Roland Brosch

Pathogenomique Mycobacterienne Integrée, Institut Pasteur, Paris, France

Affiliated withInstitut Pasteur, Paris, France

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 22	2013

Other Publications

Article	Year
Royal Society of Tropical Medicine and Hygiene Meeting at Manson House, London, 18th January 2001. Pathogen genomes and human health. Mycobacterial genomics. Transactions of the Royal Society of Tropical Medicine and Hygiene\| PubMed ID: 11925980	2002
Rapid and simple approach for identification of Mycobacterium tuberculosis complex isolates by PCR-based genomic deletion analysis. Journal of clinical microbiology\| PubMed ID: 12089245	2002
Bacterial artificial chromosome-based comparative genomic analysis identifies Mycobacterium microti as a natural ESAT-6 deletion mutant. Infection and immunity\| PubMed ID: 12228284	2002
Loss of RD1 contributed to the attenuation of the live tuberculosis vaccines Mycobacterium bovis BCG and Mycobacterium microti. Molecular microbiology\| PubMed ID: 12410828	2002
Is Mycobacterium africanum subtype II (Uganda I and Uganda II) a genetically well-defined subspecies of the Mycobacterium tuberculosis complex? Journal of clinical microbiology\| PubMed ID: 12624085	2003
Recombinant BCG exporting ESAT-6 confers enhanced protection against tuberculosis. Nature medicine\| PubMed ID: 12692540	2003
Giant plasmid-encoded polyketide synthases produce the macrolide toxin of Mycobacterium ulcerans. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 14736915	2004
Genotypic analysis of Mycobacterium tuberculosis in Bangladesh and prevalence of the Beijing strain. Journal of clinical microbiology\| PubMed ID: 14766836	2004
Macro-array and bioinformatic analyses reveal mycobacterial 'core' genes, variation in the ESAT-6 gene family and new phylogenetic markers for the Mycobacterium tuberculosis complex. Microbiology (Reading, England)\| PubMed ID: 14766927	2004
Cell envelope protein PPE68 contributes to Mycobacterium tuberculosis RD1 immunogenicity independently of a 10-kilodalton culture filtrate protein and ESAT-6. Infection and immunity\| PubMed ID: 15039340	2004
Enhanced protection against tuberculosis by vaccination with recombinant Mycobacterium microti vaccine that induces T cell immunity against region of difference 1 antigens. The Journal of infectious diseases\| PubMed ID: 15195250	2004
ESAT-6 proteins: protective antigens and virulence factors? Trends in microbiology\| PubMed ID: 15488391	2004
Common evolutionary origin for the unstable virulence plasmid pMUM found in geographically diverse strains of Mycobacterium ulcerans. Journal of bacteriology\| PubMed ID: 15716437	2005
Influence of ESAT-6 secretion system 1 (RD1) of Mycobacterium tuberculosis on the interaction between mycobacteria and the host immune system. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 15749894	2005
Structure and mechanism of the alkyl hydroperoxidase AhpC, a key element of the Mycobacterium tuberculosis defense system against oxidative stress. The Journal of biological chemistry\| PubMed ID: 15886207	2005
Modulation of the host immune response by a transient intracellular stage of Mycobacterium ulcerans: the contribution of endogenous mycolactone toxin. Cellular microbiology\| PubMed ID: 16008585	2005
Functional analysis of early secreted antigenic target-6, the dominant T-cell antigen of Mycobacterium tuberculosis, reveals key residues involved in secretion, complex formation, virulence,... The Journal of biological chemistry\| PubMed ID: 16048998	2005
Tuberculosis: from genome to vaccine. Expert review of vaccines\| PubMed ID: 16117711	2005
Ancient origin and gene mosaicism of the progenitor of Mycobacterium tuberculosis. PLoS pathogens\| PubMed ID: 16201017	2005
Dissection of ESAT-6 system 1 of Mycobacterium tuberculosis and impact on immunogenicity and virulence. Infection and immunity\| PubMed ID: 16368961	2006
Horizontal transfer of a virulence operon to the ancestor of Mycobacterium tuberculosis. Molecular biology and evolution\| PubMed ID: 16520338	2006
"A re-evaluation of M. prototuberculosis": continuing the debate. PLoS pathogens\| PubMed ID: 17009866	2006
Genome plasticity of BCG and impact on vaccine efficacy. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17372194	2007
ESAT-6 from Mycobacterium tuberculosis dissociates from its putative chaperone CFP-10 under acidic conditions and exhibits membrane-lysing activity. Journal of bacteriology\| PubMed ID: 17557817	2007
Cutting-edge science and the future of tuberculosis control. Bulletin of the World Health Organization\| PubMed ID: 17639231	2007
