a-practical-novel-method-to-extract-genomic-dna-from-blood-collection

A Practical and Novel Method to Extract Genomic DNA from Blood Collection Kits for Plasma Protein Preservation

Laboratory tests can be done on the cellular or  fluid portions of the blood. The use of different blood collection tubes  determines the portion of the ...

Emory University School of Medicine and Children's Health Care of Atlanta

Crohn's disease (CD) is highly heritable. NOD2 has emerged as the main susceptibility gene among individuals of European ancestry; however, NOD2 does not appear to contribute to CD susceptibility among many non-European populations. Today's African American (AA) population represents an admixture of West African (80%) and European (20%) ancestry. Since genotype-based tools are becoming increasingly available for CD, it is important that we validate the risk variants in different populations, such as admixed AAs.

Common NOD2 risk variants in African Americans with Crohn's disease are due exclusively to recent Caucasian admixture.

Maladie de Crohn (MC) est hautement h&eacute;ritable. NOD2 a &eacute;merg&eacute; comme le g&egrave;ne de susceptibilit&eacute; principal chez les personnes d&#39;ascendance europ&eacute;enne ; Cependant, NOD2 ne semble pas contribuer &agrave; la susceptibilit&eacute; de CD parmi de nombreuses populations extra-europ&eacute;ennes. La population afro-am&eacute;ricaine (AA) d&#39;aujourd&#39;hui repr&eacute;sente un m&eacute;lange d&#39;Afrique de l&#39;Ouest (80 %) et l&#39;ascendance (20 %). &Eacute;tant donn&eacute; que les outils bas&eacute;s sur le g&eacute;notype deviennent de plus en plus disponibles pour CD, il est important que nous validons les variantes de risque dans des populations diff&eacute;rentes, tels que l&#39;AAs inusit&eacute;s.

Variantes de risque NOD2 communes dans les Afro-am&eacute;ricains avec la maladie de Crohn sont dues exclusivement au m&eacute;lange de race blanche r&eacute;cente.

La malattia di Crohn (CD) &egrave; altamente ereditabile. NOD2 &egrave; emerso come il gene di suscettibilit&agrave; principale tra gli individui dell&#39;ascendenza europea; Tuttavia, non sembra che NOD2 contribuiscono alla suscettibilit&agrave; CD tra molte popolazioni non europee. Popolazione afro-americana (AA) odierna rappresenta una mescolanza di Africa occidentale (80%) ed europeo (20%) ascendenza. Poich&eacute; gli strumenti basati sul genotipo stanno diventando sempre pi&ugrave; disponibili per CD, &egrave; importante che noi convalidare le varianti di rischio in popolazioni diverse, quali admixed AAs.

Jon Waters

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