cd8-cd103-tregs-attenuate-dry-eye-disease-through-suppression-cd4-t

CD8+CD103+ Tregs Attenuate Dry Eye Disease Through Suppression of CD4+ T Cell-Mediated Inflammation and Protection of Ocular Surface Integrity in Mice

CD8+CD103+ regulatory T cells represent a specialized immunosuppressive population with demonstrated therapeutic potential in autoimmune disorders; ...

lipoic-acid-modulates-nrf2ho-1-pathway-to-suppress-inflammation

Lipoic Acid Modulates Nrf2/HO-1 Pathway to Suppress Inflammation in Fungal Keratitis Through Host-Directed Cytoprotective Mechanisms

Lipoic acid (LA), a dithiol antioxidant with an exemplary ocular safety profile, was investigated for its capacity to temper the oxidative-inflammatory ...

Jinan Second People's Hospital

Jinan 2nd People's Hospital

Dysregulated circular RNAs (circRNAs) is involved in the pathogenesis of age-related cataract (ARC). Here, this study aimed to explore the function and mechanism of circMAP3K4 in ARC.

CircMAP3K4 Suppresses H2O2-Induced Human Lens Epithelial Cell Injury by miR-630/ERCC6 Axis in Age-Related Cataract.

An increasing body of evidence supports the involvement of inflammation and immune responses in the occurrence and development of keratoconus (KC). However, the causal relationship between inflammatory factors and KC remains unclear. We employed a 2-way Mendelian randomization (MR) approach to investigate the interaction between KC and inflammatory factors. Instrumental variables for 41 circulating inflammatory regulators and 12 matrix metalloproteinases (MMPs) were selected from genome-wide association studies of European ancestry. Summary statistics for KC were obtained from a genome-wide association study comprising 2116 cases and 24,626 controls of European ancestry. The primary analytical method for assessing causality was the inverse-variance weighted method. Two additional MR methods (MR-Egger and weighted median) were employed to complement the inverse-variance weighted results. In addition, several sensitivity analyses were conducted to evaluate heterogeneity, horizontal pleiotropy, and stability. Our findings indicated that genetically predicted higher levels of macrophage inflammatory protein-1β (odds ratio = 1.126, 95% confidence interval: 1.029-1.232, P = .01) and MMP-13 (odds ratio = 1.211, 95% confidence interval: 1.070-1.371, P = .003) were positively associated with an elevated risk of KC. Conversely, genetically predicted KC was associated with increased levels of interferon-gamma, interleukin-4, and MMP-1. Our current study provided suggestive evidence supporting causal associations of macrophage inflammatory protein-1β and MMP-13 with the risk of KC. In addition, KC appeared to affect the expression of interferon-gamma, interleukin-4, and MMP-1.

Inflammation and keratoconus: A comprehensive bidirectional Mendelian randomization analysis.

Observational studies have suggested at a possible link between keratoconus (KC) and various mental disorders, but the exact direction of causation in these associations remains unclear. This study aims to investigate the potential causal link between KC and three prominent mental conditions: Anxiety, Depression, and Schizophrenia.

ArticleTotal : 2	Year
Publication title	2025
Publication title	2025

Article	Year
CircMAP3K4 Suppresses H2O2-Induced Human Lens Epithelial Cell Injury by miR-630/ERCC6 Axis in Age-Related Cataract. Current eye research\| PubMed ID: 38152055	2024
Inflammation and keratoconus: A comprehensive bidirectional Mendelian randomization analysis. Medicine\| PubMed ID: 39058875	2024
Mendelian randomization analysis does not reveal a causal influence between keratoconus and three major mental disorders. Frontiers in psychiatry\| PubMed ID: 39234617	2024

Fenghua Cui

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