John Condeelis

Department of Anatomy and Structural Biology, Albert Einstein College of Medicine - Yeshiva University

Affiliated withAlbert Einstein College of Medicine - Yeshiva University Einstein College of Medicine / Montefiore Medical Center Albert Einstein College of Medicine / Montefiore Medical Center

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 63	2009
Publication title Cited by 5	2023

Other Publications

Article	Year
Cofilin produces newly polymerized actin filaments that are preferred for dendritic nucleation by the Arp2/3 complex. Current biology : CB\| PubMed ID: 11790308	2002
Interactions of elongation factor 1alpha with F-actin and beta-actin mRNA: implications for anchoring mRNA in cell protrusions. Molecular biology of the cell\| PubMed ID: 11854414	2002
A new strategy for caging proteins regulated by kinases. Journal of the American Chemical Society\| PubMed ID: 11890784	2002
Single cell behavior in metastatic primary mammary tumors correlated with gene expression patterns revealed by molecular profiling. Cancer research\| PubMed ID: 12414658	2002
Spatial regulation of actin dynamics: a tropomyosin-free, actin-rich compartment at the leading edge. Journal of cell science\| PubMed ID: 12415009	2002
Cell motility: insights from the backstage. Nature cell biology\| PubMed ID: 12461536	2002
GFP expression in the mammary gland for imaging of mammary tumor cells in transgenic mice. Cancer research\| PubMed ID: 12499251	2002
Gene expression analysis on small numbers of invasive cells collected by chemotaxis from primary mammary tumors of the mouse. BMC biotechnology\| PubMed ID: 12914671	2003
Intravital imaging of cell movement in tumours. Nature reviews. Cancer\| PubMed ID: 14737122	2003
Measurement of barbed ends, actin polymerization, and motility in live carcinoma cells after growth factor stimulation. Cell motility and the cytoskeleton\| PubMed ID: 14752805	2004
Imaging sites of N-wasp activity in lamellipodia and invadopodia of carcinoma cells. Current biology : CB\| PubMed ID: 15084285	2004
Cofilin promotes actin polymerization and defines the direction of cell motility. Science (New York, N.Y.)\| PubMed ID: 15118165	2004
Synergistic interaction between the Arp2/3 complex and cofilin drives stimulated lamellipod extension. Journal of cell science\| PubMed ID: 15252126	2004
Phospholipase C and cofilin are required for carcinoma cell directionality in response to EGF stimulation. The Journal of cell biology\| PubMed ID: 15337778	2004
A paracrine loop between tumor cells and macrophages is required for tumor cell migration in mammary tumors. Cancer research\| PubMed ID: 15466195	2004
Over-expression of the p110beta but not p110alpha isoform of PI 3-kinase inhibits motility in breast cancer cells. Cell motility and the cytoskeleton\| PubMed ID: 15468162	2004
Breast cancer cells isolated by chemotaxis from primary tumors show increased survival and resistance to chemotherapy. Cancer research\| PubMed ID: 15520165	2004
Identification and testing of a gene expression signature of invasive carcinoma cells within primary mammary tumors. Cancer research\| PubMed ID: 15574765	2004
A neural Wiskott-Aldrich Syndrome protein-mediated pathway for localized activation of actin polymerization that is regulated by cortactin. The Journal of biological chemistry\| PubMed ID: 15579908	2005
How and why does beta-actin mRNA target? Biology of the cell / under the auspices of the European Cell Biology Organization\| PubMed ID: 15601261	2005
Cofilin takes the lead. Journal of cell science\| PubMed ID: 15615780	2005
Molecular mechanisms of invadopodium formation: the role of the N-WASP-Arp2/3 complex pathway and cofilin. The Journal of cell biology\| PubMed ID: 15684033	2005
Tumor cells caught in the act of invading: their strategy for enhanced cell motility. Trends in cell biology\| PubMed ID: 15752977	2005
