Hsing-Jien Kung

UC Davis Comprehensive Cancer Center, University of California, Davis

Affiliated withUniversity of California, Davis University of California, Davis National Health Research Institutes

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 3	2013
Publication title Cited by 11	2018

Other Publications

Article	Year
Identification of the bZIP and Rta homologues in the genome of rhesus monkey rhadinovirus. Virology\| PubMed ID: 12127781	2002
Expression profile of tyrosine kinases in breast cancer. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 11839650	2002
Functional analysis of 44 mutant androgen receptors from human prostate cancer. Cancer research\| PubMed ID: 11888926	2002
Identification of human male germ cell-associated kinase, a kinase transcriptionally activated by androgen in prostate cancer cells. The Journal of biological chemistry\| PubMed ID: 12084720	2002
Caspase activation of mammalian sterile 20-like kinase 3 (Mst3). Nuclear translocation and induction of apoptosis. The Journal of biological chemistry\| PubMed ID: 12107159	2002
Elevated C-met in thymic dendritic cells of New Zealand Black mice. Developmental immunology\| PubMed ID: 12353660	2002
Characterization of a novel androgen receptor mutation in a relapsed CWR22 prostate cancer xenograft and cell line. Cancer research\| PubMed ID: 12438256	2002
Lung tumorigenesis associated with erb-B-2 and erb-B-3 overexpression in human erb-B-3 transgenic mice is enhanced by methylnitrosourea. Oncogene\| PubMed ID: 12483526	2002
Kaposi's sarcoma-associated herpesvirus K-bZIP is a coregulator of K-Rta: physical association and promoter-dependent transcriptional repression. Journal of virology\| PubMed ID: 12502859	2003
Androgen-induced recruitment of RNA polymerase II to a nuclear receptor-p160 coactivator complex. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12589022	2003
K-bZIP of Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 (KSHV/HHV-8) binds KSHV/HHV-8 Rta and represses Rta-mediated transactivation. Journal of virology\| PubMed ID: 12610155	2003
Elevated expression of tyrosine kinase DDR2 in primary biliary cirrhosis. Autoimmunity\| PubMed ID: 12765478	2002
Cell cycle regulation by Kaposi's sarcoma-associated herpesvirus K-bZIP: direct interaction with cyclin-CDK2 and induction of G1 growth arrest. Journal of virology\| PubMed ID: 12915577	2003
Comparative studies of a new subfamily of human Ste20-like kinases: homodimerization, subcellular localization, and selective activation of MKK3 and p38. Oncogene\| PubMed ID: 13679851	2003
Poly(ADP-ribose) polymerase 1 and Ste20-like kinase hKFC act as transcriptional repressors for gamma-2 herpesvirus lytic replication. Molecular and cellular biology\| PubMed ID: 14585985	2003
Characterization of the chromosomal binding sites and dimerization partners of the viral oncoprotein Meq in Marek's disease virus-transformed T cells. Journal of virology\| PubMed ID: 14610205	2003
The role of tyrosine kinase Etk/Bmx in EGF-induced apoptosis of MDA-MB-468 breast cancer cells. Oncogene\| PubMed ID: 14676838	2004
The Tyr-kinase inhibitor AG879, that blocks the ETK-PAK1 interaction, suppresses the RAS-induced PAK1 activation and malignant transformation. Cancer biology & therapy\| PubMed ID: 14726663	2004
Interleukin-8 confers androgen-independent growth and migration of LNCaP: differential effects of tyrosine kinases Src and FAK. Oncogene\| PubMed ID: 14767470	2004
Pentameric procyanidins isolated from Theobroma cacao seeds selectively downregulate ErbB2 in human aortic endothelial cells. Experimental biology and medicine (Maywood, N.J.)\| PubMed ID: 14988518	2004
Marek's disease virus-encoded vIL-8 gene is involved in early cytolytic infection but dispensable for establishment of latency. Journal of virology\| PubMed ID: 15078957	2004
Molecular alterations associated with LNCaP cell progression to androgen independence. The Prostate\| PubMed ID: 15176055	2004
ORF36 protein kinase of Kaposi's sarcoma herpesvirus activates the c-Jun N-terminal kinase signaling pathway. The Journal of biological chemistry\| PubMed ID: 15247271	2004
Marek's disease virus-encoded Meq gene is involved in transformation of lymphocytes but is dispensable for replication. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15289599	2004
