differences-between-vestibular-migraine-meniere-s-disease-based-on

Differences Between Vestibular Migraine and Meniere's Disease Based on Cochlear-Vestibular Function Assessment: A 6-Year Retrospective Clinical Study

Audiological and vestibular function tests are the most commonly used noninvasive evaluation methods for vertigo diseases. Preliminary studies have shown ...

Sun Yat-sen University

 Direction-changing positional nystagmus (DCPN) had been observed as persistent horizontal apogeotropic and was considered as "cupulolithiasis or heavy cupula. " Recently, the concept of "light cupula" exhibiting persistent geotropic DCPN has been introduced. However, the light cupula is not systematically described, while the identification and diagnosis of "light cupula" should be improved. Here we investigated the underlying characteristics and therapeutic options designed to the "light" and "heavy" cupula, respectively; and summarized the clinical characteristics and therapeutic effect in the two groups.  A total of 359 cases with vertigo and bilateral DCPN were found in the supine roll test. Only 25 patients with persistent DCPN were enrolled and followed up. According to the direction of nystagmus, we further divided the patients into "heavy cupula" (apogeotropic) and "light cupula" (geotropic) groups. We compared the incidence, characteristics of nystagmus and the efficacy of repositioning maneuver in the two groups.  Nine patients with persistent horizontal geotropic DCPN were confirmed as "light cupula," other 16 patients with persistent horizontal ageotropic DCPN were confirmed as heavy cupula. All 25 patients had null plane; the mean value and standard deviation of the null plane in light cupula and heavy cupula was 25.67 ± 9.31° and 27.06 ± 6.29°, respectively. The mean value and standard deviation of the termination plane in light cupula was 28.78 ± 10.00°, and 30.25 ± 6.53° in heavy cupula. There was no statistical significance between the two groups. We found that the direction of evoked nystagmus in the supine position was toward the intact side in light cupula, while in heavy cupula, it was toward the lesion side. The null plane appeared on the lesion side. For light cupula patients, the effect was not obvious at Day-7 after the treatment, however, treatment for most heavy cupula patients were effective. All patients recovered after 30 days of treatment.  The null plane is crucial in determining the lesion side for light or heavy cupula. Although the short-term therapeutic effect of the light cupula is not as promising as the effect seen in heavy cupula, the long-term prognosis in both groups is comparable; with all patients recovered after 30 days of treatment.  This is a retrospective cohort study.

Clinical Findings in Patients With Persistent Positional Nystagmus: The Designation of "Heavy and Light Cupula".

Patients with age-related hearing loss face hearing difficulties in daily life. The causes of age-related hearing loss are complex and include changes in peripheral hearing, central processing, and cognitive-related abilities. Furthermore, the factors by which aging relates to hearing loss via changes in auditory processing ability are still unclear. In this cross-sectional study, we evaluated 27 older adults (over 60 years old) with age-related hearing loss, 21 older adults (over 60 years old) with normal hearing, and 30 younger subjects (18-30 years old) with normal hearing. We used the outcome of the upper-threshold test, including the time-compressed threshold and the speech recognition threshold in noisy conditions, as a behavioral indicator of auditory processing ability. We also used electroencephalography to identify presbycusis-related abnormalities in the brain while the participants were in a spontaneous resting state. The time-compressed threshold and speech recognition threshold data indicated significant differences among the groups. In patients with age-related hearing loss, information masking (babble noise) had a greater effect than energy masking (speech-shaped noise) on processing difficulties. In terms of resting-state electroencephalography signals, we observed enhanced frontal lobe (Brodmann's area, BA11) activation in the older adults with normal hearing compared with the younger participants with normal hearing, and greater activation in the parietal (BA7) and occipital (BA19) lobes in the individuals with age-related hearing loss compared with the younger adults. Our functional connection analysis suggested that compared with younger people, the older adults with normal hearing exhibited enhanced connections among networks, including the default mode network, sensorimotor network, cingulo-opercular network, occipital network, and frontoparietal network. These results suggest that both normal aging and the development of age-related hearing loss have a negative effect on advanced auditory processing capabilities and that hearing loss accelerates the decline in speech comprehension, especially in speech competition situations. Older adults with normal hearing may have increased compensatory attentional resource recruitment represented by the top-down active listening mechanism, while those with age-related hearing loss exhibit decompensation of network connections involving multisensory integration.

Age-related hearing loss accelerates the decline in fast speech comprehension and the decompensation of cortical network connections.

To investigate potential differences in absolute deviation values of subjective visual vertical and horizontal between unilateral acoustic neuroma patients and healthy young adults under varying degrees of static head tilt, as well as the impact of proprioception on these values, with the aim of determining the effect of acoustic neuroma on gravity sensory pathway function in patients.

Evaluation of subjective visual vertical and horizontal in patients with acoustic neuroma based on virtual reality.

This study aims to investigate whether artificial intelligence can improve the diagnostic accuracy of vertigo related diseases.

Development and Validation of a Machine Learning Model for Detection and Classification of Vertigo.

To investigate the relationship and differences between caloric test (CT) and video head impulse test (vHIT) in assessing vestibular function in patients with unilateral peripheral vertigo, and to comprehensively understand the functional status of horizontal and vertical (posterior and anterior) semicircular canals (SCCs).

Analysis of Vestibular Function Assessment Methods for Patients With Peripheral Vertigo Disease: A 5-Year Retrospective Study.

Achieving high-performance flexible organic thin-film transistors (OTFTs) operating at low voltages is vital for next-generation electronics. Here, we report a novel ladder-like polysilsesquioxane (LPSQ) dielectric with nanoscale functionalities (long alkyl chains and epoxy groups) that simultaneously enhance organic semiconductor (OSC) self-assembly and dielectric performance. Alkyl chains promote chain-on crystallization of C10-DNTT, while epoxy groups boost dielectric polarization and enable UV photopatterning. This yields an ultralow interface trap density of 6.00 × 10 cm and record-high hole mobility of 15.55 cm/V·s at 5 V. The resulting OTFTs show excellent stability (threshold shift < 1 V over 200 min) and robust flexibility on PET substrates. Moreover, leveraging the dielectric's patternability, fully solution-processed flexible logic circuits (inverters and NAND/NOR gates) with voltage gains of up to 37.2 at 5 V are demonstrated. This work provides a molecular design strategy for high-k LPSQ dielectrics toward practical low-voltage flexible electronics.

Article	Year
Clinical Findings in Patients With Persistent Positional Nystagmus: The Designation of "Heavy and Light Cupula". Frontiers in neurology\| PubMed ID: 31024424	2019
Age-related hearing loss accelerates the decline in fast speech comprehension and the decompensation of cortical network connections. Neural regeneration research\| PubMed ID: 36926721	2023
Evaluation of subjective visual vertical and horizontal in patients with acoustic neuroma based on virtual reality. Frontiers in neuroscience\| PubMed ID: 37954872	2023
Development and Validation of a Machine Learning Model for Detection and Classification of Vertigo. The Laryngoscope\| PubMed ID: 39698985	2025
Analysis of Vestibular Function Assessment Methods for Patients With Peripheral Vertigo Disease: A 5-Year Retrospective Study. Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery\| PubMed ID: 40457759	2025
Nanoscale Engineering of Ladder-Like Polysilsesquioxane Dielectric Surfaces Enables High-Performance Flexible Electronics. Nano letters\| PubMed ID: 40658877	2025

Xiaowu Tang

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