyclic nucleoside analogue (BCNA) as potential SPECT tracer for VZV-tk reporter gene imaging. Bioorganic & medicinal chemistry letters\| PubMed ID: 17446073	2007
Lentiviral nuclear import: a complex interplay between virus and host. BioEssays : news and reviews in molecular, cellular and developmental biology\| PubMed ID: 17450594	2007
New 4-[(1-benzyl-1H-indol-3-yl)carbonyl]-3-hydroxyfuran-2(5H)-ones, beta-diketo acid analogs as HIV-1 integrase inhibitors. Archiv der Pharmazie\| PubMed ID: 17562561	2007
Novel virtual screening protocol based on the combined use of molecular modeling and electron-ion interaction potential techniques to design HIV-1 integrase inhibitors. Journal of chemical information and modeling\| PubMed ID: 17608406	2007
Differential interaction of HIV-1 integrase and JPO2 with the C terminus of LEDGF/p75. Journal of molecular biology\| PubMed ID: 17669426	2007
Toward novel HIV-1 integrase binding inhibitors: molecular modeling, synthesis, and biological studies. Bioorganic & medicinal chemistry letters\| PubMed ID: 17716893	2007
Local origin and activity-dependent generation of nestin-expressing protoplasmic astrocytes in CA1. Brain structure & function\| PubMed ID: 17717696	2007
Discovery of novel non-cytotoxic salicylhydrazide containing HIV-1 integrase inhibitors. Bioorganic & medicinal chemistry letters\| PubMed ID: 17950601	2007
Efficient purification and metabolite analysis of radiotracers using high-performance liquid chromatography and on-line solid-phase extraction. Journal of chromatography. A\| PubMed ID: 18045609	2008
A p-[18F]fluoroethoxyphenyl bicyclic nucleoside analogue as a potential positron emission tomography imaging agent for varicella-zoster virus thymidine kinase gene expression. Journal of medicinal chemistry\| PubMed ID: 18047266	2007
Synthesis and evaluation of 18F- and 11C-labeled phenyl-galactopyranosides as potential probes for in vivo visualization of LacZ gene expression using positron emission tomography. Bioconjugate chemistry\| PubMed ID: 18179161	2008
Diffusion of myelin oligodendrocyte glycoprotein in living OLN-93 cells investigated by raster-scanning image correlation spectroscopy (RICS). Journal of fluorescence\| PubMed ID: 18204890	2008
The total synthesis of fukiic acid, an HIV-1 integrase inhibitor. European journal of medicinal chemistry\| PubMed ID: 18243421	2008
Quinolone 3-carboxylic acid pharmacophore: design of second generation HIV-1 integrase inhibitors. Journal of medicinal chemistry\| PubMed ID: 18281931	2008
Inhibitory profile of a LEDGF/p75 peptide against HIV-1 integrase: insight into integrase-DNA complex formation and catalysis. FEBS letters\| PubMed ID: 18331842	2008
FK506 binding protein 12 differentially accelerates fibril formation of wild type alpha-synuclein and its clinical mutants A30P or A53T. Journal of neurochemistry\| PubMed ID: 18346205	2008
Reaction of rosmarinic acid with nitrite ions in acidic conditions: discovery of nitro- and dinitrorosmarinic acids as new anti-HIV-1 agents. Journal of medicinal chemistry\| PubMed ID: 18351727	2008
Mutations in human immunodeficiency virus type 1 integrase confer resistance to the naphthyridine L-870,810 and cross-resistance to the clinical trial drug GS-9137. Antimicrobial agents and chemotherapy\| PubMed ID: 18378713	2008
A refined pharmacophore model for HIV-1 integrase inhibitors: Optimization of potency in the 1H-benzylindole series. Bioorganic & medicinal chemistry letters\| PubMed ID: 18417342	2008
Four-tiered pi interaction at the dimeric interface of HIV-1 integrase critical for DNA integration and viral infectivity. Virology\| PubMed ID: 18514248	2008
Preclinical evaluation of 1H-benzylindole derivatives as novel human immunodeficiency virus integrase strand transfer inhibitors. Antimicrobial agents and chemotherapy\| PubMed ID: 18541726	2008
Noninvasive and quantitative monitoring of adult neuronal stem cell migration in mouse brain using bioluminescence imaging. Stem cells (Dayton, Ohio)\| PubMed ID: 18599812	2008
