Alan N. Schechter

Molecular Medicine Branch, National Institutes of Health

Affiliated withNational Institutes of Health

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 2	2019

Other Publications

Article	Year
An immunologic approach to the conformational equilibria of polypeptides. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 4118873	1972
Folding of staphylococcal nuclease: magnetic resonance and fluorescence studies of individual residues. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 4332245	1971
The active site of staphylococcal nuclease: paramagnetic relaxation of bound nucleotide inhibitor nuclei by lanthanide ions. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 4528015	1974
Inhaled nitric oxide augments nitric oxide transport on sickle cell hemoglobin without affecting oxygen affinity. The Journal of clinical investigation\| PubMed ID: 10510334	1999
Relative role of heme nitrosylation and beta-cysteine 93 nitrosation in the transport and metabolism of nitric oxide by hemoglobin in the human circulation. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 10954746	2000
Role of circulating nitrite and S-nitrosohemoglobin in the regulation of regional blood flow in humans. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 11027349	2000
Quantitative analysis of globin gene induction in single human erythroleukemic cells. Nucleic acids research\| PubMed ID: 11121491	2000
Prematurity in gene therapy. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 11863409	2002
S-Nitrosohemoglobin is unstable in the reductive erythrocyte environment and lacks O2/NO-linked allosteric function. The Journal of biological chemistry\| PubMed ID: 12023289	2002
Sickle Hb polymerization in RBC components from donors with sickle cell trait prevents effective WBC reduction by filtration. Transfusion\| PubMed ID: 12421220	2002
Cell-free hemoglobin limits nitric oxide bioavailability in sickle-cell disease. Nature medicine\| PubMed ID: 12426562	2002
Hydroxyurea induces fetal hemoglobin by the nitric oxide-dependent activation of soluble guanylyl cyclase. The Journal of clinical investigation\| PubMed ID: 12531879	2003
Divergent nitric oxide bioavailability in men and women with sickle cell disease. Circulation\| PubMed ID: 12538427	2003
Red blood cell magnetophoresis. Biophysical journal\| PubMed ID: 12668472	2003
Hemoglobin and the paracrine and endocrine functions of nitric oxide. The New England journal of medicine\| PubMed ID: 12686706	2003
Nitric oxide's reactions with hemoglobin: a view through the SNO-storm. Nature medicine\| PubMed ID: 12724752	2003
Identification and characterization of mechanistically distinct inducers of gamma-globin transcription. Biochemical pharmacology\| PubMed ID: 14563486	2003
Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation. Nature medicine\| PubMed ID: 14595407	2003
Pulmonary hypertension as a risk factor for death in patients with sickle cell disease. The New England journal of medicine\| PubMed ID: 14985486	2004
Erythropoietin and hypoxia stimulate erythropoietin receptor and nitric oxide production by endothelial cells. Blood\| PubMed ID: 15205261	2004
Increasing hemoglobin oxygen saturation levels in sickle trait donor whole blood prevents hemoglobin S polymerization and allows effective white blood cell reduction by filtration. Transfusion\| PubMed ID: 15318851	2004
Linderstrom-Lang-Schellman's model for protein stabilization revisited. Current protein & peptide science\| PubMed ID: 15320734	2004
Inhaled nebulized nitrite is a hypoxia-sensitive NO-dependent selective pulmonary vasodilator. Nature medicine\| PubMed ID: 15361865	2004
Why is revitalizing clinical research so important, yet so difficult? Perspectives in biology and medicine\| PubMed ID: 15467172	2004
Erythrocytes are the major intravascular storage sites of nitrite in human blood. Blood\| PubMed ID: 15774613	2005
Hypoxia, red blood cells, and nitrite regulate NO-dependent hypoxic vasodilation. Blood\| PubMed ID: 16195332	2006
The emerging biology of the nitrite anion. Nature chemical biology\| PubMed ID: 16408064	2005
Fetal hemoglobin silencing in humans. Blood\| PubMed ID: 16735596	2006
The measurement of blood and plasma nitrite by chemiluminescence: pitfalls and solutions. Free radical biology & medicine\| PubMed ID: 16863986	2006
Hemolysis in sickle cell mice causes pulmonary hypertension due to global impairment in nitric oxide bioavailability. Blood\| PubMed ID: 17158223	2007