The PCH family member MAYP/PSTPIP2 directly regulates F-actin bundling and enhances filopodia formation and motility in macrophages. Molecular biology of the cell\| PubMed ID: 15788569	2005
Simultaneous imaging of GFP, CFP and collagen in tumors in vivo using multiphoton microscopy. BMC biotechnology\| PubMed ID: 15910685	2005
Localization of all seven messenger RNAs for the actin-polymerization nucleator Arp2/3 complex in the protrusions of fibroblasts. Journal of cell science\| PubMed ID: 15923655	2005
Macrophages promote the invasion of breast carcinoma cells via a colony-stimulating factor-1/epidermal growth factor paracrine loop. Cancer research\| PubMed ID: 15958574	2005
Description and characterization of a chamber for viewing and quantifying cancer cell chemotaxis. Cell motility and the cytoskeleton\| PubMed ID: 16025469	2005
Cell migration in tumors. Current opinion in cell biology\| PubMed ID: 16098726	2005
The great escape: when cancer cells hijack the genes for chemotaxis and motility. Annual review of cell and developmental biology\| PubMed ID: 16212512	2005
Imaging of gene expression in living cells and tissues. Journal of biomedical optics\| PubMed ID: 16292943	2005
Spatial regulation of beta-actin translation by Src-dependent phosphorylation of ZBP1. Nature\| PubMed ID: 16306994	2005
Epidermal growth factor receptor overexpression results in increased tumor cell motility in vivo coordinately with enhanced intravasation and metastasis. Cancer research\| PubMed ID: 16397232	2006
Macrophages: obligate partners for tumor cell migration, invasion, and metastasis. Cell\| PubMed ID: 16439202	2006
Invadopodia and podosomes in tumor invasion. European journal of cell biology\| PubMed ID: 16546563	2006
The activity status of cofilin is directly related to invasion, intravasation, and metastasis of mammary tumors. The Journal of cell biology\| PubMed ID: 16651380	2006
Rapid chemokinetic movement and the invasive potential of lung cancer cells; a functional molecular study. BMC cancer\| PubMed ID: 16756685	2006
Initiation of cofilin activity in response to EGF is uncoupled from cofilin phosphorylation and dephosphorylation in carcinoma cells. Journal of cell science\| PubMed ID: 16803871	2006
ROCK- and myosin-dependent matrix deformation enables protease-independent tumor-cell invasion in vivo. Current biology : CB\| PubMed ID: 16890527	2006
Regulation of the actin cytoskeleton in cancer cell migration and invasion. Biochimica et biophysica acta\| PubMed ID: 16926057	2007
Macrophages promote collagen fibrillogenesis around terminal end buds of the developing mammary gland. Developmental dynamics : an official publication of the American Association of Anatomists\| PubMed ID: 17029292	2006
Visualization of mRNA translation in living cells. The Journal of cell biology\| PubMed ID: 17030983	2006
Probing the microenvironment of mammary tumors using multiphoton microscopy. Journal of mammary gland biology and neoplasia\| PubMed ID: 17106644	2006
Spatial and temporal control of cofilin activity is required for directional sensing during chemotaxis. Current biology : CB\| PubMed ID: 17113383	2006
Moving in the right direction-nanoimaging in cancer cell motility and metastasis. Microscopy research and technique\| PubMed ID: 17279509	2007
Direct visualization of macrophage-assisted tumor cell intravasation in mammary tumors. Cancer research\| PubMed ID: 17363585	2007
Molecular cloning of hMena (ENAH) and its splice variant hMena+11a: epidermal growth factor increases their expression and stimulates hMena+11a phosphorylation in breast cancer cell lines. Cancer research\| PubMed ID: 17363586	2007
Imaging mRNA movement from transcription sites to translation sites. Seminars in cell & developmental biology\| PubMed ID: 17376719	2007
Coordinated regulation of pathways for enhanced cell motility and chemotaxis is conserved in rat and mouse mammary tumors. Cancer research\| PubMed ID: 17440055	2007
The cofilin pathway in breast cancer invasion and metastasis. Nature reviews. Cancer\| PubMed ID: 17522712	2007
