Louis R. Pasquale

Department of Ophthalmology, Icahn School of Medicine at Mount Sinai

Affiliated withIcahn School of Medicine at Mount Sinai

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2025

Other Publications

Article	Year
Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption. Molecular psychiatry\| PubMed ID: 25288136	2015
Microvasculature of the Optic Nerve Head and Peripapillary Region in Patients With Primary Open-Angle Glaucoma. Journal of glaucoma\| PubMed ID: 30585943	2019
The Relationship Between Optic Disc Parameters and Female Reproductive Factors in Young Women. Asia-Pacific journal of ophthalmology (Philadelphia, Pa.)\| PubMed ID: 30596227	2019
Philadelphia Telemedicine Glaucoma Detection and Follow-up Study: confirmation between eye screening and comprehensive eye examination diagnoses. The British journal of ophthalmology\| PubMed ID: 30770354	2019
Association of Statin Use and High Serum Cholesterol Levels With Risk of Primary Open-Angle Glaucoma. JAMA ophthalmology\| PubMed ID: 31046067	2019
Deep learning in ophthalmology: The technical and clinical considerations. Progress in retinal and eye research\| PubMed ID: 31048019	2019
Genetic Correlations Between Diabetes and Glaucoma: An Analysis of Continuous and Dichotomous Phenotypes. American journal of ophthalmology\| PubMed ID: 31121135	2019
Machine Learning in the Detection of the Glaucomatous Disc and Visual Field. Seminars in ophthalmology\| PubMed ID: 31132292	2019
An Association Between Large Optic Nerve Cupping and Cognitive Function. American journal of ophthalmology\| PubMed ID: 31163134	2019
A Convergence of Ophthalmic and Life-threatening Emergencies: Acute Angle Closure Glaucoma and Subarachnoid Hemorrhage. Journal of glaucoma\| PubMed ID: 31233457	2019
Glaucoma Management in Patients With Aniridia and Boston Type 1 Keratoprosthesis. American journal of ophthalmology\| PubMed ID: 31247168	2019
The impact of artificial intelligence in the diagnosis and management of glaucoma. Eye (London, England)\| PubMed ID: 31541215	2020
A review of systemic medications that may modulate the risk of glaucoma. Eye (London, England)\| PubMed ID: 31595027	2020
Philadelphia Telemedicine Glaucoma Detection and Follow-Up Study: Cataract Classifications Following Eye Screening. Telemedicine journal and e-health : the official journal of the American Telemedicine Association\| PubMed ID: 31721654	2020
Angle Anatomy and Glaucoma in Patients With Boston Keratoprosthesis. Cornea\| PubMed ID: 31764284	2020
Characterization of Central Visual Field Loss in End-stage Glaucoma by Unsupervised Artificial Intelligence. JAMA ophthalmology\| PubMed ID: 31895454	2020
Multitrait analysis of glaucoma identifies new risk loci and enables polygenic prediction of disease susceptibility and progression. Nature genetics\| PubMed ID: 31959993	2020
Optic disc haemorrhage and primary open-angle glaucoma: a clinical review. The British journal of ophthalmology\| PubMed ID: 32071036	2020
Artificial Intelligence Classification of Central Visual Field Patterns in Glaucoma. Ophthalmology\| PubMed ID: 32081491	2020
Low-carbohydrate-diet scores and the risk of primary open-angle glaucoma: data from three US cohorts. Eye (London, England)\| PubMed ID: 32123310	2020
Notice of Retraction and Replacement. Kang et al. Association of statin use and high serum cholesterol levels with risk of primary open-angle glaucoma. JAMA Ophthalmol. 2019;137(7):756-765. JAMA ophthalmology\| PubMed ID: 32163112	2020
Telemedicine for Glaucoma: Guidelines and Recommendations. Telemedicine journal and e-health : the official journal of the American Telemedicine Association\| PubMed ID: 32209001	2020
Ginkgo Biloba Extract in Ophthalmic and Systemic Disease, With a Focus on Normal-Tension Glaucoma. Asia-Pacific journal of ophthalmology (Philadelphia, Pa.)\| PubMed ID: 32282348	2020
Monitoring Glaucomatous Functional Loss Using an Artificial Intelligence-Enabled Dashboard. Ophthalmology\| PubMed ID: 32317176	2020
Densitometric Profiles of Optic Disc Hemorrhages in the Ocular Hypertension Treatment Study. American journal of ophthalmology\| PubMed ID: 32335057	2020