Randomization in clinical trials of titrated therapies: unintended consequences of using fixed treatment protocols. Critical care medicine\| PubMed ID: 17440420	2007
Nitrite infusion in humans and nonhuman primates: endocrine effects, pharmacokinetics, and tolerance formation. Circulation\| PubMed ID: 17893272	2007
Nitric oxide from nitrite reduction by hemoglobin in the plasma and erythrocytes. Nitric oxide : biology and chemistry\| PubMed ID: 17964300	2008
Hydroxyurea nitrosylates and activates soluble guanylyl cyclase in human erythroid cells. Blood\| PubMed ID: 17993617	2008
The reaction between nitrite and oxyhemoglobin: a mechanistic study. The Journal of biological chemistry\| PubMed ID: 18203719	2008
Oxidation of iron-nitrosyl-hemoglobin by dehydroascorbic acid releases nitric oxide to form nitrite in human erythrocytes. Biochemistry\| PubMed ID: 18225862	2008
Hemoglobin research and the origins of molecular medicine. Blood\| PubMed ID: 18988877	2008
The reaction of cell-free oxyhemoglobin with nitrite under physiologically relevant conditions: Implications for nitrite-based therapies. Nitric oxide : biology and chemistry\| PubMed ID: 19010434	2009
Evidence-based medicine again. Perspectives in biology and medicine\| PubMed ID: 19395816	2009
Stimulated stromal cells induce gamma-globin gene expression in erythroid cells via nitric oxide production. Experimental hematology\| PubMed ID: 19576950	2009
Translational medicine--doing it backwards. Journal of translational medicine\| PubMed ID: 20132543	2010
Measurement of nitrite in blood samples using the ferricyanide-based hemoglobin oxidation assay. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 21161628	2011
Erythropoietin and hypoxia increase erythropoietin receptor and nitric oxide levels in lung microvascular endothelial cells. Cytokine\| PubMed ID: 21324713	2011
Acute erythropoietin cardioprotection is mediated by endothelial response. Basic research in cardiology\| PubMed ID: 21347618	2011
Dietary nitrite and nitrate: a review of potential mechanisms of cardiovascular benefits. European journal of nutrition\| PubMed ID: 21626413	2011
Platelet inhibition by nitrite is dependent on erythrocytes and deoxygenation. PloS one\| PubMed ID: 22276188	2012
Inorganic nitrate: a major player in the cardiovascular health benefits of vegetables? Nutrition reviews\| PubMed ID: 22646129	2012
JAK-STAT and AKT pathway-coupled genes in erythroid progenitor cells through ontogeny. Journal of translational medicine\| PubMed ID: 22676255	2012
Effect of storage on levels of nitric oxide metabolites in platelet preparations. Transfusion\| PubMed ID: 22804724	2013
Angeli's salt counteracts the vasoactive effects of elevated plasma hemoglobin. Free radical biology & medicine\| PubMed ID: 23099417	2012
Comments on 'vascular effects of dietary nitrate (as found in green leafy vegetables and beetroot) via the nitrate-nitrite-nitric oxide pathway'. British journal of clinical pharmacology\| PubMed ID: 23163510	2013
Effect of blood nitrite and nitrate levels on murine platelet function. PloS one\| PubMed ID: 23383344	2013
Globin gene expression in correlation with G protein-related genes during erythroid differentiation. BMC genomics\| PubMed ID: 23425329	2013
In vivo reduction of cell-free methemoglobin to oxyhemoglobin results in vasoconstriction in canines. Transfusion\| PubMed ID: 23488474	2013
Increased reticulocytosis during infancy is associated with increased hospitalizations in sickle cell anemia patients during the first three years of life. PloS one\| PubMed ID: 23951011	2013
Effect of storage levels of nitric oxide derivatives in blood components. F1000Research\| PubMed ID: 24358838	2012
A flow cytometric analysis of the inhibition of platelet reactivity due to nitrite reduction by deoxygenated erythrocytes. PloS one\| PubMed ID: 24642865	2014
Inhibitory effect of nitrite on coagulation processes demonstrated by thrombelastography. Nitric oxide : biology and chemistry\| PubMed ID: 24858214	2014
Nitrate reduction to nitrite, nitric oxide and ammonia by gut bacteria under physiological conditions. PloS one\| PubMed ID: 25803049	2015
Construction of effective disposable biosensors for point of care testing of nitrite. Talanta\| PubMed ID: 26003719	2015
Microarray and Proteomic Analyses of Myeloproliferative Neoplasms with a Highlight on the mTOR Signaling Pathway. PloS one\| PubMed ID: 26275051	2015