Cocoa procyanidins inhibit proliferation and angiogenic signals in human dermal microvascular endothelial cells following stimulation by low-level H2O2. Experimental biology and medicine (Maywood, N.J.)\| PubMed ID: 15337830	2004
Bi-directional regulation between tyrosine kinase Etk/BMX and tumor suppressor p53 in response to DNA damage. The Journal of biological chemistry\| PubMed ID: 15355990	2004
Signal pathways in up-regulation of chemokines by tyrosine kinase MER/NYK in prostate cancer cells. Cancer research\| PubMed ID: 15492251	2004
Negative modulation of androgen receptor transcriptional activity by Daxx. Molecular and cellular biology\| PubMed ID: 15572661	2004
Ku is a novel transcriptional recycling coactivator of the androgen receptor in prostate cancer cells. The Journal of biological chemistry\| PubMed ID: 15640154	2005
vLIP, a viral lipase homologue, is a virulence factor of Marek's disease virus. Journal of virology\| PubMed ID: 15890938	2005
c-Jun controls the efficiency of MAP kinase signaling by transcriptional repression of MAP kinase phosphatases. Experimental cell research\| PubMed ID: 15950217	2005
Kaposi's sarcoma-associated herpesvirus K-bZIP represses gene transcription via SUMO modification. Journal of virology\| PubMed ID: 16014952	2005
Profiling of gene expression changes caused by p53 gain-of-function mutant alleles in prostate cancer cells. The Prostate\| PubMed ID: 16037992	2005
Marek's disease virus Meq transforms chicken cells via the v-Jun transcriptional cascade: a converging transforming pathway for avian oncoviruses. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16203997	2005
Multiplex analysis of intracellular signaling pathways in lymphoid cells by microbead suspension arrays. Molecular & cellular proteomics : MCP\| PubMed ID: 16369048	2006
Tyrosine kinase Etk/BMX is up-regulated in human prostate cancer and its overexpression induces prostate intraepithelial neoplasia in mouse. Cancer research\| PubMed ID: 16912182	2006
ACTR/AIB1/SRC-3 and androgen receptor control prostate cancer cell proliferation and tumor growth through direct control of cell cycle genes. The Prostate\| PubMed ID: 16921507	2006
Male germ cell-associated kinase, a male-specific kinase regulated by androgen, is a coactivator of androgen receptor in prostate cancer cells. Cancer research\| PubMed ID: 16951154	2006
Inappropriate activation of the androgen receptor by nonsteroids: involvement of the Src kinase pathway and its therapeutic implications. Cancer research\| PubMed ID: 17079466	2006
Kaposi's sarcoma-associated herpesvirus-encoded protein kinase and its interaction with K-bZIP. Journal of virology\| PubMed ID: 17108053	2007
Proline-, glutamic acid-, and leucine-rich protein-1/modulator of nongenomic activity of estrogen receptor enhances androgen receptor functions through LIM-only coactivator, four-and-a-half ... Molecular endocrinology (Baltimore, Md.)\| PubMed ID: 17192406	2007
The oncogenic potential of a prostate cancer-derived androgen receptor mutant. The Prostate\| PubMed ID: 17262801	2007
Heptad repeats regulate protein phosphatase 2a recruitment to I-kappaB kinase gamma/NF-kappaB essential modulator and are targeted by human T-lymphotropic virus type 1 tax. The Journal of biological chemistry\| PubMed ID: 17314097	2007
Nonreceptor tyrosine kinases in prostate cancer. Neoplasia (New York, N.Y.)\| PubMed ID: 17357254	2007
Evidence for calpain-mediated androgen receptor cleavage as a mechanism for androgen independence. Cancer research\| PubMed ID: 17909000	2007
BCL-2 functions as an activator of the AKT signaling pathway in pancreatic cancer. Journal of cellular biochemistry\| PubMed ID: 17960583	2007
An androgen-regulated miRNA suppresses Bak1 expression and induces androgen-independent growth of prostate cancer cells. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18056640	2007
Recombinant Marek's disease virus (MDV) lacking the Meq oncogene confers protection against challenge with a very virulent plus strain of MDV. Vaccine\| PubMed ID: 18313812	2008