Cohort Study of Nonmelanoma Skin Cancer and the Risk of Exfoliation Glaucoma. Journal of glaucoma\| PubMed ID: 32487970	2020
The Good News and the Bad News Regarding the Systemic Impact of Exfoliation Syndrome. Ophthalmology. Glaucoma\| PubMed ID: 32672552	2019
Iris Mass and Secondary Glaucoma: The Presenting Sign of Lung Adenocarcinoma. Ophthalmology. Glaucoma\| PubMed ID: 32672619	2020
Regional Infoveillance of COVID-19 Case Rates: Analysis of Search-Engine Query Patterns. Journal of medical Internet research\| PubMed ID: 32692691	2020
Nanoscale Characteristics of Ocular Lipid Thin Films Using Kelvin Probe Force Microscopy. Translational vision science & technology\| PubMed ID: 32832246	2020
Protecting Data Privacy in the Age of AI-Enabled Ophthalmology. Translational vision science & technology\| PubMed ID: 32855840	2020
Digital technology, tele-medicine and artificial intelligence in ophthalmology: A global perspective. Progress in retinal and eye research\| PubMed ID: 32898686	2021
An Artificial Intelligence Approach to Assess Spatial Patterns of Retinal Nerve Fiber Layer Thickness Maps in Glaucoma. Translational vision science & technology\| PubMed ID: 32908804	2020
Characterization of Prelaminar Wedge-Shaped Defects in Primary Open-Angle Glaucoma. Current eye research\| PubMed ID: 33054505	2021
Inter-Eye Association of Visual Field Defects in Glaucoma and Its Clinical Utility. Translational vision science & technology\| PubMed ID: 33244442	2020
The vital role for nitric oxide in intraocular pressure homeostasis. Progress in retinal and eye research\| PubMed ID: 33253900	2021
Predicting Global Test-Retest Variability of Visual Fields in Glaucoma. Ophthalmology. Glaucoma\| PubMed ID: 33310194	2021
Intraocular Pressure, Glaucoma, and Dietary Caffeine Consumption: A Gene-Diet Interaction Study from the UK Biobank. Ophthalmology\| PubMed ID: 33333105	2021
The GGLEAM Study: Understanding Glaucoma in the Ohio Amish. International journal of environmental research and public health\| PubMed ID: 33561996	2021
Association of Rare CYP39A1 Variants With Exfoliation Syndrome Involving the Anterior Chamber of the Eye. JAMA\| PubMed ID: 33620406	2021
Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries. Nature communications\| PubMed ID: 33627673	2021
Genome-wide polygenic risk score for retinopathy of type 2 diabetes. Human molecular genetics\| PubMed ID: 33704450	2021
Variability and Power to Detect Progression of Different Visual Field Patterns. Ophthalmology. Glaucoma\| PubMed ID: 33848653	2021
Genetic variation affects morphological retinal phenotypes extracted from UK Biobank optical coherence tomography images. PLoS genetics\| PubMed ID: 33979322	2021
Artificial Intelligence to Reduce Ocular Health Disparities: Moving From Concept to Implementation. Translational vision science & technology\| PubMed ID: 34003953	2021
Genetic pleiotropy of ERCC6 loss-of-function and deleterious missense variants links retinal dystrophy, arrhythmia, and immunodeficiency in diverse ancestries. Human mutation\| PubMed ID: 34005834	2021
Paired Optic Nerve Microvasculature and Nailfold Capillary Measurements in Primary Open-Angle Glaucoma. Translational vision science & technology\| PubMed ID: 34110389	2021
Impact of Artificial Intelligence on Medical Education in Ophthalmology. Translational vision science & technology\| PubMed ID: 34125146	2021
Development and Comparison of Machine Learning Algorithms to Determine Visual Field Progression. Translational vision science & technology\| PubMed ID: 34157101	2021
The Effect of Ametropia on Glaucomatous Visual Field Loss. Journal of clinical medicine\| PubMed ID: 34202033	2021
Prospective study of dietary intake of branched-chain amino acids and the risk of primary open-angle glaucoma. Acta ophthalmologica\| PubMed ID: 34240564	2022
Burden of Trabeculectomy and Glaucoma Drainage Implantation after Laser Trabeculoplasty: A Two-Year Follow-up Study. Ophthalmology. Glaucoma\| PubMed ID: 34284171	2022
