Michael G. Caparon

Department of Molecular Microbiology, Washington University School of Medicine

Affiliated withWashington University School of Medicine

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 1	2026

Other Publications

Article	Year
The signal recognition particle pathway is required for virulence in Streptococcus pyogenes. Infection and immunity\| PubMed ID: 18411293	2008
Alkaline phosphatase reporter transposon for identification of genes encoding secreted proteins in gram-positive microorganisms. Applied and environmental microbiology\| PubMed ID: 11823238	2002
Trigger factor-mediated prolyl isomerization influences maturation of the Streptococcus pyogenes cysteine protease. Journal of bacteriology\| PubMed ID: 12775704	2003
Contribution of glutathione peroxidase to the virulence of Streptococcus pyogenes. Infection and immunity\| PubMed ID: 14688122	2004
Role for serine protease HtrA (DegP) of Streptococcus pyogenes in the biogenesis of virulence factors SpeB and the hemolysin streptolysin S. Infection and immunity\| PubMed ID: 14977969	2004
Specificity of streptolysin O in cytolysin-mediated translocation. Molecular microbiology\| PubMed ID: 15186416	2004
The PerR regulon in peroxide resistance and virulence of Streptococcus pyogenes. Molecular microbiology\| PubMed ID: 15612930	2005
Enterococcus faecalis tropism for the kidneys in the urinary tract of C57BL/6J mice. Infection and immunity\| PubMed ID: 15784592	2005
Patterns of virulence gene expression differ between biofilm and tissue communities of Streptococcus pyogenes. Molecular microbiology\| PubMed ID: 16135223	2005
The ExPortal: an organelle dedicated to the biogenesis of secreted proteins in Streptococcus pyogenes. Molecular microbiology\| PubMed ID: 16262783	2005
A novel endogenous inhibitor of the secreted streptococcal NAD-glycohydrolase. PLoS pathogens\| PubMed ID: 16333395	2005
Specificity of Streptococcus pyogenes NAD(+) glycohydrolase in cytolysin-mediated translocation. Molecular microbiology\| PubMed ID: 17042787	2006
A novel adaptation of aldolase regulates virulence in Streptococcus pyogenes. The EMBO journal\| PubMed ID: 17066081	2006
Contribution of invariant residues to the function of Rgg family transcription regulators. Journal of bacteriology\| PubMed ID: 17098902	2007
Anionic lipids enriched at the ExPortal of Streptococcus pyogenes. Journal of bacteriology\| PubMed ID: 17142392	2007
A PerR-regulated metal transporter (PmtA) is an interface between oxidative stress and metal homeostasis in Streptococcus pyogenes. Molecular microbiology\| PubMed ID: 17238923	2007
Comparative functional analysis of the lac operons in Streptococcus pyogenes. Molecular microbiology\| PubMed ID: 17371500	2007
tRNA modification by GidA/MnmE is necessary for Streptococcus pyogenes virulence: a new strategy to make live attenuated strains. Infection and immunity\| PubMed ID: 18426891	2008
Mechanism for sortase localization and the role of sortase localization in efficient pilus assembly in Enterococcus faecalis. Journal of bacteriology\| PubMed ID: 19286802	2009
The metal homeostasis protein, Lsp, of Streptococcus pyogenes is necessary for acquisition of zinc and virulence. Infection and immunity\| PubMed ID: 19398546	2009
Contribution of autolysin and Sortase a during Enterococcus faecalis DNA-dependent biofilm development. Infection and immunity\| PubMed ID: 19528211	2009
Streptolysin S inhibits neutrophil recruitment during the early stages of Streptococcus pyogenes infection. Infection and immunity\| PubMed ID: 19687200	2009
CcpA and LacD.1 affect temporal regulation of Streptococcus pyogenes virulence genes. Infection and immunity\| PubMed ID: 19841076	2010
Characterization of Streptococcus pyogenes beta-NAD+ glycohydrolase: re-evaluation of enzymatic properties associated with pathogenesis. The Journal of biological chemistry\| PubMed ID: 20018886	2010
