Lei Xiao

School of Basic Medical Sciences, xi'an jiaotong university

Affiliated withxi'an jiaotong university

Research Area

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title	2025
Publication title	2026

Other Publications

Article	Year
Shear stress activation of nuclear receptor PXR in endothelial detoxification. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 23878263	2013
New paradigms in inflammatory signaling in vascular endothelial cells. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 24285111	2014
Roles of xenobiotic receptors in vascular pathophysiology. Circulation journal : official journal of the Japanese Circulation Society\| PubMed ID: 24859622	2014
Xenobiotic pregnane X receptor (PXR) regulates innate immunity via activation of NLRP3 inflammasome in vascular endothelial cells. The Journal of biological chemistry\| PubMed ID: 25202020	2014
Nuciferine relaxes rat mesenteric arteries through endothelium-dependent and -independent mechanisms. British journal of pharmacology\| PubMed ID: 25409881	2015
Procyanidin B2 inhibits NLRP3 inflammasome activation in human vascular endothelial cells. Biochemical pharmacology\| PubMed ID: 25450671	2014
RORα inhibits adipocyte-conditioned medium-induced colorectal cancer cell proliferation and migration and chick embryo chorioallantoic membrane angiopoiesis. American journal of physiology. Cell physiology\| PubMed ID: 25500738	2015
Homocysteine downregulates gene expression of heme oxygenase-1 in hepatocytes. Nutrition & metabolism\| PubMed ID: 25520741	2014
Plasticizer DBP Activates NLRP3 Inflammasome through the P2X7 Receptor in HepG2 and L02 Cells. Journal of biochemical and molecular toxicology\| PubMed ID: 26586371	2016
Homocysteine upregulates hepcidin expression through BMP6/SMAD signaling pathway in hepatocytes. Biochemical and biophysical research communications\| PubMed ID: 26855134	2016
Non-coding RNA LINC00857 is predictive of poor patient survival and promotes tumor progression via cell cycle regulation in lung cancer. Oncotarget\| PubMed ID: 26862852	2016
Retinoid acid receptor-related orphan receptor alpha (RORα) regulates macrophage M2 polarization via activation of AMPKα. Molecular immunology\| PubMed ID: 27788394	2016
Peroxisome proliferator-activated receptor α ligands and modulators from dietary compounds: Types, screening methods and functions. Journal of diabetes\| PubMed ID: 27863018	2017
Oleanolic acid ameliorates high glucose-induced endothelial dysfunction via PPARδ activation. Scientific reports\| PubMed ID: 28067284	2017
Statins Attenuate Activation of the NLRP3 Inflammasome by Oxidized LDL or TNF in Vascular Endothelial Cells through a PXR-Dependent Mechanism. Molecular pharmacology\| PubMed ID: 28546421	2017
Cornulin Is Induced in Psoriasis Lesions and Promotes Keratinocyte Proliferation via Phosphoinositide 3-Kinase/Akt Pathways. The Journal of investigative dermatology\| PubMed ID: 30009832	2019
Nuciferine ameliorates hepatic steatosis in high-fat diet/streptozocin-induced diabetic mice through a PPARα/PPARγ coactivator-1α pathway. British journal of pharmacology\| PubMed ID: 30129056	2018
Xenobiotic pregnane X receptor promotes neointimal formation in balloon-injured rat carotid arteries. Journal of cellular physiology\| PubMed ID: 30132884	2019
Stachydrine protects eNOS uncoupling and ameliorates endothelial dysfunction induced by homocysteine. Molecular medicine (Cambridge, Mass.)\| PubMed ID: 30134790	2018
Peroxisome proliferator-activated receptor γ (PPARγ) induces the gene expression of integrin αβ to promote macrophage M2 polarization. The Journal of biological chemistry\| PubMed ID: 30181212	2018
Sonic hedgehog signaling instigates high-fat diet-induced insulin resistance by targeting PPARγ stability. The Journal of biological chemistry\| PubMed ID: 30573683	2019
