engineering-high-fidelity-preclinical-mouse-model-for-brain

Engineering High-fidelity Preclinical Mouse Model for Brain Metastasis using Interlock Pulsatile Injection Technique and Microsurgical Vascular Repair

Brain metastasis remains a devastating clinical problem. A major challenge in brain metastasis research is the lack of high-quality models that accurately ...

Capital Medical University

Beijing Institute of Heart Lung and Blood Vessel Diseases

This study examines the impact of firms' exposures on COVID-19 sentiment on the stock price crash risk. We show the exposure on COVID-19 sentiment related to the medical, travelling and uncertain aspects significantly increases the stock price crash risk, while the exposure on COVID-19 sentiment related to vaccines significantly decreases the risk of stock price crash. Furthermore, our findings are stronger for non-state-owned firms and firms with low information transparency. Overall, we provide timely policy implication for economic impacts of the COVID-19 on the stock market.

Firms' exposures on COVID-19 and stock price crash risk: Evidence from China.

Global climate change is rapidly reshaping species distribution patterns worldwide.  (golden apple snail), an important invasive species in many countries, has experienced accelerated range expansion driven by climate change and anthropogenic activities. Owing to its high phenotypic plasticity, broad environmental tolerance, and high fecundity, this species causes severe agricultural damage and biodiversity loss. Importantly,  is a highly competent intermediate host of the rat lungworm , the causative agent of human eosinophilic meningitis, posing a growing public health threat. This article synthesizes the biological traits, invasion mechanisms, and ecological impacts of , together with the transmission cycle and epidemiology of . Using the Maximum Entropy (MaxEnt) model under two future climate scenarios (SSP2-4.5 and SSP5-8.5), we projected the spatiotemporal dynamics of suitable habitat for . Current distributions are primarily driven by hydrothermal factors, with annual precipitation (BIO12) and maximum temperature of the warmest month (BIO5) exerting dominant influences, resulting in high suitability across tropical and subtropical regions. Under future warming, habitat suitability is projected to decline in low-latitude regions while expanding poleward, with increased fragmentation under SSP5-8.5. High-stability resilience hotspots, including the lower Yangtze River Basin and the Mississippi River Basin, are identified as priority areas for management. Based on these projections, we propose a precision governance framework integrating niche-based risk stratification, low-toxicity biocontrol, habitat management, cross-border surveillance, and public education to support climate-adaptive prevention of invasive species and parasite transmission.

Article	Year
Firms' exposures on COVID-19 and stock price crash risk: Evidence from China. Finance research letters\| PubMed ID: 36471778	2023
Climate-driven invasion of and transmission risk: Ecological niche modeling forecasts and public-health governance recommendations. One health (Amsterdam, Netherlands)\| PubMed ID: 41584083	2026
PKM2 phosphorylation by c-SRC activates glycolysis and metastasis with the stimulation of tumor-associated macrophages. Cell communication and signaling : CCS\| PubMed ID: 41814323	2026

Jialu Xu

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