Roni Nielsen

Department of Cardiology, Aarhus University Hospital

Affiliated withAarhus University Hospital Aarhus University

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2026

Other Publications

Article	Year
Suppression of circulating free fatty acids with acipimox in chronic heart failure patients changes whole body metabolism but does not affect cardiac function. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 20709866	2010
Acute peripheral metabolic effects of intraarterial leg infusion of somatostatin in healthy young men. The Journal of clinical endocrinology and metabolism\| PubMed ID: 21632809	2011
Reduced mRNA and protein expression of perilipin A and G0/G1 switch gene 2 (G0S2) in human adipose tissue in poorly controlled type 2 diabetes. The Journal of clinical endocrinology and metabolism\| PubMed ID: 22535977	2012
Effect of acute hyperglycemia on left ventricular contractile function in diabetic patients with and without heart failure: two randomized cross-over studies. PloS one\| PubMed ID: 23308171	2013
Failing heart of patients with type 2 diabetes mellitus can adapt to extreme short-term increases in circulating lipids and does not display features of acute myocardial lipotoxicity. Circulation. Heart failure\| PubMed ID: 23733915	2013
A protocol for a randomised, double-blind, placebo-controlled study of the effect of LIraglutide on left VEntricular function in chronic heart failure patients with and without type 2 diabet... BMJ open\| PubMed ID: 24844271	2014
Effect of tighter glycemic control on cardiac function, exercise capacity, and muscle strength in heart failure patients with type 2 diabetes: a randomized study. BMJ open diabetes research & care\| PubMed ID: 27158520	2016
Heart failure patients with prediabetes and newly diagnosed diabetes display abnormalities in myocardial metabolism. Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology\| PubMed ID: 27473218	2018
Effect of liraglutide, a glucagon-like peptide-1 analogue, on left ventricular function in stable chronic heart failure patients with and without diabetes (LIVE)-a multicentre, double-blind,... European journal of heart failure\| PubMed ID: 27790809	2017
Effect of remote ischemic conditioning on myocardial perfusion in patients with suspected ischemic coronary artery disease. Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology\| PubMed ID: 27804070	2018
Myocardial Oxygen Consumption and Efficiency in Aortic Valve Stenosis Patients With and Without Heart Failure. Journal of the American Heart Association\| PubMed ID: 28167498	2017
Ketone Body Infusion With 3-Hydroxybutyrate Reduces Myocardial Glucose Uptake and Increases Blood Flow in Humans: A Positron Emission Tomography Study. Journal of the American Heart Association\| PubMed ID: 28242634	2017
Effect of long-term remote ischaemic conditioning on platelet function and fibrinolysis in patients with chronic ischaemic heart failure. Thrombosis research\| PubMed ID: 28319824	2017
Effect of liraglutide on myocardial glucose uptake and blood flow in stable chronic heart failure patients: A double-blind, randomized, placebo-controlled LIVE sub-study. Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology\| PubMed ID: 28770459	2019
Metoprolol Reduces Hemodynamic and Metabolic Overload in Asymptomatic Aortic Valve Stenosis Patients: A Randomized Trial. Circulation. Cardiovascular imaging\| PubMed ID: 28956773	2017
Effect of long-term remote ischemic conditioning in patients with chronic ischemic heart failure. Basic research in cardiology\| PubMed ID: 29071437	2017
Levosimendan improves cardiac function and myocardial efficiency in rats with right ventricular failure. Pulmonary circulation\| PubMed ID: 29099675	2018
Timing of focused cardiac ultrasound during advanced life support - A prospective clinical study. Resuscitation\| PubMed ID: 29246742	2018
Test-retest repeatability of myocardial oxidative metabolism and efficiency using standalone dynamic C-acetate PET and multimodality approaches in healthy controls. Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology\| PubMed ID: 29855984	2018
When appearances deceive: Echocardiographic changes due to common chest pathology. Echocardiography (Mount Kisco, N.Y.)\| PubMed ID: 30338539	2018
Cardiovascular Effects of Treatment With the Ketone Body 3-Hydroxybutyrate in Chronic Heart Failure Patients. Circulation\| PubMed ID: 30884964	2019
Quantitative estimation of extravascular lung water volume and preload by dynamic 15O-water positron emission tomography. European heart journal. Cardiovascular Imaging\| PubMed ID: 30887037	2019
