a-murine-model-of-carotid-aneurysm-formation

A Murine Model of Carotid Aneurysm Formation

Cerebral aneurysms are present in approximately 2%-5% of the population and represent a significant public health concern due to their high rates of ...

University of Pittsburgh Medical Center

Establishing central venous access is important to provide fluid resuscitation or medications intravenously to patients.

Intraoperative ultrasound evidence of accidental simultaneous cannulation of the common carotid artery and internal jugular vein: illustrative case.

Patients with Hunt-Hess (HH)5 aneurysmal subarachnoid hemorrhage (SAH) have high mortality rates. Despite an initial moribund exam, a subset of patients progress to favorable outcomes.

Hunt-Hess Score at 48 Hours Improves Prognostication in Grade 5 Aneurysmal Subarachnoid Hemorrhage.

An arachnoid web is a pathological formation of the arachnoid membrane. It is a rare phenomenon but is known to lead to syrinx formation in the spinal cord along with pain and neurological deficits. On imaging, the 'scalpel sign' is pathognomonic for an arachnoid web. The etiology of syrinx formation from an arachnoid web is currently unknown. This report documents the only two cases of arachnoid webs with an extensive syrinx in which a likely pathophysiologic mechanism is identified. Both cases presented with motor deficits. The patients had no history of trauma or infection. After extensive workup in both patients and observation of the scalpel sign an arachnoid web was suspected. In both cases, the patients were treated surgically after an arachnoid web was suspected. Intra-operative ultrasound visualized in both cases demonstrates a fenestration in the web that allowed passage of cerebrospinal fluid in a rostral-caudal direction due to a ball-valve effect.

Arachnoid webs causing rostral syrinx due to ball-valve effect: an illustrative report of two cases.

Recent literature suggests that spinal infections are increasing in prevalence. Any compartment can be infected in the spine; however, multicompartmental infections are rare.

Tetra-compartmental spinal infection with conus medullaris syndrome: illustrative case.

Intracranial aneurysms are reported to affect 2-5% of the population. Despite advances in the surgical management of this disease, diagnostic technologies have marginally improved and still rely on expensive or invasive imaging procedures. Currently, there is no blood-based test to detect cerebral aneurysm formation or quantify the risk of rupture. The aim of this review is to summarize current literature on the mechanism of aneurysm formation, specifically studies relating to inflammation, and provide a rationale and commentary on a hypothetical future blood-based test. Efforts should be focused on clinical-translational approaches to create an assay to screen for cerebral aneurysm presence and risk-stratify patients to allow for superior treatment timing and management. Cerebral Aneurysm Blood Test Considerations: There are multiple caveats to development of a putative blood test to detect cerebral aneurysm presence.

A Future Blood Test to Detect Cerebral Aneurysms.

Randomized controlled trials demonstrate that endovascular techniques yield improved outcomes compared with microsurgical approaches. However, not all patients are suitable candidates for endovascular management. This study aimed to determine if healthy patients managed microsurgically could achieve functional outcomes comparable to patients managed endovascularly.

Subarachnoid Hemorrhage Outcomes in an Endovascular Right of First Refusal Neurosurgical Environment.

Cerebral vasospasm and the resultant delayed cerebral infarction is a significant source of mortality following aneurysmal SAH. Vasospasm is currently detected using invasive or expensive imaging at regular intervals in patients following SAH, thus posing a risk of complications following the procedure and financial burden on these patients. Currently, there is no blood-based test to detect vasospasm.

Advances in biomarkers for vasospasm - Towards a future blood-based diagnostic test.

Relationships between industry and physicians are critical for innovation in the field of arthroplasty surgery. However, these relationships can present a conflict of interest (COI) for medical research and are required to be disclosed by most journals. The rate of accurate disclosures by physicians has not been studied in arthroplasty surgery.

Article	Year
Intraoperative ultrasound evidence of accidental simultaneous cannulation of the common carotid artery and internal jugular vein: illustrative case. Journal of neurosurgery. Case lessons\| PubMed ID: 36083774	2022
Hunt-Hess Score at 48 Hours Improves Prognostication in Grade 5 Aneurysmal Subarachnoid Hemorrhage. World neurosurgery\| PubMed ID: 36627019	2023
Arachnoid webs causing rostral syrinx due to ball-valve effect: an illustrative report of two cases. British journal of neurosurgery\| PubMed ID: 36636902	2024
Tetra-compartmental spinal infection with conus medullaris syndrome: illustrative case. Journal of neurosurgery. Case lessons\| PubMed ID: 36748756	2023
A Future Blood Test to Detect Cerebral Aneurysms. Cellular and molecular neurobiology\| PubMed ID: 37046105	2023
Subarachnoid Hemorrhage Outcomes in an Endovascular Right of First Refusal Neurosurgical Environment. World neurosurgery\| PubMed ID: 37879435	2024
Advances in biomarkers for vasospasm - Towards a future blood-based diagnostic test. World neurosurgery: X\| PubMed ID: 38487683	2024
Conflict of Interest Disclosure in American Arthroplasty Surgical Literature. Arthroplasty today\| PubMed ID: 39959372	2024

Aditya M. Mittal

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