Control of M. tuberculosis ESAT-6 secretion and specific T cell recognition by PhoP. PLoS pathogens\| PubMed ID: 18282096	2008
Insights from the complete genome sequence of Mycobacterium marinum on the evolution of Mycobacterium tuberculosis. Genome research\| PubMed ID: 18403782	2008
Functional analysis of a clonal deletion in an epidemic strain of Mycobacterium bovis reveals a role in lipid metabolism. Microbiology (Reading, England)\| PubMed ID: 19047741	2008
ESX/type VII secretion systems and their role in host-pathogen interaction. Current opinion in microbiology\| PubMed ID: 19155186	2009
Pathogenicity in the tubercle bacillus: molecular and evolutionary determinants. BioEssays : news and reviews in molecular, cellular and developmental biology\| PubMed ID: 19274661	2009
Benzothiazinones kill Mycobacterium tuberculosis by blocking arabinan synthesis. Science (New York, N.Y.)\| PubMed ID: 19299584	2009
Myths and misconceptions: the origin and evolution of Mycobacterium tuberculosis. Nature reviews. Microbiology\| PubMed ID: 19483712	2009
Non mycobacterial virulence genes in the genome of the emerging pathogen Mycobacterium abscessus. PloS one\| PubMed ID: 19543527	2009
Mycobacterial PE, PPE and ESX clusters: novel insights into the secretion of these most unusual protein families. Molecular microbiology\| PubMed ID: 19602151	2009
[A promising new class of antituberculous molecules]. MÃ©decine sciences : M/S\| PubMed ID: 19765374	2009
Systematic genetic nomenclature for type VII secretion systems. PLoS pathogens\| PubMed ID: 19876390	2009
High content screening identifies decaprenyl-phosphoribose 2' epimerase as a target for intracellular antimycobacterial inhibitors. PLoS pathogens\| PubMed ID: 19876393	2009
High content phenotypic cell-based visual screen identifies Mycobacterium tuberculosis acyltrehalose-containing glycolipids involved in phagosome remodeling. PLoS pathogens\| PubMed ID: 20844580	2010
Synthesis, biological activity, and evaluation of the mode of action of novel antitubercular benzofurobenzopyrans substituted on A ring. European journal of medicinal chemistry\| PubMed ID: 20961671	2010
Entrapment of intracytosolic bacteria by septin cage-like structures. Cell host & microbe\| PubMed ID: 21075354	2010
Overexpression of proinflammatory TLR-2-signalling lipoproteins in hypervirulent mycobacterial variants. Cellular microbiology\| PubMed ID: 21143571	2011
ESAT-6 secretion-independent impact of ESX-1 genes espF and espG1 on virulence of Mycobacterium tuberculosis. The Journal of infectious diseases\| PubMed ID: 21196469	2011
Deciphering the role of IS6110 in a highly transmissible Mycobacterium tuberculosis Beijing strain, GC1237. Tuberculosis (Edinburgh, Scotland)\| PubMed ID: 21256084	2011
p62 and NDP52 proteins target intracytosolic Shigella and Listeria to different autophagy pathways. The Journal of biological chemistry\| PubMed ID: 21646350	2011
Activation of the NLRP3 inflammasome by Mycobacterium tuberculosis is uncoupled from susceptibility to active tuberculosis. European journal of immunology\| PubMed ID: 22101787	2012
Phagosomal rupture by Mycobacterium tuberculosis results in toxicity and host cell death. PLoS pathogens\| PubMed ID: 22319448	2012
Disruption of the ESX-5 system of Mycobacterium tuberculosis causes loss of PPE protein secretion, reduction of cell wall integrity and strong attenuation. Molecular microbiology\| PubMed ID: 22340629	2012
Characterization of Mycobacterium orygis as M. tuberculosis complex subspecies. Emerging infectious diseases\| PubMed ID: 22469053	2012
Strong immunogenicity and cross-reactivity of Mycobacterium tuberculosis ESX-5 type VII secretion: encoded PE-PPE proteins predicts vaccine potential. Cell host & microbe\| PubMed ID: 22520463	2012
ESX-1-mediated translocation to the cytosol controls virulence of mycobacteria. Cellular microbiology\| PubMed ID: 22524898	2012
Multidrug-resistant tuberculosis in admitted patients at a tertiary referral hospital of Bangladesh. PloS one\| PubMed ID: 22808189	2012
ESX-1 dependent impairment of autophagic flux by Mycobacterium tuberculosis in human dendritic cells. Autophagy\| PubMed ID: 22885411	2012
The ESX-5 associated eccB-EccC locus is essential for Mycobacterium tuberculosis viability. PloS one\| PubMed ID: 23284869	2012
Genomic analysis of smooth tubercle bacilli provides insights into ancestry and pathoadaptation of Mycobacterium tuberculosis. Nature genetics\| PubMed ID: 23291586	2013
TBCAP; tuberculosis annotation project. Tuberculosis (Edinburgh, Scotland)\| PubMed ID: 23332402	2013