murine-surgical-model-topical-elastase-induced-descending-thoracic

Murine Surgical Model of Topical Elastase Induced Descending Thoracic Aortic Aneurysm

According to the Center for Disease Control, aortic aneurysms (AAs) were considered a leading cause of death in all races and both sexes from 1999-2016. ...

University of Florida

Tamsulosin, an α-adrenergic receptor inhibitor, is prescribed to treat benign prostatic hyperplasia in men >60 years of age, the same demographic most susceptible to abdominal aortic aneurysm. The goal of this study was to investigate the effect of tamsulosin on abdominal aortic aneurysm pathogenesis.

Tamsulosin attenuates abdominal aortic aneurysm growth.

Resolvins have been shown to attenuate inflammation, whereas NETosis, the process of neutrophils releasing neutrophil extracellular traps (NETs), produces increased inflammation. It is hypothesized that treatment of animals with resolvin D1 (RvD1) would reduce abdominal aortic aneurysm (AAA) formation by inhibiting NETosis.

Resolvin D1 decreases abdominal aortic aneurysm formation by inhibiting NETosis in a mouse model.

Few large-animal models exist for the study of aortic aneurysms. β-Aminopropionitrile (BAPN) is a compound known to cause aortic aneurysms by inhibiting lysyl oxidase, a collagen cross-linking enzyme. It is hypothesized that BAPN plus aneurysm induction surgery would result in significant aneurysm formation in swine with biologic properties similar to human disease.

A novel swine model of abdominal aortic aneurysm.

Male gender is a well-established risk factor for abdominal aortic aneurysm (AAA), whereas estrogen is hypothesized to play a protective role. Although rupture rates are higher in women, these reasons remain unknown. In the present study, we sought to determine if female mice are protected from AAA rupture.

Article	Year
Tamsulosin attenuates abdominal aortic aneurysm growth. Surgery\| PubMed ID: 30174141	2018
Resolvin D1 decreases abdominal aortic aneurysm formation by inhibiting NETosis in a mouse model. Journal of vascular surgery\| PubMed ID: 30470363	2018
A novel swine model of abdominal aortic aneurysm. Journal of vascular surgery\| PubMed ID: 30591288	2019
Female Mice Exhibit Abdominal Aortic Aneurysm Protection in an Established Rupture Model. The Journal of surgical research\| PubMed ID: 31699539	2019

Guanyi Lu

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