Regulation of Id1 expression by SRC: implications for targeting of the bone morphogenetic protein pathway in cancer. Cancer research\| PubMed ID: 18381431	2008
Impairment of the DNA repair and growth arrest pathways by p53R2 silencing enhances DNA damage-induced apoptosis in a p53-dependent manner in prostate cancer cells. Molecular cancer research : MCR\| PubMed ID: 18505925	2008
Pancreatic cancer cell lines deficient in argininosuccinate synthetase are sensitive to arginine deprivation by arginine deiminase. International journal of cancer. Journal international du cancer\| PubMed ID: 18661517	2008
RNA editing of androgen receptor gene transcripts in prostate cancer cells. The Journal of biological chemistry\| PubMed ID: 18708348	2008
Homodimerization of Marek's disease virus-encoded Meq protein is not sufficient for transformation of lymphocytes in chickens. Journal of virology\| PubMed ID: 18971275	2009
Oncogenic activation of androgen receptor. Urologic oncology\| PubMed ID: 19111798	2009
Aberrant activation of androgen receptor in a new neuropeptide-autocrine model of androgen-insensitive prostate cancer. Cancer research\| PubMed ID: 19117998	2009
Arginine deiminase as a novel therapy for prostate cancer induces autophagy and caspase-independent apoptosis. Cancer research\| PubMed ID: 19147587	2009
In vitro characterization of the Meq proteins of Marek's disease virus vaccine strain CVI988. Virus research\| PubMed ID: 19189855	2009
The Src inhibitor AZD0530 blocks invasion and may act as a radiosensitizer in lung cancer cells. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer\| PubMed ID: 19240653	2009
A novel androgen receptor splice variant is up-regulated during prostate cancer progression and promotes androgen depletion-resistant growth. Cancer research\| PubMed ID: 19244107	2009
NF-kappaB serves as a cellular sensor of Kaposi's sarcoma-associated herpesvirus latency and negatively regulates K-Rta by antagonizing the RBP-Jkappa coactivator. Journal of virology\| PubMed ID: 19244329	2009
A comprehensive analysis of recruitment and transactivation potential of K-Rta and K-bZIP during reactivation of Kaposi's sarcoma-associated herpesvirus. Virology\| PubMed ID: 19269659	2009
ADI, autophagy and apoptosis: metabolic stress as a therapeutic option for prostate cancer. Autophagy\| PubMed ID: 19276647	2009
Androgen-induced coactivator ANCCA mediates specific androgen receptor signaling in prostate cancer. Cancer research\| PubMed ID: 19318566	2009
Kruppel-associated box domain-associated protein-1 as a latency regulator for Kaposi's sarcoma-associated herpesvirus and its modulation by the viral protein kinase. Cancer research\| PubMed ID: 19584288	2009
Interleukin-6 regulates androgen synthesis in prostate cancer cells. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 19638459	2009
ERK regulates calpain 2-induced androgen receptor proteolysis in CWR22 relapsed prostate tumor cell lines. The Journal of biological chemistry\| PubMed ID: 19946123	2010
Kaposi's sarcoma-associated herpesvirus (KSHV) encodes a SUMO E3 ligase that is SIM-dependent and SUMO-2/3-specific. The Journal of biological chemistry\| PubMed ID: 20034935	2010
Microbead arrays for the analysis of ErbB receptor tyrosine kinase activation and dimerization in breast cancer cells. Assay and drug development technologies\| PubMed ID: 20035613	2010
Both homo and heterodimers of Marek's disease virus encoded Meq protein contribute to transformation of lymphocytes in chickens. Virology\| PubMed ID: 20137800	2010
Aberrant activation of the androgen receptor by NF-kappaB2/p52 in prostate cancer cells. Cancer research\| PubMed ID: 20388792	2010
KDM8, a H3K36me2 histone demethylase that acts in the cyclin A1 coding region to regulate cancer cell proliferation. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20457893	2010
Multiplex analysis of Src family kinase signaling by microbead suspension arrays. Assay and drug development technologies\| PubMed ID: 20482378	2010
Effect of the specific Src family kinase inhibitor saracatinib on osteolytic lesions using the PC-3 bone model. Molecular cancer therapeutics\| PubMed ID: 20484016	2010
Genome-wide analysis of androgen receptor binding and gene regulation in two CWR22-derived prostate cancer cell lines. Endocrine-related cancer\| PubMed ID: 20634343	2010
