Takaaki Abe

Department of Clinical Biology and Hormonal Regulation, Tohoku University Graduate School of Medicine

Affiliated withTohoku University Graduate School of Medicine

Research Area

Biography

Takaaki Abe has not added Biography.
If you are Takaaki Abe and would like to personalize this page please email our Author Liaison for assistance.

JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 1	2025

Other Publications

Article	Year
Distribution of organic anion-transporting polypeptide 2 (oatp2) and oatp3 in the rat retina. Investigative ophthalmology & visual science\| PubMed ID: 11867608	2002
Thyroid hormone transporters: recent advances. Trends in endocrinology and metabolism: TEM\| PubMed ID: 12185668	2002
Identification and characterization of novel rat and human gonad-specific organic anion transporters. Molecular endocrinology (Baltimore, Md.)\| PubMed ID: 12677006	2003
Differential inhibition of transient outward currents of Kv1.4 and Kv4.3 by endothelin. Biochemical and biophysical research communications\| PubMed ID: 14521958	2003
Distribution of rat organic anion transporting polypeptide-E (oatp-E) in the rat eye. Investigative ophthalmology & visual science\| PubMed ID: 14578412	2003
Successful treatment of severe hypertension with the combination of angiotensin converting enzyme inhibitor and angiotensin II receptor blocker. Hypertension research : official journal of the Japanese Society of Hypertension\| PubMed ID: 14621191	2003
Molecular characterization of human and rat organic anion transporter OATP-D. American journal of physiology. Renal physiology\| PubMed ID: 14631946	2003
Isolation and characterization of a digoxin transporter and its rat homologue expressed in the kidney. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 14993604	2004
PDZ binding motif-dependent localization of K+ channel on the basolateral side in distal tubules. American journal of physiology. Renal physiology\| PubMed ID: 15292049	2004
[Pheochromocytoma]. Nihon rinsho. Japanese journal of clinical medicine\| PubMed ID: 15506388	2004
Plasma renin activity revealed renal artery stenosis concealed by aneurysms. Urology\| PubMed ID: 15780390	2005
[Reninoma]. Nihon rinsho. Japanese journal of clinical medicine\| PubMed ID: 15813057	2005
Bilateral calcified renal artery aneurysms in a patient with von Recklinghausen's disease. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association\| PubMed ID: 15831552	2005
Cutting balloon angioplasty of resistant renal artery stenosis caused by fibromuscular dysplasia. Journal of vascular surgery\| PubMed ID: 15886679	2005
PDZ-binding and di-hydrophobic motifs regulate distribution of Kir4.1 channels in renal cells. Journal of the American Society of Nephrology : JASN\| PubMed ID: 16033858	2005
Predictors of undiagnosed renal artery stenosis among Japanese patients with risk factors of atherosclerosis. Hypertension research : official journal of the Japanese Society of Hypertension\| PubMed ID: 16097367	2005
Renal artery dissection after angiographic evaluation of lower extremities. Hypertension research : official journal of the Japanese Society of Hypertension\| PubMed ID: 16471180	2005
[Ectopic renin-producing tumor]. Nihon rinsho. Japanese journal of clinical medicine\| PubMed ID: 17022554	2006
A case surviving for over a year of renal tubular dysgenesis with compound heterozygous angiotensinogen gene mutations. American journal of medical genetics. Part A\| PubMed ID: 17036344	2006
Aldosterone-producing adenoma accompanied with renal artery stenosis. Journal of nephrology\| PubMed ID: 17048216	2006
Expression of organic cation transporter SLC22A16 in human endometria. International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists\| PubMed ID: 17197897	2007