Cell motility and cytoskeletal regulation in invasion and metastasis. Journal of mammary gland biology and neoplasia\| PubMed ID: 17557195	2007
The distinct roles of Ras and Rac in PI 3-kinase-dependent protrusion during EGF-stimulated cell migration. Journal of cell science\| PubMed ID: 17698922	2007
Cdc42 is required for EGF-stimulated protrusion and motility in MTLn3 carcinoma cells. Journal of cell science\| PubMed ID: 17855387	2007
ZBP1 enhances cell polarity and reduces chemotaxis. Journal of cell science\| PubMed ID: 17878234	2007
Cofilin determines the migration behavior and turning frequency of metastatic cancer cells. The Journal of cell biology\| PubMed ID: 18025308	2007
EGF-induced PIP2 hydrolysis releases and activates cofilin locally in carcinoma cells. The Journal of cell biology\| PubMed ID: 18086920	2007
Quantification of PtdIns(3,4,5)P(3) dynamics in EGF-stimulated carcinoma cells: a comparison of PH-domain-mediated methods with immunological methods. The Biochemical journal\| PubMed ID: 18215145	2008
Imaging tumor cell movement in vivo. Current protocols in cell biology / editorial board, Juan S. Bonifacino ... [et al.]\| PubMed ID: 18228501	2007
RhoA/ROCK-mediated switching between Cdc42- and Rac1-dependent protrusion in MTLn3 carcinoma cells. Experimental cell research\| PubMed ID: 18316075	2008
WASP family members and formin proteins coordinate regulation of cell protrusions in carcinoma cells. The Journal of cell biology\| PubMed ID: 18362183	2008
Mechanisms and cellular roles of local protein synthesis in mammalian cells. Current opinion in cell biology\| PubMed ID: 18378131	2008
Identification of invasion specific splice variants of the cytoskeletal protein Mena present in mammary tumor cells during invasion in vivo. Clinical & experimental metastasis\| PubMed ID: 18985426	2009
Intravital imaging of metastatic behavior through a mammary imaging window. Nature methods\| PubMed ID: 18997781	2008
Cofilin is a pH sensor for actin free barbed end formation: role of phosphoinositide binding. The Journal of cell biology\| PubMed ID: 19029335	2008
A Mena invasion isoform potentiates EGF-induced carcinoma cell invasion and metastasis. Developmental cell\| PubMed ID: 19081071	2008
A common cofilin activity cycle in invasive tumor cells and inflammatory cells. Journal of cell science\| PubMed ID: 19158339	2009
Tumor microenvironment of metastasis in human breast carcinoma: a potential prognostic marker linked to hematogenous dissemination. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 19318480	2009
N-WASP and cortactin are involved in invadopodium-dependent chemotaxis to EGF in breast tumor cells. Cell motility and the cytoskeleton\| PubMed ID: 19373774	2009
The mechanism of CSF-1-induced Wiskott-Aldrich syndrome protein activation in vivo: a role for phosphatidylinositol 3-kinase and Cdc42. The Journal of biological chemistry\| PubMed ID: 19561083	2009
Cortactin regulates cofilin and N-WASp activities to control the stages of invadopodium assembly and maturation. The Journal of cell biology\| PubMed ID: 19704022	2009
Unbalancing the phosphatidylinositol-4,5-bisphosphate-cofilin interaction impairs cell steering. Molecular biology of the cell\| PubMed ID: 19741095	2009
In vivo assay for tumor cell invasion. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 19763970	2009
Stretching the timescale of intravital imaging in tumors. Cell adhesion & migration\| PubMed ID: 19786830	2009
The cofilin activity cycle in lamellipodia and invadopodia. Journal of cellular biochemistry\| PubMed ID: 19862699	2009
Differential enhancement of breast cancer cell motility and metastasis by helical and kinase domain mutations of class IA phosphoinositide 3-kinase. Cancer research\| PubMed ID: 19903845	2009
Invasion of human breast cancer cells in vivo requires both paracrine and autocrine loops involving the colony-stimulating factor-1 receptor. Cancer research\| PubMed ID: 19934330	2009
