an-open-source-normothermic-perfusion-system-designed-for-research

An Open-Source Normothermic Perfusion System Designed for Research Scientists

The integration of ex vivo perfusion machines for human organs prior to transplantation has improved outcomes for recipients and increased organ ...

National Institutes of Health

Pancreatic neuroendocrine neoplasms (pNENs) are a heterogeneous group of tumors derived from multiple neuroendocrine origin cell subtypes. Incidence rates for pNENs have steadily risen over the last decade, and outcomes continue to vary widely due to inability to properly screen. These tumors encompass a wide range of functional and non-functional subtypes, with their rarity and slow growth making therapeutic development difficult as most clinically used therapeutics are derived from retrospective analyses. Improved molecular understanding of these cancers has increased our knowledge of the tumor biology for pNENs. Despite these advances in our understanding of pNENs, there remains a dearth of models for further investigation. In this review, we will cover the current field of pNEN models, which include established cell lines, animal models such as mice and zebrafish, and three-dimensional (3D) cell models, and compare their uses in modeling various disease aspects. While no study model is a complete representation of pNEN biology, each has advantages which allow for new scientific understanding of these rare tumors. Future efforts and advancements in technology will continue to create new options in modeling these cancers.

Models in Pancreatic Neuroendocrine Neoplasms: Current Perspectives and Future Directions.

Treatment of advanced liver tumors remains challenging. Although immune checkpoint inhibition has revolutionized treatment for many cancers, responses in colorectal liver metastases and biliary tract cancers remain suboptimal. Investigation into additional immunomodulatory therapies for these cancers is needed. Interleukin-12 (IL-12) is a pro-inflammatory cytokine with robust anti-tumor activity, but systemic adverse effects largely terminated therapeutic development of recombinant human IL-12 (rhIL-12). PDS01ADC is a novel human monoclonal antibody (NHS76) conjugated to two IL-12 heterodimers with established safety in phase I trials. The NHS76 antibody specifically targets histone/DNA complexes which are accessible only in regions of cell death and this antibody has been shown to accumulate locally in tumors.

Hepatic artery infusion pump (HAIP) therapy in combination with targeted delivery of IL-12 for patients with metastatic colorectal cancer or intrahepatic cholangiocarcinoma: a phase II trial protocol.

To investigate if underrepresentation of racial and ethnic minorities exists in metastatic colorectal carcinoma (CRC) clinical trials.

Underrepresentation of Racial and Ethnic Minorities in Metastatic Colorectal Carcinoma Clinical Trials within the United States.

A Catalog Technique for Hepatic Cytoreductive Interventions in Patients With NETs: Aid for the Future Multidisciplinary Team.

The Annals of Surgical Oncology (ASO) launched a Social Media Committee in 2022 to strategically promote surgical science, boost journal impact, and raise awareness of cutting-edge research. This study investigated the impact of the ASO Social Media Committee on journal visibility, publication engagement, and article-level metrics.

Reflections From the Annals of Surgical Oncology Social Media Committee: The Impact of Promoting Surgical Science Online.

INSIGHT: A Phase III Trial of Ripretinib Versus Sunitinib in Patients with Advanced GIST with KIT Exon 11 and Exon 17/18 Mutations Who Were Previously Treated with Imatinib.

Article	Year
Models in Pancreatic Neuroendocrine Neoplasms: Current Perspectives and Future Directions. Cancers\| PubMed ID: 37568572	2023
Hepatic artery infusion pump (HAIP) therapy in combination with targeted delivery of IL-12 for patients with metastatic colorectal cancer or intrahepatic cholangiocarcinoma: a phase II trial... Journal of gastrointestinal oncology\| PubMed ID: 38989414	2024
Underrepresentation of Racial and Ethnic Minorities in Metastatic Colorectal Carcinoma Clinical Trials within the United States. Annals of surgery\| PubMed ID: 39145378	2024
A Catalog Technique for Hepatic Cytoreductive Interventions in Patients With NETs: Aid for the Future Multidisciplinary Team. Annals of surgical oncology\| PubMed ID: 39320402	2024
Reflections From the Annals of Surgical Oncology Social Media Committee: The Impact of Promoting Surgical Science Online. Annals of surgical oncology\| PubMed ID: 39532759	2025
INSIGHT: A Phase III Trial of Ripretinib Versus Sunitinib in Patients with Advanced GIST with KIT Exon 11 and Exon 17/18 Mutations Who Were Previously Treated with Imatinib. Annals of surgical oncology\| PubMed ID: 39907875	2025

Tracey Pu

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