Pamela L. Schwartzberg

Laboratory of Immune System Biology, NIH

Affiliated withNIH National Institutes of Health

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 3	Year
Publication title Cited by 1	2025
Publication title	2025
Publication title	2025

Other Publications

Article	Year
rlk/TXK encodes two forms of a novel cysteine string tyrosine kinase activated by Src family kinases. Molecular and cellular biology\| PubMed ID: 9891083	1999
Requirements for activation and RAFT localization of the T-lymphocyte kinase Rlk/Txk. BMC immunology\| PubMed ID: 11353545	2001
Genetic approaches to tyrosine kinase signaling pathways in the immune system. Immunologic research\| PubMed ID: 12857991	2003
Fine-tuning lymphocyte regulation: what's new with tyrosine kinases and phosphatases? Current opinion in immunology\| PubMed ID: 15134778	2004
TNF-alpha is crucial for the development of autoimmune arthritis in IL-1 receptor antagonist-deficient mice. The Journal of clinical investigation\| PubMed ID: 15578092	2004
TEC-family kinases: regulators of T-helper-cell differentiation. Nature reviews. Immunology\| PubMed ID: 15803148	2005
Acinar cell apoptosis in Serpini2-deficient mice models pancreatic insufficiency. PLoS genetics\| PubMed ID: 16184191	2005
SAP regulates T cell-mediated help for humoral immunity by a mechanism distinct from cytokine regulation. The Journal of experimental medicine\| PubMed ID: 16754717	2006
Knockout of Slc25a19 causes mitochondrial thiamine pyrophosphate depletion, embryonic lethality, CNS malformations, and anemia. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17035501	2006
CBFB-MYH11 hinders early T-cell development and induces massive cell death in the thymus. Blood\| PubMed ID: 17185462	2007
Formin the way. Immunity\| PubMed ID: 17307700	2007
Impaired in vitro regulatory T cell function associated with Wiskott-Aldrich syndrome. Clinical immunology (Orlando, Fla.)\| PubMed ID: 17512803	2007
Requirements for selection of conventional and innate T lymphocyte lineages. Immunity\| PubMed ID: 18031697	2007
Selective targeting of ITK blocks multiple steps of HIV replication. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18443296	2008
Advantages of q-PCR as a method of screening for gene targeting in mammalian cells using conventional and whole BAC-based constructs. Nucleic acids research\| PubMed ID: 18710883	2008
The immunity-related GTPase Irgm1 promotes the expansion of activated CD4+ T cell populations by preventing interferon-gamma-induced cell death. Nature immunology\| PubMed ID: 18806793	2008
SAP-controlled T-B cell interactions underlie germinal centre formation. Nature\| PubMed ID: 18843362	2008
Selective expression rather than specific function of Txk and Itk regulate Th1 and Th2 responses. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 18941202	2008
Cbl enforces an SLP76-dependent signaling pathway for T cell differentiation. The Journal of biological chemistry\| PubMed ID: 19074136	2009
Rheumatologic and autoimmune manifestations of primary immunodeficiency disorders. Current opinion in rheumatology\| PubMed ID: 19077721	2009
SLAM receptors and SAP influence lymphocyte interactions, development and function. Nature reviews. Immunology\| PubMed ID: 19079134	2009
Tec kinases regulate T-lymphocyte development and function: new insights into the roles of Itk and Rlk/Txk. Immunological reviews\| PubMed ID: 19290923	2009
TREM-like transcript-1 protects against inflammation-associated hemorrhage by facilitating platelet aggregation in mice and humans. The Journal of clinical investigation\| PubMed ID: 19436112	2009
The major component in schistosome eggs responsible for conditioning dendritic cells for Th2 polarization is a T2 ribonuclease (omega-1). The Journal of experimental medicine\| PubMed ID: 19635859	2009
Differential expression of interleukin-17A and -17F is coupled to T cell receptor signaling via inducible T cell kinase. Immunity\| PubMed ID: 19818650	2009