Investigations on the 4-quinolone-3-carboxylic acid motif. 1. Synthesis and structure-activity relationship of a class of human immunodeficiency virus type 1 integrase inhibitors. Journal of medicinal chemistry\| PubMed ID: 18665580	2008
Synthesis and antiviral properties of some polyphenols related to Salvia genus. Bioorganic & medicinal chemistry letters\| PubMed ID: 18674899	2008
Alternative splicing and caspase-mediated cleavage generate antagonistic variants of the stress oncoprotein LEDGF/p75. Molecular cancer research : MCR\| PubMed ID: 18708362	2008
Transportin-SR2 imports HIV into the nucleus. Current biology : CB\| PubMed ID: 18722123	2008
Novel targets for HIV therapy. Antiviral research\| PubMed ID: 18789977	2008
Design, synthesis, and biological evaluation of a series of 2-hydroxyisoquinoline-1,3(2H,4H)-diones as dual inhibitors of human immunodeficiency virus type 1 integrase and the reverse transc... Journal of medicinal chemistry\| PubMed ID: 19053754	2008
In search of small molecules blocking interactions between HIV proteins and intracellular cofactors. Molecular bioSystems\| PubMed ID: 19081927	2009
Docking studies on a new human immunodeficiency virus integrase-Mg-DNA complex: phenyl ring exploration and synthesis of 1H-benzylindole derivatives through fluorine substitutions. Journal of medicinal chemistry\| PubMed ID: 19105658	2009
Lens epithelium-derived growth factor/p75 interacts with the transposase-derived DDE domain of PogZ. The Journal of biological chemistry\| PubMed ID: 19244240	2009
Targeting the HIV integration process in antiviral therapy. Journal of HIV therapy\| PubMed ID: 19418658	2008
Highly efficient multicistronic lentiviral vectors with peptide 2A sequences. Human gene therapy\| PubMed ID: 19419274	2009
Exploration of novel thiobarbituric acid-, rhodanine- and thiohydantoin-based HIV-1 integrase inhibitors. Bioorganic & medicinal chemistry letters\| PubMed ID: 19447621	2009
Synthesis and biological evaluation of (11)C-labeled beta-galactosyl triazoles as potential PET tracers for in vivo LacZ reporter gene imaging. Bioorganic & medicinal chemistry\| PubMed ID: 19515568	2009
Seeing genes at work in the living brain with non-invasive molecular imaging. Current gene therapy\| PubMed ID: 19519365	2009
Pharmacophore-based discovery of small-molecule inhibitors of protein-protein interactions between HIV-1 integrase and cellular cofactor LEDGF/p75. ChemMedChem\| PubMed ID: 19565598	2009
Fetal surgery is a clinical reality. Seminars in fetal & neonatal medicine\| PubMed ID: 19913467	2010
State-of-the-art lentiviral vectors for research use: risk assessment and biosafety recommendations. Current gene therapy\| PubMed ID: 20021330	2009
Inhibition of FK506 binding proteins reduces alpha-synuclein aggregation and Parkinson's disease-like pathology. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 20164329	2010
Immunohistochemical detection of transgene expression in the brain using small epitope tags. BMC biotechnology\| PubMed ID: 20167102	2010
Morphologic and functional changes in the unilateral 6-hydroxydopamine lesion rat model for Parkinson's disease discerned with microSPECT and quantitative MRI. Magma (New York, N.Y.)\| PubMed ID: 20169465	2010
LEDGF hybrids efficiently retarget lentiviral integration into heterochromatin. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 20195265	2010
Differential effects of progenitor cell populations on left ventricular remodeling and myocardial neovascularization after myocardial infarction. Journal of the American College of Cardiology\| PubMed ID: 20466204	2010
Rational design of small-molecule inhibitors of the LEDGF/p75-integrase interaction and HIV replication. Nature chemical biology\| PubMed ID: 20473303	2010
High-resolution profiling of the LEDGF/p75 chromatin interaction in the ENCODE region. Nucleic acids research\| PubMed ID: 20484370	2010