Expression of organic cation transporter SLC22A16 in human epithelial ovarian cancer: a possible role of the adriamycin importer. International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists\| PubMed ID: 17581421	2007
Mesangial proliferative glomerulonephritis with aldosterone-producing adenoma. Clinical and experimental nephrology\| PubMed ID: 17593517	2007
Human liver-specific organic anion transporter-2 is a potent prognostic factor for human breast carcinoma. Cancer science\| PubMed ID: 17760952	2007
Dilation of renal artery stenosis after administration of losartan. Hypertension research : official journal of the Japanese Society of Hypertension\| PubMed ID: 18049033	2007
Immunohistochemistry of a proliferation marker Ki67/MIB1 in adrenocortical carcinomas: Ki67/MIB1 labeling index is a predictor for recurrence of adrenocortical carcinomas. Endocrine journal\| PubMed ID: 18187873	2008
MAGI-1a functions as a scaffolding protein for the distal renal tubular basolateral K+ channels. The Journal of biological chemistry\| PubMed ID: 18303016	2008
Thyroid hormone transporters in the brain. Cerebellum (London, England)\| PubMed ID: 18418673	2008
Hypocalcemia in a patient with severe hypertension and surgically induced relative hypoparathyroidism. Journal of bone and mineral metabolism\| PubMed ID: 18470673	2008
Angiographic index for angioplasty-treatable atheromatous renal artery stenosis. Hypertension research : official journal of the Japanese Society of Hypertension\| PubMed ID: 18712043	2008
Hemodynamic index of atheromatous renal artery stenosis for angioplasty. Clinical journal of the American Society of Nephrology : CJASN\| PubMed ID: 19261820	2009
SLCO4C1 transporter eliminates uremic toxins and attenuates hypertension and renal inflammation. Journal of the American Society of Nephrology : JASN\| PubMed ID: 19875811	2009
The HMG-CoA reductase inhibitor pravastatin stimulates insulin secretion through organic anion transporter polypeptides. Drug metabolism and pharmacokinetics\| PubMed ID: 20610886	2010
Metabolomic profiling of uremic solutes in CKD patients. Hypertension research : official journal of the Japanese Society of Hypertension\| PubMed ID: 20613759	2010
Stage of chronic kidney disease is an outcome-predicting factor of angioplasty for atheromatous renal artery stenosis. Hypertension research : official journal of the Japanese Society of Hypertension\| PubMed ID: 20703231	2010
Luminal alkalinization attenuates proteinuria-induced oxidative damage in proximal tubular cells. Journal of the American Society of Nephrology : JASN\| PubMed ID: 21372211	2011
Transcriptional regulation of organic anion transporting polypeptide SLCO4C1 as a new therapeutic modality to prevent chronic kidney disease. Journal of pharmaceutical sciences\| PubMed ID: 21656517	2011
Metabolomic profiling of the autosomal dominant polycystic kidney disease rat model. Clinical and experimental nephrology\| PubMed ID: 21695416	2011
A metabolomic approach to clarifying the effect of AST-120 on 5/6 nephrectomized rats by capillary electrophoresis with mass spectrometry (CE-MS). Toxins\| PubMed ID: 23202318	2012
Mutation of the Mg2+ transporter SLC41A1 results in a nephronophthisis-like phenotype. Journal of the American Society of Nephrology : JASN\| PubMed ID: 23661805	2013
Indoxyl sulfate down-regulates SLCO4C1 transporter through up-regulation of GATA3. PloS one\| PubMed ID: 23874392	2013
Proteomics and metabolomics as tools to unravel novel culprits and mechanisms of uremic toxicity: instrument or hype? Seminars in nephrology\| PubMed ID: 24780472	2014
Conformational change in transfer RNA is an early indicator of acute cellular damage. Journal of the American Society of Nephrology : JASN\| PubMed ID: 24833129	2014
Exonic mutations in the SLC12A3 gene cause exon skipping and premature termination in Gitelman syndrome. Journal of the American Society of Nephrology : JASN\| PubMed ID: 25060058	2015