Autophagy Blockade Sensitizes Prostate Cancer Cells towards Src Family Kinase Inhibitors. Genes & cancer\| PubMed ID: 20811583	2010
miR-125b promotes growth of prostate cancer xenograft tumor through targeting pro-apoptotic genes. The Prostate\| PubMed ID: 20886540	2011
Histone demethylase JMJD2A regulates Kaposi's sarcoma-associated herpesvirus replication and is targeted by a viral transcriptional factor. Journal of virology\| PubMed ID: 21228229	2011
Targeting tyrosine kinases and autophagy in prostate cancer. Hormones & cancer\| PubMed ID: 21350583	2011
Novel flavonoids with antiproliferative activities against breast cancer cells. Journal of medicinal chemistry\| PubMed ID: 21599001	2011
Recombinant origin of the retrovirus XMRV. Science (New York, N.Y.)\| PubMed ID: 21628392	2011
Simultaneous targeting of Src kinase and receptor tyrosine kinase results in synergistic inhibition of renal cell carcinoma proliferation and migration. International journal of cancer. Journal international du cancer\| PubMed ID: 21792888	2012
Ligand-independent activation of the arylhydrocarbon receptor by ETK (Bmx) tyrosine kinase helps MCF10AT1 breast cancer cells to survive in an apoptosis-inducing environment. Biological chemistry\| PubMed ID: 21861773	2011
Statins and prostate cancer: role of cholesterol inhibition vs. prevention of small GTP-binding proteins. American journal of cancer research\| PubMed ID: 21984972	2011
MicroRNA let-7c suppresses androgen receptor expression and activity via regulation of Myc expression in prostate cancer cells. The Journal of biological chemistry\| PubMed ID: 22128178	2012
Protein arginine methyltransferase 1-directed methylation of Kaposi sarcoma-associated herpesvirus latency-associated nuclear antigen. The Journal of biological chemistry\| PubMed ID: 22179613	2012
ASC-J9 suppresses castration-resistant prostate cancer growth through degradation of full-length and splice variant androgen receptors. Neoplasia (New York, N.Y.)\| PubMed ID: 22355276	2012
MicroRNA let-7c is downregulated in prostate cancer and suppresses prostate cancer growth. PloS one\| PubMed ID: 22479342	2012
Histone methyltransferase NSD2/MMSET mediates constitutive NF-ÎºB signaling for cancer cell proliferation, survival, and tumor growth via a feed-forward loop. Molecular and cellular biology\| PubMed ID: 22645312	2012
Molecular characteristics of CTA056, a novel interleukin-2-inducible T-cell kinase inhibitor that selectively targets malignant T cells and modulates oncomirs. Molecular pharmacology\| PubMed ID: 22899868	2012
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy\| PubMed ID: 22966490	2012
Enhancing the effectiveness of androgen deprivation in prostate cancer by inducing Filamin A nuclear localization. Endocrine-related cancer\| PubMed ID: 22993077	2012
Modeling truncated AR expression in a natural androgen responsive environment and identification of RHOB as a direct transcriptional target. PloS one\| PubMed ID: 23209612	2012
Genotyping and genomic profiling of non-small-cell lung cancer: implications for current and future therapies. Journal of clinical oncology : official journal of the American Society of Clinical Oncology\| PubMed ID: 23401433	2013
Kaposi's Sarcoma-Associated Herpesvirus (KSHV) Latency Associated Nuclear Antigen Regulates KSHV Epigenome by Association with Histone Demethylase, KDM3A. Journal of virology\| PubMed ID: 23576503	2013
Oncomir miR-125b Suppresses p14(ARF) to Modulate p53-Dependent and p53-Independent Apoptosis in Prostate Cancer. PloS one\| PubMed ID: 23585871	2013
Arginine starvation-associated atypical cellular death involves mitochondrial dysfunction, nuclear DNA leakage, and chromatin autophagy. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 25122679	2014
SUMO and KSHV Replication. Cancers\| PubMed ID: 25268162	2014
Non-Coding RNAs in Castration-Resistant Prostate Cancer: Regulation of Androgen Receptor Signaling and Cancer Metabolism. International journal of molecular sciences\| PubMed ID: 26690121	2015
KDM4A Coactivates E2F1 to Regulate the PDK-Dependent Metabolic Switch between Mitochondrial Oxidation and Glycolysis. Cell reports\| PubMed ID: 27626669	2016