the-impact-cyp3a4-comt-v158m-oprm-a118g-gene-polymorphisms-on

The Impact of CYP3A4, COMT V158M, and OPRM A118G Gene Polymorphisms on the Effectiveness of Sufentanil in Labor Analgesia

Genetic polymorphisms in CYP3A4, COMT V158M, and OPRM A118G may influence analgesic response, hemodynamic regulation, and postpartum recovery, while ...

Xiamen University

Kidney is sensitive to ischemia-reperfusion (I/R) injury because of its special structure and function. In this study, we aimed to explore the mechanism of desflurane (DFE) preconditioning effecting on renal I/R injury in rats.

Desflurane Preconditioning Protects Against Renal Ischemia-Reperfusion Injury and Inhibits Inflammation and Oxidative Stress in Rats Through Regulating the Nrf2-Keap1-ARE Signaling Pathway.

This study aims to analyze the influence of different dexmedetomidine doses on cognitive function. It works on early periods of patients undergoing laparoscopic extensive total hysterectomy.

The Influence of Different Dexmedetomidine Doses on Cognitive Function at Early Period of Patients Undergoing Laparoscopic Extensive Total Hysterectomy.

 This study investigated the use of  G1947A and  A118G polymorphisms as predictive markers for sufentanil epidural analgesia.  The visual analogue scale (VAS) score, and sufentanil consumption of 136 pairs of parturients using sufentanil with lidocaine and ropivacaine for epidural analgesia were used for analysis.   AG/GG had lower VAS score difference between fifth and 0 min (1.55 vs 1.87; p = 0.012) and higher consumption (19.65 μg vs 17.11 μg; p = 0.049) than AA carriers.  GA/AA had higher VAS score difference than GG carriers (1.86 vs 1.55; p = 0.021).  Sufentanil may provide better epidural labor analgesia in  AA and  GA/AA carriers compared with  AG/GG and  GG carriers. : ChiCTR1900026897 (Chinese Clinical Trial Center Registry).

Effect of  gene polymorphisms on sufentanil labor analgesia: a cohort study based on propensity score matching.

To analyze the outcome of 147 cases of type B aortic dissection with thoracic endovascular aortic repair (TEVAR).

Article	Year
Desflurane Preconditioning Protects Against Renal Ischemia-Reperfusion Injury and Inhibits Inflammation and Oxidative Stress in Rats Through Regulating the Nrf2-Keap1-ARE Signaling Pathway. Drug design, development and therapy\| PubMed ID: 32308368	2020
The Influence of Different Dexmedetomidine Doses on Cognitive Function at Early Period of Patients Undergoing Laparoscopic Extensive Total Hysterectomy. Journal of healthcare engineering\| PubMed ID: 34621501	2021
Effect of gene polymorphisms on sufentanil labor analgesia: a cohort study based on propensity score matching. Pharmacogenomics\| PubMed ID: 37610885	2023
Complications after treatment of type B aortic dissection with TEVAR stent-graft deployment in zone 2. BMC cardiovascular disorders\| PubMed ID: 39934656	2025

Huiqiong Huang

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