development-novel-low-dmso-cryoprotectant-for-peripheral-blood-stem

Development of Novel Low-DMSO Cryoprotectant for Peripheral Blood Stem Cell Preservation

Peripheral blood hematopoietic stem cell (PBHSC) cryopreservation is critical for autologous stem cell transplantation (ASCT), but traditional ...

allogeneic-hsct-for-pediatric-extranodal-nkt-cell-lymphoma

Allogeneic HSCT For Pediatric Extranodal NK/T-Cell Lymphoma Transformed From Chronic Active Epstein&#8211;Barr Virus Infection: A Case Report

This study aimed to explore the clinical characteristics, diagnostic criteria, therapeutic regimens, and prognostic features of pediatric extranodal ...

Affiliated Nanshan Hospital of Shenzhen University

Wuhan University of Science and Technology

Chinese Academy of Medical Sciences and Peking Union Medical College

Recent studies have shown that there exists a significant correlation between oral microbiome and the occurrence of malignancies. However, the prognostic significance of oral microbiome for cancer patients remains unclear. The purpose of this meta-analysis is to evaluate the impact of oral microbiome on the survival of patients with malignant neoplasms.

Prognostic impact of oral microbiome on survival of malignancies: a systematic review and meta-analysis.

CD19-directed chimeric antigen receptor (CAR) T cell therapy has been shown to achieve a considerably durable response in patients with refractory or relapsed B cell non-Hodgkin lymphomas. Most of these CARs were generated by lentivirus. With the exception of Yescarta and Tecartus, few patients with relapsed-/refractory- lymphoma have been treated clinically with a CARs using retroviral vector (RV). Here, we reported a relapsed/refractory grade 2 follicular lymphoma patient with multiple chemotherapy failures, and was treated with a novel CD19 CAR-T cell manufactured from a RV. After tumor burden was reduced with Obinutuzumab and Duvelisib, the patient was infused novel CD19 CAR-T cells at a dose of 3 × 10 cells/ kg. Then he experienced a rapid response and achieved almost complete remission by day 26. Only grade 2 CRS, bilateral submaxillary lymph node enlargement and cytomegalovirus (CMV) infection occurred without neurotoxicity, and the patient's condition improved after a series of symptomatic treatments. In addition, CAR copy number peaked at 532,350 copies/μg on day 15 and continued to expand for 5 months. This may be the first case report of RV preparation of novel CD19 CAR-T cells for direct treatment of recurrent follicular lymphoma. We will observe its long-term efficacy and conduct trials in more patients in the future.

Rapid response in relapsed follicular lymphoma to novel anti-CD19 CAR-T therapy with pseudo-progression and cytomegalovirus infection: A case report.

Immune system impairment and chemotherapies prior to autologous hematopoietic stem cell transplantation (auto-HSCT) significantly increase the risk of respiratory tract infections (RTIs), especially within 100 days after HSCT. Prophylaxis of RTIs among patients with HSCT are of high importance, clinical experiences have been learnt previously that oropharyngeal probiotic is safe and able to significantly reduce RTIs among patients with recurrent RTIs in both children and adults, the aim of this study is to explore the safety and preventive effects of oropharyngeal probiotics BP-OM1 on RTIs among patients after HSCT.

Efficacy and Safety of Oropharyngeal Probiotic BP-OM1 on Respiratory Infection-Like Symptoms Among Patients With Lymphoma After Autologous Hematopoietic Stem Cell Transplantation: A Multicenter Randomized Controlled Pilot Study.

ArticleTotal : 2	Year
Publication title	2025
Publication title	2026

Article	Year
Prognostic impact of oral microbiome on survival of malignancies: a systematic review and meta-analysis. Systematic reviews\| PubMed ID: 38273347	2024
Rapid response in relapsed follicular lymphoma to novel anti-CD19 CAR-T therapy with pseudo-progression and cytomegalovirus infection: A case report. International immunopharmacology\| PubMed ID: 38703571	2024
Efficacy and Safety of Oropharyngeal Probiotic BP-OM1 on Respiratory Infection-Like Symptoms Among Patients With Lymphoma After Autologous Hematopoietic Stem Cell Transplantation: A Multicen... Transplantation proceedings\| PubMed ID: 40140313	2025

Zhi Guo

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