Alteration of the Intestinal Environment by Lubiprostone Is Associated with Amelioration of Adenine-Induced CKD. Journal of the American Society of Nephrology : JASN\| PubMed ID: 25525179	2015
Posterior reversible encephalopathy syndrome treated with renin-angiotensin system blockade. Journal of the neurological sciences\| PubMed ID: 26073482	2015
Mitochonic Acid 5 (MA-5), a Derivative of the Plant Hormone Indole-3-Acetic Acid, Improves Survival of Fibroblasts from Patients with Mitochondrial Diseases. The Tohoku journal of experimental medicine\| PubMed ID: 26118651	2015
Quantitative Targeted Proteomics of Pancreatic Cancer: Deoxycytidine Kinase Protein Level Correlates to Progression-Free Survival of Patients Receiving Gemcitabine Treatment. Molecular pharmaceutics\| PubMed ID: 26280109	2015
Impact of Small Renal Ischemia in Hypertension Development: Renovascular Hypertension Caused by Small Branch Artery Stenosis. Journal of clinical hypertension (Greenwich, Conn.)\| PubMed ID: 26293888	2016
Detection of Segmental Renal Ischemia by Diffusion-Weighted Magnetic Resonance Imaging: Clinical Utility for Diagnosis of Renovascular Hypertension. Journal of clinical hypertension (Greenwich, Conn.)\| PubMed ID: 26360321	2016
Quantitative Targeted Absolute Proteomics for 28 Transporters in Brush-Border and Basolateral Membrane Fractions of Rat Kidney. Journal of pharmaceutical sciences\| PubMed ID: 26367854	2016
Immuno-Northern Blotting: Detection of RNA Modifications by Using Antibodies against Modified Nucleosides. PloS one\| PubMed ID: 26606401	2015
Mitochonic Acid 5 Binds Mitochondria and Ameliorates Renal Tubular and Cardiac Myocyte Damage. Journal of the American Society of Nephrology : JASN\| PubMed ID: 26609120	2016
Metabolic alterations by indoxyl sulfate in skeletal muscle induce uremic sarcopenia in chronic kidney disease. Scientific reports\| PubMed ID: 27830716	2016
'Lead pipe'-like stiff aorta with grossly widened pulse pressure in burned-out Takayasu arteritis. European heart journal. Cardiovascular Imaging\| PubMed ID: 28369232	2017
Evaluation of the impact of gut microbiota on uremic solute accumulation by a CE-TOFMS-based metabolomics approach. Kidney international\| PubMed ID: 28396122	2017
A novel indole compound MA-35 attenuates renal fibrosis by inhibiting both TNF-α and TGF-β pathways. Scientific reports\| PubMed ID: 28507324	2017
Selective embolization therapy for intrarenal artery stenosis causing renovascular hypertension: Efficacy and follow-up renal imaging. Journal of clinical hypertension (Greenwich, Conn.)\| PubMed ID: 28560752	2017
Mitochonic Acid 5 (MA-5) Facilitates ATP Synthase Oligomerization and Cell Survival in Various Mitochondrial Diseases. EBioMedicine\| PubMed ID: 28579242	2017
Urinary stones resembling uric acid stones. NDT plus\| PubMed ID: 28657042	2010
Acute Kidney Injury from Excessive Potentiation of Calcium-channel Blocker via Synergistic CYP3A4 Inhibition by Clarithromycin Plus Voriconazole. Internal medicine (Tokyo, Japan)\| PubMed ID: 28674358	2017
Inherited, not acquired, Gitelman syndrome in a patient with Sjögren's syndrome: importance of genetic testing to distinguish the two forms. CEN case reports\| PubMed ID: 28819721	2017
The Piezo Actuator-Driven Pulsed Water Jet System for Minimizing Renal Damage after Off-Clamp Laparoscopic Partial Nephrectomy. The Tohoku journal of experimental medicine\| PubMed ID: 28943598	2017
Canagliflozin reduces plasma uremic toxins and alters the intestinal microbiota composition in a chronic kidney disease mouse model. American journal of physiology. Renal physiology\| PubMed ID: 29167170	2018
Focal Segmental Glomerulosclerosis Associated with Chronic Progressive External Ophthalmoplegia and Mitochondrial DNA A3243G Mutation. Nephron\| PubMed ID: 29190634	2018
Impact of the Oral Adsorbent AST-120 on Organ-Specific Accumulation of Uremic Toxins: LC-MS/MS and MS Imaging Techniques. Toxins\| PubMed ID: 29283413	2017
