laparoscopic-anatomical-liver-segment-vii-resection-with-liver

Laparoscopic Anatomical Liver Segment VII Resection with Liver Parenchymal Transection Following a Priority Approach

Laparoscopic liver resection procedures have rapidly developed, including surgical techniques ranging from early local resection of the liver margin and ...

electroacupuncture-therapy-for-cognitive-impairment-after-spinal-cord

Electroacupuncture Therapy for Cognitive Impairment after Spinal Cord Injury

Spinal cord injury (SCI) is a highly disabling and destructive disease of the central nervous system (CNS), which not only leads to limb motor and sensory ...

The second affiliated hospital of Guangzhou university of Chinese Medicine

Jiangsu Changshu Second People's Hospital

The long non-coding RNA FOXD2-AS1 is highly expressed in non-small cell lung cancer and promotes malignant progression. However, the role of FOXD2-AS1 in esophageal squamous cell carcinoma (ESCC) is still unclear.

Upregulation of the long noncoding RNA FOXD2-AS1 predicts poor prognosis in esophageal squamous cell carcinoma.

The reaction of benzoborirene with one equivalent of isocyanides leads to benzene-fused boretes bearing one imine function, while the reaction with two equivalents of isocyanide affords 2,3-dihydro-2,3-diiminoboroles with perfect regioselectivity. The isocyanide double insertion products represent a novel type of 1,2-diimine with a benzoborole backbone. The reduction chemistry of the benzoborole-supported 1,2-diimine was investigated. Single- and two-electron reduction allow for the isolation and full characterization of a radical anion and a dianion, respectively. In stark contrast to the ordinary boroles, which should turn aromatic by accepting two electrons, the antiaromatic character of the benzoborole backbone is highlighted upon reduction, thus presenting a rare example of antiaromatic borole dianion. Detailed quantum chemical calculations provide a rationale for the observed regioselectivity and the electronic structure of the reduced borole diimine species.

A Journey from Benzoborirene to Benzoborole-Supported 1,2-Diimine and Antiaromatic Borolediide.

Metabolic dysfunction-associated steatohepatitis (MASH) and fibrotic MASH are significant health challenges. This multi-national study aimed to validate the acMASH index (including serum creatinine and aspartate aminotransferase concentrations) for MASH diagnosis and develop a new index (acFibroMASH) for non-invasively identifying fibrotic MASH and exploring its predictive value for liver-related events (LREs).

acFibroMASH index for the diagnosis of fibrotic MASH and prediction of liver-related events: An international multicenter study.

Similar to pyridine, which is a structural analog of benzene, 2-azaborole can be viewed as a structural analog of borole, in which the CH group at the 2-position is replaced by an N atom. Due to its unique πσ electronic configuration, it should exhibit Lewis acidity, antiaromaticity, as well as Lewis basicity simultaneously. However, this uniqueness also makes its synthesis and isolation particularly challenging. One anticipated issue is its readiness for self-dimerization. This work proposes 2-azaborole and targets the synthesis and characterization of its derivatives for the first time. By reacting benzoborirene CH{BN(SiMe)} with bulky nitriles, crystalline benzo-fused 2-azaboroles have been successfully achieved and fully characterized. The importance of steric hindrance has been experimentally verified, showing that insufficient kinetic protection results in the dimerization of benzo-fused 2-azaboroles to form BN-allenophanes, a class of 10-membered macrocyclic compounds featuring two BN-allene units. The unique electronic structure of 2-azaborole as well as the mechanism of dimerization has been corroborated by theoretical calculations. In addition, its ability to act both as a Lewis acid and a Lewis base is demonstrated through its reaction with 1,3-diisopropyl-4,5-dimethylimidazolin-2-ylidene (IPr) and AlCl, respectively, which also implies the potential of the 2-azaborole motif as a σ-donor ligand for main group and organometallic chemistry.

Antiaromatic 2-Azaboroles with πσ Electronic Configuration.

Laparoscopic hepatectomy is a proven safe and technically feasible approach for liver tumor resection, but laparoscopic anatomical SVIII resection (LASVIIIR) remains rarely reported due to poor accessibility, difficult exposure, and the deep-lying Glissonean pedicle. This study examined the safety, feasibility, and perioperative outcomes of LASVIIIR  a middle hepatic fissure approach at our institution.

ArticleTotal : 2	Year
Publication title	2025
Publication title	2025

Article	Year
Upregulation of the long noncoding RNA FOXD2-AS1 predicts poor prognosis in esophageal squamous cell carcinoma. Cancer biomarkers : section A of Disease markers\| PubMed ID: 29286915	2018
A Journey from Benzoborirene to Benzoborole-Supported 1,2-Diimine and Antiaromatic Borolediide. Angewandte Chemie (International ed. in English)\| PubMed ID: 37758684	2023
acFibroMASH index for the diagnosis of fibrotic MASH and prediction of liver-related events: An international multicenter study. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association\| PubMed ID: 39362618	2024
Antiaromatic 2-Azaboroles with πσ Electronic Configuration. Journal of the American Chemical Society\| PubMed ID: 39415725	2024
Laparoscopic anatomical SVIII resection middle hepatic fissure approach: Caudal or cranio side. World journal of gastrointestinal surgery\| PubMed ID: 39734445	2024

Qing Ye

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