fixed-volume-intercept-approach-for-serial-contractility-assessment

Fixed Volume-Intercept Approach for Serial Contractility Assessment with Closed-Chest Pressure-Volume Loops in a Porcine Model

The end-systolic pressure&#8211;volume relationship (ESPVR) is widely regarded as the gold standard, load-independent descriptor of left-ventricular (LV) ...

Aarhus University Hospital

Aarhus University

Butyrate, a short-chain fatty acid, has shown potential to improve left ventricular (LV) function and induce vasorelaxation in rodents. Butyrate may either be produced by the microbiome in the colon, be ingested or administered intravenously. This study aimed to evaluate effects of butyrate on cardiac output (CO) and associated hemodynamic variables in a porcine model.

Butyrate increases cardiac output and causes vasorelaxation in a healthy porcine model.

Acute pulmonary embolism (PE) is a leading cause of cardiovascular death, primarily due to abrupt increased pulmonary vascular resistance (PVR) leading to acute right ventricular (RV) failure. Ketone bodies, especially 3-hydroxybutyrate (3-OHB), have shown potential to increase cardiac output (CO) and reduce PVR in pulmonary hypertension, suggesting possible benefits in PE. We hypothesized that 3-OHB would induce pulmonary vasorelaxation and increase CO in a porcine model of acute PE.

Article	Year
Butyrate increases cardiac output and causes vasorelaxation in a healthy porcine model. Life sciences\| PubMed ID: 39828226	2025
Ketone bodies for hemodynamic support in acute pulmonary embolism: a randomized, blinded, controlled animal study. Intensive care medicine experimental\| PubMed ID: 41420069	2025

Lasse Juul Christensen

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