Aras Kadioglu

Department of Clinical Infection Microbiology & Immunology, University of Liverpool

Affiliated withUniversity of Liverpool University of Liverpool

Research Area

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 80	2013
Publication title Cited by 8	2024

Other Publications

Article	Year
Role of inflammatory mediators in resistance and susceptibility to pneumococcal infection. Infection and immunity\| PubMed ID: 11854243	2002
Upper and lower respiratory tract infection by Streptococcus pneumoniae is affected by pneumolysin deficiency and differences in capsule type. Infection and immunity\| PubMed ID: 12010976	2002
Pneumococcal behavior and host responses during bronchopneumonia are affected differently by the cytolytic and complement-activating activities of pneumolysin. Infection and immunity\| PubMed ID: 12654795	2003
The MicAB two-component signaling system is involved in virulence of Streptococcus pneumoniae. Infection and immunity\| PubMed ID: 14573696	2003
Binding and agglutination of Streptococcus pneumoniae by human surfactant protein D (SP-D) vary between strains, but SP-D fails to enhance killing by neutrophils. Infection and immunity\| PubMed ID: 14742512	2004
The innate immune response to pneumococcal lung infection: the untold story. Trends in immunology\| PubMed ID: 15036042	2004
Protein serine/threonine kinase StkP positively controls virulence and competence in Streptococcus pneumoniae. Infection and immunity\| PubMed ID: 15039376	2004
CD4-T-lymphocyte interactions with pneumolysin and pneumococci suggest a crucial protective role in the host response to pneumococcal infection. Infection and immunity\| PubMed ID: 15102777	2004
Identification of a detrimental role for NK cells in pneumococcal pneumonia and sepsis in immunocompromised hosts. Microbes and infection / Institut Pasteur\| PubMed ID: 15893495	2005
Susceptibility and resistance to pneumococcal disease in mice. Briefings in functional genomics & proteomics\| PubMed ID: 16420749	2005
Pneumococcal neuraminidases A and B both have essential roles during infection of the respiratory tract and sepsis. Infection and immunity\| PubMed ID: 16790774	2006
Switch from planktonic to sessile life: a major event in pneumococcal pathogenesis. Molecular microbiology\| PubMed ID: 16925554	2006
The cathepsin B inhibitor, z-FA-FMK, inhibits human T cell proliferation in vitro and modulates host response to pneumococcal infection in vivo. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 16951345	2006
MobilomeFINDER: web-based tools for in silico and experimental discovery of bacterial genomic islands. Nucleic acids research\| PubMed ID: 17537813	2007
The ability to utilize mucin affects the regulation of virulence gene expression in Streptococcus pneumoniae. FEMS microbiology letters\| PubMed ID: 18053067	2008
The role of Streptococcus pneumoniae virulence factors in host respiratory colonization and disease. Nature reviews. Microbiology\| PubMed ID: 18340341	2008
Increased TNF expression in CD43++ murine blood monocytes. Immunology letters\| PubMed ID: 18468696	2008
Sialic acid: a preventable signal for pneumococcal biofilm formation, colonization, and invasion of the host. The Journal of infectious diseases\| PubMed ID: 19392624	2009
Macrophages from BALB/c and CBA/Ca mice differ in their cellular responses to Streptococcus pneumoniae. Journal of leukocyte biology\| PubMed ID: 20028774	2010
The immunising effect of pneumococcal nasopharyngeal colonisation; protection against future colonisation and fatal invasive disease. Immunobiology\| PubMed ID: 20071053	2010
Pathogenicity islands PAPI-1 and PAPI-2 contribute individually and synergistically to the virulence of Pseudomonas aeruginosa strain PA14. Infection and immunity\| PubMed ID: 20123716	2010
Human lung mast cells mediate pneumococcal cell death in response to activation by pneumolysin. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 20483738	2010
A subtype of a Pseudomonas aeruginosa cystic fibrosis epidemic strain exhibits enhanced virulence in a murine model of acute respiratory infection. The Journal of infectious diseases\| PubMed ID: 20704484	2010
Pneumolysin activates the NLRP3 inflammasome and promotes proinflammatory cytokines independently of TLR4. PLoS pathogens\| PubMed ID: 21085613	2010
The integrins Mac-1 and alpha4beta1 perform crucial roles in neutrophil and T cell recruitment to lungs during Streptococcus pneumoniae infection. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 21460207	2011
Streptococcus pyogenes antigen I/II-family polypeptide AspA shows differential ligand-binding properties and mediates biofilm formation. Molecular microbiology\| PubMed ID: 21736640	2011
Sex-based differences in susceptibility to respiratory and systemic pneumococcal disease in mice. The Journal of infectious diseases\| PubMed ID: 22021621	2011
Absence of the lectin activation pathway of complement does not increase susceptibility to Pseudomonas aeruginosa infections. Immunobiology\| PubMed ID: 22070931	2012