Preservation of vision after CaMKII-mediated protection of retinal ganglion cells. Cell\| PubMed ID: 34297923	2021
Estimating the Severity of Visual Field Damage From Retinal Nerve Fiber Layer Thickness Measurements With Artificial Intelligence. Translational vision science & technology\| PubMed ID: 34398225	2021
The Prevalence of Autoimmune Diseases in Patients with Primary Open-Angle Glaucoma Undergoing Ophthalmic Surgeries. Ophthalmology. Glaucoma\| PubMed ID: 34416426	2022
Irritable bowel syndrome and risk of glaucoma: An analysis of two independent population-based cohort studies. United European gastroenterology journal\| PubMed ID: 34431591	2021
Unsupervised Machine Learning Identifies Quantifiable Patterns of Visual Field Loss in Idiopathic Intracranial Hypertension. Translational vision science & technology\| PubMed ID: 34459860	2021
Identification of Estrogen Signaling in a Prioritization Study of Intraocular Pressure-Associated Genes. International journal of molecular sciences\| PubMed ID: 34638643	2021
Alcohol, Intraocular Pressure, and Open-Angle Glaucoma: A Systematic Review and Meta-analysis. Ophthalmology\| PubMed ID: 35101531	2022
Consensus Recommendation for Mouse Models of Ocular Hypertension to Study Aqueous Humor Outflow and Its Mechanisms. Investigative ophthalmology & visual science\| PubMed ID: 35129590	2022
Background polygenic risk modulates the association between glaucoma and cardiopulmonary diseases and measures: an analysis from the UK Biobank. The British journal of ophthalmology\| PubMed ID: 35361574	2023
Unsupervised Machine Learning Shows Change in Visual Field Loss in the Idiopathic Intracranial Hypertension Treatment Trial. Ophthalmology\| PubMed ID: 35378137	2022
Head and Neck Region Dermatological Ultraviolet-Related Cancers are Associated with Exfoliation Syndrome in a Clinic-Based Population. Ophthalmology. Glaucoma\| PubMed ID: 35470101	2022
The Association between Serum Lipids and Intraocular Pressure in 2 Large United Kingdom Cohorts. Ophthalmology\| PubMed ID: 35500606	2022
How Can We Quantify and Compare Harm in Surgical Trials? American journal of ophthalmology\| PubMed ID: 35526589	2022
Statin Use in Relation to Intraocular Pressure, Glaucoma, and Ocular Coherence Tomography Parameters in the UK Biobank. Investigative ophthalmology & visual science\| PubMed ID: 35612836	2022
Race and Ethnicity Differences in Disease Severity and Visual Field Progression Among Glaucoma Patients. American journal of ophthalmology\| PubMed ID: 35654121	2022
An Objective and Easy-to-Use Glaucoma Functional Severity Staging System Based on Artificial Intelligence. Journal of glaucoma\| PubMed ID: 35658070	2022
The Association of Female Reproductive Factors with Glaucoma and Related Traits: A Systematic Review. Ophthalmology. Glaucoma\| PubMed ID: 35691565	2022
Machine-Identified Patterns of Visual Field Loss and an Association with Rapid Progression in the Ocular Hypertension Treatment Study. Ophthalmology\| PubMed ID: 35817199	2022
Restoration of Vision in Severe, Cicatricial, Ocular Surface Disease With the Boston Keratoprosthesis Type II. American journal of ophthalmology\| PubMed ID: 35850253	2022
Cohort Study of Race/Ethnicity and Incident Primary Open-Angle Glaucoma Characterized by Autonomously Determined Visual Field Loss Patterns. Translational vision science & technology\| PubMed ID: 35877093	2022
Outcomes of the Second Aqueous Shunt Implant Versus Transscleral Cyclophotocoagulation Treatment Study: A Randomized Comparative Trial. Journal of glaucoma\| PubMed ID: 35901309	2022
Archetypal analysis of visual fields in optic neuritis reveals functional biomarkers associated with outcome and treatment response. Multiple sclerosis and related disorders\| PubMed ID: 35940021	2022
Prediagnostic Plasma Metabolomics and the Risk of Exfoliation Glaucoma. Investigative ophthalmology & visual science\| PubMed ID: 35951322	2022
Long-term Alcohol Consumption and Risk of Exfoliation Glaucoma or Glaucoma Suspect Status among United States Health Professionals. Ophthalmology\| PubMed ID: 36041586	2023
