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Chapters
- 00:05Title
- 01:47Fetal Intratracheal Injection
- 05:07Fetal Intra-amniotic Injection
- 07:15Representative Fetal Injection Results
- 09:43Conclusion
We developed a novel surgical approach for intratracheal administration of bioactive agents into the mouse fetus. The delivery route is more efficient in targeting the fetal mouse lungs than the commonly used intra-amniotic injection. This procedure has to date not been described in a mouse model.
Tags
Surgical ApproachIntratracheal AdministrationBioactive AgentsFetal Mouse ModelPrenatal Pulmonary DeliveryTherapeutic StrategiesGenetic DiseasesAcquired DiseasesCongenital AbnormalitiesInherited AbnormalitiesLong-term Gene ExpressionShort-term Gene ExpressionPharmacological InterventionNeonatal Respiratory Distress SyndromeHyperoxic InjuriesCystic Fibrosis (CF)Surfactant Deficienciesα1-antitrypsin DeficiencyPrenatal Gene TherapyEarly Therapeutic InterventionFetal OrgansCell Proliferation RateGene TransferStem Cell Transfer