Myocardial strain assessed by feature tracking cardiac magnetic resonance in patients with a variety of cardiovascular diseases - A comparison with echocardiography. Scientific reports\| PubMed ID: 31383914	2019
Optimizing heart failure treatment following cardiac resynchronization therapy. Clinical research in cardiology : official journal of the German Cardiac Society\| PubMed ID: 31559483	2020
Effect of Blood Flow Restricted Resistance Exercise and Remote Ischemic Conditioning on Functional Capacity and Myocellular Adaptations in Patients With Heart Failure. Circulation. Heart failure\| PubMed ID: 31830830	2019
Heart rate increases in liraglutide treated chronic heart failure patients: association with clinical parameters and adverse events. Scandinavian cardiovascular journal : SCJ\| PubMed ID: 32292074	2020
The impact of the glucagon-like peptide-1 receptor agonist liraglutide on natriuretic peptides in heart failure patients with reduced ejection fraction with and without type 2 diabetes. Diabetes, obesity & metabolism\| PubMed ID: 32627271	2020
A systematic approach to weaning from extracorporeal membrane oxygenation in patients with refractory cardiac failure. Acta anaesthesiologica Scandinavica\| PubMed ID: 33728635	2021
Myocardial efficiency in patients with different aetiologies and stages of heart failure. European heart journal. Cardiovascular Imaging\| PubMed ID: 34751738	2022
Randomized Trial of Metoprolol in Patients With Obstructive Hypertrophic Cardiomyopathy. Journal of the American College of Cardiology\| PubMed ID: 34915981	2021
Effects of Metoprolol on Exercise Hemodynamics in Patients With Obstructive Hypertrophic Cardiomyopathy. Journal of the American College of Cardiology\| PubMed ID: 35450573	2022
Clinical use of cardiac 18 F-FDG viability PET: a retrospective study of 44 patients undergoing post-test revascularization. The international journal of cardiovascular imaging\| PubMed ID: 36434332	2022
Metoprolol Improves Left Ventricular Longitudinal Strain at Rest and during Exercise in Obstructive Hypertrophic Cardiomyopathy. Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography\| PubMed ID: 36444740	2023
Hemodynamic Effects of Ketone Bodies in Patients With Pulmonary Hypertension. Journal of the American Heart Association\| PubMed ID: 37183871	2023
Stimulation of the Hydroxycarboxylic Acid Receptor 2 With the Ketone Body 3-Hydroxybutyrate and Niacin in Patients With Chronic Heart Failure: Hemodynamic and Metabolic Effects. Journal of the American Heart Association\| PubMed ID: 37301762	2023
Beneficial Effects of Ketone Ester in Patients With Cardiogenic Shock: A Randomized, Controlled, Double-Blind Trial. JACC. Heart failure\| PubMed ID: 37452805	2023
Impact of Coronary Artery Disease in Women With Newly Diagnosed Heart Failure and Reduced Ejection Fraction. JACC. Heart failure\| PubMed ID: 37632494	2023
Ketone body 3-hydroxybutyrate elevates cardiac output through peripheral vasorelaxation and enhanced cardiac contractility. Basic research in cardiology\| PubMed ID: 37688627	2023
Effects of ketone body 3-hydroxybutyrate on cardiac and mitochondrial function during donation after circulatory death heart transplantation. Scientific reports\| PubMed ID: 38191915	2024
Circulating 3-hydroxy butyrate predicts mortality in patients with chronic heart failure with reduced ejection fraction. ESC heart failure\| PubMed ID: 38196294	2024
Myocardial work across different etiologies of right ventricular dysfunction and healthy controls. The international journal of cardiovascular imaging\| PubMed ID: 38305942	2024
Lactate infusion elevates cardiac output through increased heart rate and decreased vascular resistance: a randomised, blinded, crossover trial in a healthy porcine model. Journal of translational medicine\| PubMed ID: 38493167	2024
Cardiovascular Effects of Oral Ketone Ester Treatment in Patients With Heart Failure With Reduced Ejection Fraction: A Randomized, Controlled, Double-Blind Trial. Circulation\| PubMed ID: 38533643	2024
Enantiomer-Specific Cardiovascular Effects of the Ketone Body 3-Hydroxybutyrate. Journal of the American Heart Association\| PubMed ID: 38563382	2024
Short-Chain Fatty Acid Butyrate Is an Inotropic Agent With Vasorelaxant and Cardioprotective Properties. Journal of the American Heart Association\| PubMed ID: 38686853	2024
Coronary Artery Disease Is A Stronger Predictor of All-Cause Mortality Than Left Ventricular Ejection Fraction Among Patients With Newly Diagnosed Heart Failure: Insights From the WDHR. Journal of the American Heart Association\| PubMed ID: 38958148	2024
Randomized Crossover Trial of 2-Week Ketone Ester Treatment in Patients With Type 2 Diabetes and Heart Failure With Preserved Ejection Fraction. Circulation\| PubMed ID: 39162035	2024