Gene expression analysis of macrophages that facilitate tumor invasion supports a role for Wnt-signaling in mediating their activity in primary mammary tumors. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 20018620	2010
N-WASP has the ability to compensate for the loss of WASP in macrophage podosome formation and chemotaxis. Experimental cell research\| PubMed ID: 20599953	2010
AACR special conference on epithelial-mesenchymal transition and cancer progression and treatment. Cancer research\| PubMed ID: 20823151	2010
Nck1 and Grb2 localization patterns can distinguish invadopodia from podosomes. European journal of cell biology\| PubMed ID: 20850195	2011
In vivo imaging in cancer. Cold Spring Harbor perspectives in biology\| PubMed ID: 20861158	2010
Cancer stem cells from human breast tumors are involved in spontaneous metastases in orthotopic mouse models. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20921380	2010
A new chemotaxis device for cell migration studies. Integrative biology : quantitative biosciences from nano to macro\| PubMed ID: 20938544	2010
Specific tyrosine phosphorylation sites on cortactin regulate Nck1-dependent actin polymerization in invadopodia. Journal of cell science\| PubMed ID: 20971703	2010
Metastasis: tumor cells becoming MENAcing. Trends in cell biology\| PubMed ID: 21071226	2011
Mena deficiency delays tumor progression and decreases metastasis in polyoma middle-T transgenic mouse mammary tumors. Breast cancer research : BCR\| PubMed ID: 21108830	2010
An EGFR-Src-Arg-cortactin pathway mediates functional maturation of invadopodia and breast cancer cell invasion. Cancer research\| PubMed ID: 21257711	2011
Visualization of actin polymerization in invasive structures of macrophages and carcinoma cells using photoconvertible Î²-actin-Dendra2 fusion proteins. PloS one\| PubMed ID: 21339827	2011
Imaging real-time gene expression in Mammalian cells with single-transcript resolution. CSH protocols\| PubMed ID: 21356977	2007
Imaging real-time gene expression in living yeast. CSH protocols\| PubMed ID: 21356978	2007
Imaging real-time gene expression in living systems with single-transcript resolution: image analysis of single mRNA transcripts. CSH protocols\| PubMed ID: 21356979	2007
Imaging Real-Time Gene Expression in Living Systems with Single-Transcript Resolution: Single mRNA Particle Tracking with ImageJ-Based Analysis. CSH protocols\| PubMed ID: 21356980	2007
Imaging real-time gene expression in living systems with single-transcript resolution: construct design and imaging system setup. CSH protocols\| PubMed ID: 21356986	2007
A novel spatiotemporal RhoC activation pathway locally regulates cofilin activity at invadopodia. Current biology : CB\| PubMed ID: 21474314	2011
Mena invasive (Mena(INV)) and Mena11a isoforms play distinct roles in breast cancer cell cohesion and association with TMEM. Clinical & experimental metastasis\| PubMed ID: 21484349	2011
A temporal model of cofilin regulation and the early peak of actin barbed ends in invasive tumor cells. Biophysical journal\| PubMed ID: 21504724	2011
Phosphorylation of CSF-1R Y721 mediates its association with PI3K to regulate macrophage motility and enhancement of tumor cell invasion. Journal of cell science\| PubMed ID: 21610095	2011
Mena invasive (MenaINV) promotes multicellular streaming motility and transendothelial migration in a mouse model of breast cancer. Journal of cell science\| PubMed ID: 21670198	2011
Chemotaxis in cancer. Nature reviews. Cancer\| PubMed ID: 21779009	2011
A photoswitchable orange-to-far-red fluorescent protein, PSmOrange. Nature methods\| PubMed ID: 21804536	2011
An EMT-driven alternative splicing program occurs in human breast cancer and modulates cellular phenotype. PLoS genetics\| PubMed ID: 21876675	2011
Setup and use of a two-laser multiphoton microscope for multichannel intravital fluorescence imaging. Nature protocols\| PubMed ID: 21959234	2011
