Igor Kramnik

National Emerging Infectious Diseases Laboratories (NEIDL), Boston University

Affiliated withBoston University Boston University Chobanian and Avedisian School of Medicine

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2025

Other Publications

Article	Year
Mouse model of necrotic tuberculosis granulomas develops hypoxic lesions. The Journal of infectious diseases\| PubMed ID: 22198962	2012
Genome-wide RNAi screen in IFN-γ-treated human macrophages identifies genes mediating resistance to the intracellular pathogen Francisella tularensis. PloS one\| PubMed ID: 22359626	2012
Autophagy protein Rubicon mediates phagocytic NADPH oxidase activation in response to microbial infection or TLR stimulation. Cell host & microbe\| PubMed ID: 22423966	2012
The autophagy regulator Rubicon is a feedback inhibitor of CARD9-mediated host innate immunity. Cell host & microbe\| PubMed ID: 22423967	2012
Evaluation of a mouse model of necrotic granuloma formation using C3HeB/FeJ mice for testing of drugs against Mycobacterium tuberculosis. Antimicrobial agents and chemotherapy\| PubMed ID: 22470120	2012
Genetic dissection of pulmonary tuberculosis: implications for drug and vaccine development. Nihon Hansenbyo Gakkai zasshi = Japanese journal of leprosy : official organ of the Japanese Leprosy Association\| PubMed ID: 22586941	2012
Identification of regulators of the innate immune response to cytosolic DNA and retroviral infection by an integrative approach. Nature immunology\| PubMed ID: 23263557	2013
The sst1 resistance locus regulates evasion of type I interferon signaling by Chlamydia pneumoniae as a disease tolerance mechanism. PLoS pathogens\| PubMed ID: 24009502	2013
Limited activity of clofazimine as a single drug in a mouse model of tuberculosis exhibiting caseous necrotic granulomas. Antimicrobial agents and chemotherapy\| PubMed ID: 24798275	2014
Lung necrosis and neutrophils reflect common pathways of susceptibility to Mycobacterium tuberculosis in genetically diverse, immune-competent mice. Disease models & mechanisms\| PubMed ID: 26204894	2015
Mouse models of human TB pathology: roles in the analysis of necrosis and the development of host-directed therapies. Seminars in immunopathology\| PubMed ID: 26542392	2016
Fine-tuning of macrophage activation using synthetic rocaglate derivatives. Scientific reports\| PubMed ID: 27086720	2016
SP110b Controls Host Immunity and Susceptibility to Tuberculosis. American journal of respiratory and critical care medicine\| PubMed ID: 27858493	2017
Capacity of Pneumococci to Activate Macrophage Nuclear Factor κB: Influence on Necroptosis and Pneumonia Severity. The Journal of infectious diseases\| PubMed ID: 28368460	2017
Protection of macrophages from intracellular pathogens by miR-182-5p mimic-a gene expression meta-analysis approach. The FEBS journal\| PubMed ID: 29197182	2018
Spatial and temporal localization of immune transcripts defines hallmarks and diversity in the tuberculosis granuloma. Nature communications\| PubMed ID: 31015452	2019
Type I interferon-driven susceptibility to Mycobacterium tuberculosis is mediated by IL-1Ra. Nature microbiology\| PubMed ID: 31611644	2019
The Diversity Outbred Mouse Population Is an Improved Animal Model of Vaccination against Tuberculosis That Reflects Heterogeneity of Protection. mSphere\| PubMed ID: 32295871	2020
Publisher Correction: Type I interferon-driven susceptibility to Mycobacterium tuberculosis is mediated by IL-1Ra. Nature microbiology\| PubMed ID: 32300234	2020
SON DNA-binding protein mediates macrophage autophagy and responses to intracellular infection. FEBS letters\| PubMed ID: 32484234	2020
Editorial: Mycobacteria-Host Interactions: Genetics, Immunity, Pathology. Frontiers in cellular and infection microbiology\| PubMed ID: 33194847	2020
The integrated stress response mediates necrosis in murine Mycobacterium tuberculosis granulomas. The Journal of clinical investigation\| PubMed ID: 33301427	2021
Visualizing the dynamics of tuberculosis pathology using molecular imaging. The Journal of clinical investigation\| PubMed ID: 33645551	2021
Role of the transcriptional regulator SP140 in resistance to bacterial infections via repression of type I interferons. eLife\| PubMed ID: 34151776	2021
Channeling macrophage polarization by rocaglates increases macrophage resistance to . iScience\| PubMed ID: 34381970	2021
CXCL1: A new diagnostic biomarker for human tuberculosis discovered using Diversity Outbred mice. PLoS pathogens\| PubMed ID: 34403447	2021
Medium throughput protocol for genome-based quantification of intracellular mycobacterial loads and macrophage survival during infection. STAR protocols\| PubMed ID: 35310069	2022
Progression and Dissemination of Pulmonary Mycobacterium Avium Infection in a Susceptible Immunocompetent Mouse Model. International journal of molecular sciences\| PubMed ID: 35682679	2022
Cell state transition analysis identifies interventions that improve control of infection by susceptible macrophages. bioRxiv : the preprint server for biology\| PubMed ID: 36798271	2023
Adjunctive Integrated Stress Response Inhibition Accelerates Tuberculosis Clearance in Mice. mBio\| PubMed ID: 36853048	2023
The Many Hosts of Mycobacteria 9 (MHM9): A conference report. Tuberculosis (Edinburgh, Scotland)\| PubMed ID: 37531864	2023
Cell state transition analysis identifies interventions that improve control of infection by susceptible macrophages. Science advances\| PubMed ID: 37756395	2023
BACH1 promotes tissue necrosis and Mycobacterium tuberculosis susceptibility. Nature microbiology\| PubMed ID: 38066332	2024
Preclinical murine models for the testing of antimicrobials against Mycobacterium abscessus pulmonary infections: Current practices and recommendations. Tuberculosis (Edinburgh, Scotland)\| PubMed ID: 38729070	2024
Systems genetics uncover new loci containing functional gene candidates in Mycobacterium tuberculosis-infected Diversity Outbred mice. PLoS pathogens\| PubMed ID: 38861581	2024
B cells in perivascular and peribronchiolar granuloma-associated lymphoid tissue and B-cell signatures identify asymptomatic lung infection in Diversity Outbred mice. Infection and immunity\| PubMed ID: 38899881	2024
Protocol for 3D multiplexed fluorescent imaging of pulmonary TB lesions using Opal-TSA dyes for signal amplification. STAR protocols\| PubMed ID: 39982826	2025
Aberrant macrophage activation and maladaptive lung repair promote tuberculosis progression uniquely in the lung. bioRxiv : the preprint server for biology\| PubMed ID: 40093068	2025
Protocol for developing a mouse model of post-primary pulmonary tuberculosis after hematogenous spread in native lungs and lung implants. STAR protocols\| PubMed ID: 40714561	2025