postoperative-length-stay-after-minimally-invasive-transforaminal

Postoperative Length of Stay After Minimally Invasive Transforaminal Lumbar Interbody Fusion: Analysis of Perioperative Predictors

Length of stay is a key quality and cost metric after minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF). Published benchmarks vary ...

People's Hospital of Chongqing Hechuan

The First Affiliated Hospital of Chongqing Medical University Hechuan District Hospital

Osteosarcoma (OS) is the most common primary bone malignancy and has a high propensity for local invasion and metastasis. The tumour microenvironment of OS is infiltrated by a large number of immune cells, which play a crucial role in its progression and prognosis. Mast cells are important innate immune cells in the tumour stroma and exhibit different phenotypes in diverse tumour microenvironments. However, the underlying mechanisms of mast cell accumulation and the phenotypic characteristics of mast cells in OS remain poorly understood. In this article, we found for the first time that mast cell accumulation in osteosarcoma tissue was modulated by the CXCL6-CXCR2 axis and that the number of infiltrating mast cells was significantly greater in tumour tissues than in adjacent nontumour tissues. These tumour-infiltrating mast cells express high levels of the immunosuppressive molecule PD-L2, and survival analyses revealed that patients in the PD-L2 high-expression group had a worse prognosis. , mast cells were induced to express PD-L2 in a time- and dose-dependent manner using OS tissue culture supernatants to mimic the tumour microenvironment. Mechanistic studies revealed that tumour cell-derived G-CSF significantly induced mast cell PD-L2 expression by activating STAT3. Importantly, mast cells overexpressing PD-L2 inhibit tumour-specific CD8 T-cell proliferation and tumour-killing cytokine secretion, which is reversed by blocking PD-L2 on mast cells. Therefore, our findings provide new insight into the immunosuppressive and tumorigenic roles of mast cells, as well as a novel mechanism by which PD-L2-expressing mast cells mediate immune tolerance.

CXCL6-CXCR2 axis-mediated PD-L2 mast cell accumulation shapes the immunosuppressive microenvironment in osteosarcoma.

Total hip arthroplasty (THA) critically influences outcomes; however, a comprehensive mapping of the research landscape remains absent. We systematically characterized the knowledge structure, collaborative networks, and research priorities within the THA approach literature from 2000 to 2026. Multi-database bibliometric analysis integrated data from the Web of Science, PubMed, Embase, and Cochrane Library. Following deduplication, 4023 publications were analyzed using Bibliometrix, VOSviewer, and CiteSpace to map publication trends, collaboration networks, thematic evolution, and citation dynamics. Annual publications demonstrated sustained expansion (annual growth rate: 9.68% over the complete-year window 2000-2024), with marked acceleration after 2020 and peak production exceeding 300 publications during 2023 to 2024. The United States emerged as the primary hub (30.7% of publications), with European and East Asian centers forming secondary nodes. The Journal of Arthroplasty anchored volume (637 publications), while high-impact general journals (JBJS-Am, CORR) achieved the greatest citation efficiency (>60 citations per publication). Keyword clustering revealed well-differentiated themes ( = 0.351,  = 0.706) centered on outcome surveillance, direct anterior approach evaluation, and positioning accuracy. Citation bursts documented a 3-phase evolution: minimally invasive descriptions (2003-2012), comparative benchmarking (2012-2020), and registry-based evidence (2018-2026). The field has matured from seeking universal approach superiority toward patient-, surgeon-, and system-specific selection paradigms. Priority directions include implementation science for learning curves, standardized patient-centered outcomes, health economic assessment, and approach-technology-pathway interaction studies. Geographic expansion beyond North American and European centers is essential for evaluating context-dependent effectiveness across diverse healthcare systems worldwide.

Article	Year
CXCL6-CXCR2 axis-mediated PD-L2 mast cell accumulation shapes the immunosuppressive microenvironment in osteosarcoma. Heliyon\| PubMed ID: 39082021	2024
Research Trends and Knowledge Evolution of Surgical Approaches in Primary Total Hip Arthroplasty: A Bibliometric Analysis. Inquiry : a journal of medical care organization, provision and financing\| PubMed ID: 42033323	2026

Chengguang Wang

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