Systemic autoimmunity and defective Fas ligand secretion in the absence of the Wiskott-Aldrich syndrome protein. Blood\| PubMed ID: 20457871	2010
Regulation of microRNA expression and abundance during lymphopoiesis. Immunity\| PubMed ID: 20605486	2010
Biochemical and genetic evidence for a SAP-PKC-theta interaction contributing to IL-4 regulation. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 20668219	2010
Constitutive reductions in mTOR alter cell size, immune cell development, and antibody production. Blood\| PubMed ID: 21079150	2011
SLAM family receptors and SAP adaptors in immunity. Annual review of immunology\| PubMed ID: 21219180	2011
Tec family kinases Itk and Rlk / Txk in T lymphocytes: cross-regulation of cytokine production and T-cell fates. The FEBS journal\| PubMed ID: 21362139	2011
The human condition: an immunological perspective. Nature immunology\| PubMed ID: 21502986	2011
A mosaic activating mutation in AKT1 associated with the Proteus syndrome. The New England journal of medicine\| PubMed ID: 21793738	2011
Early Th1 cell differentiation is marked by a Tfh cell-like transition. Immunity\| PubMed ID: 22195747	2011
Characterization of Ly108 in the thymus: evidence for distinct properties of a novel form of Ly108. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 22393150	2012
A role for Ly108 in the induction of promyelocytic zinc finger transcription factor in developing thymocytes. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 23355739	2013
T follicular helper cell diversity and plasticity. Trends in immunology\| PubMed ID: 23395212	2013
Dominant-activating germline mutations in the gene encoding the PI(3)K catalytic subunit p110δ result in T cell senescence and human immunodeficiency. Nature immunology\| PubMed ID: 24165795	2014
Itk-mediated integration of T cell receptor and cytokine signaling regulates the balance between Th17 and regulatory T cells. The Journal of experimental medicine\| PubMed ID: 24534190	2014
Global analyses of human immune variation reveal baseline predictors of postvaccination responses. Cell\| PubMed ID: 24725414	2014
Innate PLZF+CD4+ αβ T cells develop and expand in the absence of Itk. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 24928994	2014
Development of innate CD4+ and CD8+ T cells in Itk-deficient mice is regulated by distinct pathways. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 24943215	2014
TCF1 Is Required for the T Follicular Helper Cell Response to Viral Infection. Cell reports\| PubMed ID: 26365183	2015
Itk is required for Th9 differentiation via TCR-mediated induction of IL-2 and IRF4. Nature communications\| PubMed ID: 26936133	2016
CRISPR-Mediated Triple Knockout of SLAMF1, SLAMF5 and SLAMF6 Supports Positive Signaling Roles in NKT Cell Development. PloS one\| PubMed ID: 27258160	2016
Type I interferon suppresses virus-specific B cell responses by modulating CD8 T cell differentiation. Science immunology\| PubMed ID: 27812556	2016
The TCF1-Bcl6 axis counteracts type I interferon to repress exhaustion and maintain T cell stemness. Science immunology\| PubMed ID: 28018990	2016
Inducible T Cell Kinase Regulates the Acquisition of Cytolytic Capacity and Degranulation in CD8 CTLs. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 28213500	2017
Cortical actin recovery at the immunological synapse leads to termination of lytic granule secretion in cytotoxic T lymphocytes. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 28716933	2017
SAP and Lessons Learned from a Primary Immunodeficiency. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 28827384	2017
Hyperactivated PI3Kδ promotes self and commensal reactivity at the expense of optimal humoral immunity. Nature immunology\| PubMed ID: 30127432	2018
AS03-adjuvanted H5N1 vaccine promotes antibody diversity and affinity maturation, NAI titers, cross-clade H5N1 neutralization, but not H1N1 cross-subtype neutralization. NPJ vaccines\| PubMed ID: 30302282	2018
