Kezhong Zhang

Department of Neurology, The First Affiliated Hospital with Nanjing Medical University

Affiliated withThe First Affiliated Hospital with Nanjing Medical University Wayne State University

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title	2026
Publication title Cited by 75	2016

Other Publications

Article	Year
Genetic mechanisms of age regulation of protein C and blood coagulation. The Journal of biological chemistry\| PubMed ID: 11719515	2002
New function for age-related stability element in conferring strict tissue-specific expression of human factor IX and protein C genes. Thrombosis and haemostasis\| PubMed ID: 12353089	2002
Limitation in use of heterologous reporter genes for gene promoter analysis. Silencer activity associated with the cloramphenicol acetyltransferase reporter gene. The Journal of biological chemistry\| PubMed ID: 12473656	2003
Bone marrow stromal cells as a genetic platform for systemic delivery of therapeutic proteins in vivo: human factor IX model. The journal of gene medicine\| PubMed ID: 12516047	2003
TDAG51 is induced by homocysteine, promotes detachment-mediated programmed cell death, and contributes to the cevelopment of atherosclerosis in hyperhomocysteinemia. The Journal of biological chemistry\| PubMed ID: 12738777	2003
Unfolding the toxicity of cholesterol. Nature cell biology\| PubMed ID: 12951604	2003
The protein kinase PKR is required for macrophage apoptosis after activation of Toll-like receptor 4. Nature\| PubMed ID: 15029200	2004
Signaling the unfolded protein response from the endoplasmic reticulum. The Journal of biological chemistry\| PubMed ID: 15070890	2004
The unfolded protein response--a stress signaling pathway of the endoplasmic reticulum. Journal of chemical neuroanatomy\| PubMed ID: 15363493	2004
The unfolded protein response sensor IRE1alpha is required at 2 distinct steps in B cell lymphopoiesis. The Journal of clinical investigation\| PubMed ID: 15690081	2005
ER stress signaling by regulated splicing: IRE1/HAC1/XBP1. Methods (San Diego, Calif.)\| PubMed ID: 15804613	2005
The unfolded protein response: a stress signaling pathway critical for health and disease. Neurology\| PubMed ID: 16432136	2006
Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response. Cell\| PubMed ID: 16469704	2006
From endoplasmic-reticulum stress to the inflammatory response. Nature\| PubMed ID: 18650916	2008
Identification and characterization of endoplasmic reticulum stress-induced apoptosis in vivo. Methods in enzymology\| PubMed ID: 18662581	2008
Hepatocyte nuclear factor 4alpha is implicated in endoplasmic reticulum stress-induced acute phase response by regulating expression of cyclic adenosine monophosphate responsive element bind... Hepatology (Baltimore, Md.)\| PubMed ID: 18704925	2008
Association study of semaphorin 5A with risk of Parkinson's disease in a Chinese Han population. Brain research\| PubMed ID: 18950607	2008
Antioxidants reduce endoplasmic reticulum stress and improve protein secretion. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19011102	2008
An age-related homeostasis mechanism is essential for spontaneous amelioration of hemophilia B Leyden. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19416882	2009
Regulation of apoptosis by the unfolded protein response. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 19609758	2009
ER stress controls iron metabolism through induction of hepcidin. Science (New York, N.Y.)\| PubMed ID: 19679815	2009
Endoplasmic reticulum stress response in cancer: molecular mechanism and therapeutic potential. American journal of translational research\| PubMed ID: 20182583	2010
Integration of ER stress, oxidative stress and the inflammatory response in health and disease. International journal of clinical and experimental medicine\| PubMed ID: 20369038	2010
The comparison of clonidine, arginine and both combined: a growth hormone stimulation test to differentiate multiple system atrophy from idiopathic Parkinson's disease. Journal of neurology\| PubMed ID: 20405138	2010
Airborne particulate matter selectively activates endoplasmic reticulum stress response in the lung and liver tissues. American journal of physiology. Cell physiology\| PubMed ID: 20554909	2010