Nitrate as a source of nitrite and nitric oxide during exercise hyperemia in rat skeletal muscle. Nitric oxide : biology and chemistry\| PubMed ID: 27000467	2016
Tempol improves xanthine oxidoreductase-mediated vascular responses to nitrite in experimental renovascular hypertension. Redox biology\| PubMed ID: 27078869	2016
Angiogenic factors are increased in circulating granulocytes and CD34(+) cells of myeloproliferative neoplasms. Molecular carcinogenesis\| PubMed ID: 27341002	2016
Acid Test for Nitrite Pharmacology. Hypertension (Dallas, Tex. : 1979)\| PubMed ID: 27802420	2017
Skeletal and myocardial microvascular blood flow in hydroxycarbamide-treated patients with sickle cell disease. British journal of haematology\| PubMed ID: 28880374	2017
Central sensitization associated with low fetal hemoglobin levels in adults with sickle cell anemia. Scandinavian journal of pain\| PubMed ID: 28969994	2017
Effect of dietary nitrate levels on nitrate fluxes in rat skeletal muscle and liver. Nitric oxide : biology and chemistry\| PubMed ID: 29378248	2018
Phosphorylated vasodilator-stimulated phosphoprotein (P-VASPSer239) in platelets is increased by nitrite and partially deoxygenated erythrocytes. PloS one\| PubMed ID: 29505609	2018
Decreased nitrite reductase activity of deoxyhemoglobin correlates with platelet activation in hemoglobin E/ß-thalassemia subjects. PloS one\| PubMed ID: 30235277	2018
Airlie House legend. American journal of hematology\| PubMed ID: 30242871	2018
Compensatory mechanisms in myoglobin deficient mice preserve NO homeostasis. Nitric oxide : biology and chemistry\| PubMed ID: 31173908	2019
Inhaled nebulized nitrite and nitrate therapy in a canine model of hypoxia-induced pulmonary hypertension. Nitric oxide : biology and chemistry\| PubMed ID: 31299340	2019
Human skeletal muscle nitrate store: influence of dietary nitrate supplementation and exercise. The Journal of physiology\| PubMed ID: 31350908	2019
Nitrate uptake and metabolism in human skeletal muscle cell cultures. Nitric oxide : biology and chemistry\| PubMed ID: 31604144	2020
Potential roles of nitrate and nitrite in nitric oxide metabolism in the eye. Scientific reports\| PubMed ID: 32759980	2020
Control of rat muscle nitrate levels after perturbation of steady state dietary nitrate intake. Nitric oxide : biology and chemistry\| PubMed ID: 33713800	2021
Skeletal Muscle Nitrate as a Regulator of Systemic Nitric Oxide Homeostasis. Exercise and sport sciences reviews\| PubMed ID: 34669624	2022
Time course of human skeletal muscle nitrate and nitrite concentration changes following dietary nitrate ingestion. Nitric oxide : biology and chemistry\| PubMed ID: 35032643	2022
Human skeletal muscle nitrate and nitrite in individuals with peripheral arterial disease: Effect of inorganic nitrate supplementation and exercise. Physiological reports\| PubMed ID: 36461652	2022
N-labeled dietary nitrate supplementation increases human skeletal muscle nitrate concentration and improves muscle torque production. Acta physiologica (Oxford, England)\| PubMed ID: 36606507	2023
Distribution of dietary nitrate and its metabolites in rat tissues after N-labeled nitrate administration. Scientific reports\| PubMed ID: 36859526	2023
Nitrate and Nitrite Metabolism in Aging Rats: A Comparative Study. Nutrients\| PubMed ID: 37299453	2023
Dietary Nitrate Metabolism in Porcine Ocular Tissues Determined Using N-Labeled Sodium Nitrate Supplementation. Nutrients\| PubMed ID: 38674845	2024
High nitrate levels in skeletal muscle contribute to nitric oxide generation via a nitrate/nitrite reductive pathway in mice that lack the nNOS enzyme. Frontiers in physiology\| PubMed ID: 38784116	2024
Skeletal Muscle, Skin, and Bone as Three Major Nitrate Reservoirs in Mammals: Chemiluminescence and N-Tracer Studies in Yorkshire Pigs. Nutrients\| PubMed ID: 39203815	2024
Effects of low and high dietary nitrate intake on human saliva, plasma and skeletal muscle nitrate and nitrite concentrations and their functional consequences. Free radical biology & medicine\| PubMed ID: 39401733	2024
Hydroxyurea inhibits proliferation and stimulates apoptosis through inducible nitric oxide synthase in erythroid cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie\| PubMed ID: 39615166	2024
Sickle cell anaemia therapy in 2025. British journal of haematology\| PubMed ID: 39710962	2025
Nitrate as Warden of Nitric Oxide Homeostasis in Mammals. Nutrients\| PubMed ID: 40362853	2025