Efficient CRISPR/Cas9-Mediated Mutagenesis in Primary Murine T Lymphocytes. Current protocols in immunology\| PubMed ID: 30312021	2019
PI3K Orchestrates T Follicular Helper Cell Differentiation in a Context Dependent Manner: Implications for Autoimmunity. Frontiers in immunology\| PubMed ID: 30666254	2018
A mouse model of Proteus syndrome. Human molecular genetics\| PubMed ID: 31194862	2019
Mg regulation of kinase signaling and immune function. The Journal of experimental medicine\| PubMed ID: 31196981	2019
Single-cell RNA-seq reveals TOX as a key regulator of CD8 T cell persistence in chronic infection. Nature immunology\| PubMed ID: 31209400	2019
The Bone Marrow Protects and Optimizes Immunological Memory during Dietary Restriction. Cell\| PubMed ID: 31442402	2019
Defining 'T cell exhaustion'. Nature reviews. Immunology\| PubMed ID: 31570879	2019
Women in immunology: 2020 and beyond. Nature immunology\| PubMed ID: 32094649	2020
Broad immune activation underlies shared set point signatures for vaccine responsiveness in healthy individuals and disease activity in patients with lupus. Nature medicine\| PubMed ID: 32094927	2020
Common genetic susceptibility loci link PFAPA syndrome, Behçet's disease, and recurrent aphthous stomatitis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 32518111	2020
BACH2 enforces the transcriptional and epigenetic programs of stem-like CD8 T cells. Nature immunology\| PubMed ID: 33574619	2021
Author Correction: BACH2 enforces the transcriptional and epigenetic programs of stem-like CD8 T cells. Nature immunology\| PubMed ID: 33658708	2021
Lessons learned: new insights on the role of cytokines in COVID-19. Nature immunology\| PubMed ID: 33723418	2021
PI3K in T Cell Adhesion and Trafficking. Frontiers in immunology\| PubMed ID: 34421914	2021
PI3Kδ coordinates transcriptional, chromatin, and metabolic changes to promote effector CD8 T cells at the expense of central memory. Cell reports\| PubMed ID: 34644563	2021
In vivo CRISPR screens reveal a HIF-1α-mTOR-network regulates T follicular helper versus Th1 cells. Nature communications\| PubMed ID: 35145086	2022
Robust, persistent adaptive immune responses to SARS-CoV-2 in the oropharyngeal lymphoid tissue of children. Research square\| PubMed ID: 35350206	2022
A CRISPR screen targeting PI3K effectors identifies RASA3 as a negative regulator of LFA-1-mediated adhesion in T cells. Science signaling\| PubMed ID: 35857633	2022
"Stripe" transcription factors provide accessibility to co-binding partners in mammalian genomes. Molecular cell\| PubMed ID: 35863348	2022
Examining multi-level immune response to determine prevalence of COVID-19 in pediatric tonsillectomy. The Laryngoscope\| PubMed ID: 36102311	2023
Adaptive immune responses to SARS-CoV-2 persist in the pharyngeal lymphoid tissue of children. Nature immunology\| PubMed ID: 36536106	2023
Protein phosphatase 2A propels follicular T helper cell development in lupus. Journal of autoimmunity\| PubMed ID: 37001432	2023
Multiscale integration of human and single-cell variations reveals unadjuvanted vaccine high responders are naturally adjuvanted. medRxiv : the preprint server for health sciences\| PubMed ID: 37090674	2023
Eosinophil trafficking in allergen-mediated pulmonary inflammation relies on IL-13-driven CCL-11 and CCL-24 production by tissue fibroblasts and myeloid cells. The journal of allergy and clinical immunology. Global\| PubMed ID: 37781651	2023
Mind the GAP: RASA2 and RASA3 GTPase-activating proteins as gatekeepers of T cell activation and adhesion. Trends in immunology\| PubMed ID: 37858490	2023
Biallelic human SHARPIN loss of function induces autoinflammation and immunodeficiency. Nature immunology\| PubMed ID: 38609546	2024
Integrating population and single-cell variations in vaccine responses identifies a naturally adjuvanted human immune setpoint. Immunity\| PubMed ID: 38697118	2024
