therapeutic-efficacy-308-nm-excimer-laser-combined-with-matrine

Therapeutic Efficacy of 308-nm Excimer Laser Combined with Matrine in Vitiligo by Modulation of Serum Immunoglobulins and Inflammatory Cytokines

Vitiligo is a chronic autoimmune depigmenting disorder characterized by the loss of functional melanocytes and aberrant immune activation. Despite ...

Xingtai People's Hospital

To investigate the effect of phototherapy combined with melanocyte transplantation on the activity index of vitiligo.

Impact of Combined Phototherapy and Melanocyte Transplantation on Indicators of Vitiligo Activity.

Glioblastomas (GBM), the most common primary brain tumor, lack accurate prognostic markers and have a poor prognosis. Our study was designed to identify effective biomarkers for GBM prognosis analysis and development of precise treatments. Differentially expressed genes (DEGs) between GBM patients and controls were analyzed from the Xena database and GEPIA. Based on the screened DEGs, univariate COX and LASSO regression analysis were performed to identify the most relevant genes associated with GBM prognosis. Genes highly expressed in GBM patients were selected to construct receiver operating characteristic analysis and enrichment analysis was constructed on groups of high and low expression of adipocyte enhancer-binding protein 1 (AEBP1). CIBERSORT, ssGSEA and ESTIMATE were used to perform immune infiltration analysis. About 3297 DEGs were identified using data from Xena database; 8 prognostic genes were identified. AEBP1, which plays a role in neuronal differentiation and development, was positively correlated in GBMs with immune infiltration; its high expression in cancer patients is associated with short overall survival and advanced tumor staging. This study suggests that AEBP1 could serve as a prognostic marker for GBMs and that patients with high expression may have a better response to immunotherapy.

Clinical significance and potential mechanism of AEBP1 in glioblastoma.

Psoriasis is an immune-mediated skin disease that occurs worldwide and is characterized by high prevalence and chronicity. Psoriasis has a complex pathogenesis and is difficult to cure. Therefore, continuous exploration of the pathogenesis of psoriasis and the search for new drug treatment methods are crucial for improving treatment efficiency and reducing psychological damage to psoriasis patients. The active ingredients in Dihuang Zicao granules (DHZCG) can effectively treat psoriasis. Therefore, this study aimed to analyze the active ingredients of DHZCG and their potential mechanisms for treating psoriasis.

Dihuangzicao Granules Regulate the AGE/RAGE/NF-κB Signaling Pathway to Inhibit Inflammation in Psoriatic Mice  Network Pharmacology and Experimental Validation.

This study was conducted aimed at investigating the effectiveness of combined laser and topical tranexamic acid in the treatment of melasma. A total of 160 melasma patients treated in the dermatology department at the author's hospital from May 2021 to October 2022 were randomly assigned to a control group (laser treatment only, n = 80) and an observation group (combined laser and topical tranexamic acid, n = 80). General patient information was collected, and clinical analysis of melasma area and depth scores was performed before and after treatment. After treatment, the observation group showed significantly smaller melasma area and depth compared to the control group (P < 0.05). Skin quality scores post-treatment were higher in the observation group (P < 0.05). Upon re-examination at the 6th and 12th month, the observation group exhibited smaller melasma areas than the control group (P < 0.05), indicating superior long-term control. The observation group had a lower incidence of side effects (P < 0.05), higher rates of both very satisfied and totally satisfied patients (P < 0.05), and lower dissatisfaction rates (P < 0.05) than the control group. Combined laser and topical tranexamic acid treatment is significantly more effective than laser treatment alone in reducing melasma area and depth, minimizing side effects, and improving patient satisfaction.

Clinical study on the effectiveness of laser combined with topical tranexamic acid in the treatment of melasma.

The aim of the study was to analyze the risk factors for vitiligo complicated with autoimmune thyroid disease (AITD) and establish a nomogram prediction model.

Article	Year
Impact of Combined Phototherapy and Melanocyte Transplantation on Indicators of Vitiligo Activity. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]\| PubMed ID: 38984521	2024
Clinical significance and potential mechanism of AEBP1 in glioblastoma. Journal of neuropathology and experimental neurology\| PubMed ID: 39190880	2024
Dihuangzicao Granules Regulate the AGE/RAGE/NF-κB Signaling Pathway to Inhibit Inflammation in Psoriatic Mice Network Pharmacology and Experimental Validation. Combinatorial chemistry & high throughput screening\| PubMed ID: 39354758	2025
Clinical study on the effectiveness of laser combined with topical tranexamic acid in the treatment of melasma. Lasers in medical science\| PubMed ID: 40970991	2025
Analysis of Risk Factors and Establishment of a Nomogram Prediction Model for Vitiligo Complicated with Autoimmune Thyroid Disease. International archives of allergy and immunology\| PubMed ID: 41129412	2025

Chengcheng Wang

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