Stress-induced tRNA cleavage and tiRNA generation in rat neuronal PC12 cells. Journal of neurochemistry\| PubMed ID: 29431851	2018
Renovascular hypertension associated with JAK2 V617F positive myeloproliferative neoplasms treated with angioplasty: 2 cases and literature review. Journal of clinical hypertension (Greenwich, Conn.)\| PubMed ID: 29656438	2018
Low frequency of cervicocranial artery involvement in Japanese with renal artery fibromuscular dysplasia compared with that of Caucasians. Clinical and experimental nephrology\| PubMed ID: 29679353	2018
Crossroads of metabolism and CKD. Kidney international\| PubMed ID: 30031444	2018
Effects of a Novel Piezo Actuator-driven Pulsed Water Jet System on Residual Kidney After Partial Nephrectomy in a Rat Model. Urology\| PubMed ID: 30359707	2019
Immuno-Northern Blotting: Detection of Modified RNA Using Gel Separation and Antibodies to Modified Nucleosides. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 30539555	2019
tiRNAs as a novel biomarker for cell damage assessment in in vitro ischemia-reperfusion model in rat neuronal PC12 cells. Brain research\| PubMed ID: 30779912	2019
Gut microbiome-derived phenyl sulfate contributes to albuminuria in diabetic kidney disease. Nature communications\| PubMed ID: 31015435	2019
Apomorphine rescues reactive oxygen species-induced apoptosis of fibroblasts with mitochondrial disease. Mitochondrion\| PubMed ID: 31356884	2019
The guanylate cyclase C agonist linaclotide ameliorates the gut-cardio-renal axis in an adenine-induced mouse model of chronic kidney disease. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association\| PubMed ID: 31411705	2020
The indole compound MA-35 attenuates tumorigenesis in an inflammation-induced colon cancer model. Scientific reports\| PubMed ID: 31484999	2019
Drugs Repurposed as Antiferroptosis Agents Suppress Organ Damage, Including AKI, by Functioning as Lipid Peroxyl Radical Scavengers. Journal of the American Society of Nephrology : JASN\| PubMed ID: 31767624	2020
Apparent Diffusion Coefficient in the Resolution of Renal Ischemia after Angioplasty on Diffusion-weighted Imaging: Renal Artery Stenosis Caused by Progressive Thrombosis in Residual Chronic... Internal medicine (Tokyo, Japan)\| PubMed ID: 31956203	2020
Isolation and initial structure-functional characterization of endogenous tRNA-derived stress-induced RNAs. RNA biology\| PubMed ID: 32116132	2020
HPRT-related hyperuricemia with a novel p.V35M mutation in HPRT1 presenting familial juvenile gout. CEN case reports\| PubMed ID: 32128695	2020
Effects of the oral adsorbent AST-120 on fecal p-cresol and indole levels and on the gut microbiota composition. Biochemical and biophysical research communications\| PubMed ID: 32147096	2020
Patient hiPSCs Identify Vascular Smooth Muscle Arylacetamide Deacetylase as Protective against Atherosclerosis. Cell stem cell\| PubMed ID: 32413331	2020
Kidney enlargement effect of angioplasty for nonatherosclerotic renovascular disease: reversibility of ischemic kidney. Hypertension research : official journal of the Japanese Society of Hypertension\| PubMed ID: 32444857	2020
The stress specific impact of ALKBH1 on tRNA cleavage and tiRNA generation. RNA biology\| PubMed ID: 32521209	2020
Uric Acid Elevation by Favipiravir, an Antiviral Drug. The Tohoku journal of experimental medicine\| PubMed ID: 32536670	2020
Concurrent analogous organ damage in the brain, eyes, and kidneys in malignant hypertension: reversible encephalopathy, serous retinal detachment, and proteinuria. Hypertension research : official journal of the Japanese Society of Hypertension\| PubMed ID: 32719463	2021
Mitochondrial dysfunction in GnRH neurons impaired GnRH production. Biochemical and biophysical research communications\| PubMed ID: 32828307	2020