Preparation and Preclinical Characterization of a Simple Ester for Dual Exogenous Supply of Lactate and Beta-hydroxybutyrate. Journal of agricultural and food chemistry\| PubMed ID: 39214666	2024
Neurohormonal and Renal Effects of 14-Day Oral Ketone Ester Treatment in Patients With Heart Failure With Reduced Ejection Fraction. Circulation. Heart failure\| PubMed ID: 39717923	2025
Cardiovascular and Metabolic Effects of Modulating Circulating Ketone Bodies With 1,3-Butanediol in Patients With Heart Failure With Reduced Ejection Fraction. Journal of the American Heart Association\| PubMed ID: 39719429	2025
Cardiovascular effects of lactate in healthy adults. Critical care (London, England)\| PubMed ID: 39825426	2025
Clinical use of [15O]H2O/[18F]FDG viability positron emission tomography does not reliably predict left ventricular ejection fraction improvement or survival after revascularization. European heart journal. Cardiovascular Imaging\| PubMed ID: 39901814	2025
Mortality and use of implantable cardioverter defibrillators in patients with low ejection fraction following non-ST-segment elevation myocardial infarction. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology\| PubMed ID: 39960891	2025
Lactate infusion improves cardiac function in a porcine model of ischemic cardiogenic shock. Critical care (London, England)\| PubMed ID: 40083003	2025
The Venous-to-Arterial Carbon Dioxide Difference is an Indicator of Cardiac Index in Cardiogenic Shock Complicating Myocardial Infarction-A Porcine Study. Heart, lung & circulation\| PubMed ID: 40140267	2025
Lactate orchestrates metabolic hemodynamic adaptations through a unique combination of venocontraction, artery relaxation, and positive inotropy. Acta physiologica (Oxford, England)\| PubMed ID: 40167405	2025
The ketone body 3-hydroxybutyrate increases cardiac output and cardiac contractility in a porcine model of cardiogenic shock: a randomized, blinded, crossover trial. Basic research in cardiology\| PubMed ID: 40220139	2025
Coronary Artery Disease Doubles Excess Mortality in Patients With Heart Failure With Reduced Ejection Fraction. Journal of the American Heart Association\| PubMed ID: 40240924	2025
Cardiovascular effects of lactate in healthy adults: D-lactate, the forgotten enantiomer-authors' reply. Critical care (London, England)\| PubMed ID: 40270027	2025
Functional capacity and skeletal muscle morphology are linked to N-terminal proBNP but not left ventricular ejection fraction in patients with heart failure. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 40343875	2025
Biolimus-Eluting Biomatrix Stent vs a Dual-Therapy Sirolimus-Eluting Stent in PCI: The SORT OUT XI Randomized Trial. Journal of the American College of Cardiology\| PubMed ID: 40406942	2025
Gut lactate increases circulating l-Lac-Phe and key metabolites linked to GLP-1 and human health. American journal of physiology. Endocrinology and metabolism\| PubMed ID: 40418349	2025
The Cardiac and Hemodynamic Effects of Ketone Bodies Are Abnormal in Patients With Type 1 Diabetes: A Randomized Controlled Trial. Diabetes\| PubMed ID: 40526464	2025
The Immediate Cardiovascular and Mitochondrial Response in Ischemic Cardiogenic Shock. Journal of cardiovascular translational research\| PubMed ID: 40555857	2025
Should Exogenous Ketone Body Supplementation Be Considered in Patients Hospitalized for Acute Heart Failure? Rationale and Design of the KETO-AHF Trial. Journal of cardiac failure\| PubMed ID: 40789530	2025
Effects of Alcohol Septal Ablation on Exercise Hemodynamics, Symptoms, and Quality of Life in Obstructive Hypertrophic Cardiomyopathy. Journal of the American Heart Association\| PubMed ID: 40827012	2025
Mortality After Non-ST-Segment Elevation Myocardial Infarction: Impact of Left Ventricular Function and Coronary Artery Disease. JACC. Advances\| PubMed ID: 40961738	2025
Cardiovascular effects of hypertonic lactate solutions: acid-base or metabolic cause, or both? Authors' reply. Critical care (London, England)\| PubMed ID: 41121333	2025
Ketone bodies for hemodynamic support in acute pulmonary embolism: a randomized, blinded, controlled animal study. Intensive care medicine experimental\| PubMed ID: 41420069	2025
Early Detection of Pulmonary Congestion Using Quantitative CT and Lung US in a Porcine Model. Radiology. Cardiothoracic imaging\| PubMed ID: 41504643	2026
Serial measurements of myocardial efficiency in patients with aortic valve stenosis: pathophysiological mechanisms and prognostic implications. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 41661147	2026
Effect of age on 5-year excess mortality in heart failure with reduced ejection fraction. European journal of heart failure\| PubMed ID: 41889326	2026