Help me help you: emerging concepts in T follicular helper cell differentiation, identity, and function. Current opinion in immunology\| PubMed ID: 38733669	2024
Acute and persistent responses after H5N1 vaccination in humans. Cell reports\| PubMed ID: 39235945	2024
Balancing immune activation with Itk. Trends in pharmacological sciences\| PubMed ID: 39358175	2024
System vaccinology analysis of predictors and mechanisms of antibody response durability to multiple vaccines in humans. Nature immunology\| PubMed ID: 39747435	2025
A PI3Kδ-Foxo1-FasL signaling amplification loop rewires CD4 T helper cell signaling, differentiation and epigenetic remodeling. bioRxiv : the preprint server for biology\| PubMed ID: 39803425	2024
A symphony of immunity to SARS-CoV-2 in the adenoids. Nature immunology\| PubMed ID: 39890932	2025
Prior SARS-CoV-2 infection affects adaptive immune responses to Omicron BA.4/BA.5 mRNA booster. The Journal of allergy and clinical immunology\| PubMed ID: 40044048	2025
Rescue of osteoclast function by transgenic expression of kinase-deficient Src in src-/- mutant mice. Genes & development\| PubMed ID: 9353253	1997
Deficiency of PTEN in Jurkat T cells causes constitutive localization of Itk to the plasma membrane and hyperresponsiveness to CD3 stimulation. Molecular and cellular biology\| PubMed ID: 10958690	2000
Tec family kinases modulate thresholds for thymocyte development and selection. The Journal of experimental medicine\| PubMed ID: 11015440	2000
Genetic evidence for a role for Src family kinases in TNF family receptor signaling and cell survival. Genes & development\| PubMed ID: 11157779	2001
Altered lymphocyte responses and cytokine production in mice deficient in the X-linked lymphoproliferative disease gene SH2D1A/DSHP/SAP. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 11404475	2001
Beyond calcium: new signaling pathways for Tec family kinases. Journal of cell science\| PubMed ID: 12118060	2002
A critical role for IL-21 in regulating immunoglobulin production. Science (New York, N.Y.)\| PubMed ID: 12446913	2002
Itk functions to control actin polymerization at the immune synapse through localized activation of Cdc42 and WASP. Current biology : CB\| PubMed ID: 13678593	2003
Amplifying Btk's signal. Immunity\| PubMed ID: 14614849	2003
Requirement for Tec kinases in chemokine-induced migration and activation of Cdc42 and Rac. Current biology : CB\| PubMed ID: 15186750	2004
A role for thymic stromal lymphopoietin in CD4(+) T cell development. The Journal of experimental medicine\| PubMed ID: 15263024	2004
SH2D1A regulates T-dependent humoral autoimmunity. The Journal of experimental medicine\| PubMed ID: 15263031	2004
Tec kinases: shaping T-cell activation through actin. Trends in cell biology\| PubMed ID: 15308211	2004
SAP regulates T(H)2 differentiation and PKC-theta-mediated activation of NF-kappaB1. Immunity\| PubMed ID: 15539155	2004
Kinase-independent functions for Itk in TCR-induced regulation of Vav and the actin cytoskeleton. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 15661896	2005
Regulation of NKT cell development by SAP, the protein defective in XLP. Nature medicine\| PubMed ID: 15711562	2005
Tec kinases regulate TCR-mediated recruitment of signaling molecules and integrin-dependent cell adhesion. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 16237085	2005
Altered development of CD8+ T cell lineages in mice deficient for the Tec kinases Itk and Rlk. Immunity\| PubMed ID: 16860760	2006
The expression of Wiskott-Aldrich syndrome protein (WASP) is dependent on WASP-interacting protein (WIP). International immunology\| PubMed ID: 17205972	2007
Tec kinases, actin, and cell adhesion. Immunological reviews\| PubMed ID: 17624943	2007
A novel ICOS-independent, but CD28- and SAP-dependent, pathway of T cell-dependent, polysaccharide-specific humoral immunity in response to intact Streptococcus pneumoniae versus pneumococca... Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 19050242	2008