Role of unfolded protein response in lipogenesis. World journal of hepatology\| PubMed ID: 21160998	2010
Measurement of ER stress response and inflammation in the mouse model of nonalcoholic fatty liver disease. Methods in enzymology\| PubMed ID: 21266239	2011
Unfolded protein response in cancer: the physician's perspective. Journal of hematology & oncology\| PubMed ID: 21345215	2011
Real-world exposure of airborne particulate matter triggers oxidative stress in an animal model. International journal of physiology, pathophysiology and pharmacology\| PubMed ID: 21383899	2010
The unfolded protein response transducer IRE1α prevents ER stress-induced hepatic steatosis. The EMBO journal\| PubMed ID: 21407177	2011
Endoplasmic reticulum-tethered transcription factor cAMP responsive element-binding protein, hepatocyte specific, regulates hepatic lipogenesis, fatty acid oxidation, and lipolysis upon meta... Hepatology (Baltimore, Md.)\| PubMed ID: 22095841	2011
Pharmacological ER stress promotes hepatic lipogenesis and lipid droplet formation. American journal of translational research\| PubMed ID: 22347525	2012
Pharmacologic ER stress induces non-alcoholic steatohepatitis in an animal model. Toxicology letters\| PubMed ID: 22414386	2012
Endoplasmic Reticulum Stress-Associated Lipid Droplet Formation and Type II Diabetes. Biochemistry research international\| PubMed ID: 22506114	2012
ERLIN2 promotes breast cancer cell survival by modulating endoplasmic reticulum stress pathways. BMC cancer\| PubMed ID: 22681620	2012
Endoplasmic reticulum factor ERLIN2 regulates cytosolic lipid content in cancer cells. The Biochemical journal\| PubMed ID: 22690709	2012
Endoplasmic reticulum stress and lipid metabolism. Biochemistry research international\| PubMed ID: 22778961	2012
Exposure to ambient particulate matter induces a NASH-like phenotype and impairs hepatic glucose metabolism in an animal model. Journal of hepatology\| PubMed ID: 22902548	2013
Genomic amplification and a role in drug-resistance for the KDM5A histone demethylase in breast cancer. American journal of translational research\| PubMed ID: 22937203	2012
Aquaporin-assisted and ER-mediated mitochondrial fission: a hypothesis. Micron (Oxford, England : 1993)\| PubMed ID: 23416165	2013
Exposure to fine airborne particulate matter induces macrophage infiltration, unfolded protein response, and lipid deposition in white adipose tissue. American journal of translational research\| PubMed ID: 23573366	2013
The association between glycogen synthase kinase 3 beta (GSK3-Î²) polymorphisms and Parkinson's disease susceptibility: A meta-analysis. Gene\| PubMed ID: 23628795	2013
Toll-like receptor-mediated IRE1α activation as a therapeutic target for inflammatory arthritis. The EMBO journal\| PubMed ID: 23942232	2013
The serine-threonine kinase Inositol-requiring enzyme 1 Î± (IRE1Î±) promotes IL-4 production in T helper cells. The Journal of biological chemistry\| PubMed ID: 24100031	2013
Diabetes mellitus is associated with hepatocellular carcinoma: a retrospective case-control study in hepatitis endemic area. PloS one\| PubMed ID: 24386416	2013
Liver-enriched transcription factor CREBH interacts with peroxisome proliferator-activated receptor α to regulate metabolic hormone FGF21. Endocrinology\| PubMed ID: 24424044	2014
Elevated systemic expression of ER stress related genes is associated with stress-related mental disorders in the Detroit Neighborhood Health Study. Psychoneuroendocrinology\| PubMed ID: 24703171	2014
Hepatic mitochondrial and ER stress induced by defective PPARα signaling in the pathogenesis of hepatic steatosis. American journal of physiology. Endocrinology and metabolism\| PubMed ID: 24735884	2014
Correlations between plasma levels of amino acids and nonmotor symptoms in Parkinson's disease. Journal of neural transmission (Vienna, Austria : 1996)\| PubMed ID: 25059457	2015
PM2.5 in Beijing - temporal pattern and its association with influenza. Environmental health : a global access science source\| PubMed ID: 25471661	2014
Proteomics analysis of rough endoplasmic reticulum in pancreatic beta cells. Proteomics\| PubMed ID: 25546123	2015
