ex-vivo-culturing-of-whole-developing-drosophila-brains

<em>Ex vivo</em> Culturing of Whole, Developing <em>Drosophila</em> Brains

We describe a method for ex vivo culturing of whole Drosophila brains. This can be used as a counterpoint to chronic genetic manipulations for ...

National Institute of Neurological Disorders and Stroke

National Institutes of Health, Bethesda, MD

Precise connections of neural circuits can be specified by genetic programming. In the Drosophila olfactory system, projection neurons (PNs) send dendrites to single glomeruli in the antenna lobe (AL) based upon lineage and birth order and send axons with stereotyped terminations to higher olfactory centers. These decisions are likely specified by a PN-intrinsic transcriptional code that regulates the expression of cell-surface molecules to instruct wiring specificity.

Article	Year
Development (Cambridge, England)\| PubMed ID: 11880341	2002
Differentiation; research in biological diversity\| PubMed ID: 12366376	2002
Current biology : CB\| PubMed ID: 12781136	2003
Nature neuroscience\| PubMed ID: 12897787	2003
Genes & development\| PubMed ID: 14522953	2003
The Journal of biological chemistry\| PubMed ID: 15123610	2004
Mechanisms of development\| PubMed ID: 17368005	2007
Lola regulates Drosophila olfactory projection neuron identity and targeting specificity. Neural development\| PubMed ID: 17634136	2007
Developmental biology\| PubMed ID: 18062953	2008
Mechanisms of development\| PubMed ID: 18160268	2008
Development (Cambridge, England)\| PubMed ID: 20940230	2010
Developmental dynamics : an official publication of the American Association of Anatomists\| PubMed ID: 21246649	2011
Development (Cambridge, England)\| PubMed ID: 21447553	2011
The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 21775591	2011
Neural development\| PubMed ID: 22129300	2011
Disease models & mechanisms\| PubMed ID: 22228754	2012
PloS one\| PubMed ID: 22438988	2012
Current opinion in genetics & development\| PubMed ID: 22608692	2012

Edward Giniger

Biography

JoVE Journal Publications

Other Publications