Treatment of Refractory Hypertension with Timely Angioplasty in Total Renal Artery Occlusion with Atrophic Kidney. Internal medicine (Tokyo, Japan)\| PubMed ID: 32830180	2021
Germ-Free Conditions Modulate Host Purine Metabolism, Exacerbating Adenine-Induced Kidney Damage. Toxins\| PubMed ID: 32859011	2020
Prediction of Functional Outcome in Patients with Acute Stroke by Measuring tRNA Derivatives. Cerebrovascular diseases (Basel, Switzerland)\| PubMed ID: 33207351	2020
Mitochondrial dysfunction underlying sporadic inclusion body myositis is ameliorated by the mitochondrial homing drug MA-5. PloS one\| PubMed ID: 33264289	2020
L-type amino acid transporter 1 is associated with chemoresistance in breast cancer via the promotion of amino acid metabolism. Scientific reports\| PubMed ID: 33436954	2021
Effect of uremic toxins on hippocampal cell damage: analysis in vitro and in rat model of chronic kidney disease. Heliyon\| PubMed ID: 33659745	2021
CE-MS-Based Identification of Uremic Solutes Specific to Hemodialysis Patients. Toxins\| PubMed ID: 33946481	2021
Fibromuscular dysplasia with recurrence after "long-term" following percutaneous transcatheter renal angioplasty: two case reports with a review of 26 patients. BMC nephrology\| PubMed ID: 34016044	2021
Ndufs4 ablation decreases synaptophysin expression in hippocampus. Scientific reports\| PubMed ID: 34040028	2021
RNA digestion provides insights into the angiogenin's specificity towards transfer RNAs. RNA biology\| PubMed ID: 34085908	2021
Targeting Amino Acid Metabolic Reprogramming via L-Type Amino Acid Transporter 1 (LAT1) for Endocrine-Resistant Breast Cancer. Cancers\| PubMed ID: 34503187	2021
Mitochonic acid-5 ameliorates chlorhexidine gluconate-induced peritoneal fibrosis in mice. Medical molecular morphology\| PubMed ID: 34622315	2022
A massive natural disaster, the Great East Japan Earthquake, and the incidence of dialysis due to end-stage kidney disease. Journal of nephrology\| PubMed ID: 34642850	2022
Role of the microbiota in hypertension and antihypertensive drug metabolism. Hypertension research : official journal of the Japanese Society of Hypertension\| PubMed ID: 34887530	2022
SGLT-1-specific inhibition ameliorates renal failure and alters the gut microbial community in mice with adenine-induced renal failure. Physiological reports\| PubMed ID: 34921520	2021
(+)-Sesamin, a sesame lignan, is a potent inhibitor of gut bacterial tryptophan indole-lyase that is a key enzyme in chronic kidney disease pathogenesis. Biochemical and biophysical research communications\| PubMed ID: 34974305	2022
Gut Microbiota Dynamics and Uremic Toxins. Toxins\| PubMed ID: 35202173	2022
Selective Cleavage at CCA Ends and Anticodon Loops of tRNAs by Stress-Induced RNases. Frontiers in molecular biosciences\| PubMed ID: 35300117	2022
Plasma tRNA derivatives concentrations for detecting early brain damage in patients with acute large vessel occlusion and predicting clinical outcomes after endovascular thrombectomy. Clinical neurology and neurosurgery\| PubMed ID: 35802994	2022
A non-canonical vitamin K cycle is a potent ferroptosis suppressor. Nature\| PubMed ID: 35922516	2022
Mitochonic Acid 5 Improves Duchenne Muscular Dystrophy and Parkinson's Disease Model of . International journal of molecular sciences\| PubMed ID: 36076995	2022
skin colonization promotes SLE-like autoimmune inflammation via neutrophil activation and the IL-23/IL-17 axis. Science immunology\| PubMed ID: 36306369	2022
RTCB Complex Regulates Stress-Induced tRNA Cleavage. International journal of molecular sciences\| PubMed ID: 36361884	2022
Decreased β-hydroxybutyrate and ketogenic amino acid levels in depressed human adults. The European journal of neuroscience\| PubMed ID: 36750311	2023
Contribution of NRF2 to sulfur metabolism and mitochondrial activity. Redox biology\| PubMed ID: 36758466	2023