Rapid, simple, and versatile manufacturing of recombinant adeno-associated viral vectors at scale. Human gene therapy\| PubMed ID: 20497038	2010
New 2-arylnaphthalenediols and triol inhibitors of HIV-1 integrase--discovery of a new polyhydroxylated antiviral agent. Bioorganic & medicinal chemistry\| PubMed ID: 20541944	2010
New chloro,fluorobenzylindole derivatives as integrase strand-transfer inhibitors (INSTIs) and their mode of action. Bioorganic & medicinal chemistry\| PubMed ID: 20630765	2010
Efficient gene transfer into the mouse lung by fetal intratracheal injection of rAAV2/6.2. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 20664525	2010
Small molecules targeting the interaction between HIV-1 integrase and LEDGF/p75 cofactor. Bioorganic & medicinal chemistry\| PubMed ID: 20850978	2010
The transcriptional co-activator LEDGF/p75 displays a dynamic scan-and-lock mechanism for chromatin tethering. Nucleic acids research\| PubMed ID: 20974633	2011
2-hydroxyisoquinoline-1,3(2H,4H)-diones as inhibitors of HIV-1 integrase and reverse transcriptase RNase H domain: influence of the alkylation of position 4. European journal of medicinal chemistry\| PubMed ID: 21185110	2011
HIV-1 integrase strand-transfer inhibitors: design, synthesis and molecular modeling investigation. European journal of medicinal chemistry\| PubMed ID: 21227550	2011
A versatile and practical synthesis toward the development of novel HIV-1 integrase inhibitors. ChemMedChem\| PubMed ID: 21246739	2011
Interplay between HIV entry and transportin-SR2 dependency. Retrovirology\| PubMed ID: 21276267	2011
Magnesium chelating 2-hydroxyisoquinoline-1,3(2H,4H)-diones, as inhibitors of HIV-1 integrase and/or the HIV-1 reverse transcriptase ribonuclease H domain: discovery of a novel selective inh... Journal of medicinal chemistry\| PubMed ID: 21366258	2011
Depletion of PINK1 affects mitochondrial metabolism, calcium homeostasis and energy maintenance. Journal of cell science\| PubMed ID: 21385841	2011
In search of second-generation HIV integrase inhibitors: targeting integration beyond strand transfer. Future medicinal chemistry\| PubMed ID: 21426102	2009
Unraveling the role of peptidyl-prolyl isomerases in neurodegeneration. Molecular neurobiology\| PubMed ID: 21553017	2011
Comparative analysis of different peptidyl-prolyl isomerases reveals FK506-binding protein 12 as the most potent enhancer of alpha-synuclein aggregation. The Journal of biological chemistry\| PubMed ID: 21652707	2011
A PET brain reporter gene system based on type 2 cannabinoid receptors. Journal of nuclear medicine : official publication, Society of Nuclear Medicine\| PubMed ID: 21680683	2011
Association of polymorphisms in the LEDGF/p75 gene (PSIP1) with susceptibility to HIV-1 infection and disease progression. AIDS (London, England)\| PubMed ID: 21681054	2011
Toward the discovery of novel anti-HIV drugs. Second-generation inhibitors of the cellular ATPase DDX3 with improved anti-HIV activity: synthesis, structure-activity relationship analysis, c... ChemMedChem\| PubMed ID: 21698775	2011
miR669a and miR669q prevent skeletal muscle differentiation in postnatal cardiac progenitors. The Journal of cell biology\| PubMed ID: 21708977	2011
Synthesis, in vitro and in vivo evaluation of fluorine-18 labelled FE-GW405833 as a PET tracer for type 2 cannabinoid receptor imaging. Bioorganic & medicinal chemistry\| PubMed ID: 21737287	2011
In vitro DNA tethering of HIV-1 integrase by the transcriptional coactivator LEDGF/p75. Journal of molecular biology\| PubMed ID: 21763490	2011
Rilpivirine: a step forward in tailored HIV treatment. Lancet\| PubMed ID: 21763920	2011
4-[1-(4-Fluorobenzyl)-4-hydroxy-1H-indol-3-yl]-2-hydroxy-4-oxobut-2-enoic acid as a prototype to develop dual inhibitors of HIV-1 integration process. Antiviral research\| PubMed ID: 21767569	2011