Persistence of pneumolysin in the cerebrospinal fluid of patients with pneumococcal meningitis is associated with mortality. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America\| PubMed ID: 22238165	2012
Capsule type of Streptococcus pneumoniae determines growth phenotype. PLoS pathogens\| PubMed ID: 22412375	2012
P4-mediated antibody therapy in an acute model of invasive pneumococcal disease. The Journal of infectious diseases\| PubMed ID: 22457294	2012
T regulatory cells control susceptibility to invasive pneumococcal pneumonia in mice. PLoS pathogens\| PubMed ID: 22563306	2012
Nicotinamide nucleotide transhydrogenase (NNT) acts as a novel modulator of macrophage inflammatory responses. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 22593545	2012
Gene expression in fungi. IMA fungus\| PubMed ID: 22679585	2011
The lectin pathway of complement activation is a critical component of the innate immune response to pneumococcal infection. PLoS pathogens\| PubMed ID: 22792067	2012
Nasopharyngeal carriage with Streptococcus pneumoniae augments the immunizing effect of pneumolysin toxoid B. The Journal of allergy and clinical immunology\| PubMed ID: 23260752	2012
Controlled Human Infection and Re-Challenge with Streptococcus Pneumoniae Reveals the Protective Efficacy of Carriage in Healthy Adults. American journal of respiratory and critical care medicine\| PubMed ID: 23370916	2013
The AgI/II family adhesin AspA is required for respiratory infection by Streptococcus pyogenes. PloS one\| PubMed ID: 23638083	2013
Immunoactivating peptide p4 augments alveolar macrophage phagocytosis in two diverse human populations. Antimicrobial agents and chemotherapy\| PubMed ID: 23817378	2013
The pneumococcal polysaccharide capsule and pneumolysin differentially affect CXCL8 and IL-6 release from cells of the upper and lower respiratory tract. PloS one\| PubMed ID: 24664110	2014
Streptococcus pneumoniae detects and responds to foreign bacterial peptide fragments in its environment. Open biology\| PubMed ID: 24718598	2014
Density and duration of pneumococcal carriage is maintained by transforming growth factor β1 and T regulatory cells. American journal of respiratory and critical care medicine\| PubMed ID: 24749506	2014
The B lymphocyte differentiation factor (BAFF) is expressed in the airways of children with CF and in lungs of mice infected with Pseudomonas aeruginosa. PloS one\| PubMed ID: 24847941	2014
Pseudomonas aeruginosa adaptation in the nasopharyngeal reservoir leads to migration and persistence in the lungs. Nature communications\| PubMed ID: 25179232	2014
Ca²⁺-dependent repair of pneumolysin pores: A new paradigm for host cellular defense against bacterial pore-forming toxins. Biochimica et biophysica acta\| PubMed ID: 25219550	2015
Engineered liposomes sequester bacterial exotoxins and protect from severe invasive infections in mice. Nature biotechnology\| PubMed ID: 25362245	2015
Circulating Pneumolysin Is a Potent Inducer of Cardiac Injury during Pneumococcal Infection. PLoS pathogens\| PubMed ID: 25973949	2015
Alternatives to antibiotics-a pipeline portfolio review. The Lancet. Infectious diseases\| PubMed ID: 26795692	2016
Augmented Passive Immunotherapy with P4 Peptide Improves Phagocyte Activity in Severe Sepsis. Shock (Augusta, Ga.)\| PubMed ID: 27488089	2016
Recombination in Streptococcus pneumoniae Lineages Increase with Carriage Duration and Size of the Polysaccharide Capsule. mBio\| PubMed ID: 27677790	2016
The global distribution and diversity of protein vaccine candidate antigens in the highly virulent Streptococcus pnuemoniae serotype 1. Vaccine\| PubMed ID: 28081968	2017
Phage therapy is highly effective against chronic lung infections with . Thorax\| PubMed ID: 28265031	2017
Epidemiological and Molecular Characterization of an Invasive Group A Streptococcus 32.2 Outbreak. Journal of clinical microbiology\| PubMed ID: 28356413	2017
The accessory Sec system (SecY2A2) in Streptococcus pneumoniae is involved in export of pneumolysin toxin, adhesion and biofilm formation. Microbes and infection\| PubMed ID: 28456649	2017
Comparative Genomic Analysis and In Vivo Modeling of Streptococcus pneumoniae ST3081 and ST618 Isolates Reveal Key Genetic and Phenotypic Differences Contributing to Clonal Replacement of Se... The Journal of infectious diseases\| PubMed ID: 28968897	2017
Dairy Heifers Naturally Exposed to Fasciola hepatica Develop a Type 2 Immune Response and Concomitant Suppression of Leukocyte Proliferation. Infection and immunity\| PubMed ID: 28993458	2018
E-cigarette vapour enhances pneumococcal adherence to airway epithelial cells. The European respiratory journal\| PubMed ID: 29437942	2018
Erratum for Graham-Brown et al., "Dairy Heifers Naturally Exposed to Fasciola hepatica Develop a Type 2 Immune Response and Concomitant Suppression of Leukocyte Proliferation". Infection and immunity\| PubMed ID: 29789434	2018
Multiple communication mechanisms between sensor kinases are crucial for virulence in Pseudomonas aeruginosa. Nature communications\| PubMed ID: 29880803	2018
