evaluation-right-ventricular-function-experimental-models-pulmonary

Evaluation of Right Ventricular Function in Experimental Models of Pulmonary Arterial Hypertension

Pulmonary hypertension (PH) is a chronic condition associated with reduced survival, making it a critical area of research. Experimental models of PH have ...

Federal University of Rio de Janeir

Federal University of Rio de Janeiro

In December 2019, an outbreak of severe pneumonia was reported in Wuhan, China. Later described as COVID-19 (coronavirus disease 2019), this infection caused by a virus from the Coronaviridae family (SARS-CoV-2) has spread globally. Effective therapies for this new disease are urgently needed. In this short communication, we will evaluate the use of corticosteroids as an adjunctive pharmacological therapy in the management of COVID-19 and describe its pros and cons in light of the latest available evidence.

Pros and cons of corticosteroid therapy for COVID-19 patients.

Recombinant adeno-associated viruses (rAAV) are an important tool for lung targeted gene therapy. Substitution of tyrosine with phenylalanine residues (Y-F) in the capsid have been shown to protect the AAV vector from ubiquitin/proteasome degradation, increasing transduction efficiency. We tested the mutant Y733F-AAV8 vector for mucus diffusion, as well as the safety and efficacy of pigment epithelium-derived factor (PEDF) gene transfer to the lung.

Article	Year
Pros and cons of corticosteroid therapy for COVID-19 patients. Respiratory physiology & neurobiology\| PubMed ID: 32659271	2020
Tyrosine-Mutant AAV8 Vector Mediated Efficient and Safe Gene Transfer of Pigment Epithelium-Derived Factor to Mouse Lungs. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology\| PubMed ID: 37724045	2023

Fernanda Ferreira Cruz

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