Assessing Surface Shapes of the Optic Nerve Head and Peripapillary Retinal Nerve Fiber Layer in Glaucoma with Artificial Intelligence. Ophthalmology science\| PubMed ID: 36245761	2022
Association between cognitive function and large optic nerve cupping, accounting for cup-disc-ratio genetic risk score. PloS one\| PubMed ID: 36315511	2022
The Association of Alcohol Consumption with Glaucoma and Related Traits: Findings from the UK Biobank. Ophthalmology. Glaucoma\| PubMed ID: 36481453	2023
An Association Between Large Optic Cupping and Total and Regional Brain Volume: The Women's Health Initiative. American journal of ophthalmology\| PubMed ID: 36638905	2023
Anthropometric Measures and Their Relationship to Steep Cornea in the United States Population. Cornea\| PubMed ID: 36729700	2023
Genetic Associations Between Smoking- and Glaucoma-Related Traits. Translational vision science & technology\| PubMed ID: 36786746	2023
Mitochondrial TXNRD2 and ME3 Genetic Risk Scores Are Associated with Specific Primary Open-Angle Glaucoma Phenotypes. Ophthalmology\| PubMed ID: 36813040	2023
Direct Costs of Second Aqueous Shunt Implant Versus Transscleral Cyclophotocoagulation (The Assists Trial). Journal of glaucoma\| PubMed ID: 36848258	2023
Reverse translation of artificial intelligence in glaucoma: Connecting basic science with clinical applications. Frontiers in ophthalmology\| PubMed ID: 36866233	2023
Archetypal analysis of longitudinal visual fields for idiopathic intracranial hypertension patients presenting in a clinic setting. PLOS digital health\| PubMed ID: 37155610	2023
Association between HSP-Specific T-Cell Counts and Retinal Nerve Fiber Layer Thickness in Patients with Primary Open-Angle Glaucoma. Ophthalmology science\| PubMed ID: 37197701	2023
Disentangling the genetic overlap and causal relationships between primary open-angle glaucoma, brain morphology and four major neurodegenerative disorders. EBioMedicine\| PubMed ID: 37201334	2023
Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank. Nature communications\| PubMed ID: 37208353	2023
The Association of Physical Activity with Glaucoma and Related Traits in the UK Biobank. Ophthalmology\| PubMed ID: 37331483	2023
Artifact-Tolerant Clustering-Guided Contrastive Embedding Learning for Ophthalmic Images in Glaucoma. IEEE journal of biomedical and health informatics\| PubMed ID: 37347633	2023
Large-scale multitrait genome-wide association analyses identify hundreds of glaucoma risk loci. Nature genetics\| PubMed ID: 37386247	2023
Towards modifying the genetic predisposition for glaucoma: An overview of the contribution and interaction of genetic and environmental factors. Molecular aspects of medicine\| PubMed ID: 37423164	2023
Deep Learning for Localized Detection of Optic Disc Hemorrhages. American journal of ophthalmology\| PubMed ID: 37490992	2023
Metabolite and Lipid Biomarkers Associated With Intraocular Pressure and Inner Retinal Morphology: 1H NMR Spectroscopy Results From the UK Biobank. Investigative ophthalmology & visual science\| PubMed ID: 37552033	2023
Genetic Correlations Among Corneal Biophysical Parameters and Anthropometric Traits. Translational vision science & technology\| PubMed ID: 37561511	2023
Deep Ocular Phenotyping Across Primary Open-Angle Glaucoma Genetic Burden. JAMA ophthalmology\| PubMed ID: 37589995	2023
Polygenic Risk Score Improves Prediction of Primary Open Angle Glaucoma Onset in the Ocular Hypertension Treatment Study. medRxiv : the preprint server for health sciences\| PubMed ID: 37645858	2023
Calcium Channel Blocker Use and Associated Glaucoma and Related Traits Among UK Biobank Participants. JAMA ophthalmology\| PubMed ID: 37676684	2023
Generative Artificial Intelligence Through ChatGPT and Other Large Language Models in Ophthalmology: Clinical Applications and Challenges. Ophthalmology science\| PubMed ID: 37885755	2023
Estrogen dysregulation, intraocular pressure, and glaucoma risk. Experimental eye research\| PubMed ID: 37956940	2023
Comparison of Structural and Functional Features in Primary Angle Closure and Open Angle Glaucomas. Journal of glaucoma\| PubMed ID: 38031290	2024