Characterization of a novel murine model of Staphylococcus saprophyticus urinary tract infection reveals roles for Ssp and SdrI in virulence. Infection and immunity\| PubMed ID: 20176795	2010
Streptococcus pyogenes cytolysin-mediated translocation does not require pore formation by streptolysin O. EMBO reports\| PubMed ID: 20339385	2010
A tale of two pili: assembly and function of pili in bacteria. Trends in microbiology\| PubMed ID: 20378353	2010
Variation in Streptococcus pyogenes NAD+ glycohydrolase is associated with tissue tropism. Journal of bacteriology\| PubMed ID: 20494994	2010
Distinct time-resolved roles for two catabolite-sensing pathways during Streptococcus pyogenes infection. Infection and immunity\| PubMed ID: 21098101	2011
Structural basis of Streptococcus pyogenes immunity to its NAD+ glycohydrolase toxin. Structure (London, England : 1993)\| PubMed ID: 21300288	2011
Combinatorial small-molecule therapy prevents uropathogenic Escherichia coli catheter-associated urinary tract infections in mice. Antimicrobial agents and chemotherapy\| PubMed ID: 22733070	2012
Cationic antimicrobial peptides disrupt the Streptococcus pyogenes ExPortal. Molecular microbiology\| PubMed ID: 22780862	2012
The metal ion-dependent adhesion site motif of the Enterococcus faecalis EbpA pilin mediates pilus function in catheter-associated urinary tract infection. mBio\| PubMed ID: 22829678	2012
Murine vaginal colonization model for investigating asymptomatic mucosal carriage of Streptococcus pyogenes. Infection and immunity\| PubMed ID: 23460515	2013
Analysis of polymorphic residues reveals distinct enzymatic and cytotoxic activities of the Streptococcus pyogenes NAD+ glycohydrolase. The Journal of biological chemistry\| PubMed ID: 23689507	2013
Pilin and sortase residues critical for endocarditis- and biofilm-associated pilus biogenesis in Enterococcus faecalis. Journal of bacteriology\| PubMed ID: 23913319	2013
Complete Genome Sequence of emm Type 14 Streptococcus pyogenes Strain HSC5. Genome announcements\| PubMed ID: 23950122	2013
An association between peptidoglycan synthesis and organization of the Streptococcus pyogenes ExPortal. mBio\| PubMed ID: 24065630	2013
Streptococcus pyogenes arginine and citrulline catabolism promotes infection and modulates innate immunity. Infection and immunity\| PubMed ID: 24144727	2014
Streptococcus pyogenes polymyxin B-resistant mutants display enhanced ExPortal integrity. Journal of bacteriology\| PubMed ID: 24794568	2014
A novel cholesterol-insensitive mode of membrane binding promotes cytolysin-mediated translocation by Streptolysin O. Molecular microbiology\| PubMed ID: 25196983	2014
EbpA vaccine antibodies block binding of Enterococcus faecalis to fibrinogen to prevent catheter-associated bladder infection in mice. Science translational medicine\| PubMed ID: 25232179	2014
Streptococcus pyogenes malate degradation pathway links pH regulation and virulence. Infection and immunity\| PubMed ID: 25583521	2015
Citrulline protects Streptococcus pyogenes from acid stress using the arginine deiminase pathway and the F1Fo-ATPase. Journal of bacteriology\| PubMed ID: 25645553	2015
The Streptococcus pyogenes NAD(+) glycohydrolase modulates epithelial cell PARylation and HMGB1 release. Cellular microbiology\| PubMed ID: 25818652	2015
Dual modes of membrane binding direct pore formation by Streptolysin O. Molecular microbiology\| PubMed ID: 26059530	2015
Complete Genome Sequences of emm6 Streptococcus pyogenes JRS4 and Parental Strain D471. Genome announcements\| PubMed ID: 26139722	2015
Fibrinogen release and deposition on urinary catheters placed during urologic procedures. The Journal of urology\| PubMed ID: 26827873	2016