Endoplasmic reticulum stress response and transcriptional reprogramming. Frontiers in genetics\| PubMed ID: 25709614	2014
Cross talk between ER stress, oxidative stress, and inflammation in health and disease. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 25804758	2015
Genome-wide identification, evolutionary, and expression analyses of histone H3 variants in plants. BioMed research international\| PubMed ID: 25815311	2015
SMAD3 deficiency promotes vessel wall remodeling, collagen fiber reorganization and leukocyte infiltration in an inflammatory abdominal aortic aneurysm mouse model. Scientific reports\| PubMed ID: 25985281	2015
Reduced plasma taurine level in Parkinson's disease: association with motor severity and levodopa treatment. The International journal of neuroscience\| PubMed ID: 26004911	2016
Plasma antioxidant status and motor features in de novo Chinese Parkinson's disease patients. The International journal of neuroscience\| PubMed ID: 26010212	2016
Reduced plasma serotonin and 5-hydroxyindoleacetic acid levels in Parkinson's disease are associated with nonmotor symptoms. Parkinsonism & related disorders\| PubMed ID: 26028271	2015
Petroleum coke in the urban environment: a review of potential health effects. International journal of environmental research and public health\| PubMed ID: 26035666	2015
COPII-Dependent ER Export: A Critical Component of Insulin Biogenesis and β-Cell ER Homeostasis. Molecular endocrinology (Baltimore, Md.)\| PubMed ID: 26083833	2015
Exposure to fine airborne particulate matters induces hepatic fibrosis in murine models. Journal of hepatology\| PubMed ID: 26220751	2015
Lysine Acetylation of CREBH Regulates Fasting-Induced Hepatic Lipid Metabolism. Molecular and cellular biology\| PubMed ID: 26438600	2015
Regional homogeneity alterations differentiate between tremor dominant and postural instability gait difficulty subtypes of Parkinson's disease. Journal of neural transmission (Vienna, Austria : 1996)\| PubMed ID: 26666253	2016
[Study on changes of plasma levels of oxidative stress biomarkers and its relation with cognition function in patients with parkinson's disease]. Zhonghua yi xue za zhi\| PubMed ID: 26812976	2015
Microarray analysis of microRNA expression in bone marrow-derived progenitor cells from mice with type 2 diabetes. Genomics data\| PubMed ID: 26981370	2016
Alterations of functional and structural connectivity of freezing of gait in Parkinson's disease. Journal of neurology\| PubMed ID: 27230857	2016
A novel ER-microtubule-binding protein, ERLIN2, stabilizes Cyclin B1 and regulates cell cycle progression. Cell discovery\| PubMed ID: 27462423	2015
Nogo-B receptor deficiency increases liver X receptor alpha nuclear translocation and hepatic lipogenesis through an adenosine monophosphate-activated protein kinase alpha-dependent pathway. Hepatology (Baltimore, Md.)\| PubMed ID: 27480224	2016
CREBH Couples Circadian Clock With Hepatic Lipid Metabolism. Diabetes\| PubMed ID: 27507854	2016
COX7AR is a Stress-inducible Mitochondrial COX Subunit that Promotes Breast Cancer Malignancy. Scientific reports\| PubMed ID: 27550821	2016
Endoplasmic reticulum-resident E3 ubiquitin ligase Hrd1 controls B-cell immunity through degradation of the death receptor CD95/Fas. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 27573825	2016
Glucagon regulates hepatic lipid metabolism via cAMP and Insig-2 signaling: implication for the pathogenesis of hypertriglyceridemia and hepatic steatosis. Scientific reports\| PubMed ID: 27582413	2016
Inositol Requiring Enzyme 1 Facilitates Diabetic Wound Healing through Modulating microRNAs. Diabetes\| PubMed ID: 27634225	2016
Toll-like Receptor (TLR) Signaling Interacts with CREBH to Modulate High-density Lipoprotein (HDL) in Response to Bacterial Endotoxin. The Journal of biological chemistry\| PubMed ID: 27637329	2016
Relationship between the plasma levels of neurodegenerative proteins and motor subtypes of Parkinson's disease. Journal of neural transmission (Vienna, Austria : 1996)\| PubMed ID: 27878377	2016
ER Stress-induced Inflammasome Activation Contributes to Hepatic Inflammation and Steatosis. Journal of clinical & cellular immunology\| PubMed ID: 27942420	2016