antiinflammatory-effects-sesquiterpene-lactones-from-eupatorium

Antiinflammatory Effects of Sesquiterpene Lactones from <em>Eupatorium lindleyanum</em> DC. in Rodent Models

Acute inflammation is a fundamental pathological process involved in many immune-related diseases. Eupatorium lindleyanum DC., a traditional medicinal ...

Chongqing Medical University

To evaluate efficacy and safety of efdamrofusp alfa compared with aflibercept in neovascular age-related macular degeneration (nAMD).

Efficacy and safety of efdamrofusp alfa versus aflibercept in participants with neovascular age-related macular degeneration: a randomized, double-masked, active-controlled, non-inferiority, phase 2 trial.

Premature ovarian failure (POF) is characterized by oxidative stress, cellular senescence, and impaired steroidogenesis, yet current therapies remain limited in effectiveness. Thymol, a natural monoterpene, exhibits antioxidant and anti-inflammatory properties. Network pharmacology and molecular docking identified multiple potential targets, notably the Janus kinase 1 (JAK1)-signal transducer and activator of transcription 3 (STAT3) pathway. In tert-butyl hydroperoxide (t-BHP)-induced human granulosa-like tumor cells ( = 3), 40 μg/mL thymol increased cell viability by approximately 45%, restored superoxide dismutase, catalase, and glutathione peroxidase activities to nearly twice those of the model group, and reduced reactive oxygen species accumulation by about 35% ( < 0.05). It also decreased senescence markers p53, p21, and p16 by 40-60% and inhibited JAK1-STAT3 phosphorylation ( = 3,  < 0.05). In aged pregnant mice ( = 4 per group), thymol increased viable fetus numbers by about 40%, elevated serum estradiol and progesterone levels to 1.6-1.8-fold of aged controls, and downregulated ovarian aging markers ( < 0.05). Collectively, these findings indicate that thymol mitigates oxidative stress-induced ovarian aging by modulating JAK1-STAT3 signaling and restoring steroidogenic function, supporting its potential as a natural candidate for delaying ovarian senescence.

Thymol Mitigates Oxidative Stress-Induced Ovarian Aging and Restores Steroidogenesis via the JAK1-STAT3 Pathway.

Advanced maternal age (AMA, ≥35 years) is increasingly common and is accompanied by rising threatened abortion (AMA-TA) rates, yet its molecular basis remains unclear.

Article	Year
Efficacy and safety of efdamrofusp alfa versus aflibercept in participants with neovascular age-related macular degeneration: a randomized, double-masked, active-controlled, non-inferiority,... Ophthalmology. Retina\| PubMed ID: 39214250	2024
Thymol Mitigates Oxidative Stress-Induced Ovarian Aging and Restores Steroidogenesis via the JAK1-STAT3 Pathway. Current issues in molecular biology\| PubMed ID: 41296414	2025
Multi-omics analysis reveals steroid hormone biosynthesis as a key pathway in advanced maternal age threatened abortion. Biology of reproduction\| PubMed ID: 41757494	2026

Junjie Deng

Biography

JoVE Journal Publications

Other Publications