G. Angus McQuibban

Department of Biochemistry, University of Toronto

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2025

Other Publications

Article	Year
Normal mitochondrial dynamics requires rhomboid-7 and affects Drosophila lifespan and neuronal function. Current biology : CB\| PubMed ID: 16713954	2006
Rhomboid-7 and HtrA2/Omi act in a common pathway with the Parkinson's disease factors Pink1 and Parkin. Disease models & mechanisms\| PubMed ID: 19048081	2008
The dynamin-related protein Mgm1p assembles into oligomers and hydrolyzes GTP to function in mitochondrial membrane fusion. Biochemistry\| PubMed ID: 19236101	2009
Phospholipid association is essential for dynamin-related protein Mgm1 to function in mitochondrial membrane fusion. The Journal of biological chemistry\| PubMed ID: 19703904	2009
A Drosophila mutant of LETM1, a candidate gene for seizures in Wolf-Hirschhorn syndrome. Human molecular genetics\| PubMed ID: 20026556	2010
Functional alteration of PARL contributes to mitochondrial dysregulation in Parkinson's disease. Human molecular genetics\| PubMed ID: 21355049	2011
The PARLance of Parkinson disease. Autophagy\| PubMed ID: 21471738	2011
The emerging role of proteolysis in mitochondrial quality control and the etiology of Parkinson's disease. Parkinson's disease\| PubMed ID: 22666630	2012
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy\| PubMed ID: 22966490	2012
Membrane tethering and nucleotide-dependent conformational changes drive mitochondrial genome maintenance (Mgm1) protein-mediated membrane fusion. The Journal of biological chemistry\| PubMed ID: 22977249	2012
Phosphatidylserine decarboxylase 1 (Psd1) promotes mitochondrial fusion by regulating the biophysical properties of the mitochondrial membrane and alternative topogenesis of mitochondrial ge... The Journal of biological chemistry\| PubMed ID: 23045528	2012
The mitochondrial rhomboid protease: its rise from obscurity to the pinnacle of disease-relevant genes. Biochimica et biophysica acta\| PubMed ID: 24099009	2013
The atypical cadherin fat directly regulates mitochondrial function and metabolic state. Cell\| PubMed ID: 25215488	2014
Mitochondrial Genome Maintenance 1 (Mgm1) Protein Alters Membrane Topology and Promotes Local Membrane Bending. Journal of molecular biology\| PubMed ID: 25784211	2015
Deubiquitinating enzymes regulate PARK2-mediated mitophagy. Autophagy\| PubMed ID: 25915564	2015
The Mitochondrial Rhomboid Protease PARL Is Regulated by PDK2 to Integrate Mitochondrial Quality Control and Metabolism. Cell reports\| PubMed ID: 28178523	2017
A Rhomboid in the Rough: Potent Inhibitors for a Previously Undruggable Target. Cell chemical biology\| PubMed ID: 29272699	2017
Cardiolipin synthesizing enzymes form a complex that interacts with cardiolipin-dependent membrane organizing proteins. Biochimica et biophysica acta. Molecular and cell biology of lipids\| PubMed ID: 29343430	2018
Deubiquitinating enzyme USP30 maintains basal peroxisome abundance by regulating pexophagy. The Journal of cell biology\| PubMed ID: 30700497	2019
USP30: protector of peroxisomes and mitochondria. Molecular & cellular oncology\| PubMed ID: 31131315	2019
Meiotic viral attenuation through an ancestral apoptotic pathway. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 31266891	2019
ROCK inhibitors upregulate the neuroprotective Parkin-mediated mitophagy pathway. Nature communications\| PubMed ID: 31900402	2020
Author Correction: Caenorhabditis elegans is a useful model for anthelmintic discovery. Nature communications\| PubMed ID: 32709866	2020
PEX13 prevents pexophagy by regulating ubiquitinated PEX5 and peroxisomal ROS. Autophagy\| PubMed ID: 36541703	2023
PRKN/parkin-mediated mitophagy is induced by the probiotics and . Autophagy\| PubMed ID: 36708254	2023
An AI-guided screen identifies probucol as an enhancer of mitophagy through modulation of lipid droplets. PLoS biology\| PubMed ID: 36862640	2023
From jeopardy champion to drug discovery; semantic similarity artificial intelligence. Autophagy\| PubMed ID: 37179524	2024
PGAM5 is an MFN2 phosphatase that plays an essential role in the regulation of mitochondrial dynamics. Cell reports\| PubMed ID: 37498743	2023
Protocol for evaluating mitochondrial morphology changes in response to CCCP-induced stress through open-source image processing software. STAR protocols\| PubMed ID: 38039137	2023