application-of-32p-radioactive-patch-in-keloid-treatment

Application of 32P Radioactive Patch in Keloid Treatment

Keloid, as a benign fibroblastic disease of the skin, is the result of excessive proliferation of fibroblasts and abnormal deposition of collagen during ...

periodic-quality-control-methods-for-spect-ct

Periodic Quality Control Methods for SPECT-CT

In the field of medical imaging, gamma cameras, single photon emission computed tomography (SPECT), and SPECT/CT are critical diagnostic tools. Quality ...

combined-application-technetium-99m-sulfur-colloid-blue-dye-for

Combined Application of Technetium-99m Sulfur Colloid and Blue Dye for Sentinel Lymph Node Detection in Early-stage Breast Cancer

Sentinel lymph node biopsy (SLNB) is the standard procedure for axillary lymph node staging in breast cancer patients, and its application has prevented ...

dual-tracer-petct-imaging-using-18f-av-45-18f-av-1451-for-diagnosis

Dual-tracer PET/CT Imaging using 18F-AV-45 and 18F-AV-1451 for the Diagnosis of Alzheimer&#39;s Disease

Alzheimer&#8217;s disease (AD) is a progressive neurodegenerative disorder characterized by an insidious onset and gradual deterioration. Clinically, it ...

Zhejiang University School of Medicine

Fatty acid metabolism plays a critical role in cancer development. In this study, a novel medium-chain fatty acid (MCFA) PET tracer, 2-[F]fluorohexanoic acid (F-FHA), was successfully synthesized with high radiochemical yield (65 ± 5.4%) and purity (>99%). Tumor radiotracer uptake at 60 min in A431, Hek293, Kpc, 4T1, Hep3b, and Lm3 xenograft models was 7.1 ± 0.4, 8.8 ± 0.6, 7.7 ± 0.5, 7.2 ± 0.4, 5.1 ± 0.3, and 4.9 ± 0.3 percentage injected dose per gram (% ID/g), respectively. Pretreatment with salicylic acid (SA), an inhibitor of medium-chain acyl-CoA synthetase (ACSM), significantly enhanced tumor uptake ( < 0.05) but showed no effect on blood uptake ( = 0.115). The biodistribution analysis demonstrated that F-FHA exhibited rapid hepatic and cardiac accumulation followed by gradual clearance, whereas tumor uptake exhibited gradual elevation within the initial 20 min and remained relatively stable through the 90 min observation period. F-FHA warranted further investigation as a potential PET imaging agent for tumors.

Radiolabeling and Preclinical Evaluation of 2-[F]Fluorohexanoic Acid: A Novel Medium-Chain Fatty Acid Metabolism Tracer for PET Imaging of Tumors.

Accurate preoperative imaging localization is paramount to the success of targeted parathyroidectomy for primary hyperparathyroidism (PHPT). Four-dimensional (4D) CT is a promising method for preoperative localization of the parathyroid, but studies on the performance of 4D CT and technetium 99 m-sestamibi SPECT/CT for the diagnosis of diseases of the parathyroid are limited.

Comparison of four-dimensional CT and Sestamibi SPECTCT in the localization management of primary hyperparathyroidism.

The aim was to perform exploratory research on the application of technetium phytate (Tc-Phy) portal perfusion index (PPI) imaging in predicting the complications of hepatitis B cirrhosis and their severity.

99mTc-Phy portal perfusion index imaging helps predict the severity of hepatitis B virus cirrhosis: a preliminary study.

In China, the most populous developing country in the world, dementia represents a serious challenge. We performed a large-scale systematic review and meta-regression analysis to elucidate the prevalence of dementia and its subtypes and to identify potential factors underlying the differences between articles.

Prevalence of dementia in the People's Republic of China from 1985 to 2015: a systematic review and meta-regression analysis.

The prevalence of HIV among men who have sex with men (MSM) has become a significant public health challenge. The aim was to comprehensively estimate the national prevalence of HIV among MSM and its time trends through a large-scale systematic analysis.

The prevalence of HIV among MSM in China: a large-scale systematic analysis.

Parathyroid carcinoma and parathyromatosis are very rare diseases in patients on hemodialysis. Its pathogenesis, clinical features, preoperative diagnosis, and surgery are challenging. We describe a rare case of recurrent hyperparathyroidism due to synchronous parathyroid carcinoma and parathyromatosis.

ArticleTotal : 4	Year
Publication title	2025
Publication title	2025
Publication title	2025
Publication title	2026

Article	Year
Radiolabeling and Preclinical Evaluation of 2-[F]Fluorohexanoic Acid: A Novel Medium-Chain Fatty Acid Metabolism Tracer for PET Imaging of Tumors. Journal of medicinal chemistry\| PubMed ID: 40531657	2025
Comparison of four-dimensional CT and Sestamibi SPECTCT in the localization management of primary hyperparathyroidism. Cancer imaging : the official publication of the International Cancer Imaging Society\| PubMed ID: 40646585	2025
99mTc-Phy portal perfusion index imaging helps predict the severity of hepatitis B virus cirrhosis: a preliminary study. Nuclear medicine communications\| PubMed ID: 29877993	2018
Prevalence of dementia in the People's Republic of China from 1985 to 2015: a systematic review and meta-regression analysis. BMC public health\| PubMed ID: 31092218	2019
The prevalence of HIV among MSM in China: a large-scale systematic analysis. BMC infectious diseases\| PubMed ID: 31775654	2019
Recurrence hyperparathyroidism caused by synchronous parathyroid carcinoma and parathyromatosis in a patient with long-term hemodialysis. BMC nephrology\| PubMed ID: 37794407	2023

Xili Lu

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