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Murine Surgical Model of Topical Elastase Induced Descending Thoracic Aortic Aneurysm
 

Murine Surgical Model of Topical Elastase Induced Descending Thoracic Aortic Aneurysm

Article DOI: 10.3791/60105
August 24th, 2019

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Summary August 24th, 2019

We describe a surgical protocol to consistently induce robust descending thoracic aortic aneurysms in mice. The procedure involves left thoracotomy, thoracic aorta exposure, and placement of a sponge soaked in porcine pancreatic elastase on the aortic wall.

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