Hui Feng

Departments of Pharmacology and Medicine, Boston University School of Medicine

Affiliated withBoston University School of Medicine The Cancer Research Center, Boston University School of Medicine

Research Area

Biography

Trained as a physician and cancer biologist, Dr. Feng has applied the zebrafish as a model to study MYC-driven cancers over seventeen years. Her laboratory at Boston University (www.bu.edu/zgct) utilizes multiple zebrafish models of cancer to gain mechanistic insights into MYC-mediated oncogenic pathways and identify novel therapeutic targets for MYC-driven cancers.

JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 5	2020
Publication title	2026

Other Publications

Article	Year
BCL2-specific inhibitor ABT-199 synergizes strongly with cytarabine against the early immature LOUCY cell line but not more-differentiated T-ALL cell lines. Leukemia\| PubMed ID: 24342948	2014
Loss of function tp53 mutations do not accelerate the onset of myc-induced T-cell acute lymphoblastic leukaemia in the zebrafish. British journal of haematology\| PubMed ID: 24690081	2014
The c-Cbl ubiquitin ligase regulates nuclear β-catenin and angiogenesis by its tyrosine phosphorylation mediated through the Wnt signaling pathway. The Journal of biological chemistry\| PubMed ID: 25784557	2015
Hypoxia-induced expression of phosducin-like 3 regulates expression of VEGFR-2 and promotes angiogenesis. Angiogenesis\| PubMed ID: 26059764	2015
Efficient transgenesis mediated by pigmentation rescue in zebrafish. BioTechniques\| PubMed ID: 26757807	2016
Zebrafish Models of Human Leukemia: Technological Advances and Mechanistic Insights. Advances in experimental medicine and biology\| PubMed ID: 27165361	2016
CK2 inhibitor CX-4945 destabilizes NOTCH1 and synergizes with JQ1 against human T-acute lymphoblastic leukemic cells. Haematologica\| PubMed ID: 27758824	2017
Aberrant activation of the GIMAP enhancer by oncogenic transcription factors in T-cell acute lymphoblastic leukemia. Leukemia\| PubMed ID: 28028313	2017
Zebrafish B Cell Development without a Pre-B Cell Stage, Revealed by CD79 Fluorescence Reporter Transgenes. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 28739882	2017
The emerging role and targetability of the TCA cycle in cancer metabolism. Protein & cell\| PubMed ID: 28748451	2018
Towards Resolving the Pro- and Anti-Tumor Effects of the Aryl Hydrocarbon Receptor. International journal of molecular sciences\| PubMed ID: 29735912	2018
UFD1 contributes to MYC-mediated leukemia aggressiveness through suppression of the proapoptotic unfolded protein response. Leukemia\| PubMed ID: 29743725	2018
Functional and genomic analyses reveal therapeutic potential of targeting β-catenin/CBP activity in head and neck cancer. Genome medicine\| PubMed ID: 30029671	2018
SHQ1 regulation of RNA splicing is required for T-lymphoblastic leukemia cell survival. Nature communications\| PubMed ID: 30323192	2018
Data on ultrabright fluorescent cellulose acetate nanoparticles for imaging tumors through systemic and topical applications. Data in brief\| PubMed ID: 30596135	2019
Ultrabright fluorescent cellulose acetate nanoparticles for imaging tumors through systemic and topical applications. Materials today (Kidlington, England)\| PubMed ID: 31057328	2019
Promoter demethylation of the asparagine synthetase gene is required for ATF4-dependent adaptation to asparagine depletion. The Journal of biological chemistry\| PubMed ID: 31659118	2019
Glutamine Anabolism Plays a Critical Role in Pancreatic Cancer by Coupling Carbon and Nitrogen Metabolism. Cell reports\| PubMed ID: 31665640	2019
Targeting RICTOR Sensitizes SMAD4-Negative Colon Cancer to Irinotecan. Molecular cancer research : MCR\| PubMed ID: 31932471	2020
Direct Phosphorylation and Stabilization of MYC by Aurora B Kinase Promote T-cell Leukemogenesis. Cancer cell\| PubMed ID: 32049046	2020
Cross organelle stress response disruption promotes gentamicin-induced proteotoxicity. Cell death & disease\| PubMed ID: 32245975	2020
Integrated transcriptome and metabolome analysis reveals the regulation of phlorizin synthesis in Lithocarpus polystachyus under nitrogen fertilization. BMC plant biology\| PubMed ID: 38711037	2024