Erratum for Cornick et al., "Epidemiological and Molecular Characterization of an Invasive Group A Streptococcus 32.2 Outbreak". Journal of clinical microbiology\| PubMed ID: 30150291	2018
Pneumolysin binds to the mannose receptor C type 1 (MRC-1) leading to anti-inflammatory responses and enhanced pneumococcal survival. Nature microbiology\| PubMed ID: 30420782	2019
Early Signals of Vaccine-driven Perturbation Seen in Pneumococcal Carriage Population Genomic Data. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America\| PubMed ID: 31094423	2020
Impaired Alanine Transport or Exposure to d-Cycloserine Increases the Susceptibility of MRSA to β-lactam Antibiotics. The Journal of infectious diseases\| PubMed ID: 31628459	2020
IL-35 is critical in suppressing superantigenic Staphylococcus aureus-driven inflammatory Th17 responses in human nasopharynx-associated lymphoid tissue. Mucosal immunology\| PubMed ID: 31896761	2020
Exposure to diesel exhaust particles increases susceptibility to invasive pneumococcal disease. The Journal of allergy and clinical immunology\| PubMed ID: 31983527	2020
Increased pathogenicity of pneumococcal serotype 1 is driven by rapid autolysis and release of pneumolysin. Nature communications\| PubMed ID: 32312961	2020
Influenza-like illness is associated with high pneumococcal carriage density in Malawian children. The Journal of infection\| PubMed ID: 32711042	2020
Bacterial genome-wide association study of hyper-virulent pneumococcal serotype 1 identifies genetic variation associated with neurotropism. Communications biology\| PubMed ID: 33033372	2020
Hypervirulent pneumococcal serotype 1 harbours two pneumolysin variants with differential haemolytic activity. Scientific reports\| PubMed ID: 33057054	2020
Lower Density and Shorter Duration of Nasopharyngeal Carriage by Pneumococcal Serotype 1 (ST217) May Explain Its Increased Invasiveness over Other Serotypes. mBio\| PubMed ID: 33293378	2020
Author Correction: Hypervirulent pneumococcal serotype 1 harbours two pneumolysin variants with differential haemolytic activity. Scientific reports\| PubMed ID: 33731755	2021
Intestinal helminth co-infection is an unrecognised risk factor for increased pneumococcal carriage density and invasive disease. Scientific reports\| PubMed ID: 33772094	2021
Serotype 1 pneumococcus: epidemiology, genomics, and disease mechanisms. Trends in microbiology\| PubMed ID: 34949516	2022
Author Correction: Hypervirulent pneumococcal serotype 1 harbours two pneumolysin variants with differential haemolytic activity. Scientific reports\| PubMed ID: 35332175	2022
Structure-Based Discovery of Lipoteichoic Acid Synthase Inhibitors. Journal of chemical information and modeling\| PubMed ID: 35533315	2022
Mechanistic Insights into the Impact of Air Pollution on Pneumococcal Pathogenesis and Transmission. American journal of respiratory and critical care medicine\| PubMed ID: 35649181	2022
Selection of in a murine nasopharyngeal colonization model. Frontiers in cellular and infection microbiology\| PubMed ID: 35992161	2022
Exploiting lung adaptation and phage steering to clear pan-resistant Pseudomonas aeruginosa infections in vivo. Nature communications\| PubMed ID: 38378698	2024
Intranasal administration of DSM 32444 spores: safety and tolerability. Journal of medical microbiology\| PubMed ID: 38963177	2024
Spir2; a novel QTL on chromosome 4 contributes to susceptibility to pneumococcal infection in mice. BMC genomics\| PubMed ID: 23577770	2013
Neutrophil IL-1β processing induced by pneumolysin is mediated by the NLRP3/ASC inflammasome and caspase-1 activation and is dependent on K+ efflux. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 25609842	2015
Bacteriophage Delivery by Nebulization and Efficacy Against Phenotypically Diverse Pseudomonas aeruginosa from Cystic Fibrosis Patients. Journal of aerosol medicine and pulmonary drug delivery\| PubMed ID: 25714328	2015
Airborne dust and high temperatures are risk factors for invasive bacterial disease. The Journal of allergy and clinical immunology\| PubMed ID: 27523432	2017
Redeploying β-Lactam Antibiotics as a Novel Antivirulence Strategy for the Treatment of Methicillin-Resistant Staphylococcus aureus Infections. The Journal of infectious diseases\| PubMed ID: 28077586	2017
Streptolysin O concentration and activity is central to in vivo phenotype and disease outcome in Group A Streptococcus infection. Scientific reports\| PubMed ID: 34561464	2021
Comparative Genomics of Disease and Carriage Serotype 1 Pneumococci. Genome biology and evolution\| PubMed ID: 35439297	2022
Underground railway particulate matter and susceptibility to pneumococcal infection. EBioMedicine\| PubMed ID: 35598440	2022
Pseudomonas aeruginosa utilizes the host-derived polyamine spermidine to facilitate antimicrobial tolerance. JCI insight\| PubMed ID: 36194492	2022
The LytSR two-component regulatory system promotes vaginal colonization and virulence . Microbiology spectrum\| PubMed ID: 39400158	2024