Pathway specific gene expression profiling reveals oxidative stress genes potentially regulated by transcription co-activator LEDGF/p75 in prostate cancer cells. The Prostate\| PubMed ID: 21796653	2012
Role of the PWWP domain of lens epithelium-derived growth factor (LEDGF)/p75 cofactor in lentiviral integration targeting. The Journal of biological chemistry\| PubMed ID: 21987578	2011
Elvitegravir: a once daily alternative to raltegravir. The Lancet infectious diseases\| PubMed ID: 22015078	2012
Preclinical evaluation of [11C]NE40, a type 2 cannabinoid receptor PET tracer. Nuclear medicine and biology\| PubMed ID: 22154685	2012
Nitrogen-containing polyhydroxylated aromatics as HIV-1 integrase inhibitors: synthesis, structure-activity relationship analysis, and biological activity. Journal of enzyme inhibition and medicinal chemistry\| PubMed ID: 22233539	2012
The stress oncoprotein LEDGF/p75 interacts with the methyl CpG binding protein MeCP2 and influences its transcriptional activity. Molecular cancer research : MCR\| PubMed ID: 22275515	2012
Regulator of G-protein signaling 18 controls megakaryopoiesis and the cilia-mediated vertebrate mechanosensory system. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 22308195	2012
Lens epithelium-derived growth factor/p75 qualifies as a target for HIV gene therapy in the NSG mouse model. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 22334021	2012
Development of an AlphaScreen-based HIV-1 integrase dimerization assay for discovery of novel allosteric inhibitors. Journal of biomolecular screening\| PubMed ID: 22337657	2012
LEDGF/p75-independent HIV-1 replication demonstrates a role for HRP-2 and remains sensitive to inhibition by LEDGINs. PLoS pathogens\| PubMed ID: 22396646	2012
Discovery of small molecule HIV-1 integrase dimerization inhibitors. Bioorganic & medicinal chemistry letters\| PubMed ID: 22483582	2012
Development of a series of 3-hydroxyquinolin-2(1H)-ones as selective inhibitors of HIV-1 reverse transcriptase associated RNase H activity. Bioorganic & medicinal chemistry letters\| PubMed ID: 22607675	2012
Galectin-1 in melanoma biology and related neo-angiogenesis processes. The Journal of investigative dermatology\| PubMed ID: 22622427	2012
Small-molecule inhibitors of the LEDGF/p75 binding site of integrase block HIV replication and modulate integrase multimerization. Antimicrobial agents and chemotherapy\| PubMed ID: 22664975	2012
Quantitative evaluation of MRI-based tracking of ferritin-labeled endogenous neural stem cell progeny in rodent brain. NeuroImage\| PubMed ID: 22677164	2012
Quad's in it for antiretroviral therapy? Lancet\| PubMed ID: 22748575	2012
Fragment hopping approach directed at design of HIV IN-LEDGF/p75 interaction inhibitors. Journal of enzyme inhibition and medicinal chemistry\| PubMed ID: 22803661	2012
Phage Display-directed Discovery of LEDGF/p75 Binding Cyclic Peptide Inhibitors of HIV Replication. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 22828501	2012
Combinational therapies for HIV: a focus on EVG/COBI/FTC/TDF. Expert opinion on pharmacotherapy\| PubMed ID: 22849516	2012
Identification of Residues in the C-terminal Domain of HIV-1 Integrase That Mediate Binding to the Transportin-SR2 Protein. The Journal of biological chemistry\| PubMed ID: 22872638	2012
Interaction of the HIV-1 Intasome with Transportin 3 Protein (TNPO3 or TRN-SR2). The Journal of biological chemistry\| PubMed ID: 22872640	2012
Cellular cofactors of lentiviral integrase: from target validation to drug discovery. Molecular biology international\| PubMed ID: 22928108	2012
Preliminary validation of varicella zoster virus thymidine kinase as a novel reporter gene for PET. Nuclear medicine and biology\| PubMed ID: 22981986	2012
A Symmetric Region of the HIV-1 Integrase Dimerization Interface Is Essential for Viral Replication. PloS one\| PubMed ID: 23028829	2012
HRP-2 determines HIV-1 integration site selection in LEDGF/p75 depleted cells. Retrovirology\| PubMed ID: 23046603	2012