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1Respiratory Infection Group,Liverpool School of Tropical Medicine, 2Royal Liverpool and Broadgreen,University Hospital Trust, 3Comprehensive Local Research Network, 4NIHR Biomedical Research Centre in Microbial Diseases,Royal Liverpool and Broadgreen University Hospitals NHS Trust, 5Institute of Lung Health, Respiratory Biomedical Unit,University Hospitals of Leicester NHS Trust & University of Leicester, 6Department of Clinical Infection Microbiology & Immunology, Institute of Infection & Global Health,University of Liverpool
Chapters
- 00:05Title
- 01:41Inoculum Preparation and Volunteer Inoculation
- 03:41Nasal Wash (NW) Procedure
- 04:35Nasal Wash Processing
- 06:11Results: Representative Pneumococcal Blood Agar Plate Cultures and Reported Symptoms in Pneumococcal Inoculum Recipients
- 07:18Conclusion
Experimental human pneumococcal carriage offers a natural model of carriage and a potential model for use in vaccine development. This technique is valuable yet complex and involves clinical risk by introducing a pathogen into a human. We have developed a detailed protocol.