Follicular helper T cells are required for systemic autoimmunity. The Journal of experimental medicine\| PubMed ID: 19221396	2009
Optimal germinal center responses require a multistage T cell:B cell adhesion process involving integrins, SLAM-associated protein, and CD84. Immunity\| PubMed ID: 20153220	2010
T-cell signaling regulated by the Tec family kinase, Itk. Cold Spring Harbor perspectives in biology\| PubMed ID: 20519342	2010
Follicular helper T cell differentiation requires continuous antigen presentation that is independent of unique B cell signaling. Immunity\| PubMed ID: 20691615	2010
Balancing selection maintains a form of ERAP2 that undergoes nonsense-mediated decay and affects antigen presentation. PLoS genetics\| PubMed ID: 20976248	2010
Essential role for retinoic acid in the promotion of CD4(+) T cell effector responses via retinoic acid receptor alpha. Immunity\| PubMed ID: 21419664	2011
Functional and epigenetic studies reveal multistep differentiation and plasticity of in vitro-generated and in vivo-derived follicular T helper cells. Immunity\| PubMed ID: 22018472	2011
Positive and negative signaling through SLAM receptors regulate synapse organization and thresholds of cytolysis. Immunity\| PubMed ID: 22683123	2012
The receptor Ly108 functions as a SAP adaptor-dependent on-off switch for T cell help to B cells and NKT cell development. Immunity\| PubMed ID: 22683125	2012
Development of promyelocytic leukemia zinc finger-expressing innate CD4 T cells requires stronger T-cell receptor signals than conventional CD4 T cells. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22988097	2012
Cellular and molecular requirements for the selection of in vitro-generated CD8 T cells reveal a role for Notch. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 23851691	2013
Ncking BCR-mediated PI3K activation. EMBO reports\| PubMed ID: 23969954	2013
Type I IFN induces binding of STAT1 to Bcl6: divergent roles of STAT family transcription factors in the T follicular helper cell genetic program. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 24489092	2014
Inhibition of diacylglycerol kinase α restores restimulation-induced cell death and reduces immunopathology in XLP-1. Science translational medicine\| PubMed ID: 26764158	2016
X-Linked Lymphoproliferative Disease Type 1: A Clinical and Molecular Perspective. Frontiers in immunology\| PubMed ID: 29670631	2018
Genetic Defects in Phosphoinositide 3-Kinase δ Influence CD8 T Cell Survival, Differentiation, and Function. Frontiers in immunology\| PubMed ID: 30116245	2018
T and B-cell signaling in activated PI3K delta syndrome: From immunodeficiency to autoimmunity. Immunological reviews\| PubMed ID: 31402502	2019
Transient protein accumulation at the center of the T cell antigen-presenting cell interface drives efficient IL-2 secretion. eLife\| PubMed ID: 31663508	2019
LFA-1 signals to promote actin polymerization and upstream migration in T cells. Journal of cell science\| PubMed ID: 32907931	2020
The Road Less Taken: Less Appreciated Pathways for Manipulating CD8 T Cell Exhaustion. Frontiers in immunology\| PubMed ID: 35874734	2022
Inherited human ITK deficiency impairs IFN-γ immunity and underlies tuberculosis. The Journal of experimental medicine\| PubMed ID: 36326697	2023
Protein kinases: drug targets for immunological disorders. Nature reviews. Immunology\| PubMed ID: 37188939	2023
TCR-independent CD137 (4-1BB) signaling promotes CD8-exhausted T cell proliferation and terminal differentiation. Immunity\| PubMed ID: 37392737	2023
Author Correction: Protein kinases: drug targets for immunological disorders. Nature reviews. Immunology\| PubMed ID: 38012368	2024
Sulfide is a keystone metabolite for gut homeostasis and immunity. bioRxiv : the preprint server for biology\| PubMed ID: 40161817	2025