Lessons From The Glaucoma Foundation Think Tank 2023: A Patient-Centric Approach to Glaucoma. Journal of glaucoma\| PubMed ID: 38129952	2024
Integrating genetic regulation and single-cell expression with GWAS prioritizes causal genes and cell types for glaucoma. Nature communications\| PubMed ID: 38195602	2024
[Not Available]. Ophthalmology science\| PubMed ID: 38250562	2024
Recent developments of telemedicine in glaucoma. Current opinion in ophthalmology\| PubMed ID: 38295153	2024
Assessment of a Large Language Model's Responses to Questions and Cases About Glaucoma and Retina Management. JAMA ophthalmology\| PubMed ID: 38386351	2024
Polygenic Risk Scores for Glaucoma Onset in the Ocular Hypertension Treatment Study. JAMA ophthalmology\| PubMed ID: 38483402	2024
Relationship Between Oral Health and Glaucoma Traits in the United Kingdom. Journal of glaucoma\| PubMed ID: 38506820	2024
Genome-first evaluation with exome sequence and clinical data uncovers underdiagnosed genetic disorders in a large healthcare system. Cell reports. Medicine\| PubMed ID: 38642551	2024
The Association of Urinary Sodium Excretion with Glaucoma and Related Traits in a Large United Kingdom Population. Ophthalmology. Glaucoma\| PubMed ID: 38723778	2024
Description of a Nonhuman Primate Model of Retinal Ischemia/Reperfusion Injury. Translational vision science & technology\| PubMed ID: 38752575	2023
Use of Diagnostic Codes for Primary Open-Angle Glaucoma Polygenic Risk Score Construction in Electronic Health Record-Linked Biobanks. American journal of ophthalmology\| PubMed ID: 38906208	2024
The Evolving Surgical Paradigm of Scleral Allograft Bio-Tissue Use in Ophthalmic Surgery: Techniques and Clinical Indications for Ab-Externo and Ab-Interno Scleral Reinforcement. Clinical ophthalmology (Auckland, N.Z.)\| PubMed ID: 38919403	2024
Classifying and quantifying changes in papilloedema using machine learning. BMJ neurology open\| PubMed ID: 38952840	2024
Ophthalmic Drop Waste Due to Self-imposed Use Cessation Dates. Ophthalmology\| PubMed ID: 38960336	2024
Diagnostic Capability of OCTA-Derived Macular Biomarkers for Early to Moderate Primary Open Angle Glaucoma. Journal of clinical medicine\| PubMed ID: 39064230	2024
Transformer-Based Deep Learning Prediction of 10-Degree Humphrey Visual Field Tests From 24-Degree Data. Translational vision science & technology\| PubMed ID: 39110574	2024
The Clinical Usefulness of a Glaucoma Polygenic Risk Score in 4 Population-Based European Ancestry Cohorts. Ophthalmology\| PubMed ID: 39128550	2025
Impact of Demographics on Regional Visual Field Loss and Deterioration in Glaucoma. Translational vision science & technology\| PubMed ID: 39136958	2024
Technology and Methodology in Glaucoma Case Detection. Journal of glaucoma\| PubMed ID: 39149947	2024
Disc Hemorrhages in Open-Angle Glaucoma-Between a Rock and a Hard Place? JAMA ophthalmology\| PubMed ID: 39235827	2024
Using Multi-Layer Perceptron Driven Diagnosis to Compare Biomarkers for Primary Open Angle Glaucoma. Investigative ophthalmology & visual science\| PubMed ID: 39250119	2024
Primary Open-Angle Glaucoma Polygenic Risk Score and Risk of Disease Onset: A Post Hoc Analysis of a Randomized Clinical Trial. JAMA ophthalmology\| PubMed ID: 39509108	2024
Genome-wide meta-analysis identifies 22 loci for normal tension glaucoma with significant overlap with high tension glaucoma. Nature communications\| PubMed ID: 39551815	2024
Macular patterns of neuronal and visual field loss in recovered optic neuritis identified by machine learning. Scientific reports\| PubMed ID: 39730673	2024
Equitable artificial intelligence for glaucoma screening with fair identity normalization. NPJ digital medicine\| PubMed ID: 39833503	2025
Pyruvate and Related Energetic Metabolites Modulate Resilience Against High Genetic Risk for Glaucoma. bioRxiv : the preprint server for biology\| PubMed ID: 39896457	2025
Does Age Modify the Relation Between Genetic Predisposition to Glaucoma and Various Glaucoma Traits in the UK Biobank? Investigative ophthalmology & visual science\| PubMed ID: 39982391	2025