The NADase-Negative Variant of the Streptococcus pyogenes Toxin NAD⁺ Glycohydrolase Induces JNK1-Mediated Programmed Cellular Necrosis. mBio\| PubMed ID: 26838722	2016
Antibody-Based Therapy for Enterococcal Catheter-Associated Urinary Tract Infections. mBio\| PubMed ID: 27795399	2016
SpxA1 and SpxA2 Act Coordinately To Fine-Tune Stress Responses and Virulence in . mBio\| PubMed ID: 28351920	2017
induces gut intraepithelial CD4CD8αα T cells. Science (New York, N.Y.)\| PubMed ID: 28775213	2017
Catheterization alters bladder ecology to potentiate infection of the urinary tract. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 28973850	2017
Host and bacterial proteases influence biofilm formation and virulence in a murine model of enterococcal catheter-associated urinary tract infection. NPJ biofilms and microbiomes\| PubMed ID: 29134108	2017
CcpA Coordinates Growth/Damage Balance for Streptococcus pyogenes Pathogenesis. Scientific reports\| PubMed ID: 30250043	2018
Glutathione Synthesis Contributes to Virulence of in a Murine Model of Sepsis. Journal of bacteriology\| PubMed ID: 31331978	2019
Mucosal infection rewires TNFɑ signaling dynamics to skew susceptibility to recurrence. eLife\| PubMed ID: 31429405	2019
High-resolution imaging reveals microbial biofilms on patient urinary catheters despite antibiotic administration. World journal of urology\| PubMed ID: 31792577	2020
Rifampin resistance mutations in the rpoB gene of Enterococcus faecalis impact host macrophage cytokine production. Cytokine\| PubMed ID: 35030469	2022
Corrigendum to "Rifampicin resistance mutations in the rpoB gene of Enterococcus faecalis affect the production of cytokines by host macrophages" Cytokine 151 (2022) 155788. Cytokine\| PubMed ID: 35256256	2022
Complete Genome Sequence of the Uropathogenic Methicillin-Resistant Staphylococcus aureus Strain MRSA-1369. Microbiology resource announcements\| PubMed ID: 36173194	2022
Ring-fused 2-pyridones effective against multidrug-resistant Gram-positive pathogens and synergistic with standard-of-care antibiotics. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 36252016	2022
Central carbon flux controls growth/damage balance for Streptococcus pyogenes. PLoS pathogens\| PubMed ID: 37384800	2023
Fibrinolytic-deficiencies predispose hosts to septicemia from a catheter-associated UTI. Research square\| PubMed ID: 37790429	2023
Volatile profiling distinguishes from other respiratory streptococcal species. mSphere\| PubMed ID: 37791788	2023
Microbial co-occurrences on catheters from long-term catheterized patients. Nature communications\| PubMed ID: 38168042	2024
Dihydrothiazolo ring-fused 2-pyridone antimicrobial compounds treat skin and soft tissue infection. bioRxiv : the preprint server for biology\| PubMed ID: 38260261	2024
Fibrinolytic-deficiencies predispose hosts to septicemia from a catheter-associated UTI. Nature communications\| PubMed ID: 38538626	2024
Dihydrothiazolo ring-fused 2-pyridone antimicrobial compounds treat skin and soft tissue infection. Science advances\| PubMed ID: 39093975	2024
Reprogramming aerobic metabolism mitigates Streptococcus pyogenes tissue damage in a mouse necrotizing skin infection model. Nature communications\| PubMed ID: 40089471	2025
Host cysteine proteases promote the severity of catheter-associated urinary tract infection and kidney fibrosis. mBio\| PubMed ID: 40980878	2025
The Unique Efg1 Fungal Virulence Regulon in the Catheterized Bladder Environment. bioRxiv : the preprint server for biology\| PubMed ID: 41279377	2025
Metabolic cross-talk promotes persistence of in a model of polymicrobial catheter-associated urinary tract infection. bioRxiv : the preprint server for biology\| PubMed ID: 41332623	2025
An acetylation-dependent switch underlies host disease tolerance during streptococcal infection. Scientific reports\| PubMed ID: 41781659	2026