Eugene O. Major

Laboratory of Molecular Medicine and Neuroscience, National Institute of Neurological Disorders and Stroke, National Institutes of Health

Affiliated withNational Institute of Neurological Disorders and Stroke, National Institutes of Health National Institutes of Health

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 38	2012
Publication title Cited by 15	2015

Other Publications

Article	Year
HIV-1 and the brain: connections between HIV-1-associated dementia, neuropathology and neuroimmunology. Microbes and infection / Institut Pasteur\| PubMed ID: 11909740	2002
Analysis of the temporal expression of nestin in human fetal brain derived neuronal and glial progenitor cells. Brain research. Developmental brain research\| PubMed ID: 11947939	2002
Traffic of JC virus from sites of initial infection to the brain: the path to progressive multifocal leukoencephalopathy. The Journal of infectious diseases\| PubMed ID: 12424695	2002
Intracellular human immunodeficiency virus Tat expression in astrocytes promotes astrocyte survival but induces potent neurotoxicity at distant sites via axonal transport. The Journal of biological chemistry\| PubMed ID: 12551932	2003
Serological cross-reactivities between antibodies to simian virus 40, BK virus, and JC virus assessed by virus-like-particle-based enzyme immunoassays. Clinical and diagnostic laboratory immunology\| PubMed ID: 12626455	2003
Advances in the biology of JC virus and induction of progressive multifocal leukoencephalopathy. Journal of neurovirology\| PubMed ID: 12707854	2003
Basic, clinical, and epidemiological studies of progressive multifocal leukoencephalopathy: implications for therapy. Journal of neurovirology\| PubMed ID: 12709863	2003
Lineage pathway of human brain progenitor cells identified by JC virus susceptibility. Annals of neurology\| PubMed ID: 12730998	2003
Serum antibodies to JC virus, BK virus, simian virus 40, and the risk of incident adult astrocytic brain tumors. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology\| PubMed ID: 12750243	2003
Brain-derived neurotrophic factor inhibits human immunodeficiency virus-1/gp120-mediated cerebellar granule cell death by preventing gp120 internalization. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 12843275	2003
Analysis of the excreted JC virus strains and their potential oral transmission. Journal of neurovirology\| PubMed ID: 12907394	2003
HIV-2 derived lentiviral vectors: gene transfer in Parkinson's and Fabry disease models in vitro. Journal of medical virology\| PubMed ID: 12938190	2003
JC virus induces nonapoptotic cell death of human central nervous system progenitor cell-derived astrocytes. Journal of virology\| PubMed ID: 15078969	2004
Human immunodeficiency virus type 1 infection of human brain-derived progenitor cells. Journal of virology\| PubMed ID: 15220405	2004
Comparison of PCR-southern hybridization and quantitative real-time PCR for the detection of JC and BK viral nucleotide sequences in urine and cerebrospinal fluid. Journal of virological methods\| PubMed ID: 15381359	2004
Differential effects of interferon-gamma on the expression of cyclooxygenase-2 in high-grade human gliomas versus primary astrocytes. Journal of neuroimmunology\| PubMed ID: 15465602	2004
Investigation of human brain tumors for the presence of polyomavirus genome sequences by two independent laboratories. International journal of cancer. Journal international du cancer\| PubMed ID: 15499616	2005
Nuclear receptor activation and interaction with morphine. Journal of neuroimmunology\| PubMed ID: 15579281	2004
Herpes simplex virus type 1 enters human epidermal keratinocytes, but not neurons, via a pH-dependent endocytic pathway. Journal of virology\| PubMed ID: 15919913	2005
Variant-specific tropism of human herpesvirus 6 in human astrocytes. Journal of virology\| PubMed ID: 16014907	2005
Donor origin of BK virus in renal transplantation and role of HLA C7 in susceptibility to sustained BK viremia. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons\| PubMed ID: 16095500	2005
Astrocyte differentiation selectively upregulates CCL2/monocyte chemoattractant protein-1 in cultured human brain-derived progenitor cells. Glia\| PubMed ID: 16206198	2006
Evaluation of patients treated with natalizumab for progressive multifocal leukoencephalopathy. The New England journal of medicine\| PubMed ID: 16510746	2006
JC virus can infect human immune and nervous system progenitor cells: implications for pathogenesis. Advances in experimental medicine and biology\| PubMed ID: 16626042	2006
Neural progenitors and HIV-1-associated central nervous system disease in adults and children. Current HIV research\| PubMed ID: 16842084	2006
Interactions between c-Jun, nuclear factor 1, and JC virus promoter sequences: implications for viral tropism. Journal of virology\| PubMed ID: 16928756	2006
Viral proteomics: a promising approach for understanding JC virus tropism. Proteomics\| PubMed ID: 16991198	2006
Complete replication cycle and acquisition of tegument in nucleus of human herpesvirus 6A in astrocytes and in T-cells. Journal of medical virology\| PubMed ID: 17063514	2006
Induction of original phenotype of human immortalized chondrocytes: a quantitative gene expression analysis. International journal of molecular medicine\| PubMed ID: 17143552	2007
MEK1/2 inhibitors block basal and transforming growth factor 1beta1-stimulated JC virus multiplication. Journal of virology\| PubMed ID: 17409139	2007