S-nitrosation impairs KLF4 activity and instigates endothelial dysfunction in pulmonary arterial hypertension. Redox biology\| PubMed ID: 30660098	2019
PPARδ agonist prevents endothelial dysfunction via induction of dihydrofolate reductase gene and activation of tetrahydrobiopterin salvage pathway. British journal of pharmacology\| PubMed ID: 31144304	2019
Stachydrine Mediates Rapid Vascular Relaxation: Activation of Endothelial Nitric Oxide Synthase Involving AMP-Activated Protein Kinase and Akt Phosphorylation in Vascular Endothelial Cells. Journal of agricultural and food chemistry\| PubMed ID: 31407895	2019
PPARγ induces NEDD4 gene expression to promote autophagy and insulin action. The FEBS journal\| PubMed ID: 31423749	2020
Procyanidin B2 Activates PPARγ to Induce M2 Polarization in Mouse Macrophages. Frontiers in immunology\| PubMed ID: 31440258	2019
APC/Cdh1 targets PECAM-1 for ubiquitination and degradation in endothelial cells. Journal of cellular physiology\| PubMed ID: 31489637	2020
The deposition of VWO on the CuCeO microflower for the selective catalytic reduction of NO with NH at low temperatures. Journal of colloid and interface science\| PubMed ID: 31780114	2020
Procyanidin B2 mitigates endothelial endoplasmic reticulum stress through a PPARδ-Dependent mechanism. Redox biology\| PubMed ID: 32961442	2020
Xenobiotic Receptor CAR Is Highly Induced in Psoriasis and Promotes Keratinocyte Proliferation. The Journal of investigative dermatology\| PubMed ID: 34097921	2021
Sodium-Glucose Cotransporter-2 Inhibitors in Vascular Biology: Cellular and Molecular Mechanisms. Cardiovascular drugs and therapy\| PubMed ID: 34273091	2021
PPAR-δ: A key nuclear receptor in vascular function and remodeling. Journal of molecular and cellular cardiology\| PubMed ID: 35490844	2022
Procyanidin B2 Attenuates Nicotine-Induced Hepatocyte Pyroptosis through a PPARγ-Dependent Mechanism. Nutrients\| PubMed ID: 35565726	2022
CCN1/Integrin αβ Instigates Free Fatty Acid-Induced Hepatocyte Lipid Accumulation and Pyroptosis through NLRP3 Inflammasome Activation. Nutrients\| PubMed ID: 36145246	2022
Free fatty acids stabilize integrin βvia S-nitrosylation to promote monocyte-endothelial adhesion. The Journal of biological chemistry\| PubMed ID: 36470423	2023
ERK1-mediated immunomodulation of mesenchymal stem cells ameliorates inflammatory disorders. iScience\| PubMed ID: 37790278	2023
A critical role of the endothelial S-phase kinase-associated protein 2/phosphatase and tensin homologue axis in angiogenesis and psoriasis. The British journal of dermatology\| PubMed ID: 37850885	2024
, a long noncoding RNA essential for global oxygen sensing in humans. Science advances\| PubMed ID: 37992175	2023
S-nitrosylation attenuates pregnane X receptor hyperactivity and acetaminophen-induced liver injury. JCI insight\| PubMed ID: 38032737	2024
An OPRM1-SNAP-tag/CMC method to directly identify drug components in sewage. Analytical and bioanalytical chemistry\| PubMed ID: 39613988	2025
Polygalae Radix Attenuates Methamphetamine-Induced Behavioral Sensitization Through the TrkB/ERK Pathway in the Caudate Putamen of Mice. Neurochemical research\| PubMed ID: 40095175	2025
Development-Inspired Biomimetic Cell-Niche Coaggregates Safeguard Tooth Stem Cell-Based Functional Tissue Regeneration. Advanced healthcare materials\| PubMed ID: 40376872	2025
Reinforcing and psychostimulant effects of carfentanil and morphine in mice. Pharmacology, biochemistry, and behavior\| PubMed ID: 40744122	2025
Salt-sensitive hypertension promotes neuronal mitochondrial stress and neurodegenerative alterations via neuro-vascular metabolic reprogramming and local RAS signaling. Journal of neuroinflammation\| PubMed ID: 41039568	2025