Increased mitochondrial Ca contributes to health decline with age and Duchene muscular dystrophy in C. elegans. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 36935171	2023
Effects of Ndufs4 Deletion on Hearing after Various Acoustic Exposures. The Tohoku journal of experimental medicine\| PubMed ID: 37081621	2023
[Therapy for CKD and DKD]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica\| PubMed ID: 37394553	2023
Mitochonic acid 5 attenuates age-related neuromuscular dysfunction associated with mitochondrial Ca overload in Caenorhabditis elegans. npj aging\| PubMed ID: 37528117	2023
Urinary growth differentiation factor 15 predicts renal function decline in diabetic kidney disease. Scientific reports\| PubMed ID: 37532799	2023
Mitochondrial dynamics as a novel treatment strategy for triple-negative breast cancer. Cancer medicine\| PubMed ID: 38334464	2024
Polyunsaturated fatty acids-induced ferroptosis suppresses pancreatic cancer growth. Scientific reports\| PubMed ID: 38388563	2024
Human gut-associated species salvage exogenous indole, a uremic toxin precursor, to synthesize indole-3-lactic acid via tryptophan. Gut microbes\| PubMed ID: 38706226	2024
Growth Differentiation Factor-15 Is Considered a Predictive Biomarker of Long COVID in Non-hospitalized Patients. Cureus\| PubMed ID: 38826986	2024
Oral alkalinizing supplementation suppressed intrarenal reactive oxidative stress in mild-stage chronic kidney disease: a randomized cohort study. Clinical and experimental nephrology\| PubMed ID: 38872014	2024
Visualization of intracellular ATP dynamics in different nephron segments under pathophysiological conditions using the kidney slice culture system. Kidney international\| PubMed ID: 38996810	2024
Sporadic inclusion body myositis-derived myotube culture revealed muscle cell-autonomous expression profiles. PloS one\| PubMed ID: 39088432	2024
Supersulfide metabolome of exhaled breath condensate applied as diagnostic biomarkers for esophageal cancer. Cancer science\| PubMed ID: 39895210	2025
Hypoglycemia and hyperinsulinemia induced by phenolic uremic toxins in CKD and DKD patients. Scientific reports\| PubMed ID: 39962199	2025
Decreased Lactococcus lactis and Propionic Acid in Feces of Patients with Moyamoya Disease: Possible Implications of Immune Dysregulation. Cerebrovascular diseases (Basel, Switzerland)\| PubMed ID: 40139167	2025
Suppression of fecal phenol production by oral supplementation of sesamol: inhibition of tyrosine phenol-lyase by sesamol. Food & function\| PubMed ID: 40230229	2025
Characteristics of gut microbiota in high-methylated colorectal cancer. International journal of clinical oncology\| PubMed ID: 40522380	2025
Mitochondria-Homing Drug Mitochonic Acid 5 Improves Barth Syndrome Myopathy in a Human-Induced Pluripotent Stem Cell Model and Barth Syndrome Drosophila Model. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 40542649	2025
Correction: Oral alkalinizing supplementation suppressed intrarenal reactive oxidative stress in mild-stage chronic kidney disease: a randomized cohort study. Clinical and experimental nephrology\| PubMed ID: 40705104	2025
Gut microbiota contributes to the maintenance of sublingually induced regulatory T cells and tolerance in mice. Allergology international : official journal of the Japanese Society of Allergology\| PubMed ID: 40753051	2025
Lubiprostone in chronic kidney disease: Insights into mitochondrial function and polyamines from a randomized phase 2 clinical trial. Science advances\| PubMed ID: 40880481	2025
A Novel Approach for Cisplatin-Resistant Esophageal Squamous Cell Carcinoma via Amino Acid Transporter LAT1 Inhibition. Cancer medicine\| PubMed ID: 40923294	2025
Correlation of growth differentiation factor 15 level in esophageal cancer with cachectic indicators and postoperative infectious complication. Esophagus : official journal of the Japan Esophageal Society\| PubMed ID: 41016991	2025