Natalizumab treatment for multiple sclerosis: recommendations for patient selection and monitoring. Lancet neurology\| PubMed ID: 17434098	2007
Evidence of human immunodeficiency virus type 1 infection of nestin-positive neural progenitors in archival pediatric brain tissue. Journal of neurovirology\| PubMed ID: 17613718	2007
NeuroAIDS, drug abuse, and inflammation: building collaborative research activities. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology\| PubMed ID: 18040811	2006
DNA-binding transcription factor NF-1A negatively regulates JC virus multiplication. The Journal of general virology\| PubMed ID: 18474555	2008
BK virus antibody titers and intensity of infections after renal transplantation. Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology\| PubMed ID: 18676176	2008
Neuropharmacology of HIV/AIDS. Handbook of clinical neurology / edited by P.J. Vinken and G.W. Bruyn\| PubMed ID: 18808990	2007
M- and T-tropic HIVs promote apoptosis in rat neurons. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology\| PubMed ID: 19034668	2009
Glial cell type-specific subcellular localization of 14-3-3 zeta: an implication for JCV tropism. Glia\| PubMed ID: 19062179	2009
Response to Linberg et al. Natalizumab alters transcriptional expression profiles of blood cell subpopulations of multiple sclerosis patients. Journal of neuroimmunology\| PubMed ID: 19117088	2008
Progressive multifocal leukoencephalopathy after rituximab therapy in HIV-negative patients: a report of 57 cases from the Research on Adverse Drug Events and Reports project. Blood\| PubMed ID: 19264918	2009
Monoclonal antibody-associated progressive multifocal leucoencephalopathy in patients treated with rituximab, natalizumab, and efalizumab: a Review from the Research on Adverse Drug Events a... The lancet oncology\| PubMed ID: 19647202	2009
Progressive multifocal leukoencephalopathy in patients on immunomodulatory therapies. Annual review of medicine\| PubMed ID: 19719397	2010
Reemergence of PML in natalizumab-treated patients--new cases, same concerns. The New England journal of medicine\| PubMed ID: 19741226	2009
Progressive multifocal leukoencephalopathy after natalizumab monotherapy. The New England journal of medicine\| PubMed ID: 19741229	2009
Monoclonal antibodies and progressive multifocal leukoencephalopathy. mAbs\| PubMed ID: 20073129	2009
Molecular regulation of JC virus tropism: insights into potential therapeutic targets for progressive multifocal leukoencephalopathy. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology\| PubMed ID: 20401541	2010
Rearranged JC virus noncoding control regions found in progressive multifocal leukoencephalopathy patient samples increase virus early gene expression and replication rate. Journal of virology\| PubMed ID: 20686041	2010
JC virus persistence following progressive multifocal leukoencephalopathy in multiple sclerosis patients treated with natalizumab. Annals of neurology\| PubMed ID: 20818792	2010
Hexadecyloxypropyl-cidofovir (CMX001) suppresses JC virus replication in human fetal brain SVG cell cultures. Antimicrobial agents and chemotherapy\| PubMed ID: 20823288	2010
Transcription factor Spi-B binds unique sequences present in the tandem repeat promoter/enhancer of JC virus and supports viral activity. The Journal of general virology\| PubMed ID: 20826618	2010
CMX001 (1-O-hexadecyloxypropyl-cidofovir) inhibits polyomavirus JC replication in human brain progenitor-derived astrocytes. Antimicrobial agents and chemotherapy\| PubMed ID: 21402853	2011
Inhibitory interactions between BK and JC virus among kidney transplant recipients. Journal of the American Society of Nephrology : JASN\| PubMed ID: 21511831	2011
IFN-gamma mediates enhancement of HIV replication in astrocytes by inducing an antagonist of the beta-catenin pathway (DKK1) in a STAT 3-dependent manner. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 21562161	2011
Taxonomical developments in the family Polyomaviridae. Archives of virology\| PubMed ID: 21562881	2011
Natalizumab treatment for multiple sclerosis: updated recommendations for patient selection and monitoring. Lancet neurology\| PubMed ID: 21777829	2011
JC virus promoter/enhancers contain TATA box-associated Spi-B-binding sites that support early viral gene expression in primary astrocytes. The Journal of general virology\| PubMed ID: 22071512	2012
History and current concepts in the pathogenesis of PML. Cleveland Clinic journal of medicine\| PubMed ID: 22123932	2011
The link between VLA-4 and JC virus reactivation. Expert review of clinical immunology\| PubMed ID: 22149341	2012
Individuals infected with JC polyomavirus do not present detectable JC virus DNA in oropharyngeal fluids. The Journal of general virology\| PubMed ID: 22158878	2012
Neurological infections: risks of globalisation and new drugs. Lancet neurology\| PubMed ID: 22172615	2012
Molecular biology, epidemiology, and pathogenesis of progressive multifocal leukoencephalopathy, the JC virus-induced demyelinating disease of the human brain. Clinical microbiology reviews\| PubMed ID: 22763635	2012
Changes in JC Virus-Specific T Cell Responses during Natalizumab Treatment and in Natalizumab-Associated Progressive Multifocal Leukoencephalopathy. PLoS pathogens\| PubMed ID: 23144619	2012
Human Immunodeficiency Virus Type 1 (HIV-1) Transactivator of Transcription through Its Intact Core and Cysteine-Rich Domains Inhibits Wnt/Î²-Catenin Signaling in Astrocytes: Relevance to HI... The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 23152614	2012