High-resolution multiphoton imaging of tumors in vivo. Cold Spring Harbor protocols\| PubMed ID: 21969629	2011
The in vivo invasion assay: preparation and handling of collection needles. Cold Spring Harbor protocols\| PubMed ID: 21969630	2011
Cortactin phosphorylation regulates cell invasion through a pH-dependent pathway. The Journal of cell biology\| PubMed ID: 22105349	2011
Opposing roles of CXCR4 and CXCR7 in breast cancer metastasis. Breast cancer research : BCR\| PubMed ID: 22152016	2011
Directed cell invasion and migration during metastasis. Current opinion in cell biology\| PubMed ID: 22209238	2011
Correlated Immunohistochemical and Cytological Assays for the Prediction of Hematogenous Dissemination of Breast Cancer. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society\| PubMed ID: 22215635	2012
Contribution of CXCL12 secretion to invasion of breast cancer cells. Breast cancer research : BCR\| PubMed ID: 22314082	2012
Invasive breast carcinoma cells from patients exhibit MenaINV- and macrophage-dependent transendothelial migration. Science signaling\| PubMed ID: 25429076	2014
Time-lapsed, large-volume, high-resolution intravital imaging for tissue-wide analysis of single cell dynamics. Methods (San Diego, Calif.)\| PubMed ID: 28911733	2017
Black race and distant recurrence after neoadjuvant or adjuvant chemotherapy in breast cancer. Clinical & experimental metastasis\| PubMed ID: 30136072	2018
Tumor Microenvironment of Metastasis (TMEM) Doorways Are Restricted to the Blood Vessel Endothelium in Both Primary Breast Cancers and Their Lymph Node Metastases. Cancers\| PubMed ID: 31597373	2019
Intravital Imaging Techniques for Biomedical and Clinical Research. Cytometry. Part A : the journal of the International Society for Analytical Cytology\| PubMed ID: 31889408	2020
Validation of an Automated Quantitative Digital Pathology Approach for Scoring TMEM, a Prognostic Biomarker for Metastasis. Cancers\| PubMed ID: 32244564	2020
The role of the tumor microenvironment in tumor cell intravasation and dissemination. European journal of cell biology\| PubMed ID: 32800278	2020
Hematogenous Dissemination of Breast Cancer Cells From Lymph Nodes Is Mediated by Tumor MicroEnvironment of Metastasis Doorways. Frontiers in oncology\| PubMed ID: 33194666	2020
Targeting Tie2 in the Tumor Microenvironment: From Angiogenesis to Dissemination. Cancers\| PubMed ID: 34830883	2021
Primary tumor associated macrophages activate programs of invasion and dormancy in disseminating tumor cells. Nature communications\| PubMed ID: 35110548	2022
Combining TMEM Doorway Score and Mena Score Improves the Prediction of Distant Recurrence Risk in HR+/HER2- Breast Cancer Patients. Cancers\| PubMed ID: 35565297	2022
Racial disparity in distant recurrence-free survival in patients with localized breast cancer: A pooled analysis of National Surgical Adjuvant Breast and Bowel Project trials. Cancer\| PubMed ID: 35578919	2022
SWIP-a stabilized window for intravital imaging of the murine pancreas. Open biology\| PubMed ID: 35702996	2022
Assessment of MRI to estimate metastatic dissemination risk and prometastatic effects of chemotherapy. NPJ breast cancer\| PubMed ID: 36056005	2022
Interleukin 4 Controls the Pro-Tumoral Role of Macrophages in Mammary Cancer Pulmonary Metastasis in Mice. Cancers\| PubMed ID: 36077870	2022
Intravital imaging to study cancer progression and metastasis. Nature reviews. Cancer\| PubMed ID: 36385560	2023
Cooperative NF-κB and Notch1 signaling promotes macrophage-mediated MenaINV expression in breast cancer. Breast cancer research : BCR\| PubMed ID: 37024946	2023
Macrophages Promote Tumor Cell Extravasation across an Endothelial Barrier through Thin Membranous Connections. Cancers\| PubMed ID: 37046751	2023
Racial disparity in tumor microenvironment and distant recurrence in residual breast cancer after neoadjuvant chemotherapy. NPJ breast cancer\| PubMed ID: 37311792	2023